• Bulletin of the Korean Chemical Society
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• 제33권4호
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• pp.1285-1289
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• 2012

RAP80 plays a key role in DNA damage responses by recognizing K63-linked polyubiquitin moieties through its two ubiquitin-interacting motif (UIM) domains. The linker between the two UIMs possesses a phosphorylation site, but the relationship between phosphorylation and polyubiquitin recognition remains elusive. We investigated the interaction between a phosphorylation-mimic RAP80 mutant S101E and linear polyubiquitins, structurally equivalent to the K63-linked ones, using isothermal titration calorimetry (ITC). ITC analysis revealed differential binding affinities for linear tetraubiquitin by otherwise equivalent UIMs in S101E. Mutational analysis supported such differential polyubiquitin recognition by S101E. Our results suggest a potential crosstalk between polyubiquitin recognition and phosphorylation in RAP80.

• Bulletin of the Korean Chemical Society
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• 제34권2호
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• pp.406-410
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• 2013

Tetrahyropapaveroline (THP) is compound derived from dopamine metabolism and is capable of causing dopaminergic neurodegenerative disorder, such as Parkinson's disease (PD). The aim of this study was to evaluate the potential of THP to cause oxidative damage on the structure of cytochrome c (cyt c). Our data showed that THP led to protein aggregation and the formation of carbonyl compound in protein aggregates. THP also induced the release of iron from cyt c. Reactive oxygen species (ROS) scavengers and iron specific chelator inhibited the THP-mediated cyt c modification and carbonyl compound formation. The results of this study show that ROS may play a critical role in THP-induced cyt c modification and iron releasing of cyt c. When cyt c that has been exposed to THP was subsequently analyzed by amino acid analysis, lysine, histidine and methionine residues were particularly sensitive. It is suggested that oxidative damage of cyt c by THP might induce the increase of iron content in cells and subsequently led to the deleterious condition. This mechanism is associated with the deterioration of organs under neurodegenerative disorder such as PD.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2020년도 가을 학술논문 발표대회
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• pp.149-150
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• 2020

Granting self-sensing performance in a building is an important performance to ensure the degree of damage and safety of the building. Since the current research is being conducted in the state before deterioration loss occurs, it is necessary to confirm whether the self-sensing performance is maintained even in the damaged conductive cement composite. As part of the study, electrical resistance characteristics were analyzed in conductive cement composites in which freeze-thawing and chemical corrosion occurred. As a result, it was found that the change in electrical resistance value due to freeze-thawing was not as large as 1%, and chemical corrosion occurred. It was found that the change in electrical resistance value of the tested specimen increased by about 10%.

• Geomechanics and Engineering
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• 제11권3호
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• pp.373-383
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• 2016

As one natural material, the physical and mechanical properties of rock will be affected very largely by chemical erosion environment. Under chemical environment, the strength of rock will be reduced. Considering the effect of the chemical erosion, fracture factor of rock is reduced. The damage variable is applied to express the change of fracture stress. Therefore, the fracture criterion of rock under chemical environment is constructed. By one experiment of rock fracture under chemical erosion environment, the proposed fracture criterion is verified. The results show that, the fracture path by theory is agree with the testing one well.

• 한국독성학회:학술대회논문집
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• 한국독성학회 2005년도 춘계 국제심포지엄 및 학술대회
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• pp.125-126
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• 2005

• 비파괴검사학회지
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• 제9권1호
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• pp.98-105
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• 1989

Detection of creep damages in centrifugally cast HK-40 reformer furnace catalyst tube is a common problem for the safety and scheduled operation of chemical plants. This study was focused on the development of an automatic ultrasonic scanning device with which the creep damage of welded zone of HK-40 reformer tubes is detected and evaluated.

• 한국가스학회지
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• 제15권6호
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• pp.8-13
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• 2011

유해 위험 요인이 있는 시설물의 안전에 대한 의식을 고취시키기 위해서는 현장 종사자뿐만 아니라 관리자와 경영자도 해당 시설물에 대한 모니터링이 가능해야 한다. 그러나 우리나라에 있는 대부분의 CNG충전소는 로컬 형식의 모니터링 시스템이 사용되고 있으며 이러한 점을 고려하여 웹상에서 운용할 수 있는 충전소 관리 시스템을 개발 하였다. 개발된 시스템은 U-GSMS(Ubiquitous Gas Safety Management System)라고 명명 하였다. U-GSMS는 크게 프로그램 부분과 하드웨어 부분으로 나눌 수 있다. 프로그램 부분은 안전과 운영을 관리 할 수 있는 시스템으로 구성하였으며 하드웨어 부분은 가스시설물에 적용할 수 있는 센서, 센서간의 통신 그리고 센서와 기기 간의 통신을 위하여 USN(Ubiquitous Sensor Network)기술을 적용하여 무선 통신 시스템을 구축하였다. 이 논문에서는 주로 U-GSMS 중 프로그램에 관하여 기술하였다.

• 한국안전학회지
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• 제33권5호
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• pp.150-156
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• 2018

As the types and usage of chemical increase, modern countries should protect their health and environment from the risk of hazardous chemical. Chemical accidents not only affect humans but also cause huge losses to the environment. Moreover, since its effects do not end in a short period of time, it is necessary to identify the extent of the damage and establish a prevention and response system in advance. In 2015, the Chemical Substances Management Act provided a system for assessing the impact on the people and the environment around the workplace. However, it is difficult to quantitatively evaluate the impact on environmental factors such as vegetation and aquatic, with the current hazard assessment methods. The purpose of this study is to analyze the quantitative risk of environmental receptors. This study improved the existing risk assessment formula by using the environmental vulnerability index and established the end point concentration criterion which can estimate the damage range to environmental media. To verify the results of the study, a virtual accident scenario was selected and a case study was conducted. As a result, the extent of impact on the environmental medium can be calculated, and the degree of environmental risk of the zone can be quantified through the risk analysis considering the environmental vulnerability. This study is expected to increase the reliability of the reliability of the existing risk anaylsis method beacause it is a risk analysis method that can be applied when the environmental factors are absolutely necessary and when the residents and environment are complex.

• 한국가스학회지
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• 제7권4호
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• pp.61-66
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• 2003

본 연구에서는 화학설비의 취약점을 파악하여 안전성을 경제적으로 확보할 수 있는 대안에 대한 설비별 안전투자비용과 그에 따른 편익을 산출하고, 분석함으로써 경제적인 안전 투자 대안을 제시할 수 있는 시스템을 개발하였다. 이를 위해 화학설비의 위험성을 정량적으로 평가하기 위한 사고 빈도 분석 모듈과 사고 피해 예측 모듈을 개발하고, 중대산업사고 사례 및 선진국(네덜란드, 호주, 미국, 영국, 독일 등)의 사회적 위험성을 비교 $\cdot$ 분석하여 국내 현실에 반영할 수 있는 사회적 위험성(societal risk : F-N Curve) 기준을 제시하였다. 또한, 현장 방문을 통하여 공정에 대한 투자비용과 그에 따른 편익 항목을 분석$\cdot$선정하여 앞의 결과들을 통하여 화학설비에서 발생하는 비용$\cdot$편익에 대한 안전투자대안의 순현재가치(NVP, Net Present Value)를 도출하여 안전성을 향상시킬 수 있는 대안들을 분석하고 비교할 수 있는 시스템을 개발하였다.

• 콘크리트학회지
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• 제10권2호
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• pp.50-64
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• 1998