• Journal of the Korean Society for Precision Engineering
• /
• v.15 no.12
• /
• pp.72-80
• /
• 1998

In this study, a design approach based on genetic algorithm is proposed to solve the manufacturing cell design problem considering alternative process plans and alternative machines. The problem is formulated as a 0-1 integer programming model which considers several manufacturing parameters, such as demand and processing time of part, machine capacity, manufacturing cell size, and the number of machines in a machine cell. A genetic algorithm is used to determine process plan for each part, part family and machine cell simultaneously.

• IMMUNE NETWORK
• /
• v.16 no.2
• /
• pp.99-108
• /
• 2016

Colorectal cancer is the third leading cancer worldwide. Although incidence and mortality of colorectal cancer are gradually decreasing in the US, patients with metastatic colorectal cancer have poor prognosis with an estimated 5-year survival rate of less than 10%. Over the past decade, advances in combination chemotherapy regimens for colorectal cancer have led to significant improvement in progression-free and overall survival. However, patients with metastatic disease gain little clinical benefit from conventional therapy, which is associated with grade 3~4 toxicity with negative effects on quality of life. In previous clinical studies, cell-based immunotherapy using dendritic cell vaccines and sentinel lymph node T cell therapy showed promising therapeutic results for metastatic colorectal cancer. In our preclinical and previous clinical studies, cytokine-induced killer (CIK) cells treatment for colorectal cancer showed favorable responses without toxicities. Here, we review current treatment options for colorectal cancer and summarize available clinical studies utilizing cell-based immunotherapy. Based on these studies, we recommend the use CIK cell therapy as a promising therapeutic strategy for patients with metastatic colorectal cancer.

• Korean Journal of Computational Design and Engineering
• /
• v.2 no.3
• /
• pp.142-149
• /
• 1997

This study is intended to develop a Feature based modeler. It is difficult to integrate CAD and CAM/CAPP with information that is given only by a conventional CAD system. Therefore a lot of studies have concentrated on a Feature based CAD system. But conventional Feature based modelers have had limitation on providing sufficient information related to Feature interaction. If a Feature based modeler is to be used in assembly simulation, a new Feature-based modeling method needs to be developed. Also to support collision detection between parts, we have to handle Feature interaction systematically. Therefore we suggest Cell data structure which handles interaction of Features by volume. The volume created by Feature interaction is saved as a Cell. With the Cell structure we solve problems involved with Feature interaction. This study shows how the Cell data structure can manage Feature interaction and give enough information in assembly simulation.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• v.6 no.9
• /
• pp.2086-2097
• /
• 2012

A terminal-based dynamic clustering algorithm is proposed in a multi-cell scenario, where the user could select the cooperative BSs from the predetermined static base stations (BSs) set based on dynamic channel condition. First, the user transmission rate is derived based on linear precoding and per-cell feedback scheme. Then, the dynamic clustering algorithm can be implemented based on two criteria: (a) the transmission rate should meet the user requirement for quality of service (QoS); (b) the rate increment exceeds the predetermined constant threshold. By adopting random vector quantization (RVQ), the optimized number of cooperative BSs and the corresponding channel conditions are presented respectively. Numerical results are given and show that the performance of the proposed method can improve the system resources utilization effectively.

• Transactions of the Korean hydrogen and new energy society
• /
• v.31 no.6
• /
• pp.587-595
• /
• 2020

Nickel-based bimetallic catalysts were investigated for use in direct borohydride/hydrogen peroxide fuel cells. For anode and cathode, PdNi and AuNi catalysts were used, respectively. Nickel-based bimetallic catalysts have been investigated through various methods, such as inductively coupled plasma optical emission spectroscopy, transmission electron microscopy, scanning electron microscopy, and energy dispersive spectroscopy. The performance of the catalysts was evaluated through fuel cell tests. The maximum power density of the fuel cell with nickel-based bimetallic catalysts was found to be higher than that of the fuel cell with the monometallic catalysts. The nickel-based bimetallic catalysts also exhibited a stable performance up to 60 minutes.

• Journal of Korean Dental Science
• /
• v.7 no.2
• /
• pp.80-86
• /
• 2014

Purpose: Current common method of cytotoxicity evaluation for elastomeric impression materials use animal based cell lines, which the clinical relevance has been often questioned. Hence, the purpose of this study was to examine the difference in results with both human based and animal based fibroblast cell line. Materials and Methods: Three types of fibroblast cells were used in this study; conventional mouse fibroblasts of L929, human gingival fibroblasts (HGF-1), and immortalized human oral fibrobalsts (hTERT-hNOF). Test on extract and test by direct contact using different commercially available elastomeric impression materials were carried out according to the international standards. Result: There was significant difference in cell viability between types of fibroblasts cell used, where HGF-1 showed highest cell viability and L929 the lowest. Conclusion: Within the limitation of this study, careful consideration must be given when selecting the cells and interpreting the results for cytotoxicity evaluation of elastomeric impression materials, where use of human based cell lines such as hTERT-hNOF would be appropriate for both ease of cytotoxicity test and clinical relevance.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• v.6 no.7
• /
• pp.1815-1830
• /
• 2012

Existing R-tree that is based on a variety of outdoor-based techniques to manage moving objects have been investigated. Due to the different characteristics of the indoor and outdoor, it is difficult to management of moving object using existed methods in indoor setting. We propose a new index structure called ACII(adaptive Cell-based index for Indoor moving objects) for Indoor moving objects. ACII is Cell-based access structure adopting an overlapping technique. The ACII refines cells adaptively to handle indoor regional data, which may change its locations over time. The ACII consumed at most 30% of the space required by R-tree based methods, and achieved higher query performance compared with r-tree based methods.

• Journal of the Korean Operations Research and Management Science Society
• /
• v.28 no.3
• /
• pp.67-79
• /
• 2003

An efficient mobility management for mobile stations plays an important role in mobile communication networks. Even though many a mobility management schemes have been proposed, most of mobile communication networks adopt the mobility scheme based on zone-based registration. This paper studies the mobility management scheme that combines zone-based registration and 2-step selective paging. We assume cell by cell registration area, not ring by ring registration area of previous studies, and set up a new mobility model based on 2-dimensional random walk model considering the characteristic of zone-based registration to evaluate its performance exactly. We provide numerical results using proposed model to demonstrate the performance of zone-based registration and 2-step selective paging under various circumstances.

• Asian Pacific Journal of Cancer Prevention
• /
• v.16 no.5
• /
• pp.1993-1995
• /
• 2015

Purpose: This analysis was conducted to evaluate the efficacy and safety of irinotecan based regimens as second-line chemotherapy in treating patients with small cell lung cancer. Methods: Clinical studies evaluating the efficacy and safety of irinotecan based regimens as second-line chemotherapy for patients with small cell lung cancer were identified using a predefined search strategy. Pooled response rates (RRs) of treatment were calculated. Results: In irinotecan based regimens as second-line chemotherapy, 4 clinical studies which including 155 patients with small cell lung cancer were considered eligible for inclusion. In all chemotherapy consisted of irinotecan with or without nedaplatin. Pooled analysis suggested that, in all patients, the pooled RR was 27.1% (42/155) in irinotecan based regimens. Nausea, vomiting, diarrhea and myelosuppression were the main side effects. No grade III or IV renal or liver toxicity was observed. No treatment related death occurred with the irinotecan based treatments. Conclusion: This systemic analysis suggests that irinotecan based regimens as second-line chemotherapy are associated with mild response rate and acceptable toxicity for patients with small cell lung cancer.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
• /
• v.24 no.10
• /
• pp.844-849
• /
• 2011

Two kind of Ag-pastes were prepared for integrating the bulk Si solar cell. One is the Ag-paste with Pb-based glass frit and the other is that with Bi-based glass frit. The pastes were the mixture of 84 wt% Ag, 2 wt% glass frit, 11 wt% solvent of buthyl cabitol acetate, and 2 wt% additives. After fabricating the Ag-pastes, they was coated on a $SiN_x$/n+/p- stacks of a commercial mono-Si solar cell. The solar cell efficiency was 17.6% in the case of the Pb-based Ag-paste. However that was 16.2% in the solar cell integrated with the Bi-based Ag-paste. The lower performance in Bi-based Ag-paste was caused by the higher series resistance and the lower shunt resistance in comparison with the Pb-based Ag-paste.