• 인간식물환경학회지
• /
• 제21권6호
• /
• pp.485-492
• /
• 2018

This study aimed to develop and validate highly sensitive determination method of a prostaglandin ($PGE_1$, OP 1206) in human plasma by LC-MS/MS using column switching. Plasma stored at $-30^{\circ}C$ and treated with methanol effectively inhibited interferences synthesized post-sampling. Samples were added with internal standard and were separated by reversed-phase HPLC with a cycle time of 30min. The method was selective for OP 1206 and the regression models, based on internal standard, were linear across the concentration range 0.5-50 pg/mL with the limit of quantification of 0.5 pg/mL (limit of quantitation, LOQ) for OP 1206. The calibration curve of OP 1206 standards spiked in five individual plasma samples was linear ($r^2=0.9999$). Accuracy and precision at the concentrations of 0.5, 1.5, 5.0 and 40 pg/mL, and at the lower LOQ of 0.5 pg/mL were excellent at 20%. OP120 < 6 was stable in plasma samples for at least 24 hours at room temperature, 24 hours frozen at $-70^{\circ}C$, 24 hours in an auto sampler at $6^{\circ}C$, and for two freeze/unfreezing cycles. The validated determination method successfully quantified the concentrations of OP 1206 in plasma samples from simulated administrating a single $5{\mu}g$ OP 1206 formulation. Thus, this novel LC-MS/MS technique for drug separation, detection and quantitation is expected to become the standard highly-sensitive detection method in bioanalysis and to be applied to many low dose pharmaceutical products.

• 한국구조물진단유지관리공학회 논문집
• /
• 제23권5호
• /
• pp.30-36
• /
• 2019

염해에 노출된 콘크리트 구조물의 내구수명을 정량적으로 평가하기 위해서는 사용 배합을 통하여 확산계수를 평가하고 이를 이용한 염화물 침투 해석이 필요하다. 본 연구에서는 비말대에 노출된 콘크리트 구조물에 대하여 촉진 확산계수를 NT BUILD 492 및 ASTM 1202를 통하여 평가하였으며, 기존의 연구를 이용하여 겉보기 확산계수를 도출하였다. 사용배합의 특성과 가장 보수적인 조건인 임계 염화물량과 표면 염화물량을 고려하였으며, Life 365 ver.2 프로그램을 이용하여 외벽 및 기둥구조의 내구수명을 평가하였다. 10년 및 15년의 Built-up period의 변화에 대해서는 내구수명은 큰 차이를 보이지 않았으며. 슬래그를 사용한 두 개의 배합에서는 높은 시간의존성 지수와 낮은 초기 염화물 확산계수로 인해 75년 이상의 높은 내구수명이 확보되었다.

• Structural Engineering and Mechanics
• /
• 제70권1호
• /
• pp.13-31
• /
• 2019

A nonlinear finite element model (FEM) using ATENA-3D software to simulate the axially compressive behavior of circular steel tube confined concrete (CSTCC) columns infilled with ultra high performance concrete (UHPC) was presented in this paper. Some modifications to the material type "CC3DNonlinCementitious2User" of UHPC without and with the incorporation of steel fibers (UHPFRC) in compression and tension were adopted in FEM. The predictions of utimate strength and axial load versus axial strain curves obtained from FEM were in a good agreement with the test results of eighteen tested columns. Based on the results of FEM, the load distribution on the steel tube and the concrete core was derived for each modeled column. Furthermore, the effect of bonding between the steel tube and the concrete core was clarified by the change of friction coefficient in the material type "CC3DInterface" in FEM. The numerical results revealed that the increase in the friction coefficient leads to a greater contribution from the steel tube, a decrease in the ultimate load and an increase in the magnitude of the loss of load capacity. By comparing the results of FEM with experimental results, the appropriate friction coefficient between the steel tube and the concrete core was defined as 0.3 to 0.6. In addition to the numerical evaluation, eighteen analytical models for confined concrete in the literature were used to predict the peak confined strength to assess their suitability. To cope with CSTCC stub and intermediate columns, the equations for estimating the lateral confining stress and the equations for considering the slenderness in the selected models were proposed. It was found that all selected models except for EC2 (2004) gave a very good prediction. Among them, the model of Bing et al. (2001) was the best predictor.

• 대기
• /
• 제29권1호
• /
• pp.13-20
• /
• 2019

Since 1985, the Dobson Spectrophotometer has been operated at Yonsei University, and this instrument has monitored the daily representative total ozone in Seoul. Climatological value for total ozone in Seoul is updated by using the daily representative observation data from 1985 to 2017. After updating the daily representative total ozone data, seasonal and inter-annual variation of total ozone in Seoul is also estimated after calculating inter-comparison between ground (Dobson Spectrophotometer) and satellite [Total Ozone Mapping Spectrometer (TOMS) and Ozone Monitoring Instrument (OMI)] observations. The global average of total ozone measured by satellite is 297 DU, and its recent amount is about 3.5% lower than the global amount in 1980s. In Seoul, daily representative total ozone is ranged from 225 DU to 518 DU with longterm mean value of 324.3 DU. In addition, monthly mean total ozone is estimated from 290 DU (October) to 362 DU (March), and yearly average of total ozone have been continuously increased since 1985. For the long-term trend of total ozone in Seoul, this study is considered the seasonal variation, Solar Cycle, and Quasi-Biennial Oscillation. In addition to the natural oscillation effect, this study also considered to the long-term variation of sudden increase of total ozone due to the secondary ozone peak. By considering these natural effects, the long-term total ozone trends from 1985 to 2017 are estimated to be 1.11~1.46%/decade.

• The Journal of Advanced Prosthodontics
• /
• 제11권2호
• /
• pp.95-104
• /
• 2019

PURPOSE. To evaluate the effect of surface treatments and repair materials on the shear bond strength and to measure the fracture toughness of CAD/CAM provisional restoration materials. MATERIALS AND METHODS. Four CAD/CAM (3D printing: Nextdent C&B and ZMD-1000B Temporary, CAD/CAM resin block: Yamahachi PMMA disk and Huge PMMA block) and four conventional (monometacrylate: Jet and Alike, dimetacrylate: Luxatemp and Protemp 4) materials were selected to fabricate disk-shaped specimens and divided into six groups according to surface treatment (n=10). CAD/CAM materials were repaired with Jet or Luxatemp, while conventional materials were repaired with their own materials. The shear bond strength was measured by using universal testing machine. Ten rectangular column-shaped specimens for each material were fabricated to measure the fracture toughness by single edge v notched beam technique. Statistical analysis was performed by one-way ANOVA. RESULTS. The highest shear bond strength of CAD/CAM materials was achieved by SiC paper + sandblasting. It was also accomplished when repairing 3D printing materials with Luxatemp, and repairing CAD/CAM resin blocks with Jet. Yamahachi PMMA disk showed the highest fracture toughness. Nextdent C&B showed the lowest fracture toughness value but no statistically significant difference from Alike and Luxatemp (P>.05). CONCLUSION. In order to successfully repair the CAD/CAM provisional restoration, mechanical surface treatment and appropriate repair material according to the CAD/CAM material type should be selected. The CAD/CAM provisional materials have proper mechanical properties for clinical use as compared to conventional materials.

• Korean Journal of Anesthesiology
• /
• 제71권6호
• /
• pp.453-458
• /
• 2018

Background: Pain on injection is a limitation with propofol use. The effect of the Valsalva maneuver on pain during propofol injection has not been studied. This maneuver reduces pain through the sinoaortic baroreceptor reflex arc and by distraction. We aimed to assess the efficacy of the Valsalva maneuver in reducing pain during propofol injection. Methods: Eighty American Society of Anesthesiologists class I adult patients undergoing general anesthesia were enrolled and divided into two groups of 40 each. Group I (Valsalva) patients blew into a sphygmomanometer tube raising the mercury column up to 30 mmHg for 20 seconds, while Group II (Control) patients did not. Anesthesia was induced with 1% propofol immediately afterwards. Pain was assessed on a 10-point visual analog scale (VAS), where 0 represented no pain, and 10, the worst imaginable pain, and a 4-point withdrawal response score, where 0 represented no pain, and 3, the worst imaginable pain. Scores were presented as median (interquartile range). Results: We analyzed the data of 70 patients. The incidence of pain was significantly lower in the Valsalva than in the control group (53% vs. 78%, P = 0.029). The withdrawal response score was significantly lower in the Valsalva group (1.00 [0.00-1.00] vs. 2.00 [2.00-3.00], P < 0.001). The VAS score was significantly lower in the Valsalva group (1.00 [0.00-4.00] vs. 7.00 [6.25-8.00], P < 0.001). Conclusions: A prior Valsalva maneuver is effective in attenuating injection pain due to propofol; it is advantageous in being a non-pharmacological, safe, easy, and time-effective technique.

• Steel and Composite Structures
• /
• 제44권3호
• /
• pp.295-307
• /
• 2022

The objective of this research is to study experimentally the behavior of stiffened steel tubes (CFSTs). Considered parameters are stiffening methods by through-bolts or shear connectors with different configurations. In addition, the effect of global (ratio between length to diameter) and local (proportion between diameter to thickness) slenderness ratios are investigated. Load application either applied on steel only or both steel and concrete is studied as well. Case of loading on steel only happens when concrete inside the column shrinks. The purpose of the research is to improve the behavior of CFSTs by load transfer between them and different stiffening methods. A parametric experimental study that incorporates thirty-three specimens is carried out to highlight the impact of those parameters. Different outputs are recorded for every specimen such as load capacities, vertical deflections, longitudinal strains, and hoop strains. Two modes of failure occur, yielding and global buckling. Shear connectors and through-bolts improve the ultimate load by up to 5% for sections loaded at steel with different studied global slenderness and local slenderness equal 63.5. Meanwhile, shear connectors or through bolts increase the ultimate load by up to 6% for global slenderness up to 15.75 for sections loaded on composite with local slenderness equals 63.50. Recommendations for future design code development are outlined.

• 한국구조물진단유지관리공학회 논문집
• /
• 제26권6호
• /
• pp.102-111
• /
• 2022

본 논문의 목적은 팔각형 중공단면 철근콘크리트 교각의 내진성능을 평가하고 축방향철근비가 파괴거동에 미치는 영향을 분석함에 있다. 축소모형 팔각형 중공단면 기둥 실험체 4개를 제작하여 일정한 축력 하에서 반복 횡하중을 가력하는 실험을 수행하였다. 모든 실험체의 횡방향 나선철근 체적비는 0.206%로 일정하고 축방향철근비는 2.36 ~ 4.71%이다. 파괴거동과 내진성능을 분석하였고 겹침이음 실험체를 제외한 3개의 실험체는 최종단계에서 휨-전단 파괴거동을 보였다. 겹침이음 실험체를 제외한 실험결과에서 변위연성도와 누적 에너지소산 능력이 축방향철근비에 반비례하여 감소하는 경향을 나타내었다.

• Steel and Composite Structures
• /
• 제48권4호
• /
• pp.367-383
• /
• 2023

A coupled wall consists of two or more reinforced concrete (RC) shear walls (SWs) connected by RC coupling beams (CBs) or steel CBs (hybrid-coupled walls). To fill the gap in the literature on the plastic hinge length of coupled walls, including coupled and hybrid-coupled shear walls, a parametric study using experimentally validated numerical models was conducted considering the axial stress ratio (ASR) and coupling ratio (CR) as the study variables. A total of sixty numerical models, including both coupled and hybrid-coupled SWs, have been developed by varying the ASR and CR within the ranges of 0.027-0.25 and 0.2-0.5, respectively. A detailed analysis was conducted in order to estimate the ultimate drift, ultimate capacity, curvature profile, yielding height, and plastic hinge length of the models. Compared to hybrid-coupled SWs, coupled SWs possess a relatively higher capacity and curvature. Moreover, increasing the ASR changes the walls' behavior to a column-like member which decreases the walls' ultimate drift, ductility, curvature, and plastic hinge length. Increasing the CR of the coupled SWs increases the walls' capacity and the risk of abrupt shear failure but decreases the walls' ductility, ultimate drift and plastic hinge length. However, CR has a negligible effect on hybrid-coupled walls' ultimate drift and moment, curvature profile, yielding height and plastic hinge length. Lastly, using the obtained results two equations were derived as a function of CR and ASR for calculating the plastic hinge length of coupled and hybrid-coupled SWs.

• 한국전산구조공학회논문집
• /
• 제36권2호
• /
• pp.105-112
• /
• 2023

본 연구에서는 마찰모델에 따라 다른 마찰진자시스템(FPS)이 적용된 교량의 성능을 비교·분석하기 위해 구조해석을 수행하였다. 마찰해석모델 별 성능을 분석하기 위해 PVDF/MgO 마찰재의 마찰계수를 활용하여 쿨롱 마찰모델과 속도 의존 마찰모델을 구축했다. 쿨롱 마찰모델은 마찰속도와 관계없이 단일 마찰계수를 사용하며, 속도 의존 마찰모델은 마찰속도에 따른 마찰계수의 변화를 반영하는 마찰모델이다. 지진해석으로 비선형 시간 이력 해석과 지진 취약도 해석을 수행하여 구조물의 응답을 확인하였다. 마찰모델에 따른 바닥판과 교각의 지진 응답을 활용해 면진된 교량의 성능을 분석하였으며, 면진된 교량의 성능을 효과적으로 평가할 수 있는 마찰모델을 분석했다.