• Title/Summary/Keyword: channel condition

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Opening of ATP-sensitive $K^+$ Channel by Pinacidil Requires Serine/Threonine Phosphorylation in Rat Ventricular Myocytes

  • Kwak, Yong-Geun;Chae, Soo-Wan
    • The Korean Journal of Physiology and Pharmacology
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    • v.3 no.3
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    • pp.293-303
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    • 1999
  • The influences of specific protein phosphatase and protein kinase inhibitors on the ATP-sensitive $K^+\;(K_{ATP})$ channel-opening effect of pinacidil were investigated in single rat ventricular myocytes using patch clamp technique. In cell-attached patches, pinacidil $(100\;{\mu}M)$ induced the opening of the $K_{ATP}$ channel, which was blocked by the pretreatment with H-7 $(100\;{\mu}M)$ whereas enhanced by the pretreatment with genistein $(30\;{\mu}M)$ or tyrphostin A23 $(10\;{\mu}M)$. In inside-out patches, pinacidil $(10\;{\mu}M)$ activated the $K_{ATP}$ channels in the presence of ATP (0.3 mM) or AMP-PNP (0.3 mM) and in a partial rundown state. The effect of pinacidil $(10\;{\mu}M)$ was not affected by the pretreatment with protein tyrosine phosphatase 1B $(PTP1B,\;10\;{\mu}g\;ml^{-1}),$ but blocked by the pretreatment of protein phosphatase 2A $(PP2A,\;1\;U\;ml^{-1})$. In addition, pinacidil $(10\;{\mu}M)$ could not induce the opening of the reactivated $K_{ATP}$ channels in the presence of H-7 $(100\;{\mu}M)$ but enhanced it in the presence of ATP (1 mM) and genistein $(30\;{\mu}M).$ These results indicate that the $K_{ATP}$ channel-opening effect of pinacidil is not mediated via phosphorylation of $K_{ATP}$ channel protein or associated protein, although it still requires the phosphorylation of serine/threonine residues as a prerequisite condition.

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Characteristics of Turbulent Flows and Suspended Sediment Transport in Open-channel with Submerged Vegetation (침수식생 개수로에서 난류 및 부유사 이동 특성)

  • Yang, Won-Jun;Jang, Ji-Yeon;Choi, Sung-Uk
    • Journal of Korea Water Resources Association
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    • v.44 no.5
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    • pp.417-427
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    • 2011
  • The open-channel flow with submerged vegetation shows distinct features in two separate regions, namely upper and vegetation layers. In the upper layer, the flow is akin to the open-channel flow, while the flow in the vegetation layer is relatively uniform with suppressed turbulence due to vegetation stems. This paper presents laboratory experiments to investigate the characteristics of turbulent flows and suspended sediment transport in open-channel flows with submerged vegetation. An open-channel facility, 0.5 m wide and 12 m long, was used for laboratory experiments. Various discharges were employed with depth ratios of 2~3, and wooden cylinders were used for vegetation. To make equilibrium suspension, sediment particles of median diameter of 75 ${\mu}M$ were fed until capacity condition. Laser Doppler velocimeter was used to measure instantaneous velocity, and direct sampling with vinyl tube was used to measure the concentration of suspended sediment. Using the sampled data, the mean flow and turbulence structures were provided and characteristics of suspended sediment concentration with Rouse number were presented.

Classification of Streams and Application of Channel Evolution Model in Korea (국내유역의 하천분류 및 하도진화모형 적용)

  • Rim, Chang-Soo;Lee, Joon Ho;Jung, Jae Wook;Yoon, Sei Eui
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.28 no.6B
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    • pp.615-625
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    • 2008
  • In this study, classification of streams was conducted for Ji Stream, a tributary to the Geum River and Yo Stream, a tributary to the Seomjin River, and in addition, channel evolution model to the same streams was applied. The classification approaches suggested by Rosgen and Korea Institute of Construction Technology (KICT) were conducted. The channel evolution model suggested by Schumm et al. (1984) was applied. Based on the application results of Rosgen approach, Ji Stream and Yo stream show the characteristics of mountainous stream with pebbles. The application results of channel evolution model indicated that the current condition of Ji Stream and Yo Stream is a state of equilibrium, balancing the sediment supply and sediment transport capacity. The results of this study can be used as a fundamental data for water control project, river restoration and appropriate channel planning.

A Study on Effects of Hydraulic Structure on River Environment(I) : Hydraulic Characteristics (수공구조물이 하천환경에 미치는 영향에 관한 연구(I) : 수리학적특성)

  • 안승섭;최윤영;이수식
    • Journal of Environmental Science International
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    • v.11 no.3
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    • pp.191-199
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    • 2002
  • In this study, water protection reservoir is selected as the target which is located at the estuary of Taehwa river to analyze and examine the effects of hydraulic structure on river environment. This study aims at the definition of factors which cause the change of ecological environment of river due to the effects of the sediment protection reservoir, and the proposal of the direction of environmental friendly river space development through the analysis and examination of stream variation conditions and riverbed variation characteristics among many effects of hydraulic structure on river environment before and after removal of the sediment protection reservoir when design flow is yielded. Firstly, in case of removal the existing sediment protection reservoir, the hydraulic variation characteristics like depth drop due to removal of the sediment protection reservoir are thought of little because it is examined that depths drop with about 0.01m and 0.01~0.56m when low flow is yielded and design flood yielded, respectively. Nextly, as the examination result of the variation characteristics of flow velocity in case of removal the existing sediment protection reservoir, it is thought that the concern about riverbed erosion is not serious according to the analyzed result as the mean velocity of the channel section where the velocity varies in case of removal the sediment protection reservoir is about 0.07~1.36m/s when low flow is yielded, and is about 1.02~2.41m/s when design flood is yielded despite riverbed erosion is concerned as it is examined that flow velocity is getting increase as about 0.01m/s when low flow is yielded and about 0.01~0.44m/s when design flood is yielded. Lastly, from the prediction result of riverbed variation for each flow amount condition before and after removal the sediment protection reservoir, it is known that the variation range of riverbed is nearly constant when flow amount of the channel exceeds a specific limit as it is analyzed that the more flow amount, the more erosion and sediment in the channel section of down stream part of the sediment protection reservoir and the sediment protection reservoir~Samho-gyo, and the variation ranges according to flow amount between flood condition and design flood condition have little difference in the channel section of the upstream of Samho-gyo.

Effect of Water Depth on the Performance of a Direct Drive Turbine for Wave Energy Converter (파력발전용 직접구동터빈의 성능에 미치는 수심의 영향)

  • Choi, Young-Do;Kim, Chang-Goo;Cho, Young-Jin;Kim, You-Taek;Lee, Young-Ho
    • The KSFM Journal of Fluid Machinery
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    • v.11 no.6
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    • pp.38-45
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    • 2008
  • Development of high efficiency turbine with good performance is one of the main topics in the field of developing wave energy converter. For the development and improvement of the turbine performance, the effect of wave condition on the turbine performance should be considered in detail. Also, water depth is an important factor because incident wave power to the turbine is considerably influenced by the wave particle amplitude of motion and the amplitude is closely related with the water depth. Therefore, in this study, the effect of water depth on the performance of a direct drive turbine(DDT) for wave energy converter is investigated using the DDT which is installed in two types of wave channel. The experimental results show that the DDT captures more wave energy under the condition of relatively shallow water depth. When the water depth is shallow, the horizontal water particle amplitude of motion becomes wider and thus, the water power toward the turbine becomes larger.

Mobility-Adaptive Routing Update Scheme for Wireless Networks with Group Mobility (이동성 지원 메쉬 네트워크를 위한 클러스터 기반의 멀티 채널 MAC)

  • Kim, Jong-Hum;Jeon, Hahn-Earl;Lee, Jai-Yong;Park, Soo-Bum;You, Young-Bin
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.37 no.2B
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    • pp.120-129
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    • 2012
  • Wireless mesh network (WMN) has recently emerged as a promising technology for tactical operation. If a platoon is organized with MPs, this system is suitable for tactical coverage is given for battle field where there is a shortage of wired infrastructure. However, MPs of typical WMN are generally fixed. This condition does not apply to diverse tactical scenarios. In this paper, it is considered that MPs have group mobility for flexible tactical networks. We propose cluster based multi-channel MAC scheme for mobilie WMN with single antenna condition. We have reduced the collision problems and message storming problems occur by mobility, so the reliability of WMN has been improved. Consequently, reliable communication is guaranteed by our framework in mobile WMN.

Development of Three-Dimensional Finite Element Model Using Upwind Weighting Scheme for River Flow (하천흐름해석을 위한 상향가중의 3차원 유한요소모형 개발)

  • Han, Kun-Yeun;Baek, Chang-Hyun;Choi, Seung-Yong
    • Proceedings of the Korea Water Resources Association Conference
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    • 2005.05b
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    • pp.409-413
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    • 2005
  • Even though the relative importance of length scale of flow system allow us to simplify three dimensional flow problem to one or two dimensional representation, many systems still require three dimensional analysis. The objective of this study is to develop an efficient and accurate finite element model for analyzing and predicting three dimensional flow features in natural rivers and to offend to model spreading of pollutants and transport of sediments in the future. Firstly, three dimensional Reynolds averaged Navier-Stokes equations with the hydrostatic pressure assumption in generalized curvilinear coordinates were combined with the kinematic free-surface condition. Secondly. to simulate realistic high Reynolds number flow, the model employed the Streamline Upwind/Petrov-Galerkin(SU/PG) scheme as a weighting function for the finite element method in conjunction with an appropriate turbulence model(Smagorinsky scheme for the horizontal plain and Mellor-Yamada scheme for the vertical direction). Several tests is performed for the purpose of validation and verification of the developed model. A simple rectangular channel, 5-shaped and U-shaped channel are used for tests and comparisons are made with RMA-10 model. Runs for each case is converged stably without a oscillation and calculated water-surface deformation, longitudinal and transversal velocities, and velocity vector fields are in good agreement with the results of RMA-10 model.

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Application of the Landsat TM/ETM+, KOMPSAT EOC, and IKONOS to Study the Sedimentary Environments in the Tidal Flats of Kanghwa and Hwang-Do, Korea

  • Ryu Joo-Hyung;Lee Yoon-Kyung;Yoo Hong-Rhyong;Park Chan-Hong
    • Proceedings of the KSRS Conference
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    • 2004.10a
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    • pp.140-143
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    • 2004
  • The west coast of the Korean Peninsula is famous for its large tidal range (up to 9 m) and vast tidal flats. With comparison the sedimentary environments of open and close tidal flat using remote sensing, we select Kanghwa tidal flat and Hwang-Do tidal flat in Cheonsu Bay. Prior to surface sediment discrimination using remote sensing, sedimentary environments including intertidal OEM, hydraulic condition, and relationship between grain size and various tidal condition are investigated. Remote sensing has the potential to provide synoptic information of intertidal environments. The objectives of this study are: (i) to generate an intertidal digital elevation model (OEM) using the waterline method of Lansat TM/ETM+, (ii) to investigate the tidal channel distribution using texture analysis, and (iii) to analyze the relationship between surface grain size by using in-situ data and intertidal OEM and tidal channel density by using high-resolution satellite data such as IKONOS and Kompsat EOC. The results demonstrate that satellite remote sensing is an efficient and effective tool for a surface sediment discrimination and long term morphologic change estimation in tidal flats.

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A Study on Channel Mis-match Compensation Technique for Robust Speaker Verification System (강인한 화자확인 시스템을 위한 채널 불일치 보상 기법에 관한 연구)

  • 강철호;정희석
    • The Journal of the Acoustical Society of Korea
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    • v.23 no.3
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    • pp.228-234
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    • 2004
  • In this paper, we proposed the compensation technique that overcomes the limitations of the conventional approaches through summing up the bias terms between world's codebook and individual codebook vectors of feature parameters. But, mean compensation without condition can bring higher false acceptance. Therefore, the proposed technique compensates the channel mis-match condition by weighted bias sum using nonlinear function regarding to the distortion between speech and silence. The simulation results show that the FRR (flase reject rate) is decreased 14.95% when the proposed algorithm was applied.

삼각형상 그루브 채널에서 맥동유동에 의한 열전달 향상에 관한 실험적 연구

  • 권오준;이대영;김서영;강병하;김용찬
    • Korean Journal of Air-Conditioning and Refrigeration Engineering
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    • v.13 no.10
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    • pp.1009-1016
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    • 2001
  • The heat transfer enhancement by pulsatile flow in a triangular grooved channel has been experimentally investigated in this study The experiment was performed in the ranges of the Reynolds number from 270 to 910, the pulsatile fraction from 0.125 to 0.75, and the Strouhal number from 0.084 to 0.665. It was measured that the heat transfer improves up to 350% compared with the steady flow case at Re=270,$\eta=0.5$, and St=0.335. The heat transfer enhancement was found to increase as the pulsatile fraction increases and the Reynolds number decreases. It was also found that the heat transfer enhancement is maximized at a specific pulsatile frequency satisfying the resonant condition. The nondimensional frequency, i.e., the Strouhal number at the resonant condition was found to increase as the Reynolds number decreases. The flow visualization revealed that the heat transfer enhancement results from the strong mixing caused by the repeating sequence of vortex formation, rotation and subsequent ejection from the grooves by the pulsatile flow.

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