• 한국독성학회:학술대회논문집
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• 한국독성학회 2003년도 추계학술대회
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• pp.161-161
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• 2003

Different circling preference of mice is a reference of inter-individual differences in their endogenous neuroimmune circuits. I have investigated relationship between differential immune responses in mice, who have same age, gender, and genetic background, and circling behavior preference.(omitted)

• Reproductive and Developmental Biology
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• 제34권2호
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• pp.63-71
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• 2010

The spontaneous mutant circling mouse (cir/cir) shows a circling behavior and hearing loss. We produced transgenic mice overexpressing transmembrane inner ear (tmie) gene, the causative gene, for the phenotypic rescue of the circling mouse. Through the continuous breeding with circling mice, the cir/cir homozygous mice carrying the transgene (cir/cir-tg) were produced. The rescued cir/cir-tg mice were able to swim in the water with proper orientation and did not show any circling behavior like wild type mice. Western blot and immunohistochemical analysis exhibited that the transgenic tmie was expressed in the inner ear. Inner and outer hair cells were recovered in the cochlea and spiral ganglion neurons were also recovered in the rescued mice. Auditory brainstem response (ABR) test demonstrated that the cir/cir-tg mice are able to respond to sound. This study demonstrates that tmie transgene can recover the hearing impairment and abnormal behavior in the circling mouse.

• Journal of Ginseng Research
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• 제21권1호
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• pp.61-67
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• 1997

The present study examined the characteristics of behavior Induced by dopamine agonists following treatment with 6-hydroxydopamine(6-OHDA) unilaterally into left striatum in rats. 6-OHDA was administered at doses of 8,16 and 24 $\mu\textrm{g}$/$\mu\textrm{l}$(in 0.1% ascorbic acid) into dopaminergic neurons in left striatum of 7 weeks old rat under anesthetic. Locomotor activity was significantly decreased at 1 week following 6-OHDA-administration in 7 weeks old rats. The contralateral circling behavior was induced by apomorphine(5 mg/kg, i.v.) after 1 week following 6-OHDA(24$\mu\textrm{g}$/$\mu\textrm{l}$) treatment, and was further increased by repeated administration of apomorphine at 2, 3 and 4 weeks. The contralateral circling behavior was also induced by lisuride and 1-dopa in a dose dependent manner, but not by SK & F 82526 in 7 weeks old rats treated with 6-OHDA. The contralateral circling behavior was significantly higher in 21 weeks old rats but significantly lower In 35 weeks old rats when compared with 7 weeks old rats. The contralateral circling behavior induced by apomorphlne did not differ significantly in 7 and 35 weeks old male and female rats. These results suggest that 6-OHDA treatment into left striatum causes remarkable destrurtion of intrastriatal dopaminergic netcons leading to dopaminergic receptor supersensitivity. Thus, the contralateral circling behavior in duces by apomorphine may be used as indicator for neurodegenerative diseases.

• 한국동물번식학회:학술대회논문집
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• 한국동물번식학회 2004년도 춘계학술발표대회
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• pp.226-226
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• 2004

Circling (cir) mouse is a spontaneous mutant in the inner ear that was first reported in Korea. The mutation is transmitted by an autosomal recessive gene with 100 %- penetrance.. Homozygous mice are characterized by head-tossing, bi-directional circling behavior and deafness. Histologicalexamination of the inner ear reveals abnormalities of the region around the organ of Corti, spiral ganglion neurons, and outer hair cells. (omitted)

• 한국환경성돌연변이발암원학회:학술대회논문집
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• 한국환경성돌연변이발암원학회 2003년도 추계학술대회
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• pp.161-161
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• 2003

• 한국항해학회지
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• 제17권3호
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• pp.49-55
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• 1993

This study describes the accuracies of position fixes observed by the DGPS systems for the purpose of obtaining the utility basic data in the fishery and oceanography observation field. The circling sail experiments around a reterence point using the DGPS were made in water level point of National Fisheries University of Pusan and on the sea in Yongho day located on the southeast of that university. The main results are as follows ; 1) The number of the usable satellites in position fixing were all eighteen, SV 2, 3, 11-21, 23-26 and SV 28 etc. Each satellites could be observed for average seven hours a day, and position fixing was found to be always possible except about thirty minutes a day. 2) In the standard fixed position, the radius of 95% probability circle and the shifted distance between the position fixes by the DGPS and true position were respectively 5.7m, 0.9m. In the above case those of ordinary GPS was respectively 48.8, 54.2m. Therefore, the accuracy of the position fixes by DGPS was shown much higher the ordinary GPS. 3) At land, the shifted distance between the center of traces in the circling sail experiment of 15m ra-dius by DGPS and the reference position amounted to 5.5m and observed radius of circling traces was 17.5m. other than 15m. At sea, that distance the center of traces in circling experiment of 20m radius by the DGPS and the reference position amounted to 3.6m and observed radius of circling traces was 19.7m, other than 20m. Therefore, the utility of the circling experiment to obtain the accurate position fixes by the DGPS was found to be very high.

• Applied Microscopy
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• 제40권2호
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• pp.53-64
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• 2010

글루타메이트 수용체는 신경연접의 발달에서 신경연접과 정제 등에 중요한 역할을 한다. 포유류 청각뇌줄기의 가쪽위올리브 핵-안쪽마름섬유체핵 신경연접에서의 흥분성 신경전달물질의 전달은 글루타메이트와 같은 많은 흥분성 신경전달물질의 전달을 조절하므로 발생학적 연구에 매우 유용한 모델이다. 귀먹음은 흥분성 회로 또는 억제성 회로의 신경연접에서 신경전달물질들의 변화뿐 아니라 형태학적 변화도 초래하게 된다. 이런 이유로 선천적으로 태어나면서 달팽이 기관이 퇴화되는 선회생쥐는 귀먹음의 병태생리를 연구하는데 가장 좋은 동물모델이다. 그러나, 선회생쥐에서 이런 NMDA 수용체 각각의 아형들이 발달에 따라 어떻게 나타나는지에 관해서는 거의 알려진 사실이 없다. 따라서, 본 연구에서는 선천적으로 속귀에 돌연변이를 가진 선회생쥐를 이용하여 면역조직화학염색법으로 생후 7일과 16일의 쥐를 정상쥐와 비교해서 글루타메이트성의 흥분성 신호가 전달되는 청각뇌줄기의 가쪽위올리브핵(LSO)에서 N-메틸-D-아스파르 트산염(NMDA) 수용체의 아형인 NR1, NR2A, NR2B의 분포를 각각 조사하였다. 생후 7일째 선회생쥐의 NR1에 대한 면역반응성의 세기는 정상군에서 $128.67\pm8.87$로 나타났고 이형접합체에서는 $111.06\pm8.04$, 동형접합체에서는 $108.09\pm5.94$으로 나타났다. 그리고 생후 16일째 선회생쥐에서는 정상군에서 $43.83\pm10.49$, 이형접합체에서는 $40\pm13.88$, 동형접합체에서는 $55.96\pm17.35$으로 나타났다. 생후 7일째 선회생쥐의 NR2A에 대한 면역반응성의 세기는 정상군에서 $97.97\pm9.71$, 이형접합체에서 $102.87\pm9.30$, 동형접합체에서 $106.85\pm5.79$로 나타났다. 생후 16일 선회생쥐의 가쪽위올리브핵에서의 NR2A에 대한 면역반응성 세기는 정상군에서 $47.4\pm20.6$, 이형접합체에서 $43.9\pm17.5$, 동형접합체에서 $49.2\pm20.1$로 나타났다. 생후 7일의 선회생쥐의 NR2B의 면역반응성 세기는 정상군에서 $109.04\pm6.77$, 이형접합체에서 $106.43\pm10.24$, 동형접합체에서 $105.98\pm4.10$으로 나타났다. 생후 16일째 선회생쥐의 NR2B의 면역반응성의 세기는 정상군에서 $101.47\pm11.50$, 이형접합체에서 $91.47\pm14.81$, 동형접합체에서 $93.93\pm15.71$으로 나타났다. 이 결과들은 생후 7일과 16일의 선회생쥐의 가쪽위올리브핵에서 NMDA 수용체의 면역반응성의 변화를 나타낸 것으로 인간 귀먹음의 주요한 병태생리를 파악하는 데 기본적인 자료를 제시할 수 있을 것이다.

• 한국항공운항학회지
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• 제12권3호
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• pp.65-85
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• 2004

Circling to land is a relatively dangerous maneuver. It contains the worst elements of IFR flight. There is a minimum obstruction clearance, a limited space in which to maneuver, an absence of visual reference, and trying to keep the runway in sight while preparing to land. At night it is quite a bit more than dangerous. The required continuous turn in marginal conditions that keeps the airport in sight is hazardous. Therefore, this paper proposes an application of GNSS to circling approach to reduce or remove chances of accidents which may occur under such unfavorable flight conditions. The study reviews relevant documents published by ICAO and FAA and provides scenarios for non-precision and precision approaches and circling approach based on the GNSS for Kimhae airport. Also requirements for the ground facility design are studied and provided.

• 한국항공운항학회지
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• 제14권4호
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• pp.110-119
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• 2006

This research was conducted with a view to enhance the efficiency of the preventive tool which provide pilots and controllers with proper and timely safety alerts while conducting circling approach at the airport where surrounding terrains becomes threat to safe operation of flight around airport.

• 한국동물번식학회:학술대회논문집
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• 한국동물번식학회 2003년도 학술발표대회 발표논문초록집
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• pp.90-90
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• 2003

Circling mice were recorded to display profound deafness and a head-tossing and bidirectional circling behavior, showing an autosomal recessive mode of inheritance. In addition, the histological examination of inner ears revealed that the region around organ of Corti, spiral ganglion neurons and outer hair cells showed definite abnormality. On the other hand, a genetic linkage map was constructed in an intraspecific backcross between cir and C57BL/6J mice. The cir gene was mapped to a region between D9Mitl16/D9Mit15 and D9Mit38 on the mouse chromosome 9. Estimated distances between cir and D9Mitl16, and between cir and D9Mit38 are 0.70 $\pm$ 0.40 and 0.23 $\pm$ 0.23 cM, respectively. The markers in order was defined as follows: centromere-D9Mit182- D9Mit51/ D9Mit79/ D9Mit310- D9Mit212/ D9Mit184- D9Mit116/ D9Mit15- cir- D9Mit38- D9Mit20- D9Mit243- D9Mit16- D9Mit55/ D9Mit125- D9Mit281 Based on genetic mapping, we constructed for a YAC contig across cir region. They covered the entire region or cir and cir gene was located on between the lactotransferrin (ltf) and the macrotubule-associated protein (map4). It is known that sr gene is localized in 64cM of mouse chromosome 9. The two mouse were found to be allelic by complementation test. Recently the spinner mouse has been mapped to our cir region, and tmie gene were elucidated. And further study will be needed in circling mouse to prove tmie gene mutaiton.