• Journal of the Korean Chemical Society
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• v.15 no.2
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• pp.65-68
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• 1971

The possibility of the two-phase oxidation of an aldehyde to carboxylic acid was studied. Thus the ether solutions of representative aldehydes (2.0M) were treated with 1.5 mole equivalent of chromic acid solution (1.0M) for 30 minutes at room temperature. Of the ten aldehydes tested,m butanal, benzaldehyde, tolualdehyde, o-, m-, p-nitrobenzaldehyde and cinnamaldehyde could be oxidized conveniently to the corresponding carboxylic acid giving an 80-90% yield. But furfural gave only a 30% yield of furoic acid and the oxidation of salicylaldehyde was unsuccessful.

• Bulletin of the Korean Chemical Society
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• v.25 no.3
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• pp.343-344
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• 2004

• Archives of Pharmacal Research
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• v.28 no.11
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• pp.1219-1223
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• 2005

6-[2-(Benzoxazol-2-ylmethylamino)ethoxy]-1-alkyl-1H-indole-2-carboxylic acids were designed and synthesized as $\beta$-amyloid (A$\beta$) fibril assembly inhibitors. Their inhibitory activity on A$\beta$, aggregation was evaluated by thioflavin T assay although their activities were insignificant.

• Archives of Pharmacal Research
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• v.17 no.6
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• pp.476-479
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• 1994

Five pohenolic compounds were isolated from 80% aq. acetone extract of Duchesnea chyrysantha. Their crytotoxicities were screened by the colorimetric tetrazolium assay (MIT assay). Gallic acid, methyl caffeate, protocatechuic acid and pedunculagin mildly inhibited the survival of $PC_{14}{\;}and{\;}MKN_{45}$ human cancer cell. Brevifolin carboxylic acid showed a strong cytotoxic activity.

• Bulletin of the Korean Chemical Society
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• v.23 no.8
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• pp.1085-1088
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• 2002

Calix[6]arene having both carboxylic acid (1,3,5-) and carboxamide (2,4,6-) in an alternative way was synthesized. Transport rates of alkali and alkaline-earth metal ions were tested in bulk liquid membrane and polymer inclusion membrane. Ba2+ ion was found to give the highest transport rate among tested metal ions in both BLM and PIM systems. In PIM system, high durability (longer than 30 days) of the membrane was observed.

• Archives of Pharmacal Research
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• v.27 no.10
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• pp.997-1000
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• 2004

A series of 1,3-dioxoindan-2-carboxylic acid arylamides were synthesized and evaluated for in vitro cytotoxicity against four human cancer cell lines (HOP62, SK-OV-3, MD-MB-468 and T- 47D). The most active was compound 3e (1.2 ${\mu}M$ against SK-OV-3 cell line) bearing a 4- methyl substituent.

• Journal of the Korean Chemical Society
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• v.41 no.4
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• pp.214-218
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• 1997

• Archives of Pharmacal Research
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• v.14 no.4
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• pp.359-363
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• 1991

2,6-Dimethyl-4-(3'-nitrophenyl)1,4-dihydropyridine-3,5-dicarboxylic acid 5-(2'-cyanoethyl) ester 10a reacted with chloromethyl methylsulfide to give 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-methylthiomethyl 5-(2'-cyanoethyl) ester 11a in 88.1% yield. The synthesis of 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicrboxylic acid 3-methylthiomethyl ester 2a was achieved in 83% yield by alkaline hydrolysis of compound 11a in aqueous EtOH.

• Bulletin of the Korean Chemical Society
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• v.11 no.5
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• pp.376-379
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• 1990

To find out a correlation between antibacterial activity and physical properties of 7-substituted 1-ethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, dipole moments, charge distributions, and hydrophobicities were calculated. The atomic charges and the dipole moments to not give any correlations with inhibition of DNA gyrase, but the calculated hydration free energies show some correlations.

• Bulletin of the Korean Chemical Society
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• v.12 no.4
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• pp.438-440
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• 1991

Each aqueous solution (pH = 1) of acetic acid, acetamide, and acetonitrile produces carbon dioxide and hydrogen at 300 K when irradiated in the presence of semiconductors such as titanium dioxide, platinized titanium dioxide, etc. Similar results were obtained for each of benzoic acid, benzamide, and benzonitrile. Based on the relative amount of carbon dioxide, nitrile is believed to be transformed into carboxylic acid through the intermediacy of amide. A mechanism in which hydrogen atom and hydroxyl radical are involved is presented.