• YAKHAK HOEJI
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• v.43 no.2
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• pp.208-213
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• 1999

The effects of five lupane-triterpenoids from leaves of two Acanthopanax spp., chiisanogenin, chisanoside and $22{\alpha}-hydroxychiisanogenin$, acakoreoside A and acantrifoside A on the mitogen-induced proliferation were investigated in vitro. T cell proliferation (TCP) to concanavalin A (Con A) and the B cell proliferation (BCP) to lipopolysaccharide (LPS) were increased by chiisanogenin. TCP to Con A was significantly increased by chiisanoside and acankoreoside A, but not affected by chiisanogenin, $22{\alpha}-hydroxychiisanogenin$ and acantrifoside A, BCP to LPS was significantly increased by acankoreoside A and acantrifoside A, and slightly increased by chiisanoside, chiisanogenin and $22{\alpha}-hydroxychiisanogenin$.

• Natural Product Sciences
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• v.21 no.2
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• pp.82-86
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• 2015

Phytochemical constituents were isolated from the fruits of Acanthopanax chiisanensis by repeated column chromatography. Their structures were identified as $\beta$-sitosterol (1), daucosterol (2), sesamin (3), chiisanogenin (4), and $22\alpha$-hydroxy chiisanogenin (5) by spectroscopic analysis (MS, ¹H-, and ¹³C-NMR). Compounds 1 - 5 were isolated for the first time from the fruits of A. chiisanensis.

• Archives of Pharmacal Research
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• v.26 no.1
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• pp.40-42
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• 2003

Chiisanogenin (1), hyperin (2) and chiisanoside (3) were isolated from the leaves of Acanthopanax senticosus, and were tested for their inhibitory activities against 6 strains of bacteria. Among them, chiisanogenin (1) revealed broad but moderate antibacterial activities against G(+) and G(-) bacteria, the minimum inhibitory concentration (MIC) being in the range of 50-100 $\mu\textrm{g}$/ml.

• Korean Journal of Pharmacognosy
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• v.34 no.4 s.135
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• pp.269-273
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• 2003

The leaves of Acanthopanax sessiliflorus Seem. (Araliaceae), which is native plant to Korea, have not been studied yet on triterpene constituents. Three 3,4-seco-lupane triterpenoids (Compound I-III) were isolated from the MeOH extract of this plant using Diaion HP-20P, silica gel and ODS column chromatographes. Based on physicochemical and spectroscopic data, the chemical structures of these compounds were identified as follows ; chiisanogenin (Compound I), chiisanoside (Compound II), $22{\alpha}-hydroxychiisanoside$ (Compound III).

• Natural Product Sciences
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• v.12 no.3
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• pp.119-121
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• 2006

Four 3,4-seco-lupane trierpenoids were isolated from the MeOH extract of the leaves of Acanthopanax divaricatus forma flavi-flos Yook by using various column chromatography. The chemical structures of isolates were identified as chiisanogenin, chiisanoside, isochiisanoside and 11-deoxyisochiisanoside on the basis of physico-chemical and spectroscopic date($^1H-NMR,\;^{13}C-NMR$M$, 2D-NMR and FAB-MS). These compounds were isolated for the first time from A. divaricatus forma flavi-flos.

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.206.1-206.1
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• 2003

From methanol extract of Acanthopnanax senticosus, six platelet anti-aggregating compounds, chiisanogenin (1), chiisanoside (2), ursolic acid (3), oleanolic acid (4), b-sitosterol (5) and daucosterol (6) were isolated. All of the isolated compounds showed dose-dependent inhibitory activities to rat platelet aggregation induced by all the agonist employed. Compound 1 showed about 50 folds higher potency than acetylsalicylic acid (ASA) on U46619 induced platelet aggregation (IC$\sub$50/ : 6.21 ${\mu}$M) and 10 ∼ 20 folds higher effect than ASA on epinephrine and arachidonic acid (AA) induced aggregation (IC$\sub$50/ ; 2.50 and 4.81 ${\mu}$M, respectively). (omitted)