• 한국잠사곤충학회지
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• 제2권
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• pp.83-88
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• 1962

These works were carried on to study the damage due to agricultural chemicals on silkworm and to find out the best ways to use them, considering, in the horticultural field, the utilization of them has rapidly been increased. The results may be summarized as follows: 1) The mulberry leaves being more than 100m from the horticultural field used the agricultural chemicals did not harm the silkworm. 2) Even if the mulberry leaves were located less than loom from the horticultural field sprayed with the chemicals, the silkworms were not injured after washing the mulberry leaves which were attached with the chemicals. 3) The chemicals, E.P.N., B. H. C. 2%, and Selesan were more seriously injured to silkworm than the other ones.

• Environmental Analysis Health and Toxicology
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• 제18권3호
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• pp.183-191
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• 2003

Although the variety and quantities of chemicals used have been increasing, no management strategies have been developed for these chemicals in our country. Therefore, it is important to identify the hazardous characteristics of chemicals and establish reasonable and effective management plans for them. However, because insufficient resources are available to evaluate all aspects of many varieties of chemicals, studies on suitable chemical ranking and scoring (CRS) system should be performed to ensure effective screening of priority chemicals.. In addition, because most CRS systems have their own goals, it is impossible for only one generic system to be consistent with all the uses that have been developed. Therefore, priority systems should be developed with specific and clearly defined purposes in our nation. In this study, we investigated and discussed exist-ing CRS systems, and proposed several elements and principles when designing CRS systems. First of all, the system should have clearly defined goals, keep neutral, and employ simple methods. In addition, researchers need to perform sensitivity analysis to find the main variables responsible for uncertainties and use the tiered approach to compose the effective management strategies for chemicals.

• Entomological Research
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• 제48권6호
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• pp.514-521
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• 2018

Drosophila melanogaster Meigen and Drosophila suzukii Matsumura are taxonomically close Drosophila species belonging to the family Drosophilidae and melanogaster group. D. melanogaster is thought to be evolutionarily adapted to overripe, decaying, and fermented fruits, in which large amounts of chemicals such as ethanol, acetic acid, and 2-phenylethanol are produced, whereas, D. suzukii is attracted to fresh ripening fruit. Considering the distinct habitats of the two flies, D. suzukii is hypothesized to exhibit higher susceptibility to these chemicals than D. melanogaster. Therefore, in this study, we investigated the survival rate of the flies at various concentrations of three chemicals (2-phenlyethanol, acetic acid, and ethanol) and calculated the lethal concentration (LC) values to compare the tolerance and susceptibility of D. melanogaster and D. suzukii to the chemicals. Our results revealed that D. melanogaster exhibited higher tolerance than D. suzukii to all chemicals, supporting the hypothesis of different evolutionary adaptations to distinct habitats of the two flies.

• 한국유변학회:학술대회논문집
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• 한국유변학회 2001년도 Australian-Korean Rheology Conference 2001
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• pp.163.4-163
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• 2001

• 식물병연구
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• 제18권4호
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• pp.349-353
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• 2012

자두 검은점무늬병은 Xanthomonas arboricola pv. pruni에 의한 세균성 병해로 과실표면에 검은 반점형태의 병징이 발생하여 과실 상품성을 저하시켜 자두 재배농가에 큰 경제적 손실을 초래하는데 이러한 자두 검은점무늬병에 대한 효과적인 약제 방제체계를 개발하기 위하여 몇 종의 화학약제와 살포체계를 구성하여 휴면기중에는 동제 약제를 그리고 과실생육기중에는 항생제계열 약제를 살포하였는데 과실생육기중에서의 항생제계열 약제살포는 휴면기중의 동제 약제살포보다 높은 방제효과를 나타내었다. 자두의 개화만개 10일 후부터 10일 간격으로 3회의 항생제계열 약제살포는 93%의 높은 방제가를 얻을 수 있었는데 비해서 휴면기중의 동제 약제살포는 26-42%의 낮은 방제가를 얻는데 그쳤다. 또한 항생제계열 약제의 처음 살포시기가 개화만개 후 20일이나 30일 보다는 개화만개 후 10일에서 더 높은 방제효과를 얻을 수 있었다.

• 한국환경성돌연변이발암원학회지
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• 제22권4호
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• pp.215-222
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• 2002

The detection of many synthetic chemicals used in industry that may pose a genetic hazard in our environment is of great concern at present. Since these substances are not limited to the original products, and enter the environment, they have become widespread environmental pollutants, thus leading to a variety of chemicals that possibly threaten the public health. In this respect, to regulate and to evaluate the chemical hazard will be important to environment and human health. The clastogenicity of 17 synthetic chemicals was evaluated in Chinese hamster lung fibroblast cells in vitro. Two most cytotoxic chemicals, dodecyl methacrylate (CAS No. 142-90-5) and 2-ethylhexyl methacrylate (CAS No. 688-84-6), among 17 chemicals tested revealed no clastogenicity in the range of 0.0165-0.066 $\mu\textrm{g}$/$m\ell$ and 0.006-0.024 $\mu\textrm{g}$/$m\ell$ both in the presence and absence of metabolic activation system, respectively. All 17 chemicals revealed no significant induction of chromosomal aberration both in the presence and absence of metabolic activation system in this assay. From the results of chromosomal aberration assay with 17 synthetic chemicals in Chinese hamster lung cells in vitro, we did not observed positive clastogenic results in this study.

• 대한수의학회지
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• 제45권4호
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• pp.545-552
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• 2005

The major protocol features of the rodent uterotrophic assay have been evaluated using a range of reference chemicals. The protocol variables considered include the selection of the test species and route of chemical administration, the age of the test animals, the maintenance diet used, and the specificity of the assay for estrogens. The rodents were ovariectomized under general anesthesia via bilateral flank incisions and randomly assigned to groups of 5 animals. Chemicals were DEHP, DBP, BPA and NP, were injected sc once daily with combinations of chemicals treatments for 3 days. In the results, the reported estrogenic chemicals DEHP and DBP were both negative in the single dose treatments. But, in the combinations of chemicals treatments, DEHP and DBP increased in bud number of mammary gland. Treatment of ovariectomized mice with combinations of other chemicals resulted in uterine and vaginal hyperplasia. The additive estrogenic effects were seen with the combinations of $17{\beta}$-Bestradiol and DBP treatment. the competitive estrogenic effects were seen with the combinations of $17{\beta}$-Bestradiol and nonylphenol, $17{\beta}$-Bestradiol and bisphenol-A treatments. These results offers a sysmatic and mechanistically informative approach to assessing estrogenicity. it provides a useful profile of activity using a reasonable amount of resources and is compatible with the study of individual chemicals as well as the investigation of interactions among combinations of chemicals. The results described illustrate the intrinsic complexity of evaluating chemicals for estrogenic activities and conform the need for rigorous attention to experimental design and criteria for assessing estrogenic activity.

• 한국재난정보학회 논문집
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• 제8권2호
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• pp.178-187
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• 2012

화학물질의 사용량 증가에 따라 일반국민이 화학물질 또는 화학제품에 노출되는 사례가 빈번하게 발생하고 있어 응급정보 제공 수요가 급증하고 있으며, 신규 화학물질의 도입에 따라 화학물질 정보의 지속적인 구축 필요성이 제기되고 있다. 이에 따라, 환경부는 국내 유통 중인 화학제품 중심으로 상세물질정보를 지속적으로 확충하여 일반국민에게까지 정보 제공 범위를 확대하는 화학사고 응급대응정보시스템 구축사업을 단계적으로 추진하여 왔다. 이를 통해 24시간 정보제공이 가능하도록 웹 서비스 기반을 마련하여 화학제품 또는 화학물질에 노출된 일반인 또는 현장 대응요원에게 실효성 있는 응급대응정보가 전달될 수 있도록 정보시스템을 구축하여 운영하고 있다.

• Biotechnology and Bioprocess Engineering:BBE
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• 제5권6호
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• pp.395-399
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• 2000

Five different freeze-dried recombinant bioluminescent bacteria were used for the detection of cellular stresses caused by endocrine disrupting chemicals. These strains were DPD2794 (recA::luxCDABE), which is sensitive to DNA damage, DPD2540 (fabA::luxCDABE), sensitive to cellular membrane damage, DPD2511 (katG::luxCDABE), sensitive to oxidative damage, and TV1061 (grpE::luxCDABE), sensitive to protein damage. GC2, which emits bioluminescence constitutively, was also used in this study. The toxicity of several chemicals was measured using GC2. Damage caused by known endocrine disrupting chemicals, such as nonyl phenol, bisphenol A, and styrene, was detected and classified according to toxicity mode, while others, such as phathalate and DDT, were not detected with the bacteria. These results suggest that endocrine disrupting chemicals are toxic in bacteria, and do not act via an estrogenic effect, and that toxicity monitoring and classification of some endocrine disrupting chemicals may be possible in the field using these freeze-dried recombinant bioluminescent bacteria.

• 한국환경성돌연변이발암원학회지
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• 제22권3호
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• pp.149-156
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• 2002

The detection of many synthetic chemicals used in industry that may pose a genetic hazard in our environment is of great concern at present. Since these substances are not limited to the original products, and enter the environment, they have become widespread environmental pollutants, thus leading to a variety of chemicals that possibly threaten the public health. In this respect, to regulate and to evaluate the chemical hazard will be important to environment and human health. The clastogenicity of 18 synthetic chemicals was evaluated in Chinese hamster lung fibroblast cells in vitro. 4-Chloro-3,5-dimethyl phenol (CAS No. 88-04-0) induced chromosomal aberrations with significance at the concentration of 15.7 $\mu\textrm{g}$/$m\ell$ both in the presence and absence of metabolic activation system. Phenoxybenzene (CAS No. 101-84-8) which is one of the most cytotoxic chemical among 18 chemicals tested revealed no clastogenicity in the range of 0.11-0.43 $\mu\textrm{g}$/$m\ell$ both in the presence and absence of metabolic activation system. From the results of chromosomal aberration assay with 18 synthetic chemicals in Chinese hamster lung cells in vitro, 4-chloro-3,5-dimethyl phenol (CAS No. 88-04-0) revealed weak positive clastogenic results in this study.