• Journal of the Korean Institute of Oriental Medical Informatics
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• v.19 no.2
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• pp.21-28
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• 2013

Background The aim of this study is assessing the adaption of the Sasang Constitutional herbal tea to the patient complained fatigue. Method Five times assessments were accomplished for 8 weeks using Chalder fatigue scale and visual analogue scale of health status. Herbal tea was served on the point of 4 weeks from 1st visit. Results Chalder fatigue scale and visual analogue scale of health status were significantly improved. Conclusion Sasang Constitutional herbal tea can be used for the control of chronic fatigue.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.13 no.2
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• pp.78-87
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• 2009

Background and Objective: We previously developed questionnaire of subhealth status. Developed questionnaire was verified about reliability and validity, but there had a lack of concurrent validity study. On this study, we will verify concurrent Validity of the Korean Version of the Subhealth Questionnaire. Methods: Guibi-tang questionnaire, chalder questionnaire and subhealth questionnaire were applied to 113 college students. After then do correlation analysis, we calculate concurrent validity of that. Results and Conclusions: As a result, subhealth questionnaire between chalder questionnaire, and subhealth questionnaire between Guibi-tang questionnaire had a significant correlation respectively. The result of this study indicate that the developed questionnaire of subhealth status was verified about concurrent validity.

• The Journal of Internal Korean Medicine
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• v.29 no.1
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• pp.219-230
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• 2008

Objectives : Consumption is a chronic wasting disease, in oriental medicine concept. Fatigue is a common symptom experienced by many people who have consumption. However, there has been little study about the relationship between consumption and fatigue in the Oriental medicine. For this reason, we attempted to investigate the present status of fatigue of outpatients, and its relation with consumption index, public health practice index, Chalder fatigue scale and Subjective Symptoms of Fatigue Test. Methods : The subjects were 149 outpatients who complain fatigue between Nov. 1, 2006 and Oct. 31, 2007. We measured degree of consumption by consumption index. We measured degree of fatigue by Chalder fatigue scale and Subjective Symptoms of Fatigue Test. Public health practice were investigated by "Breslow's 7 health practice". Results : Studies have shown that a group who disregard public health practices have higher numerical value, in part of $q\grave{i}-x\bar{u}$, $xu\grave{e}-x\bar{u}$, and Physical symptoms than a group more concerned with public health practice. A group who has fatigue for a period over 6 months are more likely to be $q\grave{i}-x\bar{u}$, $y\bar{i}n-x\bar{u}$, Chalder fatigue scale, neuro-sensory symptoms than a group fatigued for less than 6 months. Among the subjects, 81 (55.5%) were considered as 'fatigue patients' by the Chalder scale. Chalder fatigue scale, according to the Subjective Symptoms of Fatigue Test, consumption also, The more increase of Subjective symptoms of fatigue test, the more of consumption scale. Conclusions : This study has shown that there is a link between consumption and fatigue. Moreover, oriental medicine's consumption is more concrete than fatigue scale, so consumption index will have wide application to the study of fatigue.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.14 no.1
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• pp.15-35
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• 2010

Objectives : The purpose of this study is to find out the correlation between the Vocal indicators and the 'Buzhongyiqi-Tang questionnaire' and the 'Chalder fatigue scale.' Methods : This study examined the mean value of each factor in the 'Buzhongyiqi-Tang Questionnaire,' 'Chalder fatigue scale' and the different voice indicators conducted on 81 healthy adult participants in relation to the results of the /a/ /e/ /i/ /o/ /u/ pronunciation test. Results : There was significant correlation between the pronunciation of /a/ /e/ /i/ /o/ /u/ vowels' F0 indexes and 'the Deficiency symptoms of Buzhongyiqi-Tang'. The results of the regression analysis showed the following significant findings for each pronouncing vowels: /i/ as a factor for 'the Deficiency symptoms of Buzhongyiqi-Tang'.; /a/ for 'the Consumptive fever of Buzhongyiqi-Tang'.; /i/ for 'the Vocal inflammation of Buzhongyiqi-Tang.; and /e/ as a factor of 'the Chadler physical fatigue'. Conclusions : The study showed a negative correlation between the Fundamental Frequency and the mean value of the questionnaire, which could be understood as higher the fatigue level, increased level of vocal vibration and higher pitch tone compared to the less fatigued group. We expect future studies to conduct research on methods to diagnose other illnesses using the vocal indicators based on the correlation between the vocal index and illnesses prescribed under traditional oriental medicine.

• Korean Journal of Psychosomatic Medicine
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• v.9 no.2
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• pp.164-173
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• 2001

Objectives : Fatigue is a common symptom in primary medical care and has nonspecific and highly subjective features. So it has been difficult to define and measure fatigue, especially those present without any organic diseases. This study was conducted to evaluate the validity of the Fatigue severity scale(FSS) in patients with persistent fatigue who were free of any organic diseases or psychiatric disorders of depression or anxiety. Methods : Subjects consisted of 45 controls, 44 fatigued patients and 43 psychiatric patients with depression or anxiety. They all completed the fatigue severity, modified Bepsi stress, and Hospital anxiety and depression scales. Chalder fatigue scale was administrated randomly in 30 of them. Data were analyzed for reliability and validity of the FSS. Results: Cronbach's a coeffient of FSS was 0.929, and the Pearson correlation coefficient for test-retest was 0.916(p<0.01). ANCOVA for discriminant validity revealed that there were significant differences in mean FSS values among the three groups. The fatigue group had significantly higher FSS value than the other two groups. The psychiatric group also had significantly higher FSS value than the control group. The Pearson correlation coefficient for convergent validity by comparing FSS with Chalder fatigue scale was 0.782(p<0.01). Using FSS index 3.22 as the cut-off point, sensitivity was 84.1% and specificity was 85.7% for the fatigue and control groups, respectively. Conclusion : Results suggested the clinical application of the FSS to be a useful measurement for distinguishing fatigue between patients with physiologic fatigue and psychiatric patients with depression or anxiety.

• The Journal of Internal Korean Medicine
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• v.22 no.3
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• pp.299-307
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• 2001

Objectives: Fatigue is a common symptom experienced by many people who visit Oriental medical clinics or hospital. However, there has been little study about the fatigue in the Oriental medical academic world. For this reason, we attempted to investigate the present status of fatigue of outpatients, and its relation with Health Practice Index(HPI). Methods: The subjects were 63 outpatients who visited the Tonification Clinic in Kyunghee Oriental Medical Center between January 1, 2001 and July 31, 2001. Their chief complaint was fatigue and they did not have any physical or mental problem. They were given a questionnaire which included questions reflecting general characteristics, fatigue degree and health habits. We measured degree of fatigue by Chalder scale et al. Health habits were investigated about 5 articles out of 'Breslow 7 Health habits'. Results: Among the subjects, 48 people(76.2%) were considered as 'fatigue patients' by the Chalder scale. Of this 48 fatigue patients, 27 people(56.3%) had manifested fatigue for more than 6 months. The average of scale II for all the patients was 14.05, which indicates moderate degree of fatigue. They complained fatigue, drowsiness and general weakness, dryness and discomfort of the eyes, headache, shoulder pain and neck stiffness, dizziness, heat in the upper part of the body, and poor concentration. There were no differences in degree of fatigue according to Health habits including exercise or not, smoking or not, the frequency of drinking, hours of sleeping, and body mass index. Conclusions: Many people complain fatigue symptom. Therefore doctors should have more interest in fatigue and care. This study can provide standards of prognosis of fatigue patients. Also prospective studies are needed to find relationship between health habits and fatigue degree.

• Journal of Pharmacopuncture
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• v.17 no.4
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• pp.55-60
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• 2014

Objectives: This study was designed to evaluate the efficacy and the safety of constitutional herbal tea for treating chronic fatigue with no diagnosed cause, which is called Mibyeong in Korea. Methods: Males and females with ages between 40 and 59 years who had complained of fatigue for 1 month consistently or for 6 months intermittently without a definite cause were recruited. At the same time, a Chalder fatigue scale (CFS) score of 19 was essential for participation in this study. Sixty five subjects completed the entire process, including blood tests and tests with medical devices. Five assessments of health status were accomplished over 8 weeks by using the CFS and the visual analogue scale (VAS). To ensure that the constitutional herbal tea was being safely used, we conducted and analyzed renal function and liver function tests. For the diagnosis of the Sasang constitution, the Sasang Constitutional Analysis Tool (SCAT) was used, and a specialist in Sasang constitutional medicine made the final diagnosis based on the SCAT result. Constitutional herbal tea was served four weeks after the first visit. The subjects took the constitutional herbal tea twice a day for one month. Results: The results are as follows: The CFS and the VAS scores were significantly improved for the subjects in the constitutional herbal tea. No abnormalities were found on the blood tests to evaluate safety after taking the constitutional herbal tea. The improvements in the CFS and the VAS scores due to the constitutional herbal tea had no significant differences according to the Sasang constitution. Conclusion: Constitutional herbal tea may be used to reduce fatigue and improve health and has no adverse effect on either the kidney or the liver.

• CELLMED
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• v.1 no.1
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• pp.6.1-6.4
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• 2011

For cancer patients undergoing radiation therapy (RT) or systemic chemotherapy (CHT), cancer-related fatigue (CRF) is a common problem that can negatively impact their quality of life. Guarana (Paullinia cupana) is a plant native to the Amazon basin that has been used as a stimulant since pre-Columbian times. PURPOSE: To evaluate the effectiveness of guarana extract on fatigue in BC patients undergoing either CHT or RT. A total of 137 cancer patients (85% with Breast Cancer) undergoing either CHT (101) or RT (36) were randomized to receive either a placebo or guarana. In all 3 studies, the guarana was given as an unmanipulated dry extract at a dose of 75 mg PO QD in the first two studies or 50 mg PO BID in the third study. Patients were crossed over to the other experimental arm, and we evaluated fatigue with the Chalder Scale in all three studies. Guarana significantly improved the The Chalder Scale Global Scores (- 0.85; 95% CI:-1.31 to -0.40; p = 0.0002); Physical Fatigue Scores (-0.44; 95% CI: - 0.74 to - 0.13; p = 0.005) and Mental Fatigue Scores (-0.93; 95% CI: - 1.14 to - 0.72; p < 0.00001). Guarana did not produce any CTCAE grades 3 or 4 toxicities in any of the studies. Guarana is an effective, cheap and non-toxic alternative for the treatment of fatigue in cancer patients undergoing treatment.

• The Journal of Korean Obstetrics and Gynecology
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• v.30 no.4
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• pp.45-58
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• 2017

Objectives: The aim of this trial is to investigate the effect of Ginseng and Wild Cultivated Ginseng to Heat pattern subject. Methods: Eighty-nine Subjects were diagnosed as heat pattern by Cold-Heat Patternization and divided into Ginseng group (n=30), Wild Cultivated Ginseng group (n=31) and Placebo group (n=28) in their 1 st visit. In each visit, The researchers measured the subject's facial temperature using the infrared thermometer (Testo 835-T1). After that, The subjects were asked to mark the current score of flushing on the Visual Analogue Scale (VAS) and to complete the Chalder-Fatigue Scale (CFS) in each visit. The subjects took the test drug for one week and returned the remaining drug on the 2nd visit. The trial result was analyzed with one-way ANOVA using SPSS for Windows version 18. Results: 1. Systolic blood pressure was significantly lower in the Ginseng group and Wild Cultivated Ginseng group than in the control group (p=0.021). 2. There was no significant difference in facial temperature between each groups. 3. The current score of flushing showed the greatest decrease in the Ginseng group compared to the other groups but there was no significant difference (p=0.205). 4. The score of Chalder-Fatigue Scale was decreased in all groups but not statistically significant (p=0.180). Conclusions: This study showed that taking Ginseng extract and Wild Cultivated Ginseng extract do not affect to heat-rising reaction to the subjects diagnosed as heat pattern.

• Journal of Oriental Neuropsychiatry
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• v.32 no.1
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• pp.13-23
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• 2021

Objectives: This study was conducted to investigate the emotional characteristics of adults who complained of fatigue using the Core Seven Emotion Inventory-Short Form (CSEI-s) followed by correlation analysis with the Chalder fatigue scale (CFQ) and Psychosocial Well-being Index-Short form (PWI-SF). Methods: In this study, the medical records of 45 participants who complained of fatigue and completed the CSEI-s, CFQ, and PWI-SF were evaluated. Records of a total of 45 adults were analyzed using SPSS (Statistical Package for the Social Sciences, Version 25.0). Frequency Analysis, Descriptive Analysis, Independent t-test, One Way ANOVA, and Correlation analysis were used for data analysis. Results: 1. According to the educational status of the participants, Thought (思) was identified to be significantly higher in below college graduate than in graduate school and above. 2. As the period of complaining of fatigue increased, a significant difference was observed in Depression (憂) and Fright (驚). 3. According to the degree of fatigue, there was a significant difference in Depression (憂) and Fright (驚), and especially Depression (憂) was higher in the middle fatigue group than in the low fatigue group. 4. PWI-SF, Anger (怒), Depression (憂), and Sorrow (悲) showed a positive correlation with CFQ scores. Conclusions: The results suggest that CSEI-s can be used to measure the psychological symptoms of a patient with fatigue.