• Clinical and Experimental Reproductive Medicine
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• v.28 no.1
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• pp.13-24
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• 2001

Objective: In muscle and neuronal cells, calcium channels have been classified by electrophysiological and pharmacological properties into (1) voltage-dependent $Ca^{2+}$-channel (1) P/Q-type $Ca^{2+}$-channel (2) N-type $Ca^{2+}$-channel (3) L-type $Ca^{2+}$-channel (4) T-type $Ca^{2+}$-channel (5) R-type $Ca^{2+}$-channel. The present study was done in order to investigate whether there is any difference in $Ca^{2+}$-channel distribution between activated and normally fertilized embryos. Methods: The immunocytochemical method was used to identify the existence of voltage-dependent $Ca^{2+}$-channels in parthenogenetically activated 2-cell embryos by ethanol and $SrCl_2$ treatment. These 2-cell embryos were obtained by exposure to 6% ethanol for 6 min and to 10 mM $SrCl_2$ for 2h. Results: P/Q-type $Ca^{2+}$-channels and L-type $Ca^{2+}$-channels have been identified. Whereas, three type of $Ca^{2+}$-channel P/Q-type, N-type, L-type have been identified in 2-cell embryos fertilized in vivo. Conclusion: Activation by ethanol was faster than those by $SrCl_2$. However, there was difference in DAB staining of the embryos between ethanol and $SrCl_2$ treatment (87.7% and 54.1 %). Intensity of staining was also different between ethanol- and $SrCl_2$-treated group. However, it has not been known why there was some difference in DAB staining and staining intensity in the present study.

• Proceedings of the KSRS Conference
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• 2007.10a
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• pp.29-32
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• 2007

Tidal channel development is influenced by sediment type, grain size, composition and tidal current. Tidal channels are usually characterized by channel development, density and shape. Quantitative analysis of tidal channels using remotely sensed data have rarely been studied. The objective of this study is to quantify tidal channels in terms of fractal dimension and compare different inter-tidal channel patterns. For the fractal analysis, we used Box counting method which had been successfully applied to streams, coastlines and others linear features. For a study, the southern part of Ganghwado tidal flats was selected where is famous for high dynamics of tidal currents and vast tidal flats. This area has different widths and lengths of tidal channels. IKONOS and Komsat-2 MSC images were used for extracting tidal channels, and the Box counting method was applied to obtain fractal dimensions (D) for each tidal channel. Yeochari area possesses channels with linear pattern and less dense development and accordingly show low D values ranging from 1.037 to 1.038. On other hands, area (near Donggumdo and Yeongjongdo ) of dendrites channel pattern and dense development resulted in high D values from 1.2057 to 1.2667. Also, area possesses channels with linear pattern had low density about $18{\sim}24%$. Area of dendritic channel pattern had high density about $34{\sim}69%$. The difference of fractal dimensions about 0.2 according to channel development in tidal flats is relatively large enough to use as an index for tidal channel classification. Also, area where channels showed linear pattern had low density about $18{\sim}24%$. Area of dendritic channel pattern had high density about $34{\sim}69%$. Using fractal dimension and density, it would be possible to quantify the tidal channel development in association with surface characteristics.

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.2
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• pp.571-574
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• 2004

Effects of the Cheonggansoyo-san added Injinwiryeong-tang on recovery from damaged-liver and mental-faculty improvement in alcoholism were studied using male Sprague-Dawley rats, The rats were assigned into 4 groups; normal, control and CIX group. Control group administered ethanol(25 v/v %) at a dose 3 g/kg, while CIX group administered the water extract of Cheonggansoyo-san added Injinwiryeong-tang (CIX) 30 min before treating same dose of ethanol as control group for 10 days, orally. The GOT and GPT activities of rats were checked by Reitman & Frankel method, and all groups were subjected to trials of straight channel on the 1 st day and to those of multiple T-maze during the following 3 days. The GOT and GPT activities were increased in control group, but decreased in CIX group significantly. The time required in normal group for the straight channel of the 2nd and 3rd trials was significantly shorter than that of the 1 st, while the control group showed no significance. In the time required for the multiple T-maze trials, the control group showed no significance. But in the straight or T-maze trials, the CIX group showed significant decrease in the time required against the control group.

• Korean Journal of Clinical Pharmacy
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• v.22 no.4
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• pp.330-339
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• 2012

Background : Hypertension is treated with both lifestyle modification and pharmacotherapy. The Seventh Report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure (JNC-7), published in 2003, provides a streamlined management approach to hypertension for the primary care physician. The JNC-7 is the gold standard also in Korea. According to the JNC-7, special therapeutic considerations are recommended for high-risk individuals with compelling indications. The presence of compelling indications in any given patient should be considered when selecting specific pharmacotherapy to treat hypertension. However, in patients with compelling indications, it is unknown that hepatotoxicity is caused by Calcium Channel Blocker (CCB), one of 1st anti-hypertensive drugs. Now, the CCB is the most used 1st anti-hypertensive drug in Korea Therefore, we evaluated the changes in blood liver function parameters (ALT, AST, Total bilirubin, serum albumin) for the study group. Methods : We randomly collected and retrospectively analyzed Electronic Medical Record data (n=28,788) of patients, and who took calcium channel blockers(non-dihydropyridines; diltiazem, verapamil, dihydropyridines; amlodipine, barnidipine, benidipine, clinidipine, efonidipine, felodipine, isradipine, lacidipine, lercanidipine, nicardipine, nifedipine, nimodipine), with having liver function tests (LFTs) from July 1st 2009 to June 30th 2010 at the Seoul National University Hospital in Korea. Control groups are two antihypertensive agents: RAS blockade (ARB; candesartan, irbesartan, losartan, olmesartan, telmisartan, valsartan, ACE-I; cilazapril, enalapril, fosinopril, imidapril, perindopril, ramipril) and, Diuretics (loop; furosemide, torsemide, thiazide; hydrochlorothiazide[HCTZ], indapamide). Patients not having LFT results at these three standard points of time(baseline, during, medication, and after finishing medication) were excluded. The collected data were analyzed by using the SPSS (Version12.0) and Microsoft Excel (Version2007). Results : 711 patients who were treated CCB (297), RAS blockade (232) or Diuretics (182) monotherapy were selected for the study. In selected patients, liver damage degree(changes of each LFTs value) was higher in diuretics group than other groups, followed by RAS blockade and CCB. In diuretics group's was loop-diuretics group was higher than thiazide-diuretics group. In CCB group, Nondihydropyridine-CCB's damage degree was higher than Dihydropyrine-CCB's that. Conclusions : Despite the limitations due to the retrospective study, among patients with abnormal LFTs, the use of CCBs led to a less liver damage than other 1st anti-hypertensive agents. It can be recommended CCBs as one of the initial treatments of hypertension in patients with liver disease.

• Journal of the Korean Operations Research and Management Science Society
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• v.24 no.3
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• pp.63-72
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• 1999

Recent studies on the Constant Bit Rate and Variable Bit Rate transmissions have mainly focused on the frame by frame encoder rate control based on the quantization parameter. With the existing approaches it is difficult to guarantee a consistent video quality. Also, the rate control overhead is too high for the real-time video sources. In this paper, a channel rate allocation scheme based on the control period is proposed to transmit a real-time video, in which the control period is defined by a pre-specified number of frames or group of pictures. At each control period, video traffic information is collected to determine the channel rate at the next control period. The channel rate is allocated to satisfy various channel rate constraints such that the buffer occupancy at the decoder is maintained at a target level. If the allocated channel rate approaches the level at which the negotiated traffic descriptions may be violated, the encoder rate is decreased through adjusting quantization parameters in the MPEG encoder. In the experimental results, the video quality and the overflow and underflow probabilities at the buffer are compared at different control periods. Experiments show that the video quality and the utilization of network bandwidth resources can be optimized through the suitable selection of the control period.

• Proceedings of the IEEK Conference
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• 2004.06a
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• pp.305-308
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• 2004

In this paper, we analyze system level and link level performance for MB-OFDM UWB system. we propose physical layer model of MB-OFDM UWB system in MBOA. For this analysis, Base-band channel model from IEEE 802.15 3a was adopted. we considered the channel index parameter to select any one of 100 distinct realizations provided by the IEEE working group. Our experimental results indicate BER values according to Es/No.

• 한국정보통신설비학회:학술대회논문집
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• 2007.08a
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• pp.89-91
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• 2007

Multimedia service based on interactivity, personalization, multiple channels and community distinguishes IPTV from incumbent TV. But data encoding/decoding time and image frame processing should be considered in digital TV versus analog device. Especially channel zapping time is one of the most important parameters for the service quality of IPTV. This paper proposes the mechanism for decreasing the channel zapping time with multiple decoder and image frame processing. We also implemented the multi-group video community service system using IP multicasting function supporting interactive learning service.

• Proceedings of the IEEK Conference
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• 2008.06a
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• pp.269-270
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• 2008

TD-SCDMA combines TDMA and CDMA components to provide more efficient use of radio resources, and includes a new feature called HSDPA (high-speed downlink packet access) in the R5 stage. The TD-HSDPA supports high-speed traffic with a shared channel, but the adopted mechanism causes feedback problem for scheduling. In this paper, we propose an improved mechanism that transmits channel quality indicator (CQI) more frequently, so that the TD-HSDPA scheduler can utilize all possible information about the downlink channel status.

• 한국정보통신설비학회:학술대회논문집
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• 2008.08a
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• pp.253-256
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• 2008

In this paper, we analyze the performance of RAKE receiver for impulse radio-ultra wide band (IR-UWB) systems in indoor multipath radio channel. Pulse position modulation-time hopping (PPM-TH) signal is considered. And we also consider three types of RAKE receivers, which are ideal RAKE, selective RAKE, and partial RAKE receivers. The indoor channel is modeled as the modified Saleh and Valenzuela (SV) model which has been proposed as a UWB channel model by the IEEE group, IEEE 802.15.SG3a.

• 한국정보통신설비학회:학술대회논문집
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• 2008.08a
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• pp.39-42
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• 2008

In this paper, we analyze the performance of ultra wide band (UWB) systems in indoor wireless channel in accordance with the number of pulses per bit at transmit signals and the decision types of receiver. The indoor channel is modeled as the modified Saleh and Valenzuela (SV) model which has been proposed as a UWB channel model by the IEEE group, IEEE 802.15.SG3a. Two types of UWB signals are considered One is the pulse position modulation-time hopping (PPM-TH) signal. And the other is the pulse amplitude modulation-direct sequence (PAM-DS) signal. It is assumed that the receiver is an ideal receiver which can receive all signals of the multipath.