• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.45 no.5
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• pp.267-275
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• 2019

Objectives: Metastasis in oral squamous cell carcinoma (OSCC) can occur in a variety of ways, and draining lymphatics and lymph nodes serve as a common route. Prior to metastasis, lymph nodes elicit an immune response to either wall off or create a favorable environment for homing of tumor cells. This immune response to tumor stimuli is visualized by recognizing various immunoreactive patterns exhibited by the lymph node. The present study aims to evaluate the role of immuno-morphologic patterns of the lymph node in neck dissection for cases of OSCC. Materials and Methods: Our retrospective study included 50 neck dissection cases of OSCC and a total of 1,078 lymph nodes. The grades of primary tumors with eight different immunoreactive patterns were compared. Vascularity and metastasis in lymph nodes were also evaluated. Results: The lymphocyte predominant pattern was the most common immunoreactive pattern found in 396 of 1,078 lymph nodes. Patterns of lymphocyte predominant (P=0.0005), sinus histiocytosis (P=0.0500), paracortical hyperplasia (P=0.0001), cortical hyperplasia (P=0.0001), and increased vascularity (P=0.0190) were significantly associated with tumor grade. Conclusion: The present study adds to the understanding of lymph node immunoreactivity patterns and their correlation with tumor grade. We recommend further study of lymph node patterns for all sentinel lymph node biopsies and routine neck dissections for OSCCs.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.8
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• pp.3361-3363
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• 2015

Background: Despite the majority of papillary thyroid microcarcinoma (PTMC) patients having an excellent prognosis, cervical lymph node metastases are common. The purpose of this study was to investigate the incidence and the predictive risk factors for occult central compartment lymph node metastasis (CLNM) in PTMC patients. Materials and Methods: 178 patients with clinically node-negative (cN0) PTMC undergoing prophylactic central compartment neck dissection in our hospital from January 2008 to Jun 2010 were enrolled. The relationship between CLNM and the clinical and pathological factors such as gender, age, tumor size, tumor number, tumor location, extracapsular spread (ECS), and coexistance of chronic lymphocytic thyroiditis was analyzed. Results: Occult CLNM was observed in 41% (73/178) of PTMC patients. Multivariate analysis showed that male gender, tumor size (${\geq}6mm$) and ECS were independent variables predictive of CLNM in PTMC patients. Conclusions: Male gender, tumor size (${\geq}6mm$) and ECS were risk factors of CLNM. We recommend a prophylactic central lymph node dissection (CLND) should be considered in PTMC patients with such risk factors.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.4
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• pp.1327-1330
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• 2015

Background: Squamous cell carcinoma (SCC) is the most common cancer in the oral area. Matrix metalloproteinases (MMPs) and especially MMP-2 and MMP-9 are increased in malignancy and lymph node involvement in oral SCCs. We aimed to evaluate the serum levels of MMP-2 and MMP-9 in patients with oral SCC compared to normal subjects and their relation with clinicopathological findings. Materials and Methods: In this case control study, 20 patients with oral SCC and 20 healthy subjects were included and serum levels of MMP-2 and MMP-9 were compared between groups. Also, the correlation between these markers with clinicopathological findings including grade (T) and node (N) were evaluated. Results: Patients with oral SCC had significantly higher serum levels of MMP-2 (p=0.01) and MMP-9 (p<0.001) compared to healthy subjects. With increase in grade T, MMP-2 was significantly increased (p=0.001), but in the MMP-9 case this was not significant (p=0.27). The levels of MMP-2 (p=0.002) and MMP-9 (p=0.01) in cases with lymph node involvement and that of MMP-2 in subjects with smoking history (p=0.001) were significantly high. There was significantly positive correlation between MMP-2 with grade T tumor (r=0.598, p=0.005), lymph node involvement (r=0.737, p<0.001) and smoking (r=0.674, p=0.001) and also between MMP-9 and lymph node involvement (r=0.474, p=0.03). Conclusions: Both markers are significantly increased in oral SCC compared to healthy subjects. However, MMP-2 was better for evaluating lymph node involvement and tumor grade.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.28 no.2
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• pp.155-160
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• 2002

Oral squamous cell carcinoma (OSCC), the most common head and neck cancer, shows poor prognosis as a result of frequent local invasion and lymph node metastasis that is mediated by multiple proteolytic enzymes and angiogenesis. In recent reports, angiogenesis is known to play an important role in tumor invasion and metastasis. The purpose of this study was to determine the role of angiogenesis in OSCCs, particularly with respect to the invasive and the metastatic potential. The microvessel density (CD31) in 34 human OSCC cases were investigated by immunohistochemistry, and reviewed with respect to the invasiveness and the presence of lymph node metastasis and following results were obtained. The blood vessel density $(28.8{\pm}7.9)$ in the strong invasive cases were significantly higher than those $(23.3{\pm}6.9)$ in the weak invasive cases. (p<0.05) In the 14 cases with lymph node metastasis, the average blood vessel density was $28.5{\pm}9.6$. On the other hand, in the 20 cases without lymph node metastasis, the blood vessel density was $25.2{\pm}6.4$. The blood vessel density was not statistically related to lymph node metastasis. (p>0.05) These results suggest that angiogenesis may be related to the local invasion of OSCC and further research will be needed to investigate the possibility that antiangiogenic agent can be used as an anticancer agent for OSCC.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.17 no.6
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• pp.595-603
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• 1992

It has been establisued that the reliability of communication networks is NP hard problem owing to computationally and complexity as the number of componeuts is Increased in large networks. This paper proposed an algorithm for determining upper and lower bounds In the reliability of source-to-terminal in communication networks to solve this problem. The evaluation method follows the next procedures. First, minimal pathset and minimal cut set are serched. Second, it is sorted that the number of components is the same events and the reliability bounds Is evaluated by the section function to extract common variable. The performance of proposed algorithm is also estimate(1 as compared to the reliability of Esary-Proschan, Shogan and Copal.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.29 no.12B
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• pp.1037-1041
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• 2004

In this paper we propose a new conceptual slave clock system in which remotely located clock is synchronized to the reference clock by intermediation of the satellite time, show a probability of adoption to real network by experiments. This new proposed method has lots of structural advantages over the existing methods because all of the node clocks can be maintained with the same hierarchical quality. The measurement results show that the accuracy of the experimental slave clock system can be kept within a few parts in 1012 and that the MTIE (Maximum Time Interval Error) meets the ITU-T Recommendation G.811 for the primary reference clock A prototype system having fully automatic operational functions has been realized, and it is expected to be commercially used as a node clock for synchronization in the digital communication network in the near future.

• Tuberculosis and Respiratory Diseases
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• v.60 no.6
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• pp.684-689
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• 2006

Uterine cervical cancer is the $5^{th}$ most common malignancy in Korean women. With the development of new diagnostic and therapeutic modalities, earlier stage cancers are being diagnosed with longer survival rates being anticipated. Accordingly, recurrent cancers are being encountered more often in clinical practice. Most recurrent uterine cervical cancer patients, have intra-pelvic lesions and adjacent lymph node involvement, while a distant metastasis alone is extremely rare. A mediastinal recurrence of uterine cervical cancer is not common with most manifesting as small lymph node enlargements. We report a case of a 46-year-old woman with recurrent uterine cervical cancer presenting only as a huge mediastinal mass without a local recurrence.

• Korean Journal of Bronchoesophagology
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• v.6 no.1
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• pp.21-28
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• 2000

Background:Subacute necrotizing lymphadenitis or Kikuchi's disease is unknown ethiology and self-limiting process. This disease predominantly affects young women age but rarely affects pediatrics, and usually manifests as lymphadenopathy and fever. Even though this disease is self-limited, benign process, many cases are misidentified as malignant lymphoma. The purpose of this study is to report the clinicopathologic finding, radiological finding and many labolatory test and to compare with characteristics of adult patients in this disease. Meterial and Methods:We reviewed 27 pediarics patients with subacute necrotizing lymphadenitis by excision biopsy or fineneedle aspiration cytology.Result:The most common symptomes were palpation of cervical lymh node(88.9%) and fever(66.7%). The common site of the involvement was cervical lymph node. The multiple involvement was 93% and bilateral involvement was 59%. Leukopenia(52%) and elevated erythrocyte sedimentation rates(93%) appeared in abnormal laboratory data. Microscopically, the characteristic finding was the wide area of florid nuclear dusts engulfed by histiocytes and well-circumscrbed area with eosinophilic fibrinoid material. There was a striking degree ofkaryorrhexis and an absence of granulocyte with paucity of plasma cell. All patients recovered with the conservative treatment and there was no specific complication and recurrence. Conclusion : We reviewed pediatric patients with this disease. Characteristics of this disease inpediatric patients were similar to adult patients.

• Journal of Communications and Networks
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• v.14 no.1
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• pp.51-62
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• 2012

The exponential growth in wireless services has resulted in an overly crowded spectrum. The current state of spectrum allocation indicates that most usable frequencies have already been occupied. This makes one pessimistic about the feasibility of integrating emerging wireless services such as large-scale sensor networks into the existing communication infrastructure. Cognitive radio is an emerging dynamic spectrum access technology that can be used for flexibly and efficiently achieving open spectrum sharing. Cognitive radio is an intelligent wireless communication system that is aware of its radio environment and that is capable of adapting its operation to statistical variations of the radio frequency. In ad hoc cognitive radio networks, a common control channel (CCC) is usually used for supporting transmission coordination and spectrum-related information exchange. Determining a CCC in distributed networks is a challenging research issue because the spectrum availability at each ad hoc node is quite different and dynamic due to the interference between and coexistence of primary users. In this paper, we propose a novel CCC selection protocol that is implemented in a distributed way according to the appearance patterns of primary systems and connectivity among nodes. The proposed protocol minimizes the possibility of CCC disruption by primary user activities and maximizes node connectivity when the control channel is set up. It also facilitates adaptive recovery of the control channel when the primary user is detected on that channel.

• Proceedings of the IEEK Conference
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• 2005.11a
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• pp.1023-1026
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• 2005

In the ubiquitous computing environment, an intelligent vehicle is defined as a sensor node with a capability of intelligence and communication in a wire and wireless network space. To make it real, a lot of problems should be addressed in the aspect of vehicle mobility, in-vehicle communication, common service platform and the connection of heterogeneous networks to provide a driver with several intelligent information services beyond the time and space. In this paper, we present an intelligent information system for managing in-vehicle sensor network and a vehicle gateway for connecting the external networks. The in-vehicle sensor network connected with several sensor nodes is used to collect sensor data and control the vehicle based on CAN protocol. Each sensor node is equipped with a reusable modular node architecture, which contains a common CAN stack, a message manager and an event handler. The vehicle gateway makes vehicle control and diagnosis from a remote host possible by connecting the in-vehicle sensor network with an external network. Specifically, it gives an access to the external mobile communication network such as CDMA. Some experiments was made to find out how long it takes to communicate between a vehicle's intelligent information system and an external server in the various environment. The results show that the average response time amounts to 776ms at fixed place, 707ms at rural area and 910ms at urban area.