• 한국통신학회논문지
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• 제36권8A호
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• pp.712-722
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• 2011

Wireless body area network (WBAN)은 인체 주변 영역에서의 통신서비스를 제공한다. WBAN 서비스는 인체 내부에 이식된 의료 응용을 위한 MICS 주파수 대역과 의료 응용과 consumer electronics (CE) 응용 분야 모두를 제공할 수 있는 ISM 주파수 대역에서의 서비스로 이루어지기 때문에 WBAN을 위한 MAC 프로토콜은 의료 응용과 CE 응용간의 상이한 특징과 유연성 (flexibility)을 고려하여 설계되어야 한다. 본 논문에서는 WBAN MAC 프로토콜의 요구사항을 확인하고, WBAN의 요구사항을 만족하는 WBAN MAC 프로토콜을 제안한다. WBAN의 다양한 응용을 위한 전송 유연성을 제공하기 위해서 동적 CFP(Contention Free Period) 할당(Dynamic CFP Allocation)을 제안한다. 또한, 경쟁 기반의 긴급 의료 데이터를 발생하는 의료 응용과 때때로 대량의 데이터를 발생하는 CE 응용을 지원하기 위해서 OCDP(opportunistic contention decision period) 구간과 4-mode Opportunity period를 제안하고, 제안한 방안을 이용하여 Inactive period와 Opportunity period를 일시적으로 전환하여 사용할 수 있는 기법을 제안한다. 다양한 시뮬레이션 결과 IEEE 802.15.4 MAC 프로토콜과 제안하는 WBAN MAC 프로토콜을 비교하였을 때, WBAN 환경에서의 전송 처리량, CFP 이용율, 전송지연 측면에서 증가된 성능 결과를 얻을 수 있었다.

• Kyungpook Mathematical Journal
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• 제49권3호
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• pp.425-433
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• 2009

In this paper, we give the internal characterizations of compact-covering s-(resp., ${\pi}$-)images of locally separable metric spaces. As applications of these results, we obtain characterizations of compact-covering quotient s-(resp., ${\pi}$-)images of locally separable metric spaces.

• 한국정보과학회:학술대회논문집
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• 한국정보과학회 2012년도 한국컴퓨터종합학술대회논문집 Vol.39 No.1(D)
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• pp.427-429
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• 2012

최근 통신사업자(Telco)들은 급증하고 있는 고용량의 멀티미디어 트래픽을 수익화하기 위해, 자신의 네트워크 인프라에 CDN(Contents Delivery Network)을 직접 구축하거나, 망 증설의 부담을 줄이기 위해 ALTO(Application Layer Traffic Optimization)와 같은 트래픽 지역화 기술을 적용하는 등 다양한 노력을 경주하고 있다. CDNI(CDN interconnetion)는 이러한 노력의 일환으로, 전 세계에 걸쳐 고품질의 콘텐츠 전달 서비스 인프라를 구축함과 동시에 새로운 콘텐츠 유통 체계를 정립하는데 큰 기여를 할 것으로 기대되고 있다. 본 논문에서는 글로벌 ISP를 중심으로 결성된 CFP(CDN Federation Pilot)에 대해 소개하고, 현재 진행 중인 Telco CDN 상호연동 기능시험과 그 결과를 일부 제시한다. 또한, IETF CDNI 워킹그룹을 중심으로 진행되고 있는 Telco CDN 연동과 관련된 기술 표준화에 대해서 소개한다.

• Tuberculosis and Respiratory Diseases
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• 제80권1호
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• pp.77-82
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• 2017

Background: Delayed hypersensitivity plays a large role in the pathogenesis of tuberculous pleural effusion (TPE). Macrophages infected with live Mycobacterium tuberculosis (MTB) increase the levels of adenosine deaminase2 (ADA2) in the pleural fluid of TPE patients. However, it is as yet unclear whether ADA2 can be produced by macrophages when challenged with MTB antigens alone. This study therefore evaluated the levels of ADA2 mRNA expression, using monocyte-derived macrophages (MDMs) stimulated with MTB antigens. Methods: Purified monocytes from the peripheral blood mononuclear cells of healthy volunteers were differentiated into macrophages using granulocyte-macrophage colony-stimulating factor (GM-CSF) or macrophage colony-stimulating factor (M-CSF). The MDMs were stimulated with early secretory antigenic target protein 6 (ESAT6) and culture filtrate protein 10 (CFP10). The mRNA expression levels for the cat eye syndrome chromosome region, candidate 1 (CECR1) gene encoding ADA2 were then measured. Results: CECR1 mRNA expression levels were significantly higher in MDMs stimulated with ESAT6 and CFP10, than in the unstimulated MDMs. When stimulated with ESAT6, M-CSF-treated MDMs showed more pronounced CECR1 mRNA expression than GM-CSF-treated MDMs. Interferon-${\gamma}$ decreased the ESAT6- and CFP10-induced CECR1 mRNA expression in MDMs. CECR1 mRNA expression levels were positively correlated with mRNA expression of tumor necrosis factor ${\alpha}$ and interleukin 10, respectively. Conclusion: ADA2 mRNA expression increased when MDMs were stimulated with MTB antigens alone. This partly indicates that pleural fluid ADA levels could increase in patients with culture-negative TPE. Our results may be helpful in improving the understanding of TPE pathogenesis.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제5권1호
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• pp.123-140
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• 2011

In this paper, we propose an Energy Efficient Media Access Control (EE-MAC) protocol for wireless sensor networks. The proposed scheme is designed to save power consumption and guarantee quality-of-service for real-time traffic. EE-MAC uses the superframe structure which is bounded by the transmission of a beacon frame and can have an active and an inactive portion. The active period is divided into the contention free period (CFP) for real-time traffic transmission and the contention access period (CAP) for non-real-time traffic transmission. We propose the exclusively allocated backoff scheme which assigns a unique backoff time value to each real-time node based on bandwidth allocation and admission control. This scheme can avoid collision between real-time nodes by controlling distributed fashion and take effect a statistical time division multiple access. We also propose the algorithm to change the duty cycle adaptively according to channel utilization of media depending on network traffic load. This algorithm can prolong network lifetime by reducing the amount of energy wasted on idle listening.

• International Journal of Advanced Culture Technology
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• 제8권2호
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• pp.260-269
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• 2020

The Steam Assisted Gravity Drainage (SAGD) process is an enhanced method to extract oil from bitumen which involves surface and central process facilities. This paper describes the Central Process Facilities (CPF) of SAGD and proposes several retrofit plans to the Heat Exchanger Network (HEN). In this approach, the process integration scheme is applied to estimate the energy saving in HENs, and various cases are modeled in favor of a commercial simulator. Throughout this work, a minimum approach temperature of 10℃ is assumed. The results reveal that, due to the HEN optimization using process integration, the heating and cooling duties can be reduced to 29.68MW and 1.886MW, respectively. Compared with the Husky case, all cases considered in this study indicate a potential reduction of at least 6% in total cost, including investment and operation costs.

• Journal of Communications and Networks
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• 제15권1호
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• pp.87-101
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• 2013

In industrial applications, sensor networks have to satisfy specified time requirements of exchanged messages. IEEE 802.15.4 defines the communication protocol of the physical and medium access control layers for wireless sensor networks, which support real-time transmission through guaranteed time slots (GTSs). In order to improve the performance of IEEE 802.15.4 in industrial applications, this paper proposes a new traffic scheduling algorithm for GTS. This algorithm concentrates on time-critical industrial periodic messages and determines the values of network and node parameters for GTS. It guarantees real-time requirements of periodic messages for industrial automation systems up to the order of tens to hundreds of milliseconds depending on the traffic condition of the network system. A series of simulation results are obtained to examine the validity of the scheduling algorithm proposed in this study. The simulation results show that this scheduling algorithm not only guarantees real-time requirements for periodic message but also improves the scalability, bandwidth utilization, and energy efficiency of the network with a slight modification of the existing IEEE 802.15.4 protocol.

• 인터넷정보학회논문지
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• 제16권3호
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• pp.1-11
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• 2015

인체를 중심으로 동작하는 WBAN(Wireless Body Area Network)은 의료 및 비의료 서비스를 동시에 제공하는 것을 목적으로 하며, 저전력, 다양한 전송률과 높은 데이터 신뢰성을 요구하는 근거리 통신 기술이다. 이러한 요구사항을 만족시킬 수 있는 통신기술 표준 중 IEEE 802.15.4는 WBAN 운영에 높은 호환성을 제공할 수 있어 이를 통한 다양한 연구가 진행되고 있다. 한편, IEEE 802.15.4 기반 다수의 WBAN이 밀집될 경우 발생하는 신호 간섭과 충돌은 데이터의 신뢰성을 저하시키는 주요한 원인되고 있으며, IEEE 802.15.4 표준은 다수의 네트워크가 공존하는 상황을 고려하여 설계되지 않았기 때문에 이에 대한 개선이 필요하다. 이를 해결하기 위해 본 논문에서는 사전 실험을 통해 IEEE 802.15.4 기반의 WBAN 간 공존 상황에서 발생할 수 있는 문제점들을 파악하였고, 실험 결과를 바탕으로 다수의 WBAN이 공존하는 상황에서의 신뢰성 저하를 완화하기 위한 기법을 제안한다. 제안하는 기법의 동작은 크게 두 단계로 구분될 수 있으며, 첫 번째 단계에서는 슈퍼 프레임의 CFP 구간에서의 데이터 전송 방법을 개선하여 WBAN 간 충돌을 회피하며, 두 번째 단계에서는 채널 접근 방식을 전환함으로써 충돌을 완화한다. 제안하는 기법은 표준 기반의 WBAN과 비교 실험을 수행하여 성능을 검증하였다.

• IMMUNE NETWORK
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• 제15권2호
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• pp.83-90
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• 2015

Evaluation and screening of vaccines against tuberculosis depends on development of proper cost effective disease models along with identification of different immune markers that can be used as surrogate endpoints of protection in preclinical and clinical studies. The objective of the present study was therefore evaluation of subcutaneous model of M.tuberculosis infection along with investigation of different immune biomarkers of tuberculosis infection in BALB/c mice. Groups of mice were infected subcutaneously with two different doses : high ($2{\times}10^6CFU$) and low doses ($2{\times}10^2CFU$) of M.tuberculosis and immune markers including humoral and cellular markers were evaluated 30 days post M.tuberculosis infections. Based on results, we found that high dose of subcutaneous infection produced chronic disease with significant (p<0.001) production of immune markers of infection like $IFN{\gamma}$, heat shock antigens (65, 71) and antibody titres against panel of M.tuberculosis antigens (ESAT-6, CFP-10, Ag85B, 45kDa, GroES, Hsp-16) all of which correlated with high bacterial burden in lungs and spleen. To conclude high dose of subcutaneous infection produces chronic TB infection in mice and can be used as convenient alternative to aerosol models in resource limited settings. Moreover assessment of immune markers namely mycobacterial antigens and antibodies can provide us valuable insights on modulation of immune response post infection. However further investigations along with optimization of study protocols are needed to justify the outcome of present study and establish such markers as surrogate endpoints of vaccine protection in preclinical and clinical studies in future.

• Molecules and Cells
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• 제40권11호
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• pp.828-836
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• 2017

Eukaryotic cells consist of a complex network of thousands of proteins present in different organelles where organelle-specific cellular processes occur. Identification of the subcellular localization of a protein is important for understanding its potential biochemical functions. In the post-genomic era, localization of unknown proteins is achieved using multiple tools including a fluorescent-tagged protein approach. Several fluorescent-tagged protein organelle markers have been introduced into dicot plants, but its use is still limited in monocot plants. Here, we generated a set of multicolored organelle markers (fluorescent-tagged proteins) based on well-established targeting sequences. We used a series of pGWBs binary vectors to ameliorate localization and co-localization experiments using monocot plants. We constructed different fluorescent-tagged markers to visualize rice cell organelles, i.e., nucleus, plastids, mitochondria, peroxisomes, golgi body, endoplasmic reticulum, plasma membrane, and tonoplast, with four different fluorescent proteins (FPs) (G3GFP, mRFP, YFP, and CFP). Visualization of FP-tagged markers in their respective compartments has been reported for dicot and monocot plants. The comparative localization of the nucleus marker with a nucleus localizing sequence, and the similar, characteristic morphology of mCherry-tagged Arabidopsis organelle markers and our generated organelle markers in onion cells, provide further evidence for the correct subcellular localization of the Oryza sativa (rice) organelle marker. The set of eight different rice organelle markers with four different FPs provides a valuable resource for determining the subcellular localization of newly identified proteins, conducting co-localization assays, and generating stable transgenic localization in monocot plants.