• 한국한의학연구원논문집
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• 제18권3호
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• pp.133-139
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• 2012

Objective : UMLS is 'Ontology' which establishes the database for medical terminology by gathering various medical vocabularies representing same fundamental concepts. Method : Although Chinese character are represented in the Chinese part of Korean Unicode system in a computer, writing of Chinese characters is vary depending on Chinese input systems and Chinese writers' levels of knowledge. As the result of this, representation of Chinese writing in a computer will be considerably different from an old Chinese document. Therefore, a meaningful relationship between digital Chinese terminology and translated Korean is necessary in order to build Ontology for Chinese medical terms from Oriental medical prescription in a computer system. Result : This research will present 1:1 mapping information among the Chinese characters used in the Oriental medical prescription with analysis of 'same character different sound' and 'same meaning different shape' in Chinese part of Unicode systems. Conclusions : Furthermore, the research will provide top-down menu of relationship between Chinese term and Korean term in medical prescription with assumption of that the Oriental medical prescription has its own unique meaning.

• 국제교류와 융합교육
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• 제3권1호
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• pp.77-86
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• 2023

"일대일로" 전략을 세운 이래 중국은 중의약(中醫藥)을 해외에 보급하였고 더불어 중의약 교육 및 중의약 문화의 현대화라는 큰 성과를 거두었다. 그러나 중의약의 해외 보급 및 발전은 여전히 중국의 문화 강대국으로 발전시키고자 하는 국가의 전략적 요구와 중의약의 역사적 사명 사이의 격차가 여전히 존재하고 있다. 특히, 중의약의 문화 이론, 해외 전파 방식, 전문용어 번역 등에는 여전히 어려움과 이를 해결하고자 하는 도전은 여전히 잔존하고 있다. "일대일로" 전략의 맥락에서 중의약 종사자는 문화적 이상과 자신감을 강화하여야 한다. 또한 중의약 이론의 대중화를 미디어를 충분히 이용하여 강화하여야 한다. 더불어 중의약의 해외 보급 수단을 개선하고, 다문화 언어 교류를 가속화 해야 한다. 이에 중의약 문화의 혁신을 의사 소통 실천으로 실현하고 중의약의 대외 교류와 협력을 강화하며 중의약의 해외 발전을 촉진할 것을 제언하였다.

• Journal of Ginseng Research
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• 제39권2호
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• pp.116-124
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• 2015

Background: Ginseng, the root of Panax ginseng (PG), is used widely as a herbal medicine to prevent and treat various diseases. Panax ginseng has pharmacological effects on neurodegenerative diseases such as Alzheimer's disease (AD). The present study evaluated the neuroprotective effects of PG and its possible neuroprotective mechanisms in advanced glycation end product (AGE)-induced AD in a rat model. Methods: Advanced glycation end products were injected bilaterally into the CA3 region of the rats' brains. The Morris water maze test and step-down type passive avoidance test were performed to evaluate their memory and cognitive abilities. The oxidation indexes in the hippocampus were detected. Immunohistochemistry was conducted to visualize the receptors for advanced glycation end products (RAGEs) and nuclear factor-kappa-light-chain-enhancer of activated B cell (NF-${\kappa}B$). Results: Behavioral results showed that PG (1 g/kg, 0.5 g/kg, and 0.25 g/kg) significantly shortened the escape latency, remarkably increased the number of crossing times, significantly decreased the number of errors, and prolonged the latency in rats with AGE-induced AD. Panax ginseng also significantly reduced the malondialdehyde level, increased the glutathione content, and increased superoxide dismutase activity in the hippocampus. Panax ginseng significantly decreased the expression of RAGE and NF-${\kappa}B$. The blockade of anti-RAGE antibody could significantly reduce AGE-induced impairments and regulate these expressions. Conclusion: Our results demonstrated that PG significantly inhibits AGE-induced memory impairment and attenuates Alzheimer-like pathophysiological changes. These neuroprotective effects of PG may be associated with the RAGE/NF-${\kappa}B$ pathway. Our results provided the experimental basis for applying PG in preventing and treating AD.

• 사상체질의학회지
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• 제22권3호
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• pp.59-66
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• 2010

1. Objectives: The objectives of this paper are to report Traditional Chinese Medicine (TCM) Constitution Theory and the present state of Chinese Health Administration Center. 2. Methods: We visited China for "China Technology Survey" in 2009. Our purposes were to research for the study of constitutional medicine in China and to search for the Development Plan of Constitutional Medicine Through the Research of Chinese Constitutional Medicine. This paper is the report of the "China Technology Survey". 3. Results & Conclusions: In China, the concept and diagnosis of TCM constitutions is nine(Balanced Constitution, Qi-deficient Constitution, Yang-deficient Constitution, Yin-deficient Constitution, Phlegm-dampness Constitution, Damp-heat Constitution, Stagnant blood Constitution, Stagnant qi Constitution, Inherited specific Constitution). And Chinese government established the Classification and Diagnosis Standards for the Constitutions of TCM in 2009. TCM Constitution Theory is being widely applied at Health Administration Center that treats 'predisease' patients. Theses Chinese clinical implications of constitutional medicine are a good example for "Sasang Constituional Medicine" Care Service.

• The Korean Journal of Physiology and Pharmacology
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• 제27권6호
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• pp.521-531
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• 2023

Transmembrane protein TMEM16A, which encodes calcium-activated chloride channel has been implicated in tumorigenesis. Overexpression of TMEM16A is associated with poor prognosis and low overall survival in multiple cancers including lung adenocarcinoma, making it a promising biomarker and therapeutic target. In this study, three structure-related sesquiterpene lactones (mecheliolide, costunolide and dehydrocostus lactone) were extracted from the traditional Chinese medicine Aucklandiae Radix and identified as novel TMEM16A inhibitors with comparable inhibitory effects. Their effects on the proliferation and migration of lung adenocarcinoma cells were examined. Whole-cell patch clamp experiments showed that these sesquiterpene lactones potently inhibited recombinant TMEM16A currents in a concentration-dependent manner. The half-maximal concentration (IC50) values for three tested sesquiterpene lactones were 29.9 ± 1.1 µM, 19.7 ± 0.4 µM, and 24.5 ± 2.1 µM, while the maximal effect (E_max) values were 100.0% ± 2.8%, 85.8% ± 0.9%, and 88.3% ± 4.6%, respectively. These sesquiterpene lactones also significantly inhibited the endogenous TMEM16A currents and proliferation, and migration of LA795 lung cancer cells. These results demonstrate that mecheliolide, costunolide and dehydrocostus lactone are novel TMEM16A inhibitors and potential candidates for lung adenocarcinoma therapy.

• Advances in Traditional Medicine
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• 제5권2호
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• pp.156-159
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• 2005

The protective effect of Naoxingtong (NXT) on rat cerebral microvascular endothelial cell (rCMEC) was investigated. rCMEC was injured in vitro by incubating for 4 hours at 100% NO in a hypoxia chamber. After treated with NXT-containing serum, the cellular viability rate (90.3%) was significantly elevated when compared with that of control group and the inhibitive rate of lactic dehydrogenase activity (9.2%) was far lower than the control group with dose-dependent effect. The results indicate that NXT can increase viability of rCMEC, and protect cell membrane from injury during hypoxia.

• Journal of Microbiology and Biotechnology
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• 제32권10호
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• pp.1253-1261
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• 2022

Staphylococcus aureus (S. aureus) infection causes dramatic harm to human health as well as to livestock development. As an important virulence factor, alpha-hemolysin (hla) is critical in the process of S. aureus infection. In this report, we found that bavachin, a natural flavonoid, not only efficiently inhibited the hemolytic activity of hla, but was also capable of inhibiting it on transcriptional and translational levels. Moreover, further data revealed that bavachin had no neutralizing activity on hla, which did not affect the formation of hla heptamers and exhibited no effects on the hla thermal stability. In vitro assays showed that bavachin was able to reduce the S. aureus-induced damage of A549 cells. Thus, bavachin repressed the lethality of pneumonia infection, lung bacterial load and lung tissue inflammation in mice, providing potent protection to mice models in vivo. Our results indicated that bavachin has the potential for development as a candidate hla inhibitor against S. aureus.

• Journal of Ginseng Research
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• 제44권6호
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• pp.757-769
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• 2020

Background: Panax quinquefolius and Panax notoginseng are widely used and well known for their pharmacological effects. As main pharmacological components, saponins have different distribution patterns in the root tissues of Panax plants. Methods: In this study, the representative ginsenosides were detected and quantified by desorption electrospray ionization mass spectrometry and high-performance liquid chromatography analysis to demonstrate saponin distribution in the root tissues of P. quinquefolius and P. notoginseng, and saponin metabolite profiles were analyzed by metabolomes to obtain the biomarkers of different root tissues. Finally, the transcriptome analysis was performed to demonstrate the molecular mechanisms of saponin distribution by gene profiles. Results: There was saponin distribution in the root tissues differed between P. quinquefolius and P. notoginseng. Eight-eight and 24 potential biomarkers were detected by metabolome analysis, and a total of 340 and 122 transcripts involved in saponin synthesis that were positively correlated with the saponin contents (R > 0.6, P < 0.05) in the root tissues of P. quinquefolius and P. notoginseng, respectively. Among them, GDPS1, CYP51, CYP64, and UGT11 were significantly correlated with the contents of Rg1, Re, Rc, Rb2, and Rd in P. quinquefolius. UGT255 was markedly related to the content of R1; CYP74, CYP89, CYP100, CYP103, CYP109, and UGT190 were markedly correlated with the Rd content in P. notoginseng.

• BMB Reports
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• 제46권8호
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• pp.422-427
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• 2013

Although BMP9 is highly capable of promoting osteogenic differentiation of mesenchymal stem cell (MSCs), the molecular mechanism involved remains to be fully elucidated. Here, we explore the possible involvement and detail role of JNKs (c-Jun N-terminal kinases) in BMP9-induced osteogenic differentiation of MSCs. It was found that BMP9 stimulated the activation of JNKs in MSCs. BMP9-induced osteogenic differentiation of MSCs was dramatically inhibited by JNKs inhibitor SP600125. Moreover, BMP9-activated Smads signaling was decreased by SP600125 treatment in MSCs. The effects of inhibitor are reproduced with adenoviruses expressing siRNA targeted JNKs. Taken together, our results revealed that JNKs was activated in BMP9-induced osteogenic differentiation of MSCs. What is most noteworthy, however, is that inhibition of JNKs activity resulted in reduction of BMP9-induced osteogenic differentiation of MSCs, implying that activation of JNKs is essential for BMP9 osteoinductive activity.

• 동의생리병리학회지
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• 제27권5호
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• pp.520-529
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• 2013

Needham Problem(NP) is the influential question that English historian of Chinese science Joseph Needham raised, "Why modern science had not developed in the Chinese civilisation but only in that of Europe?" Our objectives in this paper are as follows: First, we will revisit NP in the broad context of the emergence of modernity rather than treating it just as an internal problem of Chinese science. After that, the problem of modernity in Chinese medicine will be discussed from the viewpoint of NP. After NP's intellectual backgrounds are summarized, its value and implications are examined, and then Needham's own answers are presented. Afterwards, we present supplementary hypotheses, adapted from Weber, as our solution to NP in Chinese science and medicine. Needham thought that the European scientific revolution would not have been possible without the rise of modern capitalism. He also believed that Chinese bureaucratism facilitated early development of Chinese science and in turn, inhibited later radical change by interrupting the rise of capitalism. According to our hypotheses, scientific changes are related to social changes, especially to the legitimation crises, which lead to the alternations of mode of justification in sciences. The Chinese society did not go through the legitimation crises as the European society did, and therefore it failed to produce a radically different kind of justification from the traditional one. This is the reason why there was no revolution in science and medicine in China.