• Korean Journal of English Language and Linguistics
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• v.3 no.4
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• pp.527-545
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• 2003

I look at the respective responsibilities of different components of the language faculty in the description of two radically different kinds of linguistic phenomenon. The first is the production/perception mismatch in the child's acquisition of the phonology of its first language. There is strong evidence that the child's lexical representations are the same as the adult's, but I argue that the child's own pronunciations, have no linguistic status and are best treated as the product of a neural network. The second is the nature of compositionality, where I argue that compositionality in Natural Language is derivative from that in the Language of Thought. With this assumption and using evidence from quantification in ‘backward control’ structures, I argue that chain theory is intrinsically inimical to a simple view of the legibility relation between LF and LoT.

• Journal of the Daesoon Academy of Sciences
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• v.35
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• pp.147-180
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• 2020

'The Great Nest of Being (The Great Chain of Being)' is a key ontological concept in Perennial Philosophy. The Great Nest of Being shows the depth of the world's religions that have existed historically, and in this context, they represent holarchies of existence and consciousness. This paper examines the nests of various beings in order to grasp the depths of the world's mainstream religions, and reveals that the great nest of being that appear in the Daesoon Thought has the characteristic of synthesizing other nests that have emerged previously in history. According to Perennial Philosophy, the differences among different religions in regards to ultimate reality are not differences in reality but merely differences in semantics. In other words, these differences are only 'different expressions of the same ultimate reality.' Thus, linguistically, ultimate reality in the great nest of being can be summarized as the 'same in what is signifié (signified, 記意)' and 'different in the signifiant (signifier, 記標).' As stated in a preceding study; however, ultimate reality in Daesoon Thought is both transcendent and personal, as well as intrinsic and impersonal. This fact is specifically stated in the Four Tenets (4大 宗旨) of Daesoon Thought. In other words, the Tenets of Daesoon implicitly acknowledge not only the concepts of reality and the direction that emerges from the base of existence in existing systems of religious thought, but also can encompass the ideologies of those systems of religious thought. Considering the four quadrants as the Kosmos (AQAL), it encompasses a universal ideology. Therefore, the tenets of Daesoon Thought encompass the same significance (meaning) of the major systems of religious thought throughout the world in regards to ultimate reality and provide a clue to the solution to the presence of different signifiers (signs).

• Journal of Nutrition and Health
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• v.30 no.6
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• pp.658-668
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• 1997

Path of a small hydrophobic molecule through the aqueous cytoplasma is not linear. Partition may favor membrane binding by several orders of magnitude : thus significant membrane association will markedly decrease the cytosolic transport rate. The presence of high concentration of soluble binding proteins for these hydrophobic molecules would compete with membrane association and thereby increase transport rate. For long chain fatty acid molecules, a family of cytosolic binding proteins collectively known as the fatty acid binding proteins(FABP), are thought to act as intracellular transport proteins. This paper examines the mechanism of transfer of fluorescent antyroyloxy-labeled fatty acids(AOFA) from purified FABPs to phosholipid membranes. With the exception of the liver FABP, AOFA is transferred from FABP by collisional interaction of the protein with a acceptor membrane. The rate of transfer increased markedly when membranes contain anionic phospholipids. This suggests that positively charged residues on the surface of the FABP may interact with the membranes. Neutralization of the surface lysine residues of adipocyte FABP decreased fatty acid transfer rate, and transfer was found to proceed via aqueous diffusion rather than collisional interaction. Site specific mutagenesis has further shown that the helix-turn-helix domain of the FABP is critical for interaction with anionic acceptor membranes. Thus cytosolic FABP may function in intracellular transport of fatty acid to decrease their membranes association as well as to target fatty acid to specific subcellular sites of utilization.

• The Microorganisms and Industry
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• v.13 no.1
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• pp.4-9
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• 1987

The regulation of gene expression in procaryotes is accomplished primarily at the level of transcription. Initiation of transcription is subject to numerous promoter-specific controls which act to ensure coordinate expression of disparate genes. The kinetics of formation of a functional("open") complex at a promoter, prior to the catalytic steps of RNA chain initiation and elongation, is thought to play a major role in controlling the efficiency of transcription of that promotor, since the subsequent processes of nucleotide binding and phosphodiester bond formation are rapid and are not promoter-specific (Mangel and Chamberlin, 1974 Shimamoto et al., 1981)

• Journal of Periodontal and Implant Science
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• v.41 no.1
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• pp.30-43
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• 2011

Purpose: Under different culture conditions, periodontal ligament (PDL) stem cells are capable of differentiating into cementoblast-like cells, adipocytes, and collagen-forming cells. Several previous studies reported that because of the stem cells in the PDL, the PDL have a regenerative capacity which, when appropriately triggered, participates in restoring connective tissues and mineralized tissues. Therefore, this study analyzed the genes involved in mineralization during differentiation of human PDL (hPDL) cells, and searched for candidate genes possibly associated with the mineralization of hPDL cells. Methods: To analyze the gene expression pattern of hPDL cells during differentiation, the hPDL cells were cultured in two conditions, with or without osteogenic cocktails (${\beta}$-glycerophosphate, ascorbic acid and dexamethasone), and a DNA microarray analysis of the cells cultured on days 7 and 14 was performed. Reverse transcription-polymerase chain reaction was performed to validate the DNA microarray data. Results: The up-regulated genes on day 7 by hPDL cells cultured in osteogenic medium were thought to be associated with calcium/iron/metal ion binding or homeostasis (PDE1A, HFE and PCDH9) and cell viability (PCDH9), and the down-regulated genes were thought to be associated with proliferation (PHGDH and PSAT1). Also, the up-regulated genes on day 14 by hPDL cells cultured in osteogenic medium were thought to be associated with apoptosis, angiogenesis (ANGPTL4 and FOXO1A), and adipogenesis (ANGPTL4 and SEC14L2), and the down-regulated genes were thought to be associated with cell migration (SLC16A4). Conclusions: This study suggests that when appropriately triggered, the stem cells in the hPDL differentiate into osteoblasts/cementoblasts, and the genes related to calcium binding (PDE1A and PCDH9), which were strongly expressed at the stage of matrix maturation, may be associated with differentiation of the hPDL cells into osteoblasts/cementoblasts.

• Annual Conference on Human and Language Technology
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• 2023.10a
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• pp.648-653
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• 2023

관계 추출 태스크는 주어진 텍스트로부터 두 개체 간의 적절한 관계를 추론하는 작업이며, 지식 베이스 구축 및 질의응답과 같은 응용 태스크의 기반이 된다. 최근 자연어처리 분야 전반에서 생성형 거대 언어모델의 내재 지식을 활용하여 뛰어난 성능을 성취하면서, 대표적인 정보 추출 태스크인 관계 추출에서 역시 이를 적극적으로 활용 가능한 방안에 대한 탐구가 필요하다. 특히, 실 세계의 추론 환경과의 유사성에서 기인하는 저자원 특히, 제로샷 환경에서의 관계 추출 연구의 중요성에 기반하여, 효과적인 프롬프팅 기법의 적용이 유의미함을 많은 기존 연구에서 증명해왔다. 따라서, 본 연구는 한국어 관계 추출 분야에서 거대 언어모델에 다각적인 프롬프팅 기법을 활용하여 제로샷 환경에서의 추론에 관한 비교 연구를 진행함으로써, 추후 한국어 관계 추출을 위한 최적의 거대 언어모델 프롬프팅 기법 심화 연구의 기반을 제공하고자 한다. 특히, 상식 추론 등의 도전적인 타 태스크에서 큰 성능 개선을 보인 사고의 연쇄(Chain-of-Thought) 및 자가 개선(Self-Refine)을 포함한 세 가지 프롬프팅 기법을 한국어 관계 추출에 도입하여 양적/질적으로 비교 분석을 제공한다. 실험 결과에 따르면, 사고의 연쇄 및 자가 개선 기법 보다 일반적인 태스크 지시 등이 포함된 프롬프팅이 정량적으로 가장 좋은 제로샷 성능을 보인다. 그러나, 이는 두 방법의 한계를 지적하는 것이 아닌, 한국어 관계 추출 태스크에의 최적화의 필요성을 암시한다고 해석 가능하며, 추후 이러한 방법론들을 발전시키는 여러 실험적 연구에 의해 개선될 것으로 판단된다.

• Annual Conference on Human and Language Technology
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• 2023.10a
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• pp.448-453
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• 2023

대규모 언어 모델 (Large Language Model, LLM)을 인간의 선호도 관점에서 평가하는 것은 기존의 벤치마크 평가와는 다른 도전적인 과제이다. 이를 위해, 기존 연구들은 강력한 LLM을 평가자로 사용하여 접근하였지만, 높은 비용 문제가 부각되었다. 또한, 평가자로서 LLM이 사용하는 주관적인 점수 기준은 모호하여 평가 결과의 신뢰성을 저해하며, 단일 모델에 의한 평가 결과는 편향될 가능성이 있다. 본 논문에서는 엄격한 기준을 활용하여 편향되지 않은 평가를 수행할 수 있는 평가 프레임워크 및 평가자 모델 'FubaoLM'을 제안한다. 우리의 평가 프레임워크는 심층적인 평가 기준을 통해 다수의 강력한 한국어 LLM을 활용하여 연쇄적 사고(Chain-of-Thought) 기반 평가를 수행한다. 이러한 평가 결과를 다수결로 통합하여 편향되지 않은 평가 결과를 도출하며, 지시 조정 (instruction tuning)을 통해 FubaoLM은 다수의 LLM으로 부터 평가 지식을 증류받는다. 더 나아가 본 논문에서는 전문가 기반 평가 데이터셋을 구축하여 FubaoLM 효과성을 입증한다. 우리의 실험에서 앙상블된 FubaoLM은 GPT-3.5 대비 16% 에서 23% 향상된 절대 평가 성능을 가지며, 이항 평가에서 인간과 유사한 선호도 평가 결과를 도출한다. 이를 통해 FubaoLM은 비교적 적은 비용으로도 높은 신뢰성을 유지하며, 편향되지 않은 평가를 수행할 수 있음을 보인다.

• Journal of Genetic Medicine
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• v.11 no.1
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• pp.22-26
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• 2014

Maple syrup urine disease (MSUD) is a disorder that involves the metabolism of branched chain amino acids, arising from a defect in branched-chain ${\alpha}$-keto acid dehydrogenase complex. Mutations have been identified in the BCKDHA, BCKDHB, or DBT genes, which encode different subunits of the BCKDH complex. Although encephalopathy and progressive neurodegeneration are its major manifestations, the severity of the disease may range from the severe classic type to milder intermediate variants. We report two Korean siblings with the milder intermediate MSUD who were diagnosed with MSUD by a combination of newborn screening tests using tandem mass spectrometry and family genetic screening for MSUD. At diagnosis, the patients' plasma levels were elevated for leucine, isoleucine, valine, and alloisoleucine, and branched-chain ${\alpha}$-keto acids and branched-chain ${\alpha}$-hydroxy acids were detected in their urine. BCKDHA, BCKDHB, and DBT analysis was performed, and two novel mutations were identified in BCKDHB. Our patients were thought to have the milder intermediate variant of MSUD, rather than the classic form. Although MSUD is a typical metabolic disease with poor prognosis, better outcomes can be expected if early diagnosis and prompt management are provided, particularly for milder forms of the disease.

• The Journal of Asian Finance, Economics and Business
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• v.9 no.1
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• pp.325-332
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• 2022

The aim of this research is to use a conceptual model to experimentally evaluate the mediating impact of government financial and training support on structural social capital and non-financial performance of family farms. Questionnaires were used to collect data from family farms in Guangxi, China, from August 25^th to September 8^th, 2021. There were 759 valid responses, accounting for 94.99 percent of the total number of respondents. The scales' reliability and validity, and the research's mediating effects and hypotheses, are tested using SPSS 22.0 and AMOS 26.0. The findings suggest that the impact of government financial assistance on family farms' non-financial performance cannot be substantiated. The intermediary chain connection of financial and training support, on the other hand, has a significant mediating effect between structural social capital and family farm non-financial performance. Direct financial assistance could be thought to encourage family farms to rely too much on funding, making them less competitive in market competition, innovation, and long-term operations. According to the conclusions of the study, government assistance to family farms could take a variety of forms, including providing diversified skills training programs in farming practices, managerial skills, and other areas.

• Applied Chemistry for Engineering
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• v.10 no.4
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• pp.628-634
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• 1999

The orientational binding of ${\omega}$-phenylakylammonium ions to the sodium dodecyl (SDS) micellar interface has been studied from $^{1}H\;NMR$ chemical shift data. The NMR resonaces of the methylene protons of SDS and aromatic protons embedded into the micellar interior have shown the upfield shift. The aromatic induced chemical shifts of the alkyl chain methylene protons of SDS demonstrate the deep penetration into the palisade layer by these organic salts. Alkylammonium groups have been considered to be oriented toward outside of the micellar interface. Aromatic rings have been thought to be oriented toward the micellar core. The depth of penetration by organic salts has been observed to increase with the length of alkyl chain.