• International Journal of Fluid Machinery and Systems
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• v.5 no.3
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• pp.126-133
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• 2012

The transfer matrix and unsteady cavitation characteristics, cavitation compliance and mass flow gain factor, of cavitating inducer were evaluated by CFD using commercial software. Quasi-steady values of cavitation compliance and mass flow gain factor were obtained first by using steady calculations at various flow rate and inlet cavitation number. Then unsteady calculations were made to determine the transfer matrix and the cavitation characteristics. The results are compared with experiments to show the validity of calculations.

• International Journal of Fluid Machinery and Systems
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• v.9 no.2
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• pp.160-168
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• 2016

In high speed turbopumps, cavitation occurs and often causes the flow instabilities such as cavitation surge and rotating cavitation. The occurrence of these cavitation instabilities is considered to relate to dynamic characteristics of the cavitation, which are modelled using a cavitation compliance and a mass flow gain factor. Various types of cavitation such as a blade surface cavitation, a tip leakage vortex cavitation, and a backflow vortex cavitation occur at the same time in the inducer and the dynamic characteristics of each cavitation have not been clarified yet in experiments. Focusing on the blade surface cavitation as one of fundamental cavitation, we investigated the dynamic characteristics of the blade surface cavitation on a flat plate hydrofoil in experiments in the present study.

• International Journal of Fluid Machinery and Systems
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• v.2 no.1
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• pp.40-54
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• 2009

Cavitation instabilities in turbo-machinery such as cavitation surge and rotating cavitation are usually explained by the quasi-steady characteristics of cavitation, mass flow gain factor and cavitation compliance. However, there are certain cases when it is required to take account of unsteady characteristics. As an example of such cases, cavitation surge in industrial centrifugal pump caused by backflow vortex cavitation is presented and the importance of the phase delay of backflow vortex cavitation is clarified. First, fundamental characteristics of backflow vortex structure is shown followed by detailed discussions on the energy transfer under cavitation surge in the centrifugal pump. Then, the dynamics of backflow is discussed to explain a large phase lag observed in the experiments with the centrifugal pump.

• Journal of Biomedical Engineering Research
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• v.23 no.4
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• pp.309-315
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• 2002

Since the discovery, in the 1980s, of erosion-pit-induced fractures in implanted mechanical heart valves. cavitation on the surface of mechanical heart valves has been widely studied as a possible cause of pitting. Several factors, including peak dp/dt of the ventricular pressure. maximum closing velocity of the leaflet, and squeeze flow. have been studied as indices of the cavitation threshold. In the present study. cavitation erosion on the surface of a mechanical valve was examined by focusing on squeeze flow and the water hammer phenomenon during the closing period of the valve. In this study, we measures pressure wave forms near a valve and closing velocities of a disk, which were placed in a holder with and without compliance. In case of all holders, pressure drop of below vapor pressure expect at near the surface disk. It was also found that the closing velocity of the disk increased and that cavitation erosion was enhanced too. These results suggest that disk closing velocity during the closing phase has signifiant effects on pitting erosion.

• International Journal of Fluid Machinery and Systems
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• v.10 no.3
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• pp.197-208
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• 2017

When Francis turbines operate at partial load, residual swirl in the draft tube causes low-frequency pulsation of pressure and power output. Scale effects and system response may bias the prediction of prototype behavior based on laboratory tests, but could be overcome by means of a 1D analytical model. This paper deals with the two most important features of such a model, the compliance and the source of excitation. In a distributed-parameter version, compliance should be represented as an exponential function of local pressure. Lack of similarity due to different Froude number can thus be compensated. The normally unknown gas content in the vortex cavity has significant influence on the pulsation, and should therefore be measured and considered as a test parameter.

• Journal of Biomedical Engineering Research
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• v.19 no.3
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• pp.285-290
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• 1998

There are various reports on the fracture of mechanical heart valves implanted in human or animal, and they are pointed out that problems are induced by an erosion of disk surface, due to a cavitation effect. We have been investigating this mechanism using accelerated fatigue tester, and it was found that erosion was enhanced by a compliance effect in the test circuit. In this study, effects of compliance value and location on erosion were discussed, while disk closing velocity was measured by a high speed video camera. It was clarified that faster closing velocity was resulting in a enhancement of erosion on the disk surface.

• Journal of the Korean institute of surface engineering
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• v.49 no.1
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• pp.26-31
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• 2016

In this paper, the characteristics of a cavitation-erosion damage behavior on the STS 304 and hot-dip aluminized STS 304 under cavitation environment in sea water solution was investigated. The electrochemical experiments were carried out by potential measurement, anodic/cathodic polarization test, Tafel analysis, and also galvanostatic experiment in current density variables for the samples. The apparatus of cavitation-electrochemical experiment was manufactured in compliance with modified ASTM G-32 standard, with the conditions of sea water temperature of $25^{\circ}C$ and the measurement, amplitude of $30{\mu}m$. The damage behavior was analyzed by an observation of surface mophologies and a measurement of damage depth by a scanning electron microscope(SEM) and a 3D microscope, respectively, after electrochemical test. After polarization experiment under cavitation environment, much higher damage depths for the hot-dip aluminized STS 304 were observed comparing to the untreated STS 304. In addition, higher corrosion current density in hot-dip aluminized STS 304 presented than that of untreated STS 304 as a result of Tafel analysis.

• Tuberculosis and Respiratory Diseases
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• v.77 no.4
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• pp.161-166
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• 2014

Since tuberculosis (TB) remains a major global health concern and the incidence of multi-drug resistant (MDR)-TB is increasing globally, new modalities for the detection of TB and drug resistant TB are needed to improve TB control. The Xpert MTB/RIF test can be a valuable new tool for early detection of TB and rifampicin resistance, with a high sensitivity and specificity. Late-generation fluoroquinolones, levofloxacin, and moxifloxacin, which are the principal drugs for the treatment of MDR-TB, show equally high efficacy and safety. Systemic steroids may reduce the overall TB mortality attributable to all forms of TB across all organ systems, although inhaled corticosteroids can increase the risk of TB development. Although fixed dose combinations were expected to reduce the risk of drug resistance and increase drug compliance, a recent meta-analysis found that they might actually increase the risk of relapse and treatment failure. Regarding treatment duration, patients with cavitation and culture positivity at 2 months of TB treatment may require more than 6 months of standard treatment. New anti-TB drugs, such as linezolid, bedaquiline, and delamanid, could improve the outcomes in drug-resistant TB. Nontuberculous mycobacterial lung disease has typical clinical and immunological phenotypes. Mycobacterial genotyping may predict disease progression, and whole genome sequencing may reveal the transmission of Mycobacterium abscessus. In refractory Mycobacterium avium complex lung disease, a moxifloxacin-containing regimen was expected to improve the treatment outcome.

• The Journal of Korean Physical Therapy
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• v.13 no.3
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• pp.719-726
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• 2001

Transdermal drug delivery offers various advantages over conventional drug delivery systems, such as avoidance gastrointestinal degradation and hepatic first-pass effect. encourages patient compliance. and possible sustained release of drugs. However, transdermal transport of drugs is low permeability of the stratum corneum, the superficial layer of the skin. Many physicochemical and biological factors influencing transdermal transport is described together with the corresponding experimental and clinical results. Phonophoresis is medical treatment with drugs introduced into the skin by ultrasound energy. Enhanced drug penetration is through to result from the biophysical alterations of skin structure by ultrasound waves. The frequency used for phonophoresis is usually from 20 kHz to 15MHz. Phonophoresis can be categorized in to three ranges: low-frequency range(below 1 MHz). therapeutic frequency range(1 to 3MHz), and high-frequency range(above 3 MHz). The depth of penetration of ultrasound into skin is inversely proportional to the frequency. Cavitation may cause mechanical stress. temperature elevation, or enhanced chemical reactivity causing drug transport. One theory is that ultrasound affects the permeation of the stratum corneum lipid structure as the limiting step in permeating through the skin. The range of indications for phonophoresis is wide. Aspecific classification of the range of indications is obtained by classification of pathological conditions. The continuous research is needed for many interesting issucs of phonophoretic transdermal delivory in new future.