• 한국가시화정보학회지
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• 제10권2호
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• pp.32-38
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• 2012

In recent years a unique drug delivery system named as the transdermal drug delivery system has been developed which can deliver drug particles to the human skin without using any external needle. The solid drug particles are accelerated by means of high speed gas flow through a shock tube imparting enough momentum so that particles can penetrate through the outer layer of the skin. Different systems have been tried and tested in order to make it more convenient for clinical use. One of them is the contoured shock tube system (CST). The contoured shock tube consists of a classical shock tube connected with a correctly expanded supersonic nozzle. A set of bursting membrane are placed upstream of the nozzle section which retains the drug particle as well as initiates the gas flow (act as a diaphragm in a shock tube). The key feature of the CST system is it can deliver particles with a controllable velocity and spatial distribution. The flow dynamics of the contoured shock tube is analyzed numerically using computational fluid dynamics (CFD). To validate the numerical approach pressure histories in different sections on the CST are compared with the experimental results. The key features of the flow field have been studied and analyzed in details. To investigate the performance of the CST system flow behavior through the shock tube under different operating conditions are also observed.

• 한국실내디자인학회논문집
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• 제23호
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• pp.100-108
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• 2000

The study intends to systematically arrange and classify the museum layouts in terms of their structure of exhibition space. The exhibition space, here, means the whole area where visitors are allowed to move and visit in museums. Through this, I tied to understand the characteristics and trends comparing and analyzing international and national exhibition space layout, and then grope the standard in case of establishing museum. The first criteria is based on the point of view that the typical museum experience is made in the exhibition space. Accordingly, the exhibition space can be grouped into two categories; one is 'room type' consisting mostly of individual rooms as in classical museums, and the other is 'open plan type' consisting free standing walls as in miesian free plan. The second criteria is dependent on the way how visitors move about in exhibition spaces. In other words, museum layouts can be categorized in terms of mutual connection between individual spaces including exhibition spaces and corridor spaces designated for the purpose of moving. consequently, the layouts can be categorized into five groups such as 'free plan', 'linear type', 'room to room', 'room & corridor' and 'composition type'. The third criteria is about the overall structure of museum layouts including such elements as whether it contains a certain type of central major space or not and whether and how the exhibition spaces are connected to it. By applying these classificatory criteria, the study analyzed and classified 90 sample of museum layouts in order to understand clearly and succintly the spatial characteristics and implications contained in them.

• Geomechanics and Engineering
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• 제15권1호
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• pp.645-657
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• 2018

The paper aims to analyze the behaviour of torsional type surface waves propagating through fluid saturated inhomogeneous porous media clamped between two inhomogeneous anisotropic media. We considered three types of inhomogeneities in upper anisotropic layer which varies exponentially, quadratically and hyperbolically with depth. The anisotropic half space inhomogeneity varies linearly with depth and intermediate layer is taken as inhomogeneous fluid saturated porous media with sinusoidal variation. Following Biot, the dispersion equation has been derived in a closed form which contains Whittaker's function and its derivative, for approximate result that have been expanded asymptotically up to second term. Possible particular cases have been established which are in perfect agreement with standard results and observe that when one of the upper layer vanishes and other layer is homogeneous isotropic over a homogeneous half space, the velocity of torsional type surface waves coincides with that of classical Love type wave. Comparative study has been made to identify the effects of various dimensionless parameters viz. inhomogeneity parameters, anisotropy parameters, porosity parameter, and initial stress parameters on the torsional wave propagation by means of graphs using MATLAB. The study has its own relevance in connection with the propagation of seismic waves in the earth where fluid saturated poroelastic layer is present.

• BMB Reports
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• 제37권5호
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• pp.629-633
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• 2004

NADPH-cytochrome P450 reductase (CPR) transfers electrons from NADPH to cytochrome P450, and catalyzes the one-electron reduction of many drugs and foreign compounds. Various forms of spectrophotometric titration have been performed to investigate the electron-accepting properties of CPR, particularly, to examine its ability to reduce cytochrome c and ferricyanide. In this study, the reduction of 1,1-diphenyl-2-picrylhydrazyl (DPPH) by CPR was assessed as a means of monitoring CPR activity. The principle advantage of DPPH is that its reduction can be assayed directly in the reaction medium by a continuous spectrophotometry. Thus, electrons released from NADPH by CPR were transferred to DPPH, and DPPH reduction was then followed spectrophotometrically by measuring $A_{520}$ reduction. Optimal assay concentrations of DPPH, CPR, potassium phosphate buffer, and NADPH were first established. DPPH reduction activity was found to depend upon the strength of the buffer used, which was optimal at 100 mM potassium phosphate and pH 7.6. The extinction coefficient of DPPH was $4.09\;mM^{-1}\;cm^{-1}$. DPPH reduction followed classical Michaelis-Menten kinetics ($K_m\;=\;28\;{\mu}M$, $K_{cat}\;=\;1690\;min^{-1}$). This method uses readily available materials, and has the additional advantages of being rapid and inexpensive.

• Journal of Chest Surgery
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• 제19권4호
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• pp.558-562
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• 1986

The extracorporeal circulation has been much improved recently, but has yet much complex problems such as the protein denaturation and the activation of the complement system by the exposure of the blood to the foreign surface, which may result in such as the postperfusion syndrome. We studied the changes of the plasma protein fractions by the electrophoresis and the complement consumption [C3, C4] by the immunodiffusion method in the patients undergoing cardiac operation from Mar. 1, 1986 to Aug. 31, 1986. The results were summarized as follows: 1. y-globulin fraction was decreased [p<0.02 by paired t-test, N=25], but a,-globulin was increased [p<0.001 by paired t test, N=25] after operation. 2. C3,C4 were significantly reduced [p<0.001 by paired t-test, N=14] postoperatively and normalized from 24 hours after operation. 3. The consumption of C3,C4 had significant linear correlation [correlation coefficient r=0.97] and C, was more markedly reduced comparing with C3, which probably means the complement activation by classical pathway in our bubble oxygenator group.

• International Journal of Automotive Technology
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• 제2권1호
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• pp.9-16
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• 2001

The lifetime of power train components can be improved dramatically by finding crack initiation points with suitable software tools and optimization of the critical areas. With increasing capacities of computers the prediction of the lifetime for components by numerical methods gets more and more important. This paper discusses some applications of the outstanding fatigue simulation program FEMFAT supporting the assessment of uniaxially and multiaxially loaded components (as well as welding seams and spot joints). The theory applied in FEMFAT differs in some aspects from classical approaches like the nominal stress concept or the local one and can be characterized by the term "influence parameter method". The specimen S/N-curve is locally modified by different influence parameters as stress-gradient to take into account notch effects, mean-stress influence which is quantified by means of a Haigh-diagram, surface roughness and treatments, temperature, technological size, etc. It is possible to consider plastic deformations resulting in mean-stress rearrangements. The dynamic loading of power train components is very often multiaxial, e.g. the stress state at each time is not proportional to one single stress state. Hence, the directions of the principal axes vary with time. We will present the way how such complex load situations can be handled with FEMFAT by the examples of a crank case and a gear box.

• 한국실내디자인학회논문집
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• 제14권3호
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• pp.95-102
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• 2005

Guarini's architectural contribution has simply focused on the dome structure that has been known to us; however, his geometric and spatial construction has been overlooked so far Through this study, it has been demonstrated that the dome structure was simply part of geometrical forms that Guarini wanted to express ultimately and it functioned as a geometrical element such as the network combined with the entire spatial structure. The purpose of this study is to reevaluate Guarini's architectural thought by means of investigating the ultimate principles of spatial composition appeared in the late Baroque architecture through the analysis of the principles of spatial composition and organized formal Idioms by Guarini's geometrical concepts. Besides, it has been assumed that such geometrical concepts by Guarini's mathematical proportion and his reiteration and change of diagrams could be clearly distinguished from the Classical geometry in the Renaissance and Guarini. suggested a way to create a new space through more active and amusing application and transformation. In this aspect, Guarini's principles of geometric composition will be one of the role models that need to be seriously reconsidered in chaotic reality of modern architecture.

• 한국실내디자인학회논문집
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• 제15권2호
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• pp.3-12
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• 2006

The renaissance architects had considered perspective system as accurate tool for the visual representation, but Palladio did not agree with this belief and demonstrated that it is a system based on optical illusionism. On the base of this faith, he created another optical illusion system can be called 'scenographic space'. But the remainder of his works reveals many perspective installations mobilized as well as it. In this context, this study aimed to analyze the meaning and usage of these two space composition systems in the Palladio's architecture. For the purpose of it, a preliminary study examine the background of his idea and make a comparative analysis between the two systems, and then finally analyze the concrete works in compliance with the building types. And then, this study comes to the following conclusion. The scenographic space create the cognition of discontinuity which was produced by the perceptual mask perpendicular to the subject's eye. In opposition to it, the perspective techniques join the space between the subject and his outer world. In result, the viewer lost or attach his attention on the connection between the real and the virtual, the secular and the divine, and the inside and the outside. Palladio applied these two illusion systems to all types of his architecture. By means of it, he could achieve the desire of his patrons and reconstruct the classical architecture of the late renaissance age.

• Structural Engineering and Mechanics
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• 제23권1호
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• pp.63-74
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• 2006

In this paper, the scattering of harmonic elastic anti-plane shear waves by two collinear cracks in functionally graded materials is investigated by means of nonlocal theory. The traditional concepts of the non-local theory are extended to solve the fracture problem of functionally graded materials. To overcome the mathematical difficulties, a one-dimensional non-local kernel is used instead of a two-dimensional one for the anti-plane dynamic problem to obtain the stress field near the crack tips. To make the analysis tractable, it is assumed that the shear modulus and the material density vary exponentially with coordinate vertical to the crack. By use of the Fourier transform, the problem can be solved with the help of a pair of triple integral equations, in which the unknown variable is the displacement on the crack surfaces. To solve the triple integral equations, the displacement on the crack surfaces is expanded in a series of Jacobi polynomials. Unlike the classical elasticity solutions, it is found that no stress singularities are present at crack tips.

• 대한기계학회논문집A
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• 제28권11호
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• pp.1760-1767
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• 2004

Sequential sampling approaches of a metamodel that sampling points are updated sequentially become a significant consideration in metamodeling technique. Sequential sampling design is more effective than classical space filling design of all-at-once sampling because sequential sampling design is to add new sampling points by means of distance between sampling points or precdiction error obtained from metamodel. However, though the extremum points can strongly reflect the behaviors of responses, the existing sequential sampling designs are inefficient to approximate extremum points of original model. In this research, new sequential sampling approach using the sensitivity of Kriging model is proposed, so that new approach reflects the behaviors of response sequentially. Various sequential sampling designs are reviewed and the performances of the proposed approach are compared with those of existing sequential sampling approaches by using mean squared error. The accuracy of the proposed approach is investigated against optimization results of test problems so that superiority of the sensitivity approach is verified.