• Proceedings of the Korean Society of Veterinary Clinics Conference
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• 2007.10a
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• pp.569-569
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• 2007

• Proceedings of the Korean Society of Veterinary Clinics Conference
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• 2007.10a
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• pp.605-605
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• 2007

• Journal of Veterinary Clinics
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• v.18 no.3
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• pp.279-283
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• 2001

Eleven years old cocker spaniel referred to Veterianry Medical Teaching Hospital, Seoul National University was diagnosed as pheochromocytoma. The patient was transferred to the hospital after hit by car and the main clinical signs were tachypnea, tachycardia, edema of hindlimb and lethargy. On ultrasonographic examination, hyperechoic foci was detected and it was invaded into the caudal vena cava. Venography showed the filling defect and local dilation of the caudal vena. The diagnosis of pheochromocytoma is challenging due to the nonspecific clinical signs and severe concurrent disease in dogs. This report describes one dog with invasive pheochromocytoma in which radiography, ultrasonography and venacavography were key diagnositc tools. Ultrasonography was a usuful method for assessment of size, shape and margination of the tumor and invasiveness to the major vessels.

• Journal of Veterinary Clinics
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• v.35 no.1
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• pp.17-18
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• 2018

A 12-year-old spayed female Cocker Spaniel was presented with vomiting, diarrhea, depression, and hyporexia of 3-day duration. Microscopic examination of the abdominal fluid from a dog showed basophilic, amorphous to fibrillar materials without bile pigments or crystals. Total bilirubin concentration of the fluid was 19 times higher than the serum bilirubin concentration and exploratory laparotomy revealed a ruptured gallbladder and mucoceles in the abdominal cavity. Rupture of gallbladder mucoceles may cause atypical bile peritonitis in which mucinous material is observed instead of bile pigment.

• Korean Journal of Veterinary Research
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• v.62 no.2
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• pp.12.1-12.4
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• 2022

A 16-year-old, 7.4 kg, castrated male Cocker Spaniel presenting anorexia and weight loss was referred due to a splenic mass, and total splenectomy was performed to resolve clinical signs. Following surgery, the dog developed mild hyperkalemia (6.27 mmol/L) without any clinical symptoms. Further investigations were conducted to determine the cause of hyperkalemia. The serum-plasma potassium difference was measured (1.05 mmol/L), and pseudohyperkalemia was diagnosed. The cause of pseudohyperkalemia was considered as thrombocytosis after splenectomy. The dog did not receive any specific treatment to lower blood potassium. To our knowledge, we report the first case of post-splenectomy pseudohyperkalemia in a dog.

• Journal of Veterinary Clinics
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• v.40 no.1
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• pp.50-55
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• 2023

A 10-year-old spayed female Cocker spaniel weighing 6.64 kg was presented with a sign of syncope. Electrocardiographic findings revealed pathologic atrioventricular (AV) block alternating 3rd degree AV block, non-responsive to atropine. Before pacemaker implantation, several anti-hypertensive medications were administered, but there was no improvement. After pacemaker implantation, the heart rate and systemic arterial systolic blood pressure were immediately improved. This is the first report on the resolution of an AV block and malignant systemic hypertension after a pacemaker implant in veterinary medicine.

• Journal of Veterinary Clinics
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• v.23 no.1
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• pp.72-76
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• 2006

A 1-year-old, female English cocker spaniel (ECS) dog was presented with 3-month history of vomiting and retaking of the vomitus, and chronic weight loss. The client had noticed mild abdominal distension 10 days before. The dog was diagnosed as chronic hepatitis with hepatic cirrhosis based on complete blood count (CBC), serum chemistry profiles, radiography, ascites assessment, bile acid evaluation, and liver biopsy through exploratory laparotomy and necropsy. CBC and serum chemistry profiles revealed mild anemia, slightly elevated hepatic enzymes (ALT and AST), increased creatinine kinase (CK), hyperammonemia, and hypoproteinemia with hypoalbuminemia. Ascites was transudate according to analysis of components. Bile acid assessment (fasting; $174.4{\mu}mol/L$ and postprandial; $198.4{\mu}mol/L$) showed strongly suspected hepatic insufficiency. On radiological findings, ascites was evident. Atrophied liver (especially left side lobes) and distended mesenteric vasculatures were observed by exploratory laparotomy. Histopathological examination of marginal lesion of left lateral lobe of liver by biopsy revealed the necrosis of hepatic cells, dilation of sinusoids, infiltration of neutrophils in sinusoids, and vacuolation of hepatic cytoplasm. The patient had been managed with careful low protein diet and specific supportive therapy (ursodeoxycholic acid, prednisolone, vitamine E, and interferon). Vomiting and ascites disappeared with medical management. The dog was monitored periodically by CBC, serum chemistry and radiographic examination. The dog survived more 18 months with medical therapy. After spontaneous death, necropsy and histopathologic examination were performed.

• Journal of Veterinary Clinics
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• v.28 no.1
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• pp.122-127
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• 2011

A 5-year old, intact male, Cocker spaniel dog was referred with paraplegia and loss of deep pain perception. Physical, neurological examinations, radiography, and computed tomography were evaluated. Based on the clinical examinations, the dog was diagnosed with severe disc herniation ($L_2$ to $L_3$ intervertebral disc space). On the next day of presentation (6 days after loss of deep pain perception), hemilaminectomy was performed. After decompression of spinal cord and removal of herniated disc materials, $1{\times}10^6$ canine allogenic adipose tissue-derived mesenchymal stem cells (MSCs) diluted by $50{\mu}l$ saline were directly applied to the injured site of the spinal cord. Ten weeks of follow-up after surgery, full recovery of deep pain perception and motor function were evaluated in both hind limbs. Based on the result, we suggest that the transplantation of allogenic adipose tissue-derived MSCs to dogs with spinal cord injuries could be a considerable method to expect better clinical outcomes in veterinary practice.

• Journal of Veterinary Clinics
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• v.36 no.4
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• pp.190-195
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• 2019

We aimed to identify genomic variations as well as the marker genes related with chronic mitral valve disease (CMVD) in Canis lupus familiaris using whole genome resequencing, which provides valuable resources for further study. Two ten-year old female Canis lupus familiaris English cocker spaniels were used for this study, one control and one who had been diagnosed as CMVD. For the whole genome resequencing, muscles from the left ventricular wall were collected from each dog. With the HiSeq DNA Shotgun library and $HiSeq^{TM}$ 2000 platform, whole genome resequencing was performed. From the results, we identified 5 million and 6 million variants in gene expression in the control and CMVD-diagnosed subject, respectively. We then selected the top 1,000 genes from the SNP, INS, and DEL mutation and 675 genes among them were overlapped for every mutation between the control and CMVD-diagnosed patient. Interestingly, in both groups, the intron variant (91.16 and 91.18%) and upstream variant (3.10 and 3.08%) are most highly related. Among the overlapped 675 genes, gene ontology for intracellular signal transduction is highly counted in INS, and DEL, and SNPs (35, 33, 31, respectively). In this study, we found that the COL and CDH gene families could be key molecules in identifying the difference in gene expression between control and CMVD-diagnosed dogs. We believe further studies will prove the importance of variants in key molecule expression and that these data will serve as a valuable foundation stone the study of canine CMVD.

• Journal of Veterinary Clinics
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• v.21 no.3
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• pp.276-279
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• 2004

Ninety-nine dogs diagnosed as tracheal collapse were reviewed for 2002-2003 year at Veterinary Medical Teaching Hospital, Seoul National University with clinical records and radiographs. Dogs were ranged in age from 1 to 15 years old (average 8.23 years old) and in weight from 1.2kg to 10.3kg (average 3.3kg). The population included 58 females (6 spayed) and 41 males (8 castrated). It is highly predominant in Yorkshire terrier (64, 64.6%) followed by Pomeranian (10, 10.1 %), Poodle and Chihuahua (8, 8.1%), Maltese (4, 4.0%), mixed breed (3, 3.0%), Cocker Spaniel and Pug (1, 1.0%). The incident rate of female dogs (59%) exhibited relatively higher than that of male dogs (41%). The most prevalent occurrence location was thoracic inlet (60%) of all and carina region (15%), intrathoracic trachea (14%) and cervical trachea (11 %) showed similar rate. Conclusively, tracheal collapse was observed in completely matured or old small breed dogs, largely Yorkshire terrier, on thoracic inlet primarily regardless of gender. These tendencies were apparently similar to previous reports.