• Journal of the korean academy of Pediatric Dentistry
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• v.35 no.3
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• pp.556-561
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• 2008

Neurofibromatosis is an autosomal dominant disorder caused by a mutation of a tumor supressor gene on the long arm of chromosome 17. There are two types of neurofibromatosis, and development of neurofibroma is one of clinical diagnostic criteria for neurofibromatosis. The clinical signs of neurofibromatosis include as skin lesions, bone deformities, and tumors involving central nervous system. About 25% of neurofibromatosis involves oral neurofibroma. Radiographically, oral neurofibroma is well-defined unilocular radiolucency, which involves mandibular canal, mandibular foramen and mental foramen. When a lesion is small and approachable, complete resection, including 1cm of marginal connective tissue, is feasible. However, there are studies reporting that the recurrence rate after surgical resection is high and frequent recurrence may even increase the risk of malignant transformation. This case reports a patient with neurofibromatosis type I, accompanying oral neurofibroma, who shows a favorable result after surgical resection of the oral lesion.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.8
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• pp.4661-4666
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• 2013

Background: The wide spectrum of clinical features in advanced stages of non-small cell lung cancer (NSCLC) probably contributes to disparities in outcomes because of different prognostic variables significant for stage IIIB/IV patients. Hence the aim of this study was to check for favorable response of patients to various chemotherapeutic combinations with respect to patient survival in stage IIIB and stage IV NSCLC disease. We selected those patients for our study who were receiving treatment with paclitaxel, gemcitabine or etoposide in combination with platinum based drugs. Materials and Methods: Seventy-two patients who visited the hospital from June 2009 to November 2012 with confirmed diagnosis of lung cancer were included, and data were collected for follow up and classified according to treatment received with respect to patients' regimen and response, and overall survival. This study analyzed tumor variables that were associated with clinical outcome in advanced NSCLC patients who were undergoing first-line chemotherapy for stage IIIB/IV NSCLC. Results: Comparative data on various parameters like age, gender, stage, histology, site of disease, metastatic site and chemo-regimens was analyzed; these parameters predicted variable significant improvement for overall survival ($p{\geq}0.05$). One and two year survival rates were 20.8% and 15.3%. Conclusions: In this study we found slight improvement in survival rates in NSCLC and clinical outcomes with one combination (carboplatin+paclitaxel). Overall there were only marginal differences in survival rates for other chemo-regimens evaluated in this study.

• Fisheries and Aquatic Sciences
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• v.3 no.2
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• pp.97-110
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• 2000

To investigate characteristics of water masses and current structures around Noto Peninsula located in south-east coastal region of the East Sea, observation results of CREAMS (Circulations Research of the East Asian Marginal Seas) cruise and data report of oceanographic observation (Japan Meteorological Agency) in June, 1995 and 1996 were used. Water mass showing characteristics of Tsushima Warm Current (TWC) exists over the continental shelf. The depth is shallower than 200m and its width and thickness are 190km and 200m, respectively. Minimum level of dissolved oxygen occurred at the layers of maximum salinity. In the current structure, a noteworthy phenomenon is that the positions of the high-salinity water (more than 34.6 psu) match well with the distributions of the southwestward flow. In June of 1995 and June of 1996, a southwestward flow were separated into two parts along line C and line G. Current directions derived from the temperature and salinity match well with the distributions of the geostrophic currents in the vertical sections. The isothermal lines and the isohaline, which exist horizontally along the coastal area of the Japan, change abruptly at the frontal area of the Noto Peninsula, then turn toward the center of the East Sea. The dynamic depth anomalies centering around the region far northwest of the Noto Peninsula were relatively high, compared to those of other regions. The isopycnic surface (sigma-t, 25.8) existed near the surface in the central part of the East Sea, but, at the depth of 100m, the isopycnic surface was found in the coastal waters.

• Journal of Microbiology and Biotechnology
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• v.16 no.2
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• pp.312-317
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• 2006

The chromosomal sprD gene encoding Streptomyces griseus protease D (SGPD), a chymotrypsin-like protease, was disrupted in Streptomyces griseus by insertion of the neomysin-resistance gene. The production of chymotrypsin activity of sprD disruptant was not completely abolished, but delayed by 24 h, compared with that of wild-type strain. The aerial mycelial formation of sprD disruptant was retarded, and specifically the formation of spores was not observed in the central region of colonies. However, normal morphological development into spores was observed in the marginal region of colonies. In addition, the production of yellow pigment that might be dependent on A-factor was also decreased in the sprD disruptant, compared with that of the wild-type strain. Introduction of the sprD gene, which was placed on a high copy-numbered plasmid into S. griseus ${\Delta}sprD$, partially restored the ability of morphological development, and a significant level of sporulation was observed. When the overexpression vector for sprD, pWHM3-D, was introduced in S. griseus, there was no significant change in the chymotrypsin activity or colonial morphology, in contrast to Streptomyces lividans, indicating the presence of a tight regulation system for the overexpression of the sprD gene in S. griseus.

• Archives of Plastic Surgery
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• v.42 no.3
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• pp.334-340
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• 2015

Background Full-thickness skin grafts (FTSGs) are generally considered unreliable for coverage of full-thickness finger defects with bone or tendon exposure, and there are few clinical reports of its use in this context. However, animal studies have shown that an FTSG can survive over an avascular area ranging up to 12 mm in diameter. In our experience, the width of the exposed bones or tendons in full-thickness finger defects is <7 mm. Therefore, we covered the bone- or tendon-exposed defects of 16 fingers of 10 patients with FTSGs. Methods The surgical objectives were healthy granulation tissue formation in the wound bed, marginal de-epithelization of the normal skin surrounding the defect, preservation of the subdermal plexus of the central graft, and partial excision of the dermis along the graft margin. The donor site was the mastoid for small defects and the groin for large defects. Results Most of the grafts (15 of 16 fingers) survived without significant surgical complications and achieved satisfactory functional and aesthetic results. Minor complications included partial graft loss in one patient, a minimal extension deformity in two patients, a depression deformity in one patient, and mild hyperpigmentation in four patients. Conclusions We observed excellent graft survival with this method with no additional surgical injury of the normal finger, satisfactory functional and aesthetic outcomes, and no need for secondary debulking procedures. Potential disadvantages include an insufficient volume of soft tissue and graft hyperpigmentation. Therefore, FTSGs may be an option for treatment of full-thickness finger defects with bone or tendon exposure.

• Journal of the Korean association of regional geographers
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• v.8 no.3
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• pp.281-294
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• 2002

Inhabitants make a specific cultural landscape in various ways according to his culture. In this paper, I consider the characteristics of cultural landscapes distributed in Sangju. I divide Sangju-City Area owing to physical criteria(relief and drainage basin}, appreciate them according to human criteria(administrative district of Joseon Period, dialects, periodical market area} and classify into 6 small regions: (1) Nakyang Region is the traditionally central place based on alluvial plain marginal to Byeongseong stream and Dong stream, and on hills of Sabeol. (2) Nakdong Region is the traffic center which the water transport of Nakdong river and the land transport of Yeongnamdaero cross each other. (3) The upstream region of Byungseong stream is the agricultural region connected with Nakyang Region. (4) Jungmo Region is a intermontane basin where grape cultivation using its specific climate flourish. (5) Wharyeong Region is a mountainous sightseeing district based on the beautiful scenery and Gyeonwhueon's remains of Sogni mountains and Yongyu valley. (6) Hamnyeong Region is the district of Goryeonggaya realm where 3 whites(cocoon, dried persimmon, rice) are abundant.

• The Korean Journal of Ecology
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• v.18 no.1
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• pp.189-201
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• 1995

In order to clarify regeneration processes and mechanisms of the disturbed Pinus densiflora forest, responses of Pinus densiflora to gap formed by disturbance were analysed by growth of saplings and mature and growth equations were obtained from branch growth of mature trees and height growth of saplings, and age distribution of saplings and young trees recruited within gap was analysed in relation to gap age. Height growth of saplings within gaps was accelerated after gap formation. Such abrupt increases of growth of saplings after the gap formation might be resulted in the difference of growth of saplings between gap and non-gap areas. In fact, height and diameter of saplings in the central part of gap were larger than those of saplings in marginal parts of gap and non-gap area. However, density of saplings was not different in both parts. In addition, growth of annual rings of mature trees bordering on gap also increased after gap formation. Branch growth of mature trees bodering on gap was 6.3 - 6.5 cm /year and the mean radius of gaps created by death of only one canopy tree was about 3 m. Therefore, for those gaps to be closed by branch growth it will take 46 years. Growth of saplings within gap showed exponential equation. Fifty years will be required for the saplings to enter the forest canopy by the exponential growth equation. Therefore, gap created by only one tree might be closed by branch growth of surrounding canopy trees in advance of being done by height growth of saplings. But gaps created by death of trees more than 2 will be closed by the growth of saplings. Among the regenerating saplings and young trees within gaps, individuals established in advance of gap formation were more than those established after the gap formation. From these results, it was assumed that the disturbed Pinus densiflora forests in these sites were regenerated by height growth of saplings recruited in advance of gap formation.

• Journal of the korean academy of Pediatric Dentistry
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• v.30 no.4
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• pp.654-659
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• 2003

Intrusive luxation that takes approximately three percent of permanent teeth commonly occures at anterior teeth. This intrusion frequently leads to pulp necrosis, root resorption, marginal bone loss and these complications are influenced by depth of intrusion and stage of root development. Various treatment approaches have been suggested to manage of intrusive luxation. Techniques aiming to reposition the intruded tooth include an observation for spontaneous re-eruption, surgical or orthodontic repositioning. We report two cases with clinically satisfactory results for traumatically intruded maxillary central incisor. In one case which has a large open apex and mild intrusion depth, we observed for spontaneous eruption and then repositioning by forced eruption method. In other case, which has been completely intruded, was repositioned by surgical extrusion and followed by apexification.

• Archives of Craniofacial Surgery
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• v.22 no.5
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• pp.260-267
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• 2021

Background: Elastic ear cartilage is a good source of tissue for support or augmentation in plastic and reconstructive surgery. However, the amount of ear cartilage is limited and excessive use of cartilage can cause deformation of the auricular framework. This animal study investigated the potential of periosteal chondrogenesis in an ear cartilage defect model. Methods: Twelve New Zealand white rabbits were used in the present study. Four ear cartilage defects were created in both ears of each rabbit, between the central artery and marginal veins. The defects were covered with perichondrium (group 1), periosteum taken from the calvarium (group 2), or periosteum taken from the tibia (group 3). No coverage was performed in a control group (group 4). All animals were sacrificed 6 weeks later, and the ratio of neo-cartilage to defect size was measured. Results: Significant chondrogenesis occurred only in group 1 (cartilage regeneration ratio: mean±standard deviation, 0.97±0.60), whereas the cartilage regeneration ratio was substantially lower in group 2 (0.10±0.11), group 3 (0.08±0.09), and group 4 (0.08±0.14) (p= 0.004). Instead of chondrogenesis, osteogenesis was observed in the periosteal graft groups. No statistically significant differences were found in the amount of osteogenesis or chondrogenesis between groups 2 and 3. Group 4 showed fibrous tissue accumulation in the defect area. Conclusion: Periosteal grafts showed weak chondrogenic potential in an ear cartilage defect model of rabbits; instead, they exhibited osteogenesis, irrespective of their embryological origin.

• The Journal of the Petrological Society of Korea
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• v.28 no.2
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• pp.71-83
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• 2019

The volcanic rocks in Saryangdo area are composed of Witseom Andesite, Punghwari Tuff, Araetseom Andesite, Obido Formation, Namsan Rhyolite and Saryangdo Tuff in ascending order. The volcanic rocks has a range of andesite-rhyodacite-rhyolite, which indicates calc-alkaline series and volcanic arc of orogenic belt. In Harker diagrams for trace element and REE pattern, these are also distinguished into so three groups(Witseom Andesite, Araetseom Andesite and Saryangdo Tuff) that each unit is interpreted to have originated in different magma chamber. The Saryangdo Tuff exhibits systematically(chemical zonations that gradually change) from lower dacite to upper rhyolite in section. The systematic sequence of compositional variations suggests that the tuffs were formed by successive eruptions of upper to lower part of a zoned magma chamber in which relatively dacitic magma is surrounded around rhyolitic magma of the central part. The zoned magma chamber was formed from marginal accretion and crystal settling that resulted form magmatic differentiations by fractional crystallization.