• Environmental Analysis Health and Toxicology
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• 제3권1_2호
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• pp.55-64
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• 1988

Experiments were performed on mice to investigate the influences of ampicillin and ethanol on the immune response. Ampicillin was injected intraperitoneally and ethanol was administered in the drinking water. Mice were sensitized and challenged with sheep red blood cells. Immune responses were evaluated by humoral immunity, cellular immunity, peripheral circulating white blood cell and phagocyte activity. 1. The combined administration of ampicillin and ethanol as compared to ampicillin had not influence on the weight of spleen, but increased the weight of thymus. 2. Humoral immune response was slightly reduced by ampicillin. Especially, the combined administration of ampicillin and ethanol significantly reduced hemclysin production. 3. Cellural immune response was reduced by ampicillin. The combine administration of ampicillin and ethanol significantly reduced cellural immune response. 4. Peripheral circulating white blood cell was reduced by the combined administration of ampicillin and ethanol as compared to ampicillin. 5. The combined administration of ampicillin and ethanol as compared to ampicillin had not influence on the phagocyte activity.

• 약학회지
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• 제50권1호
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• pp.58-63
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• 2006

The antioxidant enzyme (AOE) system plays an important role in the defense against oxidative stress damage. To determine whether myricetin or myricetin/taurine can exert antioxidative effects not only by modulating the AOE system directly but also by scavenging free radical, we investigated the influence of the myricetin and taurine on cell viability ROS level, activities of different antioxidant enzyme, and the expression of different antioxidant enzyme. As results, the cell viability showed inhibition of the proliferation with treatment of 'myricetin' or 'myricetin with taruine', respectively, with dose-dependent manner. Compared to control, the treatment of 'myricetin' decreased activities and gene expressions of superoxide dismutase (SOD), and glutathione peroxidase (GPx). However, combined treatment of 'myricetin with taurine' increased activities and gene expressions of the SOD, GPx, and catalase (CAT). In addition, the combined treatment of 'myricetin with taurine' somewhat decreased ROS levels, compared to the treatment of 'myricetin'. In conclusion, our study provides that the combined treatment of different antioxidants can enhance antioxidant effects.

• 소성∙가공
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• 제9권3호
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• pp.242-248
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• 2000

This paper is concerned with the family of parts that generally feature a central hub with radial protrusions. Radial Extrusion is usually used in order to produce complex parts, which is combined with upsetting and/or forward and backward extrusion. Typical parts that fall into this category include cross pieces for universal joints, key-shaft type parts, tube fittings, and differential gears. In this paper, the forming characteristics of radial extrusion combined with forward extrusion is investigated by comparing the punch and mandrel loads. The design factors during radial extrusion combined with forward extrusion are applied to the simulation to see how much those factors have effect on the forming loads. The rigid-plastic FEM is applied to the simulation.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2004년도 추계학술대회 논문집
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• pp.110-113
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• 2004

Aluminum and CFRP tube is light-weight material representatively but collapse mechanism is different under axial loading. Aluminum tube absorbs energy by stable plastic deformation under axialloading. While CFRP(Carbon Fiber Reinforced Plastics)tube absorb synergy by unstable brittle failure but its specific strength and stiffness is higher than that of aluminum tube. In this study, for complement of detect and synergy effect by combination with the advantages of each member, the axialcollapsetests were performed for combined aluminum CFRP tubes which are composed of aluminum tubes wrapped with CFRP out side aluminum square tubes. Collapsecharacteristics were analyzed for combined square tubes which have different CFRP orientation angle and thickness. Test results were compared with that of aluminum tubes and CFRP tubes.

• Environmental Analysis Health and Toxicology
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• 제4권1_2호
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• pp.1-10
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• 1989

Experiments were performed on mice to investigate the influences of doxycycine and ethanol on the immune responses. Doxycycline was injected intraperitoneally and ethanol was administered in the drinking water. Mice were sensitized and challenged with sheep red blood cells. Immune responses were evaluated by humoral immunity, cellular immunity, peripheral circulating white blood cell and phagocyte activity. Pathotoxicological influences were measured by serum protein and albumin. The weight of spleen, thymus and liver were measured. Doxycline and ethanol combined administration decreased the weight of thymus and spleen. Humoral and cellular immune response were reduced by doxycycline administration. Especially ethanol combined administration significantly reduced humoral and cellular immune response. Phagocyte activity was increased by ethanol combined administration and peripheral circulating white blood cell was significantly increased by ethanol adminstration. Ethanol combined administration decreased serum A/G ratio.

• 전기학회논문지
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• 제56권10호
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• pp.1836-1843
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• 2007

In this paper, we study the NvBAT treatment for AIDS patients that is combined with PI rather than RTI, while the Previous results have been focused on the NvBAT in conjuction with RTI. To this end, we obtain a bifurcation diagram which shows a change in the equilibrium points, and in their stability properties as the PI drug effect is varied. Based on the bifurcation diagram, we show that the NvBAT can be combined with drug PI for the treatment of AIDS patients. Various computer simulation results are included, which show the superiority of the NvBAT with PI over that with RTI. Accordition to simulation result, the NvBAT combined with PI is able to keep virus load level lower than that combined with RTI, which is crucial to avoid the emergence of drug-resistant mutants. Moreover, it is shown that, for some AIDS patients, NvBAT with RTI cannot make patients into long term non-progressor, while NvBAT with PI can.

• Structural Engineering and Mechanics
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• 제28권2호
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• pp.167-188
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• 2008

This study is concerned with the establishment of the characteristic equation of a combined system consisting of a cantilever beam with a tip mass and an in-span visco-elastic helical spring-mass, considering the mass of the helical spring. After obtaining the "exact" characteristic equation of the combined system, by making use of a boundary value problem formulation, the characteristic equation is established via a transfer matrix method, as well. Further, the characteristic equation of a reduced system is obtained as a special case. Then, the characteristic equations are numerically solved for various combinations of the physical parameters. Further, comparison of the results with the massless spring case and the case in which the spring mass is partially considered, reveals the fact that neglecting or considering the mass of the spring partially can cause considerable errors for some combinations of the physical parameters of the system.

• Journal of Pharmaceutical Investigation
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• 제14권1호
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• pp.1-10
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• 1984

Effects of water soluble carrier on the dissolution characteristics of indomethacin coprecipitates were investigated. Water soluble carriers used were polyvinylpyrrolidone, dextrose, mannitol and their mixtures of various ratios. The dissolution rates of indomethacin from coprecipitate with ratios of drug-to-carrier, kinds of carrier and ratios of carriers were as follows: 1. The dissolution rates increased proportionally to the ratios of carrier in the case of both single and combined carrier, and the dissolution rate of coprecipitate with the combined carrier was more rapid than that with single carrier. 2. The combined carrier of PVP-dextrose (1 : 2) in the case of the coprecipitate of drug-to carrier (1 : 1) and PVP-dextrose (4 : 1) in the case of the coprecipitate of drug-to carrier (1 : 3) yield the most rapid dissolution rate. 3. The dissolution rate of indomethacin was the most markedly enhanced in the case of the combined carrier of PVP and dextrose.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 2003년도 The 8th Asian Symposium on Precision Forging ASPF
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• pp.162-166
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• 2003

In combined forward-backward extrusion with controlled forward speed by a counter punch, accurate parts with forward rod can be formed. As an extension of this method, reverse extrusion is proposed, in which the extruded forward rod is pushed back while the main punch is kept at the final position after the forward-backward extrusion process. The experiment is carried out using lead as a model material. With the reverse extrusion method, longer forward rods can be formed without under-filling defect than that by combined extrusion with controlling extrusion speed.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2005년도 추계 학술발표회 제17권2호
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• pp.407-410
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• 2005

This research investigates experimentally an effect on the properties of the combined high flowing concrete by mix design factors. The purpose of this study is to determine the optimum mix proportion of the combined high flowing concrete having good flowability, viscosity, no-segregation and design strength(40.0MPa). For this purpose, trial mixings used belite cement+lime stone powder(LSP) are tested by mix design factors including water-cement ratio($47.9\~54.0\%$), fine aggregate volume ratio($41\~45\%$) and coarse aggregate volume ratio($41\~45\%$). As test results of this study, the optimum mix proportion for the combined high flowing concrete is as followings. Water-cement ratio $51.0\%$, fine aggregate volume ratio $43{\pm}1\%$ and coarse aggregate volume ratio $0.30{\pm}0.05m^3/m^3$ and replacement ratio of LSP $42.7\%$.