• The Journal of Internal Korean Medicine
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• v.40 no.5
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• pp.999-1006
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• 2019

Objectives: The purpose of this study was to report the improvement of symptoms by Korean medicine in acute hemorrhagic infarction. Method: The patient was diagnosed with a cerebral infarction of the right temporal lobe accompanied by cerebral hemorrhage of the left basal ganglia. He did not receive intravenous thrombolytic treatment. Sunghyangjungi-san-gamibang was initially administered, and Gami-daebo-tang was administered during the recovery phase, together with Uhwangchungsim-won, Simjeok-hwan, and acupuncture. The prognostic observation was conducted using the manual muscle test (MMT), the Korean version of the modified Bathel index (K-MBI), and subjective assessment. Results: After Korean medicine treatment, the K-MBI score was improved from 52 to 93. The MMT score and subjective assessment also showed improvement. Conclusions: For patients who cannot be treated with intravenous thrombolytic treatment, Korean medicine treatment is effective during the early and recovery stages of stroke.

• Journal of TMJ Balancing Medicine
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• v.10 no.1
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• pp.21-25
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• 2020

Objectives: The aim of this study was to report the effectiveness of TMJ balancing therapy and Traditional Korean Medicine (TKM) treatments on a thalamus cerebral infarction patient with hemiparesis and gait disturbance. Methods: The patient was treated with TMJ balancing therapy, along with korean herbal medicine, acupuncture, moxibustion, cupping and physical therapy. The motor function was evaluated through the Manual Muscle Test (MMT), Grasp power and Functional Ambulatory Category (FAC). And the daily life ability was evaluated by the Korean version of the Modified Barthel Index (K-MBI) and Korean National Institute of Health Stroke Scale (K-NIHSS). Results: After 17 days of TMJ balancing therapy and TKM treatments, the score of MMT did not improved, but the score of FAC, K-MBI, K-NIHSS improved. Conclusions: This study suggested that TMJ balancing therapy and TKM treatments could be effective for hemiparesis and gait disturbance in patients with thalamus cerebral infarction.

• The Journal of the Society of Stroke on Korean Medicine
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• v.10 no.1
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• pp.1-7
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• 2009

Objectives : This Study was prepared for investigating the safety of oriental medicine and continuous intravenous urokinase combined therapy in acute cerebral infarction. Methods : We prospectively estimate safety of hemorrhagic transformation occurred in oriental medical therapy and continuous intravenous urokinase combined therapy. We estimate National Institute of Health Stroke Scale Score and Modified Barthel Index. Results : Hemorrhagic transformation was not noted. and Others are not fatal complication. Conclusions : oriental medical therapy and continuous intravenous urokinase combined therapy are safety method in treatment of acute cerebral infarction. We think this can be a good model of Oriental and western cooperative therapy.

• Journal of Korean Neurosurgical Society
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• v.42 no.4
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• pp.337-341
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• 2007

Objective : Repeated administration of mannitol in the setting of large hemispheric infarction is a controversial and poorly defined therapeutic intervention. This study was performed to examine the effects of multiple-dose mannitol on a brain edema after large hemispheric infarction. Methods : A middle cerebral artery was occluded with the rat suture model for 6 hours and reperfused in 22 rats. The rats were randomly assigned to either control (n=10) or the mannitol-treated group (n=12) in which intravenous mannitol infusions (0.8 g/kg) were performed six times every four hours. After staining a brain slice with 2,3,5-triphenyltetrazolium chloride, the weight of hemispheres, infarcted (IH) and contralateral (CH), and the IH/CH weight ratio were examined, and then hemispheric accumulation of mannitol was photometrically evaluated based on formation of NADH catalyzed by mannitol dehydrogenase. Results : Mannitol administration produced changes in body weight of $-7.6{\pm}1.1%$, increased plasma osmolality to $312{\pm}8\;mOsm/L$. It remarkably increased weight of IH ($0.77{\pm}0.06\;gm$ versus $0.68{\pm}0.03\;gm$ : p<0.01) and the IH/CH weight ratio ($1.23{\pm}0.07$ versus $1.12{\pm}0.05$ : p<0.01). The photometric absorption at 340 nm of the cerebral tissue in the mannitol-treated group was increased to $0.375{\pm}0.071$ and $0.239{\pm}0.051$ in the IH and CH, respectively from $0.167{\pm}0.082$ and $0.162{\pm}0.091$ in the IH and CH of the control group (p<0.01). Conclusion : Multiple-dose mannitol is likely to aggravate cerebral edema due to parenchymal accumulation of mannitol in the infarcted brain tissue.

• The Journal of Internal Korean Medicine
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• v.24 no.2
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• pp.213-219
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• 2003

Objectives : This study was to investigated using National Institutes of Health Strokes Scale score in 36 patients with middle cerebral artery infarction and to enaluate prognosis. Method : The subjects oh this study were 36 patients who were admitted to the Wonkwang oriental medicine. Improving rate were measured by using the National Institutes of Health Strokes Scale score. Each patient was diagnosed with Brain Computerized Tomography, Magnetic Resonance Imaging and clinical observation. Results : There were significant results statistically between National Institutes of Health Strokes Scale score and middle cerebral artery territories. While sex, age, hypertension, diabetes mellitus and heart disease were not siginificant meaning statistically. Conclusions: Sex, age, hypertension, diabetes mellitus and heart disease were relevant factors in predicting the functional outcome in the patients with middle cerebral artery infarction. In this study, middle cerebral artery territory affects the functional outcome.

• The Journal of the Society of Stroke on Korean Medicine
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• v.6 no.1
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• pp.33-43
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• 2005

Objectives : This study was prepared for investigating the clinical features of stroke patients. Methods : We retrospectively reviewed the medical records of 169 patients who were admitted to Dept. of Internal Medicine, College of Oriental Medicine, Kyung-Won University with a diagnosis of stroke from Jan. 1, 2003 to Dec. 31, 2003. Results : Ischemic stroke(include TIA, 85.2%) was more common than hemorrhagic stroke(14.8%). The incidence in male was 46.7%, in female was 53.3% and the most prevalent age group is over-sixties. Cerebral infarction was most frequently noticed in MCA territory and lacunar-inf., hemorrhage in putamen. Hypertention, the most preceding diseases, followed by diabetes mellitus. The rate of recurrence was 30.18%. Cerebral infarction and cerebral hemorrhage was much occurred in acting. The most patients visited the hospital after 5 days. The most common symptoms in admission time were motor weakness and speech disorder. The complication was mostly urinary tract infection. Physical treatment from onset, in cerebral infarction was 9.14 days and in cerebral hemorrhage was 18.33 days. Conclusions : Our study on CVA patients was similar to previous studies from 1994 to 2002. In most cases, western and oriental treatment and medicine were given synthetically.

• The Journal of Internal Korean Medicine
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• v.24 no.4_2
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• pp.1014-1022
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• 2003

Aphasia is speech disorder caused by injuries on the speech nerve center. It usually occur due to a disease in the right cerebral cortex and is divided into the various aphasia such as Global aphasia, Broca's aphasia, Wernicke's aphasia, conduction aphasia, Anomic aphasia, etc. Jihwangumja is used the cerebral infarction with Aphasia due to deficiency syndrome of kidneys. The purpose of this study is to examine the efficacy of oriental treatment for cerebral infarction with aphasia by Jihwangumsa. In the hospital, the patient showed the symptoms of mental disorder, Rt. hemiparesis G3/G4, aphasia, chest discomfort, obstipation, frequent urination, etc. The case showed that acute infarction on Lt. fronto-temporo-parietal lobe in Brain-CT. We identified the patient's clinical conditions and treated accordingly. As a result of treatment, symptoms were markedly improved and he was discharged. Further elaboration of oriental diagnostic classification could possibly lead to the fundamental treatment.

• Journal of Korea Multimedia Society
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• v.21 no.6
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• pp.723-735
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• 2018

Indicators to quantitatively assess the physical conditions can help optimize the effectiveness of rehabilitation therapy for stroke patients. The body composition variations in the paretic and non-paretic regions of stroke patients with cerebral infarction (7 males, 31 females) were analyzed using multi-frequency bioelectrical impedance. Specifically, resistance (R), lean mass (LM), fat mass (FM), extracellular water (ECW), intracellular water (ICW), R/LM relation, basal metabolic rate (BMR)/LM relation were utilized to evaluate the paretic and non-paretic regions of subjects with cerebral infarction. These values showed significant differences in gender and paretic/non-paretic regions. R and FM were high but LM and ICW were lower in female and paralysis. ECW was lower in females than males, but there was no considerable difference between paralysis and non-paralysis in both males and females. In addition, there was an inverse distribution between R and LM in paretic and non-paretic regions, with males on the upper left and females on the lower right. Furthermore, the relationship between BMR and LM showed excellent linearity (slope: 22.17 kcal/day/kg) irrespective of gender, paralysis, and non-paralysis. An easy, non-invasive and quantitative assessment using bioelectrical impedance would provide an useful tool for evaluating patients with cerebral infarction receiving rehabilitation therapy.

• The Journal of Internal Korean Medicine
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• v.39 no.2
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• pp.147-153
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• 2018

Objective: The purpose of this case report is to evaluate the effect of electroacupuncture on Pal-sa (EX-UE9) for unilateral motor disturbance of the hand after cerebral infarction. Methods: One patient with unilateral motor disturbance of the hand following cerebral infarction (right basal ganglion and corona radiata) was treated with acupuncture, herbal medication, and electroacupuncture on Pal-sa (EX-UE9) once daily from June 30, 2016 to July 4, 2016. We evaluated improvement using the Box and Block Test (BTT) and 10-seconds Test, including the Finger Individual Movement Test (FIMT), the Hand Pronation and Supination Test (HPST), and the Finger Tapping Test (FTT). Results: After five days of treatment, increase of FIMT and FTT scores was observed after electroacupuncture on Pal-sa (EX-UE9). However, no increase was observed in BBT or HPST scores. Conclusions: This study suggests that electroacupuncture on Pal-sa (EX-UE9) can help treat motor disturbance of the hand after cerebral infarction.

• Journal of Korean Neurosurgical Society
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• v.59 no.4
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• pp.346-351
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• 2016

Objective : Early progressive infarction (EPI) is frequently observed and related to poor functional outcome in patients with middle cerebral artery (MCA) infarction caused by MCA occlusion. We evaluated the perfusion parameters of magnetic resonance imaging (MRI) as a predictor of EPI. Methods : We retrospectively analyzed patients with acute MCA territory infarction caused by MCA occlusion. EPI was defined as a National Institutes of Health Stroke Scale increment ${\geq}2$ points during 24 hours despite receiving standard treatment. Regional parameter ratios, such as cerebral blood flow and volume (rCBV) ratio (ipsilateral value/contralateral value) on perfusion MRI were analyzed to investigate the association with EPI. Results : Sixty-four patients were enrolled in total. EPI was present in 18 (28%) subjects and all EPI occurred within 3 days after hospitalization. Diabetes mellitus, rCBV ratio and regional time to peak (rTTP) ratio showed statically significant differences in both groups. Multi-variate analysis indicated that history of diabetes mellitus [odds ratio (OR), 6.13; 95% confidence interval (CI), 1.55-24.24] and a low rCBV ratio (rCBV, <0.85; OR, 6.57; 95% CI, 1.4-30.27) was significantly correlated with EPI. Conclusion : The incidence of EPI is considerable in patients with acute MCA territory infarction caused by MCA occlusion. We suggest that rCBV ratio is a useful neuro-imaging parameter to predict EPI.