• Molecular & Cellular Toxicology
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• 제2권1호
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• pp.60-66
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• 2006

Methylmercury (MeHg), one of the heavy metal compounds, can cause severe damage to the central nervous system in humans. Many reports have shown that MeHg is poisonous to human body through contaminated foods and has released into the environment. Despite many studies on the pathogenesis of MeHg-induced central neuropathy, no useful mechanism of toxicity has been established so far. This study, using of suppression subtractive hybridization (SSH) method, was peformed to identify differentially expressed genes by MeHg in SH-SY5Y human neuroblastoma cell line. We prepared to total RNA from SH-SY5Y cells treated with solvent (DMSO) and $6.25\;{\mu}M\;(IC_{50})$ MeHg and performed forward and reverse SSH. Differentially expressed cDNA clones were screened by dot blot, sequenced and confirmed that individual clones indeed represent differentially expressed genes with real time RT-PCR. These sequences were identified by BLAST homology search to known genes or expressed sequence tags (ESTs). Analysis of these sequences may provide an insight into the biological effects of MeHg in the pathogenesis of neurodegenerative disease and a possibility to develop more efficient and exact monitoring system of heavy metals as ubiquitous environmental pollutants.

• Animal Systematics, Evolution and Diversity
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• 제33권2호
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• pp.123-130
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• 2017

The family Geometridae, which is one of the most species-rich taxa of Lepidoptera, includes more than 23,000 species worldwide and over 800 species in South Korea. Herein, we record six species of Geometridae for the first time in Korea. Jodis urosticta and Jodis amamiensis can be characterized by their greenish wings and strongly dentate ante- and postmedial lines on the fore and hindwings. These species can also be separated by the shape of the valva of the male genitalia. Pelagodes antiguadraria can be characterized by their greenish wings, whitish medial bands on the forewing and whitish postmedial line on the hindwing. Brabira kasaii can be characterized by the thick grayish band-shaped central fascia of their fore- and hindwings. Sauris marginepunctata can be characterized by the greenish ground color of the forewing, the dark ochreous medial bands and subterminal line and the grayish hindwing. Philereme vetulata can be characterized by their dark brownish wing color and the band-shaped central fascia of the forewing, as well as the medially projected postmedial line of the hindwing. Echthrocollix minuta can be characterized by their pale grayish wing color, brownish postmedial and subterminal lines and large discal dot.

• 한국항공운항학회지
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• 제32권1호
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• pp.71-78
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• 2024

In this study, we reviewed access transportation, operating companies, and airport infrastructure to revitalize Cheongju International Airport. Regarding access transportation infrastructure, it is necessary to promote a railway network connecting the metropolitan inland line and the central inland region. In addition, active administrative support from local governments is required to ensure smooth progress in railway and highway infrastructure linkage projects, such as the Osong Connecting Line and Chungbuk Line, high-speed rail network promotion, and expansion of the Chungbuk Eastern Axis Expressway and Central Expressway. Regarding operator access infrastructure, continuous efforts are required to add and attract airlines based at Cheongju International Airport. Regarding airport infrastructure, the Cheongju International Airport runway needs complete resurfacing due to its deterioration. Domestic passenger capacity has exceeded 6.5%, and considering the increase in import and export of high value-added goods in the North Chungcheong region, it is necessary to build and expand passenger terminals and cargo terminals. Cheongju International Airport's runway does not have enough runway length to operate large and ultra-large aircraft, so if it is extended from the existing 2,744m to 456m to 3,200m, several benefits can be expected in terms of revitalizing Cheongju Airport, such as route expansion.

• 농촌계획
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• 제23권1호
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• pp.53-63
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• 2017

Although some indicators for evaluating rural settlement conditions have been offered, these indicators could not reflect unique characteristics that rural has its own peculiarities. The rural area is identified with central districts functioned as service provision and hinterlands used its service. The aim of this study is to find a central district of rural villages and define range of its hinterlands using various physical characteristics of rural areas. Targeting areas are Yongsan and Hwanggan in Yeongdong-gun. The physical characteristics are represented by building density, number of shops among secondary and tertiary industries, official land price, and density of bus line. The rural central district is estimated by linear programming using defined the physical characteristics. Also its hinterlands used Huff model and social accessibility. The results of this study are as follows; (1) The physical characteristics in Hwanggan myeon is higher than Yongsan myeon because Hwanggan area has a large floating population for using Hwanggan station and ticket office; (2) The central district in Hwanggan has wider regional range than Yongsan. When central district estimate in rural areas, we suggest a grid diameter of Hexagon for controlling errors; (3) Considering accessibility, the life zone of 4 districts defined legally in Hwanggan use Yongsan and 2 legal districts in Hwanggan are possible to take advantage of Yongsan's life zone; (4) The results of survey targeting boundary villages between Yongsan and Hwanggan, individual drivers use central districts both Yongsan and Hwanggan, however users by public transportation (especially bus) go more to Hwanggan because bus lines to Hwanggan have many routes than to Yongsan. Evaluating the rural settlement conditions by national unit through grasping central districts and its hinterlands, these results can use as base line data and the evidence for regional development projects.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.189.2-190
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• 2003

Methylmercury (MeHg), one of the heavy metal compounds. can cause severe damage to the central nervous system in humans. Many reports have shown that MeHg is poisonous to human body through contaminated foods and has released into the environment. Despite many studies on the pathogenesis of MeHg-induced central neuropathy, no useful mechanism of toxicity has been established so far. (omitted)

• Advances in pediatric surgery
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• 제13권1호
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• pp.72-75
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• 2007

The use of subcutaneously tunneled, cuffed central venous catheters like Broviac's or Hickman's has increased and complications related to catheter removal has also increased. However, there are only few reports of complications that occur at the time of removal. The authors report an unusual case of catheter fracture during removal of Broviac catheter.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2006년도 제37회 하계학술대회 논문집 전기설비
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• pp.71-72
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• 2006

• 한국독성학회:학술대회논문집
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• 한국독성학회 2002년도 Molecular and Cellular Response to Toxic Substances
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• pp.153-153
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• 2002

Methylmercury (MeHg), one of the heavy metal compound, can cause severe damage to the central nervous system in humans. Many reports have contributed MeHg poisoning to contaminated foods and release into the environment. Despite many studies on the pathogenesis of MeHg-induced central neuropathy, no useful mechanism of toxicity has been established.(omitted)

• Journal of Trauma and Injury
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• 제27권2호
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• pp.33-37
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• 2014

Central venous catheterization through a subclavian approach is indicated for some special purposes but it may cause many complications such as infection, bleeding, pneumothorax, thrombosis, air embolization, arrhythmia, myocardial perforation, and nerve injury. A case involving a mistaken central venous catheterization into the right vertebral artery through the subclavian artery is presented. A 33-year-old man who had deteriorated mentality after head injury underwent an emergency craniotomy for acute epidural hematomas on the right frontal and temporal convexities. His mentality improved rapidly, but he complained of continuous severe pain in the right posterior neck even though he had no previous symptom or past medical history of such pain. Three-dimensional cervical spine computed tomography (3D-CT) was performed first to rule out unconfirmed cervical injuries and it revealed a linear radiopaque material intrathoracically from the level of the 1st rib up to the level of C6 in the right vertebral foramen. An additional neck CT was performed, and the subclavian catheter was indwelling in the right vertebral artery through right subclavian artery. For the purpose of proper fluid infusion and central venous pressure monitoring, the subclavian vein catheterization had been performed in the operation room after general anesthesia induction before the craniotomy. Sufficient anatomical consideration and prudence is essential because inadvertent arterial cannulation at a non-compressible site is a highly risky iatrogenic complication of central venous line placement.

• Mycobiology
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• 제34권3호
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• pp.143-147
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• 2006

In the present study, in order to investigate the anti-proliferative phenomenon of PLME, the effects of mycelial extract of Phellinus linteus (PLME) on the growth of human lung carcinoma cell line A549 was examined. We studied on the effects of PLME on the release of nitric oxide (NO) in mouse macrophage Raw 264.7 cells. Treatment of PLME to A549 cells resulted in the growth inhibition, morphological change and induction of apoptotic cell death in a dose-dependent manner as measured by MTT assay. We found that PLME stimulated a dose-dependent increase in NO production. These findings suggest that PLME enhances the anti-tumoral activity of macrophage and may be a potential therapeutic agent for the control of human lung carcinoma cells.