• The Korean Journal of Physiology and Pharmacology
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• 제2권3호
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• pp.287-295
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• 1998

Diazepam is known to have cardiovascular depressive effects through a combined action on benzodiazepinergic receptor and the GABA receptor-chloride ion channel complex. Moreover, it is known that barbiturates also have some cardiovascular regulatory effects mediated by the central GABAergic system. Therefore, this study was undertaken to delineate the regulatory actions and interactions of these systems by measuring the responses of the cardiovascular system and renal nerve activity to muscimol, diazepam and pentobarbital, administered intracerebroventricularly in rabbits. When muscimol $(0.03{\sim}0.3\;{\mu}\;g/kg)$, diazepam $(10{\sim}100\;{\mu}\;g/kg)$ and pentobarbital $(1{\sim}10\;{\mu}\;g/kg)$ were injected into the lateral ventricle of the rabbit brain, there were similar dose-dependent decreases in blood pressure (BP) and renal nerve activity (RNA). The relative potency of the three drugs in decreasing BP and RNA was muscimol ＞ pentobarbital ＞ diazepam. Muscimol and pentobarbital also decreased the heart rate in a dose-dependent manner; however, diazepam produced a trivial, dose-independent decrease in heart rate. Diazepam $(30\;{\mu}g/kg)$ augmented the effect of muscimol $(0.1\;{\mu}g/kg)$ in decreasing blood pressure and renal nerve activity, but pentobarbital $(3\;{\mu}g/kg)$ did not. Bicuculline $(0.5\;{\mu}g/kg)$, a GABAergic receptor blocker, significantly attenuated the effect of muscimol in decreasing BP and RNA, either alone or with diazepam, and that of pentobarbital in decreasing BP and RNA, either alone or with muscimol. We inferred that the central benzodiazepinergic and barbiturate systems help regulate peripheral cardiovascular function by modulating the GABAergic system, which adjusts the output of the vasomotor center and hence controls peripheral sympathetic tone. Benzodiazepines more readily modulate the GABAergic system than barbiturates.

• Journal of Chest Surgery
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• 제46권1호
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• pp.72-75
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• 2013

Percutaneous vertebroplasty is a relatively easy and minimally invasive procedure used in treating vertebral fractures. However, the procedure has many complications, one of which is bone cement leakage, which happens frequently. Leakage to the paravertebral venous system, in particular, may lead to especially devastating consequences. Here we report a case of a 65-year-old male patient with an intracardiac foreign body (bone cement) that generated a perforation on the right ventricle, and result in hemopericardium after percutaneous vertebroplasty. We performed open heart surgery to remove the foreign body.

• Clinical and Experimental Pediatrics
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• 제53권2호
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• pp.248-252
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• 2010

관상동맥의 이상 기시는 소아에서 드문 질환이다. 이러한 이상 기시들은 대동맥과 폐동맥간과의 해부학적인 관계에 의해 3가지 형태로 분류할 수 있다. 우리 환자의 경우와 같이 기형 동맥이 대동맥과 폐동맥사이로 주행하는 경우 젊은 연령에서 급사의 위험도가 증가하기 때문에 빠른 진단과 치료가 필요하다. 관상동맥의 이상 기시를 교정하는 방법으로는 잘 알려진 re-implantation, 관상동맥 우회술과 unroofing의 세가지 방식이 있고, 아직까지 좌 관상동맥의 이상 기시의 치료에 대해서는 많은 견해들이 있으나 일단 수술적 교정이 되면 좋은 결과를 보인다. 우리는 운동 중 발생한 흉통과 실신을 주소로 내원한 12세 여아에서 심초음파와 관상동맥 전상화 단층촬영을 통하여 좌 관상동맥의 우 관상동맥동으로부터의 이상 기시를 진단받고 re-implantation, 관상동맥 우회술, 그리고 unroofig 방법을 통해 치료받은 1례를 경험하여 이를 보고하고자 한다.

• Journal of Chest Surgery
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• 제41권5호
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• pp.630-632
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• 2008

AESOP (Automated Endoscope System for Optimal Positioning)을 이용한 최소 침습적 심장 수술은 고식적인 정중흉골 절개술을 이용한 심장 수술에 비하여 수술 상처가 작고, 수술 후 환자의 회복이 빠르며, 입원 기간을 단축시키는 등의 장점이 알려져 있다. 저자들은 26세 여자 환자에서 좌측 최소 개흉술을 이용한 동맥하형 심실중격 결손증의 교정수술을 성공적으로 시행하였기에 문헌고찰과 함께 보고하는 바이다.

• Journal of Chest Surgery
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• 제35권11호
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• pp.831-834
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• 2002

감염된 심박조율기의 부분적 제거 후에 발생되는 재감염율은 51%에서 77%에 이르기 때문에 심박조율기의 어느 부위라도 감염이 된다면 모든 심박조율기의 하드웨어는 제거되어야 한다. 심폐기 가동하에서 감염된 심박조율기를 제거하는 것은 감염과 증식물의 확산 뿐만 아니라 기계적 손상을 방지 할 수 있다. 저자 등은 좌쇄골하 정맥에서 심장내로 이동된, 감염된 경정맥 심박조율기 도관에 의해 발생한 심내막염의 1예를 보고 한다. 심장내로 이동된 심박조율기 도관과 증식물이 부착된 전극은 심폐우회를 이용하여 제거하였다.

• Journal of Chest Surgery
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• 제43권4호
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• pp.409-412
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• 2010

이차공형 심방 중격 결손 환자에서 다빈치 로봇을 이용하여 8∼12 mm 크기의 포트만을 이용한 심방 중격 결손 폐쇄술 다섯 예를 경험하여 문헌 고찰과 함께 보고하는 바이다.

• 대한한의학회지
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• 제29권1호
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• pp.146-155
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• 2008

Objectives : This study was to assess the effectiveness of oriental medical therapy (OM) on acute Bell's palsy, comparing its outcome with that of oriental-western medical therapy (OWM). Methods : Subjects were enrolled atKyung Hee Medical Center from March 2007 to December 2007. We prescribed Igigeopung-san and acupuncture therapy to both the OM and OWM groups, and prednisolone only to the OWM group. Effectiveness was assessed by the House-Brackmann facial nerve grading system (HBGS) and Yanagihara's unweighted grading system (YUGS) every week. Results : There were 31 patients in the OM group and 34 in the OWM group. About grading system scores and weekly score gaps, no significant differences were revealed between the two groups, but statistical significant difference was detected at recovery time. After 2 weeks of treatment, the OM group's HBGS score showed significant difference from baseline score, but the OWM group showed it after 1 week. After 3 weeks of medication, pain was reduced in 22% of OM group patients, but 50% in the OWM group (p=0.028). We made the same comparison study for patients treated within 4 days from onset, but there was no significant difference between the two groups. 3 cases of adverse effect of hyperglycemia were found in the OWM group, which could be due to hyperglycemic side-effect of prednisolone. Conclusion : This work could help us to understand the effectiveness of OM compared to OWM on acute Bell's palsy.

• 한국임상약학회지
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• 제22권1호
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• pp.41-46
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• 2012

Adverse drug reaction (ADR) is a global problem of major concern in health care. ADRs can be accrued in any organs or systems. However, cardiovascular ADRs could be a more serious problem if they are irreversible or severe. For this reason, this study was conducted to analyze pattern and severity of cardiovascular ADRs, and suspicious medication. Total 646 reports including cardiovascular ADRs reported to the KFDA between January and June 2010 were analyzed. Amlodipine besylate (36 reports, 3.3%), iopromide (29 reports, 2.7%), tramadol HCl (28 reports, 2.6%) were most suspicious drugs that occurred cardiovascular ADRs. The most common cardiovascular ADRs were hypotension( 236 reports, 33.1%), palpitation (134 reports, 18.8%), and hypertension (89 reports, 12.5%). The most frequent ADRs were occurred in the age group of more than 60. This result could be of help to prescribers and other healthcare providers to predict and prevent cardiovascular ADRs. Also this study suggested that patients with cardiovascular ADR risk factors should be intensively monitored during the medications.

• Journal of Chest Surgery
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• 제54권2호
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• pp.88-98
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• 2021

Background: This study aimed to develop a new risk prediction model for operative mortality in a Korean cohort undergoing heart valve surgery using the Korea Heart Valve Surgery Registry (KHVSR) database. Methods: We analyzed data from 4,742 patients registered in the KHVSR who underwent heart valve surgery at 9 institutions between 2017 and 2018. A risk prediction model was developed for operative mortality, defined as death within 30 days after surgery or during the same hospitalization. A statistical model was generated with a scoring system by multiple logistic regression analyses. The performance of the model was evaluated by its discrimination and calibration abilities. Results: Operative mortality occurred in 142 patients. The final regression models identified 13 risk variables. The risk prediction model showed good discrimination, with a c-statistic of 0.805 and calibration with Hosmer-Lemeshow goodness-of-fit p-value of 0.630. The risk scores ranged from -1 to 15, and were associated with an increase in predicted mortality. The predicted mortality across the risk scores ranged from 0.3% to 80.6%. Conclusion: This risk prediction model using a scoring system specific to heart valve surgery was developed from the KHVSR database. The risk prediction model showed that operative mortality could be predicted well in a Korean cohort.

• Journal of Chest Surgery
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• 제39권10호
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• pp.749-753
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• 2006

배경: 본 연구는 관상동맥 우회로술의 수술위험도를 예측할 수 있는 스코어 시스템을 만들고자 하였다. 대상 및 방법: 2000년 1월부터 2005년 9월까지 본원에서 시행되었던 관상동맥 우회로술 2,993예를 대상으로 여러 가지 수술 전후의 인자들에 대하여 후향적 연구를 진행하였다. 결과: 총 조기 수술사망률은 2.4%였으며 조기 사망에 통계적으로 의의 있게 연관된 것으로 나타난 7가지 인자(수술 전의 좌심실기능 부전(좌심실 구출률 30% 이하), 수술 전 신부전의 진단, 수술 전 1주일 이내 심근 경색, 재수술, 복합수술, 수술 전 심전도상에서의 심방 세동, 수술 전 대동맥 내 풍선 삽입술의 시행)의 베타지수(beta coefficient)를 지수화하여 스코어 시스템을 구하였다. 이 스코어 시스템에 대하여 ROC 커브와 Hosmer and Lemeshow goodness of fit test를 시행하여 적정성을 검증하였다. 결론: 본 시스템은 적정성 검사 결과 적정함을 나타냈지만 이후 더 많은 증례와 다른 병원과의 공조를 통하여 더 좋은 시스템의 확립이 중요하다.