• Title/Summary/Keyword: circling

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Differential Humoral Immune Responses in Pb-exposed Mice with Different Circling Preference

  • Kim, Dongsoo
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2003.10b
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    • pp.161-161
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    • 2003
  • Different circling preference of mice is a reference of inter-individual differences in their endogenous neuroimmune circuits. I have investigated relationship between differential immune responses in mice, who have same age, gender, and genetic background, and circling behavior preference.(omitted)

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Introduction of tmie Gene Can Recover the Hearing Impairment and Abnormal Behavior in the Circling Mouse

  • Shin, Mi-Jung;Park, Seo-Jin;Pare, Hum Dai;Ryoo, Zae-Young
    • Reproductive and Developmental Biology
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    • v.34 no.2
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    • pp.63-71
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    • 2010
  • The spontaneous mutant circling mouse (cir/cir) shows a circling behavior and hearing loss. We produced transgenic mice overexpressing transmembrane inner ear (tmie) gene, the causative gene, for the phenotypic rescue of the circling mouse. Through the continuous breeding with circling mice, the cir/cir homozygous mice carrying the transgene (cir/cir-tg) were produced. The rescued cir/cir-tg mice were able to swim in the water with proper orientation and did not show any circling behavior like wild type mice. Western blot and immunohistochemical analysis exhibited that the transgenic tmie was expressed in the inner ear. Inner and outer hair cells were recovered in the cochlea and spiral ganglion neurons were also recovered in the rescued mice. Auditory brainstem response (ABR) test demonstrated that the cir/cir-tg mice are able to respond to sound. This study demonstrates that tmie transgene can recover the hearing impairment and abnormal behavior in the circling mouse.

일측성선조체의 6-OHDA손상 후 도파민효능약물 투여로 발현된 회전운동의 특성

  • 이순철;문민선
    • Journal of Ginseng Research
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    • v.21 no.1
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    • pp.61-67
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    • 1997
  • The present study examined the characteristics of behavior Induced by dopamine agonists following treatment with 6-hydroxydopamine(6-OHDA) unilaterally into left striatum in rats. 6-OHDA was administered at doses of 8,16 and 24 $\mu\textrm{g}$/$\mu\textrm{l}$(in 0.1% ascorbic acid) into dopaminergic neurons in left striatum of 7 weeks old rat under anesthetic. Locomotor activity was significantly decreased at 1 week following 6-OHDA-administration in 7 weeks old rats. The contralateral circling behavior was induced by apomorphine(5 mg/kg, i.v.) after 1 week following 6-OHDA(24$\mu\textrm{g}$/$\mu\textrm{l}$) treatment, and was further increased by repeated administration of apomorphine at 2, 3 and 4 weeks. The contralateral circling behavior was also induced by lisuride and 1-dopa in a dose dependent manner, but not by SK & F 82526 in 7 weeks old rats treated with 6-OHDA. The contralateral circling behavior was significantly higher in 21 weeks old rats but significantly lower In 35 weeks old rats when compared with 7 weeks old rats. The contralateral circling behavior induced by apomorphlne did not differ significantly in 7 and 35 weeks old male and female rats. These results suggest that 6-OHDA treatment into left striatum causes remarkable destrurtion of intrastriatal dopaminergic netcons leading to dopaminergic receptor supersensitivity. Thus, the contralateral circling behavior in duces by apomorphine may be used as indicator for neurodegenerative diseases.

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A 40 Kb Genomic Deletion Including tmie (Transmembrane Inner Ear Protein) Gene Causes Deafness, Circling and Head Tossing in Circling Mice

  • Kyoung In Cho;Jeong Woong Lee;Eun Ju Lee;Sol Ha Hwang;Myoung Ok Kim;Sung Hyun Kim;Jun Hong Park;Boo Kyoung Jung;Hee Chul Kim
    • Proceedings of the KSAR Conference
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    • 2004.06a
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    • pp.226-226
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    • 2004
  • Circling (cir) mouse is a spontaneous mutant in the inner ear that was first reported in Korea. The mutation is transmitted by an autosomal recessive gene with 100 %- penetrance.. Homozygous mice are characterized by head-tossing, bi-directional circling behavior and deafness. Histologicalexamination of the inner ear reveals abnormalities of the region around the organ of Corti, spiral ganglion neurons, and outer hair cells. (omitted)

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Accuracies of the Position Fixes by the Differential GPS measured in Pusan (부산에서의 Diferential GPS의 측위정도)

  • 이희상;신형일;김기윤;이대재
    • Journal of the Korean Institute of Navigation
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    • v.17 no.3
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    • pp.49-55
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    • 1993
  • This study describes the accuracies of position fixes observed by the DGPS systems for the purpose of obtaining the utility basic data in the fishery and oceanography observation field. The circling sail experiments around a reterence point using the DGPS were made in water level point of National Fisheries University of Pusan and on the sea in Yongho day located on the southeast of that university. The main results are as follows ; 1) The number of the usable satellites in position fixing were all eighteen, SV 2, 3, 11-21, 23-26 and SV 28 etc. Each satellites could be observed for average seven hours a day, and position fixing was found to be always possible except about thirty minutes a day. 2) In the standard fixed position, the radius of 95% probability circle and the shifted distance between the position fixes by the DGPS and true position were respectively 5.7m, 0.9m. In the above case those of ordinary GPS was respectively 48.8, 54.2m. Therefore, the accuracy of the position fixes by DGPS was shown much higher the ordinary GPS. 3) At land, the shifted distance between the center of traces in the circling sail experiment of 15m ra-dius by DGPS and the reference position amounted to 5.5m and observed radius of circling traces was 17.5m. other than 15m. At sea, that distance the center of traces in circling experiment of 20m radius by the DGPS and the reference position amounted to 3.6m and observed radius of circling traces was 19.7m, other than 20m. Therefore, the utility of the circling experiment to obtain the accurate position fixes by the DGPS was found to be very high.

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Immunohistochemical Localization of NMDA Receptor in the Auditory Brain Stem of Postnatal 7, 16 Circling Mouse (생후 7일, 16일된 circling mouse 청각 뇌줄기에서 N-메틸-D 아스파르트산염 수용체(NMDA receptor)에 대한 면역염색학적 분포)

  • Choi, In-Young;Park, Ki-Sup;Kim, Hye-Jin;Maskey, Dhiraj;Kim, Myeung-Ju
    • Applied Microscopy
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    • v.40 no.2
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    • pp.53-64
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    • 2010
  • Glutamate receptors may play a critical role in the refinement of developing synapses. The lateral superior olivary nucleus (LSO)-medial nucleus of trapezoid body (MNTB) synaptic transmission in the mammalian auditory brain stem mediate many excitatory transmitters such as glutamate, which is a useful model to study excitatory synaptic development. Hearing deficits are often accompanied by changes in the synaptic organization such as excitatory or inhibitory circuits as well as anatomical changes. Owing to this, circling mouse whose cochlea degenerates spontaneously after birth, is an excellent animal model to study deafness pathophysiology. However, little is known about the development regulation of the subunits composing these receptors in circling mouse. Thus, we used immunohistochemical method to compare the N-Methyl-D-aspartate receptor (NMDA receptor) NR1, NR2A, NR2B distribution in the LSO which project glutamergic excitatory input into the auditory brainstem, in circling mouse of postnatal (p) 7 and 16, which have spontaneous mutation in the inner ear, with wild-type mouse. The relative NMDAR1 immunoreactive density of the LSO in circling mouse p7 was $128.67\pm8.87$ in wild-type, $111.06\pm8.04$ in heterozygote, and $108.09\pm5.94$ in homozygote. The density of p16 circling mouse was $43.83\pm10.49$ in wild-type, $40\pm13.88$ in heterozygote, and $55.96\pm17.35$ in homozygote. The relative NMDAR2A immunoreactive density of LSO in circling mouse p7 was $97.97\pm9.71$ in wild-type, $102.87\pm9.30$ in heterozygote, and $106.85\pm5.79$ in homozygote. The density of LSO in p16 circling was $47.4\pm20.6$ in wild-type, $43.9\pm17.5$ in heterozygote, and $49.2\pm20.1$ in homozygote. The relative NMDAR2B immunoreactive density of LSO in circling mouse p7 was $109.04\pm6.77$ in wild-type, $106.43\pm10.24$ in heterozygote, and $105.98\pm4.10$ in homozygote. the density of LSO in p16 circling mouse was $101.47\pm11.5$ in wild-type, $91.47\pm14.81$ in heterozygote, and $93.93\pm15.71$ in homozygote. These results reveal alteration of NMDAR immunoreactivity in LSO of p7 and p16 circling mouse. The results of the present study are likely to be relevant to understand the central change underlying human hereditary deafness.

Application of GNSS Non-Precision and Precision Approaches to a Circle-to-Land Approach Airport (선회착륙공항에서의 GNSS 비정밀접근 및 정밀접근 적용 연구)

  • Kim, Y.M.;Kang, J.Y.
    • Journal of the Korean Society for Aviation and Aeronautics
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    • v.12 no.3
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    • pp.65-85
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    • 2004
  • Circling to land is a relatively dangerous maneuver. It contains the worst elements of IFR flight. There is a minimum obstruction clearance, a limited space in which to maneuver, an absence of visual reference, and trying to keep the runway in sight while preparing to land. At night it is quite a bit more than dangerous. The required continuous turn in marginal conditions that keeps the airport in sight is hazardous. Therefore, this paper proposes an application of GNSS to circling approach to reduce or remove chances of accidents which may occur under such unfavorable flight conditions. The study reviews relevant documents published by ICAO and FAA and provides scenarios for non-precision and precision approaches and circling approach based on the GNSS for Kimhae airport. Also requirements for the ground facility design are studied and provided.

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An Empirical case Study on the Improvement of Surveillance Systems in performing Circling Approach at the airport (선회접근용 활주로 감시도구의 개선에 관한 실증적 사례 연구)

  • Yang, Han-Mo;Shin, Hyon-Sam
    • Journal of the Korean Society for Aviation and Aeronautics
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    • v.14 no.4
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    • pp.110-119
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    • 2006
  • This research was conducted with a view to enhance the efficiency of the preventive tool which provide pilots and controllers with proper and timely safety alerts while conducting circling approach at the airport where surrounding terrains becomes threat to safe operation of flight around airport.

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The Mouse Mutations Circling and Spinner are Allelic

  • Kyoung in Cho;Lee, Eun-Ju;Kim, Myoung-Ok;Kim, Sung-Hyun;Pakr, Jun-Hong;Jung, Boo-Kyung;Kim, Hee-Chul;Sol ha Hwang;Suh, Jun-Gyo
    • Proceedings of the KSAR Conference
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    • 2003.06a
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    • pp.90-90
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    • 2003
  • Circling mice were recorded to display profound deafness and a head-tossing and bidirectional circling behavior, showing an autosomal recessive mode of inheritance. In addition, the histological examination of inner ears revealed that the region around organ of Corti, spiral ganglion neurons and outer hair cells showed definite abnormality. On the other hand, a genetic linkage map was constructed in an intraspecific backcross between cir and C57BL/6J mice. The cir gene was mapped to a region between D9Mitl16/D9Mit15 and D9Mit38 on the mouse chromosome 9. Estimated distances between cir and D9Mitl16, and between cir and D9Mit38 are 0.70 $\pm$ 0.40 and 0.23 $\pm$ 0.23 cM, respectively. The markers in order was defined as follows: centromere-D9Mit182- D9Mit51/ D9Mit79/ D9Mit310- D9Mit212/ D9Mit184- D9Mit116/ D9Mit15- cir- D9Mit38- D9Mit20- D9Mit243- D9Mit16- D9Mit55/ D9Mit125- D9Mit281 Based on genetic mapping, we constructed for a YAC contig across cir region. They covered the entire region or cir and cir gene was located on between the lactotransferrin (ltf) and the macrotubule-associated protein (map4). It is known that sr gene is localized in 64cM of mouse chromosome 9. The two mouse were found to be allelic by complementation test. Recently the spinner mouse has been mapped to our cir region, and tmie gene were elucidated. And further study will be needed in circling mouse to prove tmie gene mutaiton.

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