• Journal of the Korean Geotechnical Society
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• v.21 no.8
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• pp.95-105
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• 2005

Generally, a modified version of limit equilibrium method can be used to evaluate a slope stability of the geosynthetic reinforced soil slopes. In most cases, resisting effects of geosynthetic reinforcement are dealt with considering an increased shear strength on the potential slip surface. However, it is not clear that the methods satisfy all three equilibrium equations. As we know, the pattern of normal stress distribution along the slip surface is the key factor in calculating the safety factor of slopes. In this study, the new slope stability analysis method in which not only reinforcing effects of geosynthetics can be considered but also all three equilibrium equations can be satisfied was proposed with assuming the normal stress distribution along the slip surface as quadratic curve with horizontal $\chi-coordinate$. A number of illustrative examples, including published slope stability analysis examples for the reinforced and unreinforced soil slopes, loading test of large scale reinforced earth wall and centrifuge model tests on the geotextile reinforced soil slopes, were analyzed. As a result, it is shown that the newly suggested method yields a relatively accurate factor of safety for the reinforced and unreinforced soil slopes.

• Journal of the Korean Geotechnical Society
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• v.38 no.12
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• pp.45-65
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• 2022

In this paper, a diaphragm wall that supports soils and rock was modeled using FLAC, a finite difference analysis program, to evaluate the seismic behavior of temporary retaining structures in a deep excavation. The appropriateness of the numerical model was verified by comparing its results with those of the centrifuge test performed in a similar condition. The bending moment distribution along the diaphragm wall shows a very similar tendency, and the maximum acceleration obtained at the backfill and top of the wall shows a difference within 5%. Based on the developed model, a parametric study was conducted in various input earthquake, ground, and excavation conditions. The maximum structural forces and bending moment under earthquake loading were compared with the maximum values during excavation, from which the critical condition that requires a seismic design was roughly sorted out. The maximum bending moment of a wall that retains soil layers increased 17%. Particularly, the axial force of struts located in loose soils increased 32% under 100 years return period of an earthquake event, which strongly is estimated to require seismic design for structural safety.

• Journal of the Korean Geotechnical Society
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• v.38 no.9
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• pp.5-17
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• 2022

Recently, several studies have been conducted on virtual fixed-point and elastic soil spring methods to simulate the soil-pile interaction in response to spectrum analysis of pile-supported structures. However, the soil spring stiffness has not been properly considered due to the seismic load magnitude, and studies on the response spectrum analysis of pile-supported structures considering this circumstance are inadequate. Therefore, in this study, the response spectrum analysis was performed considering the soil spring stiffness according to the seismic load magnitude, and the dynamic behavior of the pile-supported structure was evaluated by comparing it with existing virtual fixed-point and elastic soil spring methods. Comparing the experiment and analysis, the moment differences occurred up to 117% and 21% in the virtual fixed-point and elastic soil spring models, respectively. Moreover, when the analysis was performed using an API p-y curve considering the soil spring stiffness according to the seismic load magnitude, the moment difference between the experiment and analysis was derived at a maximum of < 4%, and it is the most accurate method to simulate the experimental model response.

• The Korean Journal of Nuclear Medicine Technology
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• v.15 no.1
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• pp.113-116
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• 2011

Purpose: Acetylcholine receptor antibodies cause acetylcholine receptor loss, which is responsible for failure of the neuromuscular junction in the acetylcholine receptor autoantibody. The disease characterized by muscle weakness and fatigue, myasthenia gravis(MG) occurs when the body inappropriately produces antibodies against acetylcholine receptors, and thus inhibits proper acetylcholine signal transmission. And this reason, the measurement of acetylcholine receptor antibodies can be of considerable value in disease diagnosis. Methods: From 2010. August to September, we tested orderd AchRAb 19 samples to get the results. 1. Pipette $5{\mu}{\ell}$ undiluted patient sera and kit control and add 125I AChR $50{\mu}{\ell}$ and incubate at R.T for 2 hours. 2. Pipette $50{\mu}{\ell}$ of anti-human IgG into each tube, and incubate at $2{\sim}8^{\circ}C$ for 2 hours. 3. Pipette $25{\mu}{\ell}$ precipitation enhancer into each tube and add 1mL washing solution into all tubes. 4. Centrifuge each tube for 20minutes at $2{\sim}8^{\circ}C$ at 1500g. 5. Aspirate or decant the supernatant. 6. Pipette 1 mL washing solution into all tubes and resuspend the pellet and repeat centrifugation. 7. Aspirate or decant the supernatant and count all tubes on a gamma counter. Results: Cut off value is 0.2 nmol/L and the results taken below 0.2 nmol/L are negative, the results above that identified as being positive values. We assayed the 19 patients samples and got 7 positive results. Of which, 6 patients were diagnosed as MG.(85.7%). Conclusions: Acetylcholine Receptor autoantibody test is intended for use by persons only for the quantitative determination of it in human serum. Even if measurement of the antibodies is not a routine test, it can be of considerable value in disease diagnosis.