• 응용통계연구
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• 제22권1호
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• pp.115-127
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• 2009

The purpose of statistical analyses of array-CGH experiment data is to divide the whole genome into regions of equal copy number, to quantify the copy number in each region and finally to evaluate its significance of being different from two. Several statistical procedures have been proposed which include the circular binary segmentation, and a Gaussian based local regression for detecting break points (GLAD) by estimating a piecewise constant function. We propose in this note a penalized spline regression and its simultaneous confidence band(SCB) approach to evaluate the statistical significance of regions of genetic gain/loss. The region of which the simultaneous confidence band stays above 0 or below 0 can be considered as a region of genetic gain or loss. We compare the performance of the SCB procedure with GLAD and hidden Markov model approaches through a simulation study in which the data were generated from AR(1) and AR(2) models to reflect spatial dependence of the array-CGH data in addition to the independence model. We found that the SCB method is more sensitive in detecting the low level copy number alterations.

• 전력전자학회:학술대회논문집
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• 전력전자학회 2000년도 전력전자학술대회 논문집
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• pp.493-497
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• 2000

A battery is the device that transforms the chemical energy into the direct-current electrical energy without a mechanical process. Unit cells are connected in series to obtain the required voltage while being connected in parallel to organize capacity for load current. Because the voltage drop down in one set of battery is faster than in two one it may result in the low efficiency of power converter with the voltage drop and cause the system shutdown. However when the system being shutdown. However when the system being driven in parallel a circular-current can be generated,. It is shown that as a result the new batteries are heated by over-charge and over-discharge and the over charge current increases rust of the positive grid and consequently shortens the lifetime of the new batteries. The difference between the new batteries and old ones is the amount of internal resistance. In this paper we can detect the unbalance current using the microprocessor and achieve the balance current by adjusting resistance of each set, The internal resistance of each set becomes constant and the current of charge and discharge comes to be balanced by inserting the external resistance into the system and calculating the change of internal resistance.

• 방사성폐기물학회지
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• 제18권2호
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• pp.169-177
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• 2020

Here, the stability of stainless steel 316 (SS-316) was investigated to identify its applicability in the oxide reduction process, as a component in related equipment, to produce a complicated gas mixture composed of O₂ and Cl₂ under an argon (Ar) atmosphere. The effects of the mixed gas composition were investigated at flow rates of 30 mL/min O₂, 20 mL/min O₂ + 10 mL/min Cl₂, 10 mL/min O₂ + 20 mL/min Cl₂, and 30 mL/min Cl₂, each at 600℃, during a constant argon flow rate of 170 mL/min. It was found that the corrosion of SS-316 by the chlorine gas was suppressed by the presence of oxygen, while the reaction proceeded linearly with the reaction time regardless of gas composition. Surface observation results revealed an uneven surface with circular pits in the samples that were fed mixed gases. Thermodynamic calculations proposed the combination of Fe and Ni chlorination reactions as an explanation for this pit formation phenomenon. An exponential increase in the corrosion rate was observed with an increase in the reaction temperature in a range of 300 ~ 600℃ under a flow of 30 mL/min Cl₂ + 170 mL/min Ar.

• Earthquakes and Structures
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• 제12권2호
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• pp.201-211
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• 2017

This paper experimentally investigates the effect of yield strength of reinforcing bars and stirrups on the seismic performance of reinforced concrete (RC) circular piers. Reversed cyclic loading tests of nine-large scale specimens with longitudinal and transverse reinforcement of different yield strengths (varying between HRB335, HRB500E and HRB600 rebars) were conducted. The test parameters include the yield strength and amount of longitudinal and transverse reinforcement. The results indicate that the adoption of high-strength steel (HSS) reinforcement HRB500E and HRB600 (to replace HRB335) as longitudinal bars without reducing the steel area (i.e., equal volume replacement) is found to increase the moment resistance (as expected) and the total deformation capacity while reducing the residual displacement, ductility and energy dissipation capacity to some extent. Higher strength stirrups enhance the ductility and energy dissipation capacity of RC bridge piers. While the product of steel yield strength and reinforcement ratio ($f_y{\rho}_s$) is kept constant (i.e., equal strength replacement), the piers with higher yield strength longitudinal bars are found to achieve as good seismic performance as when lower strength bars are used. When higher yield strength transverse reinforcement is to be used to maintain equal strength, reducing bar diameter is found to be a better approach than increasing the tie spacing.

• 한국농공학회지
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• 제30권2호
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• pp.44-54
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• 1988

This study was carried out to investigate the applicability of the conventional design method for ground supported circular cylindrical shell structures. For this purpose, the ensiled farm silo was adopted as a model structures. Herein, the conventional design method was based on the assumption that such structures are clamped at the bottom edges or the ground pressure is independent of the deflection at the surface. In the present paper, the applicability of above assumption was checked out by comparison with an exact method considering soil-structure interaction. Some results of numerical calculation show us ; When the ground is very hard, for example Winkler's constant k is larger than 100 kg / cm$^2$ / cm, or the bottom plate of structures has a infinitely stiffness, for example the bottom plate thickness is larger than 100 cm, the sectional forces, obtained from the conventional method at any wall of structures resting on an elastic foundation, can used for design purpose. Therefore, if the above condition is satisfied then the conventional assumptions can be justified for the design purpose. In this case, the assumption that such structures are fixed at the lower edges was more realistic than the assumption that the reaction pressure acting on structures is uniformly disributed since the accuracy of results of the analysis by the former assumption was higher than that obtained from the latter assumption. But the sectional forces in the bottom plate resting on ground directly could not be evaluate correctly by the conventional method.

• Journal of Microbiology and Biotechnology
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• 제2권2호
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• pp.141-151
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• 1992

Physiological changes of the murine hybridoma cell line $S3H5/\gamma{2bA2}$ during adaptation to RPMI 1640 medium with 1%(v/v) fetal bovine serum were characterized in terms of cell growth, antibody production, morphology, and metabolic quotients. Cells adapted to 1% serum medium in T-flasks became sensitive to shear induced by mechanical agitation and required at least 5% serum in the medium or spent medium for cell growth in spinner flasks, while cells adapted to 10% serum medium in T-flasks could grow in 1% serum medium in spinner flasks. Consequently, long-term adaptation to low serum media may not give the expected growth enhancement. After adaptation to 1% serum medium, changes in cell morphology were observed. The cells in 10% serum medium were uniform and circular, while cells in 1% medium were irregularly shaped. The DNA contents, which were measured by flow cytometry, were almost constant among the cells in the range of 1% to 10%. Further, no significant changes in energy metabolism and specific monoclonal antibody production rate were observed among these cells.

• 대한기계학회논문집
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• 제19권5호
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• pp.1269-1279
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• 1995

An experimental study is carried out on turbulent diffusion flames stabilized by a circular cylinder in a divergent duct flow. A commercial grade gaseous propane is injected from two slits on the rod as fuel. Flame stability limits, as well as size and temperrature of recirculation zone, are measured by direct and schlieren photographs to clarify the characteristics and structure of diffusion flames and to assess the effect of various divergent angle of duct. The results of the present study are as follows. Temperature in the recirculation zone decreases with increasing divergent angle. The blow-off velocity in parallel duct is higher than that in divergent duct. Critical blow-off velocity is expected to be about 8-12 degree through blow-off velocity pattern. Regardless of divergent angles, the length of recirculation zone is nearly constant, and this length becomes longer with rod diameter. Pressure gradient has an effect on the eddy structure in shear layer behind the rod. With the increase of divergent angle, large scale eddies by dissipated energy in shear layer are split into small scale eddies, and the flame becomes a typical distributedreacting flame.

• 대한기계학회논문집A
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• 제27권3호
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• pp.440-449
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• 2003

Residual strength of fiber metal laminates after impact was studied. 3/4 lay up FML was fabricated using 4 ply prepreg, 2 ply aluminum sheets, and 1 ply steel sheet. Quasi isotropic ([0/45/90/-45]s) and orthotropic ([0/90/0/90]s) FRP were also fabricated to compare with FML. Impact test were conducted by using instrumented drop weight impact machine (Dynatup, Model 8250). Penetration load and absorbed energy of FML were superior to those of FRPs. Tensile tests were conducted to evaluate the residual strength after impact. Strength degradation of FML was less than that of FRP. This means that the damage tolerance of FML is excellent than that of FRP. Residual strength of each specimen was predicted by using Whitney and Nuismer(WN) Model. Impact damage area is assumed as a circular notch in WN model. Damage width is defined as the average of back face and top face damage width of each specimen. Average stress and point stress criterions were used to calculate the characteristic length. It is supposing that a characteristic length is a constant. The distribution of characteristic length shows that the assumption is reasonable. Prediction was well matched with experiment under both stress criterions.

• 대한화학회지
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• 제31권5호
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• pp.471-475
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• 1987

수용액에서 Fe(II)-poly(D-glutamic acid) (PGA) 복합물 형성이 pH와 농도에 따라서 흡수와 원이색성 분광 광도계로 확인되었으며, 철 이온과 복합물 형성에 의한 PGA의 구조 변화와 안정도 상수도 검토되었다. PGA와 Fe(II)사이에 형성된 후 pH4.3에서는 ${\alpha}$-helix를 파괴(${\alpha}$-helix 파괴 효과)하고 pH5.7에서는 ${\alpha}$-helix를 유도(${\alpha}$-helix유도 효과)하는 것을 알 수 있었다. ${\alpha}$-helix의 PGA구조가 random coil의 PGA구조 보다 전 안정도 상수 값이 큰 것으로 보아 random coil의 PGA구조에서 더욱 안정된 복합물을 형성하고 있음을 알 수 있었다.

• Nuclear Engineering and Technology
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• 제47권4호
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• pp.389-397
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• 2015

The effects of mixing vanes (MVs) attached to a grid spacer on the characteristics of air-water annular flows were experimentally investigated. To know the effects, a grid spacer with or without MV was inserted in a vertical circular pipe of 16-mm internal diameter. For three cases (i.e., no spacer, spacer without MV, and spacer with MV), the liquid film thickness, liquid entrainment fraction, and deposition rate were measured by the constant current method, single liquid film extraction method, and double liquid film extraction method, respectively. The MVs significantly promote the re-deposition of liquid droplets in the gas core flow into the liquid film on the channel walls. The deposition mass transfer coefficient is three times higher for the spacer with MV than for the spacer without MV, even for cases 0.3-m downstream from the spacer. The liquid film thickness becomes thicker upstream and downstream for the spacer with MV, compared with the thickness for the spacer without MV and for the case with no spacer.