• Title/Summary/Keyword: college of science and engineering

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Efficient and Selective Construction of Pyrrolo[3,2-d]pyrimidine Derivatives

  • He, Ping;Wu, Jing;Hu, Yang-Gen;Li, Zai-Fang;Hou, Qiu-Fei;Wang, Yan-Ling;Zhao, Kun;Zhang, Erli
    • Bulletin of the Korean Chemical Society
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    • v.35 no.2
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    • pp.617-621
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    • 2014
  • An efficient and selective method for the synthesis of ethyl 2-amino/aryloxy-3-aryl-4-oxo-5-phenyl-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidine-7-carboxylate derivatives has been developed. The main process involved the reaction of diethyl 1-phenyl-3-((triphenylphosphoranylidene)amino)-1H-pyrrole-2,4-dicarboxylate and aromatic isocyanates, followed by addition of amines/phenols in the presence of catalytic amount of sodium ethoxide or solid potassium carbonate.

Study of an Optical Goniometer Using a Multi-Photodiode Sensor

  • Kim, Ji-Sun;Kim, A-Hee;Oh, Han-Byeol;Kim, Jun-Sik;Goh, Bong-Jun;Lee, Eun-Suk;Choi, Ju-Hyeon;Baek, Jin-Young;Jun, Jae-Hoon
    • Journal of the Optical Society of Korea
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    • v.20 no.1
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    • pp.22-28
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    • 2016
  • The monitoring and measurement of the motion of a human joint is very important in screening for degenerative brain diseases and tracking the rehabilitation process. Since there are various medical fields to benefit from angular motion measurement, the necessity for monitoring of human joint movement is increasing. In this study, the optical sensor is composed of a light emission unit with a red LED and an optical fiber, and a reception unit with an arrangement of three photodiodes. The angular detection range was widened with the use of multiple photodiodes and the developed algorithm. The result will be useful for designing an effective angular sensor with low cost and small size.

Development of a Respiration Sensor Using Plastic Optical Fiber (플라스틱 광섬유를 이용한 호흡센서의 개발)

  • Yoo, Wook-Jae;Baek, Ji-Yun;Cho, Dong-Hyun;Jang, Kyoung-Won;Seo, Jeong-Ki;Heo, Ji-Yeon;Lee, Bong-Soo;Cho, Young-Ho;Park, Byung-Gi;Moon, Joo-Hyun
    • Journal of Biomedical Engineering Research
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    • v.30 no.6
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    • pp.489-494
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    • 2009
  • In this study, we fabricated a plastic optical fiber based sensor which can monitor the respiration of a patient. The circumference changes of the abdomen were measured using a mirror, a light source and optical detectors because the circumferences of the abdomen could be varied with respiration. The intensity of the reflected lights were measured according to the changes of distance between mirror and plastic optical fiber connected to a light source and a photodiode-amplifier system using a Y-coupler. The respiration signals of fiber-optic sensor system were compared with those of the respiratory and temperature transducers of the $BIOPAC^{(R)}$ system. It is expected that a fiber-optic respiration sensor could be developed for real time respiration monitoring during MRI procedure based on this study.

Effect on Viability of Microencapsulated Lactobacillus rhamnosus with the Whey Protein-pullulan Gels in Simulated Gastrointestinal Conditions and Properties of Gels

  • Zhang, Minghao;Cai, Dan;Song, Qiumei;Wang, Yu;Sun, Haiyue;Piao, Chunhong;Yu, Hansong;Liu, Junmei;Liu, Jingsheng;Wang, Yuhua
    • Food Science of Animal Resources
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    • v.39 no.3
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    • pp.459-473
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    • 2019
  • Lactobacillus rhamnosus GG (LGG) has low resistance to low pH and bile salt in the gastrointestinal juice. In this study, the gel made from whey protein concentrate (WPC) and pullulan (PUL) was used as the wall material to prepare the microencapsulation for LGG protection. The gelation process was optimized and the properties of gel were also determined. The results showed the optimal gel was made from 10% WPC and 8.0% PUL at pH 7.5, which could get the best protective effect; the viable counts of LGG were 6.61 Log CFU/g after exposure to simulated gastric juice (SGJ) and 9.40 Log CFU/g to simulated intestinal juice (SIJ) for 4 h. Sodium dodecyl sulphite polyacrylamide gel electrophoresis (SDS-PAGE) confirmed that the WPC-PUL gel had low solubility in SGJ, but dissolved well in SIJ, which suggested that the gel can protect LGG under SGJ condition and release probiotics in the SIJ. Moreover, when the gel has highest hardness and water-holding capacity, the viable counts of LGG were not the best, suggesting the relationship between the protection and the properties of the gel was non-linear.

Effects of stocking density on the homeostasis of uric acid and related liver and kidney functions in ducks

  • Peiyi Lin;Sui Liufu;Jinhui Wang;Zhanpeng Hou;Yu Liang;Haiyue Wang;Bingxin Li;Nan Cao;Wenjun Liu;Yunmao Huang;Yunbo Tian;Danning Xu;Xiujin Li;Xinliang Fu
    • Animal Bioscience
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    • v.37 no.5
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    • pp.952-961
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    • 2024
  • Objective: Stocking density (SD) is an important issue in the poultry industry, which is related to the production performance, intestinal health and immune status. In the present study, the effects of SD on the metabolism and homeostasis of uric acid as well as the related functions of the liver and kidney in ducks were examined. Methods: A total of 360 healthy 56-day-old Shan-ma ducks were randomly divided into the low stocking density (n = 60, density = 5 birds/m2), medium stocking density (n = 120, density = 10 birds/m2) and high stocking density groups (HSD; n = 180, density = 15 birds/m2). Samples were collected in the 3rd, 6th, and 9th weeks of the experiment for analysis. Results: The serum levels of uric acid, lipopolysaccharide and inflammatory cytokines (interleukin-1β [IL-1β], IL-8, and tumor necrosis factor-α [TNF-α]) were increased significantly in the HSD group. Serious histopathological lesions could be seen in both the livers and kidneys in the HSD group in the 9th week. The mRNA expression levels of inflammatory cytokines (IL-8 and TNF-α) and related pathway components (toll-like receptor 4, myeloid differentiation primary response gene 88, and nuclear factor-κB) were increased significantly in both the livers and kidneys in the HSD group. The mRNA expression levels of enzymes (adenosine deaminase, xanthine oxidase, phosphoribosyl pyrophosphate amidotransferase, and phosphoribosyl pyrophosphate synthetase 1) related to the synthesis of uric acid increased significantly in the livers in the HSD group. However, the mRNA expression level of solute carrier family 2 member 9, which plays an important role in the excretion of uric acid by the kidney, was decreased significantly in the kidneys in the HSD group. Conclusion: These results indicated that a higher SD could cause tissue inflammatory lesions in the liver and kidney and subsequently affect the metabolism and homeostasis of uric acid, and is helpful for guiding decisions related to the breeding and production of ducks.