• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2022년도 가을 학술논문 발표대회
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• pp.247-248
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• 2022

The microfluidic controlled droplet production system is one of the most powerful methods for capsule manufacturing. However, stable production is not possible when the powder is included. We solved the above problem by developing an off-chip droplet production system. we checked the droplet creation mechanism and created a simple repair model. It was possible to produce a uniform and stable droplet regardless of the powder content.

• 한국어류학회지
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• 제21권4호
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• pp.283-286
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• 2009

고려홍어의 모식산지인 한반도 남서해안에서 포획한 암컷개체의 자궁에서 직접 적출한 난각 2개를 새롭게 기재하였다. 본종의 난각은 다른 종과 비교하여 보통 크기이고, 뿔(horn)을 포함한 전장은 124.5~133.7 mm, 뿔을 제외한 주부(main portion)의 체장은 102.8~109.4 mm, 최대폭은 41.0~42.2 mm이다. 측면에서 볼 때 배쪽으로 불룩한 비대칭이고, 표면은 비교적 부드러운 편이지만 세로로 미세한 고랑(longitudinal striations)은 뚜렷하고, 매우 발달한 섬유다발(견상사(絹狀絲) silky fibers)로 덥혀 있다. 앞뒤의 apron은 뚜렷하며, 네 뿔은 짧고 튜브모양이고 그 횡단면은 타원형이고, 앞쪽 뿔은 안쪽으로 심하게 구부러져 있으며, 호흡공(respiratory fissure)은 네 뿔의 끝부분에 위치한다. 신선한 상태에서 밝은 갈색이다.

• Archives of Plastic Surgery
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• 제42권2호
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• pp.179-185
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• 2015

Background Capsular contracture is the most troublesome complication in breast implant surgery. Although capsule formation can be seen as a normal reaction to a foreign body, it can induce pain, hardness, deformity, and other pathologic problems. Surgical intervention is required in severe cases, but even surgery cannot guarantee a successful outcome without recurrence. This experimental study confirms that single topical administration of leukotriene antagonist zafirlukast (Accolate, Astrazeneca) reduces peri-implant capsule formation and prevents capsular contracture. Methods Twelve smooth-surfaced cohesive gel implants were implanted in New Zealand White rabbits. These miniature implants were designed to be identical to currently used products for breast augmentation. The rabbits were divided into 2 groups. In the experimental group (n=6), the implant and normal saline with zafirlukast were inserted in the submuscular pocket. In the control group (n=6), the implant and normal saline alone were used. Two months later, the implants with peri-implant capsule were excised. We evaluated capsule thickness and collagen pattern and performed immunohistochemical staining of myofibroblasts, transforming growth factor $(TGF)-{\beta}1$, 2. Results The thickness of the capsules in the experimental group was reduced in both dorsal and ventral directions. The collagen pattern showed parallel alignment with low density, and the number of myofibroblasts as well as the amounts of $TGF-{\beta}1$ and $TGF-{\beta}2$ were reduced in the experimental group. Conclusions We suggest that single topical administration of leukotriene antagonist zafirlukast can be helpful in reducing capsule formation and preventing capsular contracture via myofibroblast suppression, modulation of fibroblastic cytokines, and anti-inflammatory effect.

• Journal of Advanced Marine Engineering and Technology
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• 제35권1호
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• pp.32-39
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• 2011

항해자료기록기(VDR) 캡슐은 항해사고와 같은 극한환경에서 저장된 정보를 안전하고 재사용이 가능한 형태로 보존하는 것을 목적으로 한다. 본 연구에서는 VDR 캡슐에 대하여 관통저항력과 고온 및 저온내화의 극한환경시험에 대한 구조 및 방열측면의 모델링, 해석, 실험을 통한 검증에 대하여 기술하였다. 특히 관통시험에서 캡슐을 보호하는 캡슐하우징의 두께에 따른 영향성을 LS-DYNA를 이용한 모델링과 해석을 통하여 검토하였으며, 고온 및 저온내화시험에서 VDR 캡슐을 보호하기 위해 사용되는 상변화물질과 단열재의 체적비에 따른 열적특성을 Icepak을 이용한 열해석을 통하여 수행하였다. 또한 실험을 통하여 VDR 캡슐의 구조 및 열적신뢰성을 검증하였다.

• Journal of Pharmaceutical Investigation
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• 제23권3호
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• pp.179-186
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• 1993

In vitro dissolution test and pharmacokinetic study in human volunteers were conducted to evaluate the pharmacokinetic characteristics of 150 mg furbiprofen sustained-release capsule (FPSR-150). As a reference product, 50 mg flurbiprofen conventional-release capsule (FPCR-50) was used. Dissolution tests of two products were run using the paddle method in 450 : 540 (v/v %) mixture of simulated gastric and intestinal fluids (K.P. VI) by adjusting medium pH according to time. FPCR-50 was dissolved very rapidly, and it took about 1.5 hr for FPCR-50 to be dissolved over 90%, whereas 15 hr for FPSR-150. Also, in pharmacokinetic study, ten healthy male volunteers were administered one capsule of FPSR-150 or two capsules of FPCR-50 (FPCR-l00) with randomized two period cross-over study. Significant differences between FPCR-l00 and FPSR-150 were found in mean times to reach peak concentration, mean resident times and mean terminal phase halflives, while not in AUC/Dose (Student's t-test). In ANOVA for AUC/Dose to compare the bioavailabilities of two FP products, there was no significant difference. From the comparison of the simulated steady-state plasma concentration-time curves following multiple medications of FPCR-50 (3 capsules a day, dosing interval=8 hrs) and FPSR-150 (1 capsule a day) based on the above results obtained from single doses of two FP products, it was noted that the medication of FPSR-150 is more useful in clinical application rather than FPCR-50.

• 로봇학회논문지
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• 제4권1호
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• pp.62-67
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• 2009

For diagnoses of digestive organs, capsule endoscopes are widely used and offer valuable information without patient's discomfort. A general capsule endoscope which consists of image sensing module, telemetry module and battery is able to move along gastro-intestinal tracts passively only through peristaltic waves. Thus, it is likely to have some limitations for doctor to acquire images from the desired organs and to diagnose them effectively. As solutions to these problems, a locomotive function of capsule endoscopes has being developed. We have proposed a capsule-type microrobot with synchronized multiple legs. However, the proposed capsular microrobot also has some limitations, such as low speed in advancement, inconvenience to controlling the microrobot, lack of an image module, and deficiency in a steering module. In this paper, we will describe the limitations of the locomotive microrobot and propose solutions to the drawbacks. The solutions are applied to the capsular microrobot and evaluated by in-vitro tests. Based on the experimental results, we conclude that the proposed solutions are effective and appropriate for the locomotive microrobot to explore inside intestinal tracts.

• Journal of Pharmaceutical Investigation
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• 제41권5호
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• pp.309-315
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• 2011

A sensitive and specific liquid chromatographic method coupled with tandem mass spectrometry (LC-MS/MS) was developed for the analysis of ambroxol (active moiety of acebrophylline). After acetonitrile precipitation of proteins from plasma samples, ambroxol and the domperidone (internal standard, IS) were eluted on a C18 column. The isocratic mobile phase was consisted of 10 mM ammonium acetate and methanol (10 : 90, v/v), with flow rate at 0.2 mL/min. A tandem mass spectrometer, as detector, was used for quantitative analysis in positive mode by a multiple reaction monitoring mode to monitor the m/z 379.2${\rightarrow}$264.0 and the m/z 426.2${\rightarrow}$175.1 transitions for ambroxol and the IS, respectively. Twenty four healthy Korean male subjects received two capsules (100 mg ${\times}$ 2) of either the test or the reference formulation of acebrophylline HCl in a 2 ${\times}$ 2 crossover study, this was followed by a 1week washout period between either formulation. $AUC_{0-t}$ (the area under the plasma concentration-time curve) was calculated by the linear trapezoidal rule. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma concentration-time data. The 90% confidence intervals for the log transformed data were acceptable range of log 0.8 to log 1.25 (e.g., log 0.8964 - log 0.9910 for $AUC_{0-t}$ log 0.8690 - log 1.0750 for $C_{max}$). The major parameters, $AUC_{0-t}$ and $C_{max}$ met the criteria of Korea Food and Drug Administration for bioequivalence indicating that Acephyll$^{(R)}$ capsule (test) is bioequivalent to Surfolase$^{(R)}$ capsule (reference).

• 한국작물학회지
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• 제31권3호
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• pp.304-310
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• 1986

참깨 다수성신품종육성의 중요성에 비추어 다수계통의 선발에 관한 기초정보를 얻고자 참깨 82품종을 공시재료로 하여 기대되는 선발지수와 수량에 대한 관계효율을 산출한 바 그 결과를 요약하면 다음과 같다. 1. 선발대상형질을 4개로 하여 이들 조합에 따라 선발된 유전진전은 2개형질의 조합에 있어서는 개화일수와 주당착삭수, 3개 형질조합에서는 개화일수, 착삭부위장, 주당착삭수와 개화일수, 착삭절수, 주당착삭수가 다른 형질의 조합보다 높았다. 2. 단일형질에 있어서 유전진전치는 주당착삭수가 가장 높았다. 3. 형질별 또는 형질의 조합별로 작성된 유전진전은 전형질의 조합이 가장 높았으나 실제선발 시는 무리가 있을 것으로 추정되었다. 따라서 유전진전치에 대한 관계비율도 개화일수와 주당착삭수 또는 개화일수와 착삭부위장 및 주당착삭수나 개화일수와 착삭절수 및 주당착삭수의 조합들이 높아 이들 형질들을 선발대상으로 한다면 실제의 선발효과를 높일 수 있을 것으로 생각된다.

• 한국발생생물학회지:발생과생식
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• 제17권1호
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• pp.25-35
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• 2013

We investigated the effects of shell height on reproductive potential of the female Rapana venosa in three regions of different salinities (the coastal zone of the Gwangyang Bay (S-1); the upper reaches (S-3); lower reaches (S-2) of the Seomjin River). The number of egg capsules, egg capsule height, and fecundity associated with reproductive potential of larger female rapa whelks were higher than those of smaller individuals in all three regions. Correlation analyses showed that there is a significant positive correlation between egg capsule and female shell height. Mean of shell heights, egg capsule heights, the number of egg capsules in an egg mass, and fecundity in an egg capsule produced from female individuals inhabiting S-1 region were markedly higher than those inhabiting S-2 and S-3 regions. In particular, the fecundity of the rapa whelk increased with the salinity and shell height. Although large rapa whelks produced a large number of egg capsules at S-1 region, those at S-3 habitat laid less egg capsules with smaller size. If these rapa whelks were put into S-2 region, the number of egg capsules produced by a female at S-2 region was slightly larger than those produced by a female at S-3 region. This provides a clear evidence that the number of the egg capsules can be controlled by the salinity. In the coastal zone of the Gwangyang Bay and the upper reaches of Seomjin River, the fecundity of this species was estimated to be approximately 182,000-1,302,000 eggs/ind./yr.

• 한국연초학회지
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• 제20권2호
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• pp.166-171
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• 1998

In order to improve the efficiency of F$_1$ hybrid seeds production(KF 114), some experiments were carried out in a greenhouse this year. Mother plant(MSNC567) and pollen plant(NC) were grown in some pots (30 x 30cm, WxH). The gathered pollens were mixed with celite, pollen deluent dusts and stored in refrigerator at l$0^{\circ}C$ before pollination. To establish the critical range of the mixed rate and the storage period of pollens, the change in a percent of capsule set, number of seed and seed weight per capsule, weight of 1000 seeds and germination percent of seed resulted of pollination with pollen deluent dusts were investigated. The results are as follows; Percent of capsule set showed the mixed rate 1:5 resulted in no difference and those of 1:10 and 1:20 decreased about 5 ～15% when compared with trials using pollen alone. There was no difference among duration of storage in a same mixed rate. Numbers of seed per capsule showed a significant difference among the mixed rates and among durations of storage. Numbers of seed per capsule were decreased about 55 ～ 90 % as the mixed rate increase, about 2 ～ 28 % as the duration of storage increase. Weight of seed per capsule decreased about 16 ～ 23 % as the duration increase and decreased about 3 ～ 89 % as the mixed rate increase when compared with trials using pollen alone. Weight of 1000 seeds showed non significant difference among duration of storage but were higher than trials used pollen alone as the mixed rate increase.