• Archives of Pharmacal Research
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• 제14권3호
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• pp.199-203
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• 1991

7H-thiazolo-[3,2-a]-pyridines as potential antimicrobial agents were prepared by reaction of $\alpha,\beta$-unsaturated nitriles and thioglycolic acid.

• Archives of Pharmacal Research
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• 제13권4호
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• pp.342-346
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• 1990

Several new pyridine, pyridinethione, pyrazole [3, 4-b]-pyridine, pyrido [1, 2-a]-1, 3-thiazine and pyrido[1, 2-a] pyridine thione derivatives have be synthesised via the reactions of 2-methyl-3-ethoxycarbonyl-4-phenyl-5-cyano-1, 4, 5, 6-tetrahydro-pyridine-6-one 2 with different rfeagents. The structures of the newly synthesised derivatives were established on the basis of elemental analyses and spectral data studies.

• Archives of Pharmacal Research
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• 제17권5호
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• pp.298-303
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• 1994

4-Arylazo-1H-pyrazol-3, 5-idimines 1a-c reacted with bromomalononitrile (2) to yield the corresponding imidazo[1, 2-b]pyrazoles 3a-c. The latter reacted with some active methylene compounds and with .alpha.-cinnamonitriles to afford the corresponding pyrazoloimidazopyridines 6, 8, 9 and 15, respectively. Compounds 3 reacted with each of formic acid, formamide, trichlo-roacetonitrile and with guanidine to yield the corresponding pyrazoloimidazopyrimidines 16-19 respectively.

• 대한화학회지
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• 제45권5호
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• pp.448-453
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• 2001

피라졸로아진은 농업이나 의약품에서 매우 유용한 화합물등이다. 본 논문에서는 몇 가지 새로운 피라졸로아진의 합성을 보고하고자 한다. 표제 화합물인 3-아미노-1H-피라졸-4-카복실산 에틸을 다이아조화한 후 활성화된 메틸렌 화합물들과 반응시키고 고리화하여 피라졸로[5,1-c][1,2,4]트라이아진 유도체들을 합성하였다. 또한 표제 화합물을 $\alpha$-치환된 신남나이트릴과 반응시켜 피라졸로[1,5-a]피리미딘 유도체들을 합성하였다. 새로 합성된 화합물들의 구조는 화학적 방법과 분광학적 방법을 사용하여 확립하였다.

• Archives of Pharmacal Research
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• 제20권6호
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• pp.620-628
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• 1997

6-Aryl-5-cyano-4-pyrimidinon-2-thione derivatives 1a-c reacted with ethyl iodide to give the corresponded 2-S-ethylpyrimidin-4-one-derivatives 2a-c. Compounds 2a-c was, in turn, reacted with hydrazine hydrate to give the sulfur free reaction products, 3a-c. These reaction products were taken as the starting materials for the synthesis of several newly synthesized heterocyclic derivatives. Reactions with several halogenated ketones, esters, chloroacetic acid and chloroacetamide give pyrimidotriazines 8,12 and 15 while their reactions with formic acid, acetic acid and carbon disulfide gave the corresponded triazolopyrimidines 17 and 21. The reaction with both acetyl acetone and ethylacetoacetate gave the corresponded 2-$(3^{I},5^{I}-dimethyl-1^{I}-pyrazoly$pyrimidine derivatives 20a-c and 24a-c respectively while the reaction with cinnamonitriles 25a-h afforded the corresponded aryl hydrazopyrimidines 27a-f. The structure of these reaction products were eatablished based on both elemental anlayses and spectral data studies.