• Title/Summary/Keyword: co-administration

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Habitat Evaluation of Japanese Black Bear using GIS

  • Masuyama, Tetsuo;Yamamoto, Toshiharu;Hara, Keitarou;Yasuda, Yoshizumi
    • Proceedings of the KSRS Conference
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    • 2003.11a
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    • pp.1134-1136
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    • 2003
  • In this research, GIS based evaluation methods were applied to habitats of Japanese black bear (Ursus thibetanus japonicus Schlegel) in northern Honshu. The study area was divided into 828 small watershed units , and five GIS indexes, Vegetation Type(V.T.), Extent of Forest Cover (E.F.C.) Slope Incline (S.I), Average Altitude (A.A.) and Road Density(R.D.), were used to evaluate each watershed unit in terms of suitability as black bear habitat. In addition, Interspersion and Juxtaposition spatial indices were calculated for each watershed unit. The results clearly identified the regions with the most suitable habitats, indicating that this methodology is suitable for application to various environmental planning efforts, such as regional development master plans, project-specific environmental impact assessments, species management plans and biodiversity conservation plans.

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Enhancement of Immunological Activities in Mice by Oral Administration of Pectic Polysaccharides from Eleutherococcus senticosus

  • Sung, Ji-Yun;Yoon, Taek-Joon;Yu, Kwang-Won;Lee, Kwang-Ho;Lee, Ho
    • Food Science and Biotechnology
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    • v.15 no.1
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    • pp.117-121
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    • 2006
  • Ability of pectic polysaccharides isolated from Eleutherococcus senticosus EN-3 to inhibit tumor metastasis and induce antigen-specific immune response after oral administration in mice was assessed. Consecutive oral administration of EN-3 before tumor inoculation dramatically inhibited tumor metastasis produced by colon26-M3.1 and B16-BL6 cells. When Peyer's patch cells isolated from mouse intestine were co-cultured with EN-3, proliferation of Peyer's patch cells was induced. Mice co-administered with EN-3 and ovalbumin (OVA) showed significantly higher production of OVA-specific IgA in intestinal washing as well as IgG in serum than those administered with OVA alone. Payer's patch cells of mice immunized with OVA plus EN-3 showed much higher proliferating activity than those of mice immunized with OVA alone. Proliferating activity increased dose-dependently, indicating EN-3 specifically enhanced mucosal immune response to OVA. These results suggested EN-3 could significantly stimulate Peyer's patch cells either non-specifically or antigen-specifically, possibly playing important role in enhancement of mucosal and systemic immune systems.

Effects of Sam so on Pye Tang Water Extract on the plasma cortisol Concentration and Plasma $CO_2$ in the rabbit (삼소온폐탕(蔘蘇溫肺湯) 전탕액(煎湯液)이 가토(家兎) 혈장(血漿) Cortisol 농도(濃度) 및 혈장(血漿) $CO_2$에 미치는 영향(影響))

  • Sin, Jo-Yeong;Han, Sang-Whan;Lee, Byung-Soon
    • The Journal of Internal Korean Medicine
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    • v.11 no.2
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    • pp.112-119
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    • 1990
  • To evaluate effects of Sam so on Pye Tang(SSOPT) Water Extract plasma cortisol concentration and plasma $CO_2$ in the Rabbit. The results obtained were as follows. 1. Intravenous administration of SSOPT water extract at the dose of 0.5ml/kg remarkably increased plasma cortisol concentration on 1 hour. 2. Intravenous adminitration of SSOPT Water extract at the does of 1.0ml/kg significantly decreased plasma $CO_2$ on 1 hour. 3. Intravenous adminitration of SSOPT Water extract at the does of 0.5ml/kg remarkable decreased plasma $Na^+$ from 1 to 4 hour and 1.0ml/kg significantly decreased plasma $Na^+$ on 1 hour. 4. Intravenous administration of SSOPT Water extract at the does of 1.0ml/kg remarkably increased plasma $k^+$ from 1 to 3 hour. 5. Intravenous administration of SSOPT water extract at the does of 0.5ml/kg significantly decreased plasma $CI^-$ on 3, 4 hours. and 1.0ml/kg remarkably increased plasma $CI^-$ on 4 hour. These results suggest that therapeutic action of SSOPT water extract for athma may be reated with the increment of plasma cortisol concentration and the decrease plsma $CO_2.$.

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Patterns of Collaboration Networks:Co-authorship Analysis of MIS Quarterly from 1996 to 2004 (협력 네트워크 패턴에 관한 연구: MIS Quarterly 공저자 분석을 중심으로)

  • Huang, Ming-Hao;Ahn, Joong-Ho;Jahng, Jung-Joo
    • The Journal of Society for e-Business Studies
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    • v.13 no.4
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    • pp.193-207
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    • 2008
  • The study investigates the co-authorship networks of MIS Quarterly as one of the leading journals in IS field and examines patterns of collaboration networks of the intellectuals. These issues are addressed through a systematic Social Network Analysis (SNA) of 242 articles published from 1996 to 2004 in MIS Quarterly. Results of co-authorship network analysis indicate that the whole incomplete network has a low degree of density. Thus, we analyzed three biggest sub-networks to find out who the key players of each sub-network are. Then, following the keyword classification scheme, relevant data from the articles were collected and coded to analyze three major co-authorship networks of MIS Quarterly community. Some implications are drawn from different research keywords of each sub-network.

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The protective effect of methanol extract of Corni Fructus on brain injury caused by unilateral common carotid artery occlusion in mice (산수유(山茱萸) 메탄올 추출물이 편측 경동맥 폐색으로 유도된 생쥐의 허혈성 뇌손상에 미치는 영향)

  • Choi, Na Ri;Jo, Sung Hyeon;Lee, Se-Eun;Lee, Min Ji;Cho, Suin
    • The Korea Journal of Herbology
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    • v.35 no.1
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    • pp.1-8
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    • 2020
  • Objectives : This study was conducted to evaluate the effects of Corni Fructus, the dried fruits of Cornus officinalis Sieb., on unilateral common carotid artery occlusion (UCCAO) in mouse model. Methods : The Corni Fructus used in the experiment was extracted with anhydrous methanol, then filtered and freeze-dried. C57BL/6 mice used in the experiments were conducted left UCCAO surgery to set up UCCAO rodent model for mice. The mice were divided into five groups for evaluate the effect of methanol extract of Corni Fructus (COM) on UCCAO induced ischemic brain injury. The expression levels of nitric oxide in cerebrum and serum, body weight change were measured. To determine the effect of UCCAO and COM administration on brain neurons, morphological changes of the cerebrum through a microscope was conducted. And western blot was performed to confirm the underlying mechanism of neuroprotective effect of COM administration. Results : COM administered UCCAO groups (CO50, CO150, and CO500) had no significant effects on nitric oxide production in ipsilateral hemisphere proteins and sera. The CO500, 500 mg/kg COM administration, attenuated UCCAO-induced p38 inflammatory signaling pathway and inflammatory mediators such as iNOS and COX-2. The CO500 group showed resilient morphological changes of hippocampus neuronal cells about brain damage caused by decreased flow of blood. These group also showed decreased inflammation and cellular stress response in neuronal cells. Conclusions : From these results, COM has a neuroprotective property via moderating inflammatory factors and cellular stress inducing factors in brain cells.

Nonlinear Structural Analysis of E/R Longitudinal Frame of Ice Class Vessel (ICE CLASS가 적용되는 선박의 E/R longitudinal frame 비선형 구조 해석)

  • Cho, Sung-Am;Leem, Hyo-Kwan;Kim, Ho-Kyeong
    • Special Issue of the Society of Naval Architects of Korea
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    • 2006.09a
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    • pp.40-45
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    • 2006
  • For ships of ice class, finish Maritime Administration(FMA) requires brackets on intersections between longitudinal frames and the web frames within the ice-strengthened area. The main object of this paper is to verify ultimate load carrying capacity of longitudinal frame without brackets of engine room region of 74,100 DWT Product Oil Tanker. Comparative approach between proposed structures from builder (the proposed structure) and structures satisfying the Finnish-Swedish ice class rules (the rule structure) is used for the analysis.

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Erectogenic Effect of the Selective Phosphodiesterase Type 5 Inhibitor DA-8159

  • Oh, Tae-Young;Kang, Kyung-Koo;Ahn, Byoung-Ok;Yoo, Moo-hi;Kim, Won-Bae
    • Archives of Pharmacal Research
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    • v.23 no.5
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    • pp.471-476
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    • 2000
  • DA-8159, a new phosphodiesterase 5 inhibitor, was assessed for its erectogenic potential by a penile erection test in rats, the relaxation of isolated rabbit corpus cavernosum (CC), and estimation of the intracavernous pressure (ICP) in the anesthetized dog. Oral administration of DA-8159 (0.3 to 1 ${\mu}g/kg$ ) increased the number of erections in rats with increasing dosage, with the highest penile erection index at 10 ${\mu}g/kg$ DA-8159 induced the relaxation of phenylephrine (PHE)-induced contractions in the rabbit CC and decreased the $IC_{50}$ of the nitric oxide donor sodium nitroprusside (SNP) in a dose-dependent fashion. In pentobarbital-anesthetized dogs, the intravenous administration of DA-8159 (1~300 ${\mu}g/kg$ ) potentiated the increase in ICP induced by the intracavernosal SNP in a dose-related manner. These findings suggest that DA-8159 has significant therapeutic potential in the treatment of erectile dysfunction.

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