• Membrane and Water Treatment
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• 제7권2호
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• pp.127-141
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• 2016

Electrodialysis (ED) is known to be a useful membrane process for desalination, concentration, separation, and purification in many fields. In this process, it is desirable to work at high current density in order to achieve fast desalination with the lowest possible effective membrane area. In practice, however, operating currents are restricted by the occurrence of concentration polarization phenomena. Many studies showed the occurrence of a limiting current density (LCD). The limiting current density in the electrodialysis process is an important parameter which determines the electrical resistance and the current utilization. Therefore, its reliable determination is required for designing an efficient electrodialysis plant. The purpose of this study is the development of a predictive model of the limiting current density in an electrodialysis process using response surface methodology (RSM). A two-factor central composite design (CCD) of RSM was used to analyze the effect of operation conditions (the initial salt concentration (C) and the linear flow velocity of solution to be treated (u)) on the limiting current density and to establish a regression model. All experiments were carried out on synthetic brackish water solutions using a laboratory scale electrodialysis cell. The limiting current density for each experiment was determined using the Cowan-Brown method. A suitable regression model for predicting LCD within the ranges of variables used was developed based on experimental results. The proposed mathematical quadratic model was simple. Its quality was evaluated by regression analysis and by the Analysis Of Variance, popularly known as the ANOVA.

• Journal of Microbiology and Biotechnology
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• 제29권7호
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• pp.1061-1070
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• 2019

In the present study, the optimization of poly(${\gamma}$-glutamic acid) (${\gamma}$-PGA) production by Bacillus sp. FBL-2 was studied using a statistical approach. One-factor-at-a-time method was used to investigate the effect of carbon sources and nitrogen sources on ${\gamma}$-PGA production and was utilized to select the most significant nutrients affecting the yield of ${\gamma}$-PGA. After identifying effective nutrients, response surface methodology with central composite design (CCD) was used to obtain a mathematical model to identify the optimum concentrations of the key nutrients (sucrose, $\text\tiny{L}$-glutamic acid, yeast extract, and citric acid) for improvement of ${\gamma}$-PGA production. The optimum amount of significant medium components appeared to be sucrose 51.73 g/l, $\text\tiny{L}$-glutamic acid 105.30 g/l, yeast extract 13.25 g/l, and citric acid 10.04 g/l. The optimized medium was validated experimentally, and ${\gamma}$-PGA production increased significantly from 3.59 g/l (0.33 g/l/h) to 44.04 g/l (3.67 g/l/h) when strain FBL-2 was cultivated under the optimal medium developed by the statistical approach, as compared to non-optimized medium.

• Computers and Concrete
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• 제30권6호
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• pp.393-407
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• 2022

Due to the enormous cement content, pozzolanic materials, and the use of different aggregates, sustainable controlled low-strength material (CLSM) has a higher material cost than conventional concrete and sustainable construction issues. However, by selecting appropriate materials and formulations, as well as cement and aggregate content, whitethorn costs can be reduced while having a positive environmental impact. This research explores the desire to optimize plastic properties and 28-day unconfined compressive strength (UCS) of CLSM containing powder content from unprocessed-fly ash (u-FA) and recycled fine aggregate (RFA). The mixtures' input parameters consist of water-to-cementitious material ratio (W/CM), fly ash-to-cementitious materials (FA/CM), and paste volume percentage (PV%), while flowability, bleeding, segregation index, and 28-day UCS were the desired responses. The central composite design (CCD) notion was used to produce twenty CLSM mixes and was experimentally validated using MATLAB by an Artificial Neural Network (ANN). Variance analysis (ANOVA) was used for the determination of statistical models. Results revealed that the plastic properties of CLSM improve with the FA/CM rise when the strength declines for 28 days-with an increase in FA/CM, the diameter of the flowability and bleeding decreased. Meanwhile, the u-FA's rise strengthens the CLSM's segregation resistance and raises its strength over 28 days. Using calcareous powder as a substitute for cement has a detrimental effect on bleeding, and 28-day UCS increases segregation resistance. The response surface method (RSM) can establish high correlations between responses and the constituent materials of sustainable CLSM, and the optimal values of variables can be measured to achieve the desired response properties.

• 한국환경보건학회지
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• 제48권3호
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• pp.167-175
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• 2022

Background: Disinfection is essential to provide drinking water from a water source. The disinfection process mainly consists of the use of chlorine and ozone, but when chlorine is used as a disinfectant, the problem of disinfection by-products arises. In order to resolve the issue of disinfection by-products, electro-chlorination technology that produces chlorine-based disinfectants from salt water through electrochemical principles should be applied. Objectives: This study surveys the possibility of optimally producing active chlorine from synthetic NaCl solutions using an electro-chlorination system through RSM. Methods: Response surface methodology (RSM) has been used for modeling and optimizing a variety of water and wastewater treatment processes. This study surveys the possibility of optimally producing active chlorine from synthetic saline solutions using electrolysis through RSM. Various operating parameters, such as distance of electrodes, sodium chloride concentration, electrical potential, and electrolysis time were evaluated. Results: Various operating parameters, such as distance of electrodes, sodium chloride concentration, electrical potential, and electrolysis time were evaluated. A central composite design (CCD) was applied to determine the optimal experimental factors for chlorine production. Conclusions: The concentration of the synthetic NaCl solution and the distance between electrodes had the greatest influence on the generation of hypochlorite disinfectant. The closer the distance between the electrodes and the higher the concentration of the synthetic NaCl solution, the more hypochlorous acid disinfectant was produced.

• 공업화학
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• 제31권2호
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• pp.147-152
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• 2020

본 연구에서는 천연오일인 cashew nut shell liquid (CNSL)의 구성성분인 cardanol을 이용하여 내화학성이 향상된 에폭시계 수지용 반응성 희석제 제조 공정을 최적화하였다. 이를 위해 반응표면분석법 중 중심합성계획법을 이용하여 최적화과정를 설계하였다. 계량인자로는 cardanol/ECH 반응몰비, 반응시간, 반응온도이고, 반응치는 수율, 에폭시 당량(EEW), 점도이다. 기초실험으로부터 계량인자 범위를 각각 cardanol/ECH 반응몰비(2~4), 반응시간(4~8 h), 반응온도(100~140 ℃)로 설정한 후 최적화과정을 진행한 결과 최적의 조건은 cardanol/ECH 반응몰비(3.33), 반응시간(6.18 h), 반응온도(120 ℃)로 산출되었으며, 이 조건에서의 예측값은 수율(100%), EEW (429.89 g/eq.), 점도(41.65 cP)로 나타났다. 실제 실험을 통해 알아본 결과 오차율은 0.3% 이하로 나타나 중심합성계획모델을 이용하여 cardanol 원료 반응성 희석제의 제조 공정을 최적화할 수 있었다.

• Advances in environmental research
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• 제2권4호
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• pp.291-308
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• 2013

In the present study, an experimental design methodology was used to optimize the adsorptive removal of Basic Yellow 13 (BY13) using Turkish coal powder. A central composite design (CCD) consisting of 31 experiments was employed to evaluate the simple and combined effects of the four independent variables, initial dye concentration (mg/L), adsorbent dosage (g/L), temperature ($^{\circ}C$) and contact time (min) on the color removal (CR) efficiency (%) and optimizing the process response. Analysis of variance (ANOVA) showed a high coefficient of determination value ($R^2=0.947$) and satisfactory prediction of the polynomial regression model was derived. Results indicated that the CR efficiency was not significantly affected by temperature in the range of $12-60^{\circ}C$. While all other variables significantly influenced response. The highest CR (95.14%), estimated by multivariate experimental design, was found at the optimal experimental conditions of initial dye concentration 30 mg/L, adsorbent dosage 1.5 g/L, temperature $25^{\circ}C$ and contact time 10 min.

• Natural Product Sciences
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• 제27권4호
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• pp.264-273
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• 2021

Simultaneous quantification of multiple marker compounds in herbal medicine by high performance liquid chromatography (HPLC) analysis is still a challenge due to the complexity in various parameters to be considered and co-existing multi-components. As a case study, a reliable HPLC method for simultaneous quantification of paeoniflorin from Paeoniae Radix and decursin from Angelicae Gigantis Radix in various commercial herbal medicine was developed based on analytical quality by design (AQbD) strategy. As a first step, risk assessment was performed to select the critical method parameters (CMPs) which were decided as organic mobile phase ratio and column oven temperature. In order to evaluate the effect of the CMPs on critical method attributes (CMAs) of peak resolution and tailing, central composite design (CCD) was employed. The final chromatographic conditions were optimized as follows: column- C₁₈, 4.6 × 250 mm, 5 ㎛ particle size; mobile phase- A: acetonitrile, B: 0.1% acetic acid water; detection wavelength- 235 nm for paeoniflorin, 325 nm for decursin; column oven temperature- 25℃; flow rate- 1.0 mL/min; gradient mobile phase system as Time (min) : % A, 0:14, 25:14, 30:50, 60:50, 61:100, 65:100, 66:14, 75:14. The method was successfully validated according to the International Conference on Harmonization (ICH) guidelines and piloted for ten commercial herbal medicines.

• 한국식품조리과학회지
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• 제32권3호
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• pp.279-289
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• 2016

Purpose: This study was to determine the optimal composite recipe of rice cookie with 3 concentrations of Spergularia Marina L. Griseb, sugar and grape seed oil, using central composite design (CCD). Methods: The mixing condition of rice cookie was optimized by subjecting it to sensory evaluation and mechanical and physicochemical analysis using response surface methodology (RSM). Results: The results of mechanical and physicochemical analysis showed significant values for lightness, redness, yellowness, hardness, spread factor, loss rate, leavening rate, density, pH, moisture, sweetness and saltiness (p<0.05), and the results of sensory evaluation showed significant values for color, flavor, taste, texture, appearance and overall quality (p<0.05). As a result, the optimal sensory ratio was found to be 6.40 g of Spergularia Marina L. Griseb, 63.49 g of sugar and 106.19 g of grape seed oil. Conclusion: In conclusion, Spergularia Marina L. Griseb is a good source in natural antioxidant aimed at replacing salt, and it is possible to use in cookie or other food products to substitute salt.

• Advances in environmental research
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• 제9권1호
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• pp.65-84
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• 2020

The potential use of Sargassum boveanum algae for the removal of uranium from aqueous solution has been studied by varying three independent parameters (pH, initial uranium ion concentration, S. boveanum dosage) using a central composite design (CCD) under response surface methodology (RSM). Batch mode experiments were performed in 20 experimental runs to determine the maximum metal adsorption capacity. In CCD design, the quantitative relationship between different levels of these parameters and heavy metal uptake (q) were used to work out the optimized levels of these parameters. The analysis of variance (ANOVA) of the proposed quadratic model revealed that this model was highly significant (R² = 0.9940). The best set required 2.81 as initial pH(on the base of design of experiments method), 1.01 g/L S. boveanum and 418.92 mg/L uranium ion concentration within 180 min of contact time to show an optimum uranium uptake of 255 mg/g biomass. The biosorption process was also evaluated by Langmuir, Freundlich, Temkin and Dubinin-Radushkevich isotherm models represented that the experimental data fitted to the Langmuir isotherm model of a suitable degree and showed the maximum uptake capacity of 500 mg/g. FTIR and scanning electron microscopy were used to characterize the biosorbent and implied that the functional groups (carboxyl, sulfate, carbonyl and amine) were responsible for the biosorption of uranium from aqueous solution. In conclusion, the present study showed that S. boveanum could be a promising biosorbent for the removal of uranium pollutants from aqueous solutions.

• 공업화학
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• 제35권4호
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• pp.329-334
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• 2024

정제된 시벅턴오일을 사용하여 자외선차단 크림을 제조하고, 자외선 흡수능 및 유화안정성을 최적화하기 위해 중심합 성계획모델 반응표면분석법(CCD-RSM)로 실험 조건을 설계하였다. 실험의 독립변수는 유화제 첨가량, 유화시간, 점증제 첨가량으로 설정하였고, 반응치로는 ESI, MDS, 290 nm에서의 흡광도로 설정 후 실험을 진행하였다. RSM 최적화를 통해 산출된 회귀방정식 계수의 F-value와 P-value을 통해 반응치에 가장 영향을 주는 주효과도와 교호효과도를 분석하였고 P-value를 통해 계수의 통계적 유의성을 평가하였다. 반응표면분석법을 통해 산출된 최적 유화조건은 유화제 첨가량(4.39 wt%), 유화시간(25.42 min) 및 점증제 첨가량(1.24 wt%)으로 산출되었고, 이때 반응치 값은 ESI (98.5%), MDS (322.9 nm), 그리고 UV 흡광도(2.73)이다. 산출된 최적 조건으로 실제 실험을 진행한 결과 평균 오차율은 ± 2.7% 로 측정되었다.