• Title/Summary/Keyword: chemical poisoning

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Application Review of a Systemic Accident Analysis Method in the Field of Occupational Health - Focused on the Analysis of Methanol Poisoning Accidents Using STAMP - (산업보건 분야에서 시스템적 사고 분석 방법의 활용성 검토 - STAMP를 이용한 메탄올 중독사고 분석을 중심으로 -)

  • Dong-Hyun Seo;Jang-Hyun Park;Jong-Soo Hyun;Jin-Hyun Kim
    • Journal of Korean Society of Occupational and Environmental Hygiene
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    • v.33 no.2
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    • pp.188-205
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    • 2023
  • Objectives: Methanol poisoning accidents in smartphone parts manufacturing facilities were analyzed using a systemic accident analysis method, and the necessity and possibility of the application of this systemic method in the field of occupational health were reviewed. Methods: A STAMP model for accident analysis was created based on the previously published literature. CAST analysis was performed to find the causal factors of the components and between the components. Results: The STAMP model visually showed the abstract and complex system control structure. The CAST analysis results could include all the causal factors from the previously published literature, and presented them holistically. Additional causal factors that were not presented in the literature were found. Conclusions: The holistic accident analysis results in this study will be helpful to establish comprehensive measures to prevent methanol or other chemical poisoning accidents. Therefore, it will be necessary to use systemic accident analysis methods in the field of occupational health.

The Performance Degradation of PEMFCs Fabricated with Different GDLs During Exposure to Simultaneous Sulfur Impurity Poisoning Condition (서로 다른 GDL을 이용한 고분자전해질 막 연료전지의 황불순물 복합피독에 의한 성능 저하)

  • Lee, Soo;Kim, Jae-Hyun;Jin, Seok-Hwan
    • Journal of the Korean Applied Science and Technology
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    • v.30 no.1
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    • pp.146-151
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    • 2013
  • This paper reveals the performance decrease and recovery of PEMFC when the contaminated fuel gas and air source with sulfur impurities such as hydrogen sulfide and sulfur dioxide were simultaneously introduced to anode and cathode, respectively. Three different GDLs were fabricated with different carbon black and activated carbon to prevent an introduction of sulfur compound impurities into MEA. components. The severity of $SO_2$ and $H_2S$ poisoning was depended on concentrations(3 ppm - 10 ppm) of sulfur impurities. Especially, cell performance degradation rate was rapid when MEA fabricated with CN-2 GDL because it had little porosity on GDL surface. Moreover, the cell performance can be recovered up to 90%-95% only with neat hydrogen and fresh air feeding.. Conclusively, MEA fabricated with porous CN-1 GDL showed the best cell performance and recovery efficiency during exposure to poisoning condition by simultaneous sulfur impurities.

H2S Poisoning Effect and Recovery Methods of Polymer Electrolyte Membrane Fuel Cell (황화수소 피독이 고분자전해질 연료전지에 미치는 영향과 회복기법)

  • Chun, Byungdo;Kim, Junbom
    • Korean Chemical Engineering Research
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    • v.55 no.1
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    • pp.107-114
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    • 2017
  • The performance of polymer electrolyte membrane fuel cell (PEMFC) could be deteriorated when fuel contains contaminants such as carbon monoxide (CO) or hydrogen sulfide ($H_2S$). Generally, $H_2S$ is introduced in hydrogen by steam reforming of hydrocarbon which has mercaptan as odorant. $H_2S$ poisoning effect on PEMFC performance was examined on this study. Pure hydrogen injection, voltage cycling and water circulation methods were compared as performance recovery methods. The PEMFC performance was analyzed using electrochemical methods such as polarization curve, electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). Pure hydrogen injection and voltage cycling methods showed low recovery ratio, however, water circulation method showed high recovery ratio over 95%. Because anode was directly poisoned by $H_2S$, anode water circulation showed higher recovery ratio compared to the other methods. Water circulation method was developed to recover PEMFC performance from $H_2S$ poisoning. This method could contribute to PEMFC durability and commercialization.

A Case Study on the FDA Approval of Medical Treatments against Nerve Agent Poisoning (신경작용제 해독제 의약품 품목허가 사례 연구)

  • Lee, Keunwoo;An, Seoyeon;Hur, Byungil
    • Journal of the Korea Institute of Military Science and Technology
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    • v.19 no.1
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    • pp.119-126
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    • 2016
  • The US Army used MARK-1 composed of atropine autoinjector and 2-PAM autoinjector as a medical countermeasure against nerve agent poisoning. Recently, it has been being replaced by the ATNAA(Antidote Treatment Nerve Agent AutoInjector) for improvement the convenience in use and rapid detoxification effect. ATNAA(FDA approval, NDA 21-175, 2002. 1. 17) is a multi-chambered autoinjector that sequentially delivers atropine and 2-PAM through a single needle to allow Warfighters to survive against lethal exposure to nerve agents. In this paper, our group investigated the case of FDA approval of ATNAA in a point of the various data required by FDA guideline, thereby making it easy to meet the KFDA guideline for the approval of the prototype our group has been developed. The purpose of this study is to provide a reference for efficient research activities to minimize time and cost. Additionally, the purpose of this study is to provide a reference for the planning for the development of similar drug.

What must be done to prevent another humidifier disinfectant disaster?

  • Lee, Jong-Hyeon
    • Environmental Analysis Health and Toxicology
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    • v.31
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    • pp.24.1-24.7
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    • 2016
  • The humidifier disinfectant disaster (HDD) was not a simple poisoning accident by biocides, but a singular disaster in history created by chemicals in household products. This disaster was a result of the failure of a system for the management of chemical and product safety. Since the management authority for chemical usage safety is different from those for chemical safety in products, many blind areas for chemical safety management in products still remain. The 'Act on the Registration and Evaluation, etc. of Chemical Substances (ARECS)' or the new 'Biocidal Product Act' must not only address the blind areas in the management system for chemical and product safety, but also prevent a second HDD. To prevent another HDD, an integrated registration, evaluation, and management system for chemicals and consumer products must be incorporated into the 'ARECS' as an essential part for chemical safety in consumer products.

Clinico-pathological findings of experimental ethylene glycol poisoning in dogs (Ethylene glycol 중독견의 임상병리학적 소견)

  • Sung, Eun-ju;Lee, Hyun-beom
    • Korean Journal of Veterinary Research
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    • v.37 no.4
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    • pp.883-897
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    • 1997
  • Present study was undertaken in order to find out the most significant laboratory test for the early diagnosis of ethylene glycol poisoning in dogs. Seven dogs weighing from 5.0kg to 19.3kg were administered orally 6ml or l0ml of ethylene glycol per kilogram of body weight. In addition to clinical observations, blood samples were taken from the jugular vein on 0, 1, 3, 6, 12, 24 and 48 hours or until death after the adminisration and examined for the hematological, blood chemical, venous blood gas and electrolyte changes. Urine samples were simultaneously taken and examined for pH, protein, glucose and calcium oxalate crystals in the sediments. The results were as follows : 1. All dogs showed marked hypothermia in addition to the characteristic signs of ethylene glycol poisoning until death. 2. No significant hematological changes were observable after the administration of ethylene glycol except the secondary dehydration and stress leukogram. 3. Chemical values related to the liver function(serum glutamic pyruvic transaminase, total serum protein, serum albumin, serum total bilirubin) showed no significant changes during the experimental period in all dogs. 4. Chemical values related to the renal function(BUN and creatinine) showed significant(p<0.0l, p<0.001) increase from 24 hours to death in all dogs. 5. All dogs showed significant(p<0.01, p<0.001) decrease in blood pH from 3 hours to death after the ethylene glycol administration. 6. All dogs showed significant(p<0.05, p<0.01, p<0.001) increaes in anion gap from 1 hour to death after the ethylene glycol administration. 7. All dogs showed significant(p<0.05, p<0.01) decrease in urine pH from 1 hour to 6 hours after the administration of ethylene glycol. 8. Characteristic envelope form of calcium oxalate crystals were found in the urinary sediment from 6 hours after the administration of ethylene glycol in all dogs. 9. Histologically calcium oxalate crystals were found in the renal rubles in all dogs. 10. From these results, it may be concluded that the examinations of urinary sediments for the calcium oxalate crystals, blood or urinary pH and blood anion gap are most reliable tests for the early diagnosis of ethylene glycol poisoning in dogs.

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Lead Tolerance of Noble Metal Catalysts for CO Oxidation

  • Chang, Tu-Won;Sohn, Youn-Soo
    • Bulletin of the Korean Chemical Society
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    • v.7 no.1
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    • pp.12-15
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    • 1986
  • Lead tolerance of $Pt/Al_2O_3$ catalysts was evaluated for CO oxidation depending on the properties of the alumina supports and base metals added as promoter. Among the four different alumina supports, the support with a large macropore volume (0.45 cc/g) and 5% Ce has shown the best resistence to lead poisoning. Most of the base metals added to the Pt-catalysts were found to be ineffective for improving lead resistence, but boron has shown an excellent lead tolerence, although it decreases the initial catalytic activity.