• Biomedical Science Letters
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• v.12 no.4
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• pp.311-318
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• 2006

The GJB2 mutation is mostly recessive in non-syndromic hearing loss, but specific mutations display a dominant type and syndromic hearing impairment. Both U54K and R75Q mutations present a dominant type in pedigrees with associated skin disorders. The purpose of this study was to investigate whether two GJB2 mutations can exhibit a dominant-negative effect on the growth abrogation and the gap junctional intercellular communication capacity exerted by wild-type connexin 26. A specific mutant region of GJB2 showed a loss of gap junction activity and a dominant negative effect on wild-type GJB2. The two mutants exerted a dominant-negative effect on the GJIC capacity and have independently effected GJB2 regulated growth of Hela cells; however, they have no dominant-negative growth effect on wild-type GJB2. It is proposed that the different mechanisms of the dominant-negative effect on wild-type GJB2 involve cell growth and GJIC function. This study describes mutations found in Korean deaf patients and that are typical of other east Asian regions.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.17 no.9
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• pp.972-981
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• 1992

In this paper, the performance of linear and hard-limiting correlation receivers for DS/SSMA BPSK power line communication system is analyzed. Strong impulsive noise of power line is modeled with Chan's noise model, and the performance of both receivers is analyzed in terms of parameters such as ratio of power spectrum density of impulsive noise to that background noise, ratio in impulsive noise width th that of data bit, and interarrival time of impulsive noise. And also multiple access capacity is evaluated with Gaussian approximation of multiple access interference. The results of this analysis reveal that the performance of linear correlation receiver is superior to that of hard-limiting correlation receiver when $N_1/N_b$ is small and is close to 1. But the BER and the multiple access capacity of hard-limiting correlation receiver becomes better in comparison with linear correlation receiver as $N_1/N_b$ increases.

• Food Engineering Progress
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• v.13 no.3
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• pp.216-220
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• 2009

The several functional properties of freeze-dried powder of Aloe vera gel was examined as influenced by pre-concentration degrees of the gel solution. As a pre-treatment prior to freeze drying, the gel solution was vacuum-concentrated by three levels (unit: g-water/g-solids) - high (H), 76; medium (M), 119; low (L), 159. In FT-IR spectra, the sample H showed the highest absorbance in the range of 1600-1550 $cm^{-1}$ and 1450-1400 $cm^{-1}$, which corresponded to level of the acetyl group in glucomannan. The sample H of freeze-dried powder was the highest in polysaccharide content, jack bean urease inhibition rate, and FAC (fat adsorption capacity). It could be inferred that the sample H had an effect on Helicobacter pylori inhibition and fat adsorption suppression according to urease inhibition rate and FAC, respectively.

• KEPCO Journal on Electric Power and Energy
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• v.5 no.2
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• pp.75-81
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• 2019

In this study 24 power transmission towers were selected by considering various variables such as power transmission capacity, height and structural type to evaluate their seismic performance using the standard design response spectrum recently announced by the government. In addition, the stresses and sectional forces generated by the current design wind loads and revised seismic ones were compared to review the effects on the design of power transmission towers when the government-required seismic standards were raised. The results of seismic performance evaluation for the target power transmission towers showed that they had seismic capacity of 0.31~0.91g, and that they met the level of the earthquake-resistant special grade, which is the 2,400-year earthquake return periods and secured seismic safety. Further, the sectional forces caused by earthquakes in the towers were 33~82.5% of the ones due to wind loads, and it was also confirmed that the design wind loads were more dominant than design earthquake ones under the elevated seismic standards.

• Journal of Advanced Navigation Technology
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• v.25 no.5
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• pp.357-362
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• 2021

UWB(ultra wide band) communication systems employ short pulses to transmit information which spreads the signal energy over a very wide frequency spectrum. Received signal-to-noise power ratio of UWB signals is an important factor in determining the accuracy of a positioning system. As the signal to noise power ratio gets higher, positioning errors decrease since noise becomes less effective. Calculation of signal to noise power ratio as a function of communication distance provides important guidelines for the system design. And the performance of a positioning system also depends heavily on the channel model. As a result of the analysis, it was found that the performance of the received signal to noise power ratio according to the communication distance was better in the LOS channel environment than in the Non LOS(line of sight) channel environment. And as the symbol interval of the preamble signal increases at a specific communication distance, the channel capacity of the UWB system increases.

• Journal of the Earthquake Engineering Society of Korea
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• v.26 no.3
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• pp.105-116
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• 2022

Seismic demand on nonstructural components (NSCs) is highly dependent on the coupled behavior of a combined supporting structure-NSC system. Because of the inherent complexities of the problem, many of the affecting factors are inevitably neglected or simplified based on engineering judgments in current seismic design codes. However, a systematic analysis of the key affecting factors should establish reasonable seismic design provisions for NSCs. In this study, an idealized 2-DOF model simulating the coupled structure-NSC system was constructed to analyze the parameters that affect the response of NSCs comprehensively. The analyses were conducted to evaluate the effects of structure-NSC mass ratio, structure, and NSC nonlinearities on the peak component acceleration. Also, the appropriateness of component ductility factor (R_p) given by current codes was discussed based on the required ductility capacity of NSCs. It was observed that the responses of NSCs on the coupled system were significantly affected by the mass ratio, resulting in lower accelerations than the floor spectrum-based response, which neglected the interaction effects. Also, the component amplification factor (a_p) in current provisions tended to underestimate the dynamic amplification of NSCs with a mass ratio of less than 15%. The nonlinearity of NSCs decreased the component responses. In some cases, the code-specified R_p caused nonlinear deformation far beyond the ductility capacity of NSCs, and a practically unacceptable level of ductility was required for short-period NSCs to achieve the assigned amount of response reduction.

• Animal Bioscience
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• v.37 no.6
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• pp.1041-1052
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• 2024

Objective: Bacillus subtilis, a kind of probiotic with broad-spectrum antibacterial function, was commonly used in livestock and poultry production. Recent research suggested that Bacillus subtilis may have antioxidant properties and improve immune response. This study aimed to verify the probiotic function of Bacillus subtilis in the production of broiler chickens. Methods: A total of 324 (1-day-old) Arbor Acres broilers were selected and randomly divided into three groups: basal diet group (Ctr Group), basal diet + antibiotic growth promoter group (Ctr + AGP) and basal diet + 0.5% Bacillus subtilis preparation group (Ctr + Bac). The experiment lasted for 42 days. Muscle, serum and liver samples were collected at 42 days for determination. Results: The results showed that Bacillus subtilis could decrease malondialdehyde content in the serum and liver (p<0.05) and increase superoxide dismutase 1 mRNA expression (p<0.01) and total superoxide dismutase (p<0.05) in the liver. In addition, compared with AGP supplementation, Bacillus subtilis supplementation increased interleukin-10 (IL-10) and decreased tumor necrosis factor-α and IL-1β level in the serum (p<0.05). At 45 minutes after slaughter Ctr + Bac presented a higher a^* value of breast muscle than Ctr Group (p<0.05), while significant change in leg muscle was not identified. Moreover, there was no difference in weight, shear force, cooking loss and drip loss of breast and leg muscle between treatments. Conclusion: Our results demonstrate that Bacillus subtilis in diet can enhance antioxidant capacity and optimize immune response of broilers.

• Smart Structures and Systems
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• v.8 no.4
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• pp.399-412
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• 2011

This study compares the performance of two smart isolation systems that utilize superelastic shape memory alloys (SMAs) for seismic protection of bridges using energy balance concepts. The first isolation system is a SMA/rubber-based isolation system (SRB-IS) and consists of a laminated rubber bearing that decouples the superstructure from the bridge piers and a SMA device that provides additional energy dissipation and re-centering capacity. The second isolation system, named as superelastic-friction base isolator (S-FBI), combines the superelastic SMAs with a flat steel-Teflon bearing rather than a laminated rubber bearing. Seismic energy equations of a bridge structure with SMA-based isolation systems are established by absolute and relative energy balance formulations. Nonlinear time history analyses are performed in order to assess the effectiveness of the isolation systems and to compare their performance. The program RSPMatch 2005 is employed to generate spectrum compatible ground motions that are used in time history analyses of the isolated bridge. Results indicate that SRB-IS produces higher seismic input energy, recoverable energy and base shears as compared to the S-FBI system. Also, it is shown that combining superelastic SMAs with a sliding bearing rather than rubber bearing significantly reduce the amount of the required SMA material.

• ETRI Journal
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• v.34 no.6
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• pp.892-899
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• 2012

We analyze a wideband spectrum in a cognitive radio (CR) network by employing the optimal adaptive multiband sensing-time joint detection framework. This framework detects a wideband M-ary quadrature amplitude modulation (M-QAM) primary signal over multiple nonoverlapping narrowband Gaussian channels, using the energy detection technique so as to maximize the throughput in CR networks while limiting interference with the primary network. The signal detection problem is formulated as an optimization problem to maximize the aggregate achievable secondary throughput capacity by jointly optimizing the sensing duration and individual detection thresholds under the overall interference imposed on the primary network. It is shown that the detection problems can be solved as convex optimization problems if certain practical constraints are applied. Simulation results show that the framework under consideration achieves much better performance for M-QAM than for binary phase-shift keying or any real modulation scheme.

• Journal of the Korea institute for structural maintenance and inspection
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• v.10 no.4
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• pp.175-184
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• 2006

Two methods of the nonlinear static pushover analysis have been presented for the performance-based seismic design and evaluation of MDOF continuous bridges. Guidelines for buildings presented in FEMA-273 applying the Displacement Coefficient Method (DCM) and in ATC applying the Capacity Spectrum Method(CSM) have been modified for MDOF bridges. Two methods are compared with the time- history analysis. The lateral load distribution pattern for seismic loads has been examined in the static pushover analysis. The force-based fiber frame finite element has been implemented in the modeling of reinforced concrete piers.