• The Korean Journal of Pharmacology
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• v.30 no.2
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• pp.227-242
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• 1994

The general pharmacological effects of a new anthracycline anticancer agent, DA-125 $[7-0-(2,\;6-dideoxy-2-fluoro-{\alpha}-L-talopyranosyl)-adriamycinone-14-{\beta}-alaninate{\cdot}HCI]$ were investigated in mice, rats, guinea pigs, rabbits and dogs. Intravenous administration of DA-125 presented no significant effects on the central and peripheral nervous systems of ICR mice except a decrease in the numbers of acetic acid-induced writhing response at a dose of 10 mg/kg. In anesthetized rats and dogs, DA-125 produced a transient depression of blood pressure and an increase in heart rate, but did not affect the peripheral blood flow in the isolated ear vessels of rabbits and the mechanical functions of the isolated hearts of guinea pigs. No significant effects were observed on the gastrointestinal functions and the contractilities of smooth muscle preparations obtained from guinea pig trachea, rabbit ileum, pregnant and non-pregnant uterus and vas deferens of rats. DA-125 Increased the contractility of the isolated ileum of guinea pigs in a dose range of $10^{-6}{\sim}10^{-9}g/ml$, and also increased, but weaker than adriamycin, the vascular permeability in rat skin. DA-125 had no effect on the kallikrein-induced increase in permeability and the permeability of the visceral organs. DA-125 did not adversely affect the liver function and the blood coagulation system, and did not induce hemolysis in vitro. It is concluded from the results that the general pharmachological effects of DA-125 are similar to or weaker than those of adriamycin, and that little adverse effects are anticipated with a therapeutic dose range.

• Tribology and Lubricants
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• v.33 no.3
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• pp.119-125
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• 2017

In this study, we perform a numerical analysis to predict the film thickness and lubrication regions for a thrust ball bearing under different operating conditions. Film thinning and replenishment affect the film thickness in starved lubrication. As the inlet meniscus position is brought to the edge of the Hertz contact, the thin film thickness is calculated as starved equation. We use a film replenishment model to determine the recovery film thickness between rolling elements. We use a hydrodynamic model to describe film recovery, that results from the effects of surface tension. In this model, we consider the surface tension gradient in fluid depression as the driving force for fluid recovery. We use Fourier transform method to determine the time-dependent depth of depressed oil. We calculate the change in the central film thickness graphically by using the recovery equation in starved elastohydrodynamic lubrication(EHL) under operating conditions that include numbers of balls, sliding velocity, applied force, and ambient film thickness. We evaluate the degree of starvation by using the distance from the center of the contact area to the meniscus position. Parched lubrication, a phenomenon where the film thickness decreases consistently, occurs at the severe condition. We determine optimal values with respect to the numbers of balls, and sliding velocity. The investigation can contribute to the design operating conditions for proper lubrication.

• Economic and Environmental Geology
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• v.32 no.3
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• pp.217-225
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• 1999

Nine cauldrons have been recognized in the PVD (Pusan- Taegu Volcano-tectonic Depression) zone covering an area of nearly 7,000 $km^{2}$. They form characteristic landscape features with various mountains in the southeastern Kyongsang basin. Economically important ore deposits are also developed either in the ring fracture zone or the central pluton within the resurgent cauldrons or in the marginal area of the PVD, suggesting that these cauldrons played a major role in the distribution of ore deposits in the southeastern Kyongsang basin. Furthermore, the cauldron subsidences were more frequent with the more felsic volcano-plutonic complex, possibly indicating that the amounts of water and volatile components also acted as a controlling factor to cause the caldera subsidence and to concentrate the ore-forming elements in economic concentrations. The review of the relationship and variations of ore mineralization and cauldron subsidence is rather sketchy, but it provides a skeleton to carry out more detailed and quantitative studies related to temporal and spatial relationships between each cauldron subsidence accompanying its own ore mineralization. In the southeastern Kyongsang basin, additional calderas and associated ore deposits undoubtedly can be discovered through future detailed studies. The concept that cauldron subsidence are an important control for the formation of ore deposits will appear to be vindicated.

• The Journal of the Petrological Society of Korea
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• v.7 no.3
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• pp.147-160
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• 1998

The Samrangjin Caldera, a trapdoor-type, formed by the voluminous eruption of the silicic ash-flows of the Samrangjin Tuff which is above 630m thick at the northern inside of the caldera and thinnerly 80m at the southern inside. The caldera volcanism eviscerated the magma chamber by a series of explosive eruptions during which silicic magma was ejected to form the Samrangjin Tuff. The explosive eruptions began with phreatoplinian eruption, progressed through small plinian eruption and transmitted with ash-flow eruption. During the ash-flow eruption, contemporaneous collapse of the roof of the chamber resulted in the formation of the Samrangjin caldera, a subcircular depression subsiding above 550m deep. During postcaldera volcanism after the collapse, flow-banded rhyolite was emplaced as cental plug along the central vent and ring dikes along the caldera margins. Subsequently rhyodacite porphyry and dacite porphyry were emplaced along the inner side of the ring dike. After their emplacement, residual magma was emplaced as a hornblende biotite granite stock into the southwestern caldera margin. In the northeastern part, the eastern dikes were cut final intrusions of granodioritic to granitic composition along the fault zone of $^{\circ}$W trend.

• International Commerce and Information Review
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• v.11 no.1
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• pp.441-463
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• 2009

FTA is acting as a central axis to accomplish the worldwide trade liberalization as FTA has been globally spreading with competition. As the global economic depression and the trend of new protectionism are getting grave, and the trade liberalization of GATT and WTO is getting delayed, FTA is spread as an alternative. FTA is often called as RTA: Regional Trade Agreement(regional free trade agreement) which takes place mainly around the neighbor nations or regular districts, and these days, it is tending towards agreements between long distant nations, so, it's not limited to the regular districts. Among the FTA agreement items, in addition to the customs abolition, the opening and investment liberalization of service market like finance, communication etc., intellectual property rights are included in the government's target range. Korea also is actively proceeding FTA conclusion. Korean government has concluded the agreements with Singapore, european nations beginning from Chile concluded in 2003, and is proceeding more the negotiations with Japan, Canada, Mexico, India etc. Now in 2009, FTA of Korea-United States is actually waiting for just the passage of assembly ratification. But, if FTA becomes effective, because our domestic market should be entirely opened, it is expected that the blow against our domestic agricultural field which is weak, compared with that of the United States, a nation of worldwide agricultural products, is not an ordinary one. According to it, we need a whole plan to cope with, so, the purpose of this study is to suggest the strategy by comparing and analysing the Korean agricultural competitive power, and to find the other development stratagem.

• Korean Journal of Biological Psychiatry
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• v.19 no.1
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• pp.29-37
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• 2012

The loudness dependence of the auditory evoked potential (LDAEP) has been proposed as a valid biomarker of central serotoninergic activity in humans. The specificity and sensitivity of the LDAEP to changes in serotonergic neurotransmission have recently been explored in many studies about pharmacology and genetics. The majority of evidence for an association between the LDAEP and serotonin activity has come from animal studies. Genetic association studies with the LDAEP have provided conflicting reports with additional evidence outlining sensitivity to other neurotransmitter systems including the dopamine and glutamatergic systems. The LDAEP has been revealed to reflect the pathophysiology of various psychiatric illnesses. There is supporting evidence that major psychiatric disorders have differential LDAEP activities. Overall, the LDAEP shows strong evidence as a potential predictor of antidepressant treatment response. It need to be explored whether the LDAEP could be a biological marker of various psychiatric diseases and treatment prediction of antidepressants and serotonin related drugs.

• Fashion & Textile Research Journal
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• v.17 no.3
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• pp.351-363
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• 2015

This research explores diachronic fashion design trends through a structure analysis of a connection network based on fashion show concepts implemented by modern fashion designers from S/S 2009 to F/W 2013. The findings from this research are as follows. First, four categories affect the inspiration and thinking of design: the experience of the designer, social atmosphere and phenomena, natural sensitivity (or formative characteristics of natural objects), and the influence and quality of other fields. Second, in cases where the designers' experiences influenced design inspiration and thinking, designers express personal memories with keywords like high school, grandmother's closet, prom, beauty and the beast, heritage, past, and reminiscence through design elements such as lines, silhouettes, materials, and colors. Third, the representative example of the social atmosphere and phenomena that influenced design inspiration and thinking was the 2008 Global Financial Crisis that reflected the social climate through design concepts of keywords such as Recession, Black, Economy, US, Depression, Gray, Dark Age, White and New York. Fourth, inspired by nature and the formative characteristics in design, the designers employed ornamental elements to collections and design concepts that focused on nature words connected to light, sun, wild, dirt, rock, moss, and trees. Fifth, the designers took their ideas from different fields of personal interest in the arts, science and humanities (sports, architecture, sculpture, painting, and literature) that were decisive in determining materials, design colors and silhouettes. The theme of architecture was analyzed as a central element that had an ongoing impact on the concepts of designers.

• Journal of the Korean Geophysical Society
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• v.9 no.4
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• pp.409-416
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• 2006

Reflection seismic survey has been conducted using R/V Yuzmogeologia of Russia on the area of between northern part of Powell basin and South Scotia Ridge. 48-channel seismic data have been processed using Promax system. Hesperides and Eastern Deep located in the central part of the South Scotia Ridge show similar geological structure comprising two distinct sedimentary layers. The lower layer filled with fault breccia is considered to be formed with the expansion of the deeps. The upper layer is filled with pelagic sediments which implies this layer is formed after the spreading of the deeps has stopped. The south branch of the South Scotia Ridge is characterized by bigger width than the north branch. Topographical depression shown in the south branch is formed by many faults accompanied with the seafloor expansion of Powell basin.

• Journal of the Korean Society of Clothing and Textiles
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• v.26 no.2
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• pp.193-204
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• 2002

Many fashion forecasting companies propose the fashion colors in every season. Modern fashion consumer respond to fashionable trends with utmost sensitivity. Therefore to satisfy the consumer with an trendy image, the fashion design must be found first, as image matters, followed by an analysis of each design element's effect on the total image composition. In previous studies of fashion image, has been discussed the positive correlation between fashion design elements of color, fabric, and form as the central issue. In this thesis, two of the fashion design elements, color and fabric are simultaneously considered to classify the image of fabric in fashion. For the color variables, 10 hues are selected from Munsell's system of color notation, and 12 tones from PCCS color notation., which are currently used in the domestic fashion industry. Texture variables used in this survey are classified by luster, prominence-depression of surface, thickness, and density of fabric. Graduate students from 20 to 50 years old and the specialists in fashion companies participated in the survey. The results of this survey are as follows: 1. The fashion fabric image is classified as 5 main images: 'elegant', 'comfortable', 'characteristic', 'light'and 'simple'. 2. The influence of hue, tone and texture is significant to the fashion fabric image. Following colors, yellow-red, red hues and light grayish, dark grayish tones convey the elegant image. The texture property for the elegant image is luster, thin and low density. Properties of fabric conveying the comfortable image are yellow-red and green-yellow hue, soft, light tones, matte and high density. Furthermore, hue turned out to be a insignificant variables for the unique image, whereas dark grayish, grayish tone, luster and prominent texture convey a unique image. For light image, properties of fabric are blue-green, purple hues, light, bright tones with thin, low density texture. Properties of fabric conveying the simple image are blue-green, purple-blue, green-yellow hues, and strong, vivid tones, with luster and flat texture.

• Journal of Oriental Neuropsychiatry
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• v.11 no.2
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• pp.43-52
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• 2000

This sudy aimed to evaluate the effect of Punsimgieum-gamibang(分心氣飮加味方) on emotionality and sleep disorder. Punsimgieum(分心氣飮) has been used for insomnia, trembling, emotionality caused by strong mental stimulation and continuous stress in Oriental Medicine. And it was reported that Punsimgieum had anti-stress and anti-depression effect. Animals were devided into two groups : control group and Punsimgieum-gamibang group.Emotionality was tested in open-field with five indexes : walking, rearing, grooming, excretion and start latency. For the study of sleep disorder, after two groups had been given caffeine into abdomen, activity amount in animals was assessed for daytime and then the average percentage of sleep in two groups was calculated.The following results were observed.1. In peripheral and central partition, meditaion group walked more than control group. The difference between two groups was statistically significant.2. In rearing and grooming frequency, there was difference between two groups, but it was not statistically significant. 3. In grooming. excretion and start latency. there was no difference between two groups.4. There was no difference in the average percentage of sleep between two groups.