• Korean Journal of Geomatics
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• v.2 no.1
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• pp.57-64
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• 2002

Measuring the depth of water is very important in ensuring the protection and safety of seaside. There are many difficulties in making the contour bathymetric map, and contour line due to the limitation of continuous measurement of water depth and collimation with the conventional measuring and positioning methods. But the real-time kinematic GPS (RTK GPS) positioning using a carrier phase enables us to decide a precise position without breaking a signal even under the condition of a moving environment. It is also possible to obtain an accurate depth of water in real time with a fathometer through the measuring of time delay between sending and receiving epochs. This research aims at investigation of accuracy potential of RTK GPS in combination with Echo Sounder(E/S) for the coastal mapping. Apart from this purpose, the accuracy of ambiguity resolution with the OTF(On the Fly) method was tested with respect to the initialization time. The result shows that the accuracy is better than 1cm with 5-minute initialization in the distance of 10km baseline. The seaside topography was measured by the RTK GPS only, on the other hand the seafloor topography was surveyed in combination of RTK GPS and E/S. Comparing to the volume of seaside measured by RTK GPS and digital topographical map, the difference of only 2 % was achieved. This indicates that the coastal mapping with RTK GPS is successfully conducted. In addition it is also demonstrated that the 3-dimensional perspective model resulted from the undersea topography measured by RTK GPS and E/S is very close to that from the digital map. Through this study, it was verified that RTK GPS is to be very useful method in the analysis of coastal morphology owing to its capability of getting the precise DTM for the using of harbor reclamation, dredging, and the estimation of soil movement in a river.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2004.11a
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• pp.234-238
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• 2004

A stoichiometric mixture of evaporating materials for $CuInSe_2$ single crystal thin films was prepared from horizontal electric furnace. To obtain the single crystal thin films, $CuInSe_2$ mixed crystal was deposited on thoroughly etched semi-insulating GaAs(100) substrate by the hot wall epitaxy (HWE) system. The source and substrate temperatures were $620^{\circ}C$ and $410^{\circ}C$, respectively. The crystalline structure of the single crystal thin films was investigated by the photoluminescence and double crystal X-ray diffraction (DCXD). The carrier density and mobility of $CuInSe_2$ single crystal thin films measured with Hall effect by van der Pauw method are $9.62{\times}10^{l6}\;cm^{-3}$ and $296\;cm^2/V{\cdot}s$ at 293 K, respectively. The temperature dependence of the energy band gap of the $CuInSe_2$ obtained from the absorption spectra was well described by the Varshni's relation, $E_g(T)\;=\;1.1851\;eV\;-\;(8.99{\times}10^{-4}\;eV/K)T^2/(T+153K)$. The crystal field and the spin-orbit splitting energies for the valence band of the $CuInSe_2$ have been estimated to be 0.0087 eV and 0.2329 eV at 10K, respectively, by means of the photocurrent spectra and the Hopfield quasicubic model. These results indicate that the splitting of the ${\Delta}_{so}$ definitely exists in the $\Gamma_6$ states of the valence band of the $CuInSe_2$. The three photocurrent peaks observed at 10K are ascribed to the $A_1-$, $B_1-$, and $C_1$-exciton peaks for n = 1.

• Archives of Pharmacal Research
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• v.29 no.4
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• pp.318-322
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• 2006

Many quaternary ammonium salts are incompletely absorbed after their oral administration and may also be actively secreted into the intestine. However, the underlying mechanism(s) that control the transport of these cations across the intestinal epithelium is not well understood. In this study, the mechanism of absorption of quaternary ammonium salts was investigated using Caco-2 cell monolayers, a human colon carcinoma cell line. Tributylmethylammonium (TBuMA) was used as a model quaternary ammonium salts. When TBuMA was administrated at a dose of 13.3 imole/kg via iv and oral routes, the AUC values were $783.7{\pm}43.6\;and\;249.1{\pm}28.0{\mu}mole\;min/L$ for iv and oral administration, indicating a lower oral bioavailability of TBuMA $(35.6\%)$. The apparent permeability across Caco-2 monolayers from the basal to the apical side was 1.3 times (p<0.05) greater than that from the apical to the basal side, indicating a net secretion of TBuMA in the intestine. This secretion appeared to be responsible for the low oral bioavailability of the compound, probably mediated by p-gp (p-glycoprotein) located in the apical membrane. In addition, the uptake of TBuMA by the apical membrane showed a $Na^+$ dependency. Thus, TBuMA appears to absorbed via a $Na^+$ dependent carrier and is then secreted via p-gp related carriers.

• Biomolecules & Therapeutics
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• v.27 no.3
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• pp.290-301
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• 2019

Paeonol has neuroprotective function, which could be useful for improving central nervous system disorder. The purpose of this study was to characterize the functional mechanism involved in brain transport of paeonol through blood-brain barrier (BBB). Brain transport of paeonol was characterized by internal carotid artery perfusion (ICAP), carotid artery single injection technique (brain uptake index, BUI) and intravenous (IV) injection technique in vivo. The transport mechanism of paeonol was examined using conditionally immortalized rat brain capillary endothelial cell line (TR-BBB) as an in vitro model of BBB. Brain volume of distribution (VD) of [$^3H$]paeonol in rat brain was about 6-fold higher than that of [$^{14}C$]sucrose, the vascular space marker of BBB. The uptake of [$^3H$]paeonol was concentration-dependent. Brain volume of distribution of paeonol and BUI as in vivo and inhibition of analog as in vitro studies presented significant reduction effect in the presence of unlabeled lipophilic compounds such as paeonol, imperatorin, diphenhydramine, pyrilamine, tramadol and ALC during the uptake of [$^3H$]paeonol. In addition, the uptake significantly decreased and increased at the acidic and alkaline pH in both extracellular and intracellular study, respectively. In the presence of metabolic inhibitor, the uptake reduced significantly but not affected by sodium free or membrane potential disruption. Similarly, paeonol uptake was not affected on OCTN2 or rPMAT siRNA transfection BBB cells. Interestingly. Paeonol is actively transported from the blood to brain across the BBB by a carrier mediated transporter system.

• Journal of the Korean Society of Marine Environment & Safety
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• v.23 no.7
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• pp.933-940
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• 2017

Draught and trim conditions are highly related to the loading condition of a vessel and are important factors in predicting ship manoeuverability. This paper estimates hydrodynamic coefficients from sea trial measurements with three different trim and draught conditions. A mathematical optimization method for system identification was applied to estimate the forces and moment acting on the hull. Also, fast time simulation software based on the Rheinmetall Defense model was applied to the whole estimation process, and a 4,500 Twenty-foot Equivalent Unit (TEU) class container carrier was chosen to collect sets of measurement data. Simulation results using both optimized coefficients and newly-calculated coefficients for validation agreed well with benchmark data. The results show mathematical optimization using sea measurement data enables hydrodynamic coefficients to be estimated more simply.

• Korean Journal of Acupuncture
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• v.38 no.3
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• pp.133-139
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• 2021

Objectives : Parkinson's disease is a neurodegenerative disease caused by a decrease in the dopaminergic neurons in the substantia nigra. The abnormal expression of solute carrier family 6 member 4 (Slc6a4) has been reported in patients with Parkinson's disease. Methods : In this study, we used MPTP to examine the changes in the expression of Slc6a4 in the brain of mice with Parkinson's disease and investigate its effect on dopaminergic neuronal cell death. Results : In the examination of the Slc6a4 expression in the substantia nigra of MPTP-treated mice for 4 weeks. The gene expression was increased compared to the normal group. To investigate the relationship between Slc6a4 and dopaminergic neurons, we performed a study using siRNA of Slc6a4 in the dopaminergic neuronal cell line SH-SY5Y. Using the siRNA of Slc6a4 to evaluate gene expression, it revealed that the tyrosine hydroxylase (TH) expression increases when Slc6a4 decreases. Moreover, this confirms its effects on the dopaminergic neurons. Additionally, through the evaluation of factors related to apoptosis, in particular, it was established that the value of bax/bcl2 decreased and was affected. These results suggest that a decreased Slc6a4 expression induces an increase in TH expression, providing a mechanism of action for dopaminergic neurons regulated by Slc6a4 expression. Conclusions : Slc6a4 is deemed to be involved in the regulation of dopaminergic neurons, suggesting that an increased Slc6a4 expression induced by MPTP may influence a reduction of dopaminergic neurons.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.20 no.3
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• pp.92-99
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• 2021

An automatic transmission, which consists of several decks of planetary gear sets, provides multiple speed and torque ratios by actuating brakes and clutches (mechanical friction components) for connecting central members of the planetary gear sets. The gear set consists of the sun gear, the ring gear, and the carrier supporting multiple planet gears with pin shafts. In designing a new automatic transmission, there are many steps to design and analyze: gears, brakes and clutches, shafts, and other mechanical components. Among them, selecting thrust bearings that not only allow the relative rotation of the central members and other mechanical components but also support axial forces coming from them is important; doing so yields superior driving performance and better fuel efficiency. In selecting thrust bearings, the magnitude of axial forces on them is a critical factor that affects their bearing size and performance; its results are systematically related to the direction of the helical angle of each planetary gear set (a geometric design profile). This research presents the effects of the helical angle direction on the axial forces acting on thrust bearings in an automatic transmission consisting of planetary gear sets. A model transmission was built by analyzing kinematics and power flows and by designing planetary gear sets. The results of the axial forces on thrust bearings were analyzed for all combinations of helix angle directions of the planetary gear sets.

• Journal of Positioning, Navigation, and Timing
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• v.10 no.4
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• pp.379-385
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• 2021

In order to synchronize a remote system time to the reference time like Coordinated Universal Time (UTC), it is required to compare the time difference between the two clocks. GNSS Precise Point Positioning (PPP) is one of the most general geodetic positioning methods and can be used for time and frequency transfer applications which require more precise time comparison performance than GNSS code. However, the PPP technique has a main drawback of day-boundary discontinuity which comes from the PPP model that the code measurements are applied to resolve the floating carrier-phase ambiguities. The Integer PPP (IPPP) technique is one of the methods which has been studied to compensate the day-boundary discontinuities exited in the conventional PPP. In this paper, we investigate the time and frequency capabilities of PPP and IPPP by using the measurement data obtained from two time transfer receivers which are closely located and using common reference 1 Pulse Per Second (PPS) and RF signals. From the experiment, it is investigated that the IPPP method can effectively compensate the day-boundary discontinuities without producing frequency offset. However, the PPP method can generating frequency offset which can severely degrade the time comparison performance with long-term period data.

• Journal of Veterinary Clinics
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• v.40 no.2
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• pp.85-92
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• 2023

Fractures in the horse industry are challenging and a common cause of death in racehorses. To accelerate fracture healing, tissue engineering (TE) provides promising ways to regenerate bone tissues. This study aimed to evaluate the osteogenic effects of biphasic calcium phosphate collagen (BCPC) graft, bone morphogenetic protein 2 (BMP2), mesenchymal stem cell (MSC), and platelet-rich plasma (PRP) treatments in horses. Four thoroughbred horses were included in the study, and, in each horse, three cortical defects with a diameter of 5 mm and depth of 10 mm were formed in the third metacarpal bones (MC) and metatarsal bones (MT). The defects were randomly assigned to one of six treatment groups (saline, BCPC, BMP2, MSC, PRP, and control). Injections of saline, BMP2, PRP, or MSCs were made at 1, 3, and 5 weeks after defect surgery. Bone regeneration effects were assessed by radiography, quantitative computed tomography (QCT), micro-computed tomography (μCT), histopathological, and histomorphometric evaluation. The new bone ratio (%) in the histomorphometric evaluation was higher in the BMP2 group than in the control and saline groups. Radiographic and QCT values were significantly higher in the BCPC groups than in the other groups. QCT values of the BMP2 group were significantly higher than in the control and saline groups. The present study demonstrated that BCPC grafts were biologically safe and showed osteoconductivity in horses and the repeated injections of BMP2 without a carrier can be simple and promising TE factors for treating horses with bone fractures.

• The Bulletin of The Korean Astronomical Society
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• v.44 no.2
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• pp.48.4-48.4
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• 2019

We studied the metal-distribution of isolated Milky-way mass galaxy using various hydrodynamic solvers and investigated the difference of the result between AMR and SPH codes. In particle-based codes, physical quantities like mass or metallicity defined in each particle are conserved unless being injected explicitly by the effect of the supernova, whereas in the Eulerian codes the diffusion is simply accomplished by hydro-equation. Therefore, without including explicit physics of diffusion on the SPH- codes, the metal mixing in the galaxy or CGM only can be accomplished by the direct motion of the particles, however, the standard-SPH codes depress the instability of the turbulent fluid mixing. In this work, we simulated under common initial conditions, common gas-physics like cooling-heating models, and star-formation feedback using ENZO(AMR) GIZMO and GADGET-2 codes. We additionally included a metal-diffusion algorithm on the SPH-codes, which follows the subgrid-turbulent mixing model investigated by Shen et al. (2010) and compared the effect of the metal-outflow on the halo region of the galaxy in different hydro-solvers. We also found that for the implementation of the diffusion scheme in the SPH-codes, the existence of a sufficient number of the gas-particles, which is the carrier of the metals, is necessary. So we tested a new initial condition for proper implementation of the diffusion scheme on the SPH simulations. By comparing the metal-contamination of the circumgalactic medium with different hydrodynamics models, we quantify the diffusion strength of AMR codes using diffusion parameterization of the SPH codes and also suggest the calibration solutions in the different behavior of codes in metal-outflow.