• 한국임상수의학회지
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• 제30권6호
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• pp.473-477
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• 2013

중성화한 수컷 7년 령의 Maltese가 요도결석으로 인한 요도루조성술 후에 3일 동안 지속된 빈혈 증상으로 충남대학교 동물병원에 진료 의뢰되었다. 수혈 후 복수 소견을 발견 하였다. 복수 검사 결과 Candida albicans 이 검출되었다. Candida albicans 에 의한 복막염으로 진단하여 항진균제로 fluconazole을 정맥 주사 하였다. 임상증상이 호전된 후 경구제로 전환 하였으며 진료 의뢰 후 37일후에 완전히 회복이 되었다. Candida albicans 복막염을 조기에 진단하고 치료를 하여 좋은 예후를 보인 증례였다.

• 대한방사선기술학회지:방사선기술과학
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• 제39권3호
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• pp.443-449
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• 2016

본 연구에서는 Candida albicans로 유도한 염증반응에 대해 스쿠알렌의 처치를 통해 염증반응을 경감시키는가에 대해 확인하였다. 실험동물은 (ICR계 생쥐) 각 실험군별 7마리씩을 사용하여 생체 내 실험을 하였다. Candida albicans-유도 염증인자 중 종양괴사인자-알파, 인터루킨-6, 산화질소는 ELISA kits 방법을 이용하여 관찰하였다. 실험을 통해 다음과 같은 결론을 얻었다. 1. Candida albicans를 감염시킨 군에서 1, 3일째 모두 신장조직 내에서의 산화질소 생성량을 감소시키는 것을 확인할 수 있었다 (p< 0.05). 2. 스쿠알렌 (80ml/kg)을 7일간 1일 1회 전 처치(복강투여)한 다음, Candida albicans를 감염시킨 군에서 3일째 군에서만 신장 조직 내에서의 종양괴사인자-알파 생성량을 감소시키는 것을 확인할 수 있었다(p< 0.05). 3. 스쿠알렌 (80m/kg)을 7일간 1일 1회 전 처치(복강투여)한 다음. Candida albicans를 감염 시킨 군에서 3일째 군에서만 신장 조직 내에서의 인터루킨-6 생성량을 감소시키는 것을 확인할 수 있었다(p< 0.05). 결론적으로 스쿠알렌이 Candida albicans-유도 염증인자들의 억제를 위해서는 예방적 차원에서 스쿠알렌을 공급하는 것이 효과가 있음을 알 수 있었다. 따라서 스쿠알렌 처치가 Candida albicans-유도 면역억제에 대해 회복 효과를 기대할 수 있을 것으로 사료된다.

• The Journal of Advanced Prosthodontics
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• 제9권5호
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• pp.402-408
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• 2017

PURPOSE. The goal of this study was to compare the adhesion of Candida albicans to the surfaces of CAD/CAM and conventionally fabricated complete denture bases. MATERIALS AND METHODS. Twenty discs of acrylic resin poly (methyl methacrylate) were fabricated with CAD/CAM and conventional procedures (heat-polymerized acrylic resin). The specimens were divided into two groups: 10 discs were fabricated using the CAD/CAM procedure (Wieland Digital Denture Ivoclar Vivadent), and 10 discs were fabricated using a conventional flasking and pressure-pack technique. Candida colonization was performed on all the specimens using four Candida albicans isolates. The difference in Candida albicans adhesion on the discs was evaluated. The number of adherent yeast cells was calculated by the colony-forming units (CFU) and by Fluorescence microscopy. RESULTS. There was a significant difference in the adhesion of Candida albicans to the complete denture bases created with CAD/CAM and the adhesion to those created with the conventional procedure. The CAD/CAM denture bases exhibited less adhesion of Candida albicans than did the denture bases created with the conventional procedure (P<.05). CONCLUSION. The CAD/CAM procedure for fabricating complete dentures showed promising potential for reducing the adherence of Candida to the denture base surface. Clinical Implications. Complete dentures made with the CAD/CAM procedure might decrease the incidence of denture stomatitis compared with conventional dentures.

• Mycobiology
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• 제38권4호
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• pp.328-330
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• 2010

In this study, we demonstrate that equol has fungicidal activities against Candida albicans. The minimum inhibitory and minimum fungicidal concentrations of equol against C. albicans were 516 and $1,032{\mu}M$, respectively. Two separate viability assays found that equol changed the integrity of the C. albicans cell membrane, possibly by formation of membrane lesions. Scanning electron microscopy demonstrated ultrastructural changes.

• 약학회지
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• 제47권3호
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• pp.190-194
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• 2003

As previously reported, an immunoglobulin M (IgM) monoclonal antibody (MAb) B6.1, specific for a cell wall B-l,2-mannotriose, was protective against vaginal infection due to Candida albicans when mice were treated with the antibody. In this study, the role of neutrophil was examined in the protective effect of MAb B6.1 against vaginal infection. To deplete neutrophils, mice were given intravenously rat anti-mouse neutrophile MAb RB6-8C5 prior to intraperitoneal administration of MAb B6.1 to these mice. The mice were examined for antibody in their reproductive tract. By an ELISA, MAb B6.1 was found in the vaginal homogenates, but no antibody was detected in vaginal lavage materials. The neutropenia was induced by a single dose of the anti-neutrophil antibody, but lymphocytes were also partially depleted. The protective effect of MAb B6.1 was decreased when mice pretreated with MAb RB6-8C5 were given the anti-Candida antibody before challenge with C. albicans yeast cells intravaginally. These results show that neutrophils are involved in the MAb B6.1 protection against Candida vaginal infection.

• Mycobiology
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• 제44권2호
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• pp.99-104
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• 2016

Candida spp. is an invasive infectious fungus, a major risk factor that can increase morbidity and mortality in hospitalized patients. In this study, 2,508 Candida spp. were isolated from various clinical specimens collected from university hospitals from July 2011 to October 2014. They were identified in order to determine isolation frequencies and characteristics by specimen, gender, age group, year, season, and month. The strain-specific isolation rate of Candida spp. is in the order of Candida albicans (1,218 strains, 48.56%), Candida glabrata (416 strains, 16.59%), Candida utilis (305 strains, 12.16%), Candida tropicalis (304 strains, 12.12%), and Candida parapsilosis (116 strains, 4.63%) and these five species accounted for more than 94% of the total strains. Of the specimens, Candida spp. were most frequently isolated from urine-catheter, followed by urinevoided, blood, sputum, other, open pus, vaginal discharge, Tip, ear discharge, bronchial aspiration and bile, in that order. Looking at the age distribution, the detection rate of patients in their 60s and older was significantly higher at 75.8% (1,900/2,508). The detection rate of patients in their 20s and younger was shown to be very low at 2.55% (64/2,508). By year, the detection rate of non-albicans Candida spp. showed a tendency to gradually increase each year compared with C. albicans. As isolation of Candida spp. from clinical samples at the specie level can vary depending on characteristics of the patient, sample, season, etc., continual studies are required.

• Journal of Oral Medicine and Pain
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• 제23권4호
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• pp.343-352
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• 1998

This experiment was performed to investigate effects of zinc containing solution on the major normal flora Staphylococccus aureus, Streptococus mutans and Candida albicans and to observe the variation according to anionic change and concentration difference. Zinc chloride, zinc iodide and zinc acetate solution were added to werially diluted broth culture so that each final concentration might be 0.25%, 0.5%. 1%. After that, 100ul of each aliquot was spreaded on each selective media plate( Mannitol Salts Agar plate for Staphylococcus aureus, Mitis Salivarius Agar plate for Streptococcus mutans and Sabouraud Destrose Agar plate for Candida albicans). The % killing was calculated bu CFU count after incubation under the appropriate condition. 1. zinc iodide, zinc chloride, and zinc acetate solutions showed inhibitory effects on Staphylococcus aureus, Streptococcus mutans and Candida albicans. 2. The inhibitory effects on Staphylococcus aureus were ranked in order of ainc iodide, zinc chloride and zinc actate. 3. The inhibitory effects on Streptococcus mutans were ranked in orfer of zinc iodide, zinc chloride and zinc acetate. 4. the inhibitory effects on Candida albicans showed no difference among zinc iodide, zinc chloride and zinc acetate. 5. The inhibitory effects of zinc chloride and zinc acetate on Staphylococcus aureus and Streptococcus mutnas showed increasing pattern as the concentration increase. But the inhibitory effects of zinc iodide on Staphylococcus aureus and Streptococcus mutans showed no apparent difference according to concentrations and it was the case with the inhibitory effects of zinc iodide, zinc chloride and zinc acetate on Candida albicans.

• 한국임상수의학회지
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• 제19권4호
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• pp.426-428
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• 2002

유산후 반복적인 자궁내 항생물질 주입의 병력이 있는 7세의 말이 자궁내막염을 나타내었다. 이 말은 자궁경관 점막의 충혈과 부종을 보였고, 회백색의 화농성 삼출액이 배설되었다. Candida albicans가 원인균으로 증명되었으며 이 진단은 자궁 삼출액의 직접 현미경 검사와 순수 배양물의 검사에 의해 증명하였다. 실험실적 디스크 확산실험에서 병원체가 amphotericin B, clotrimazole, fluconazole 및 nystatin 등 네 가지의 항진균제에 모두 감수성을 나타내었다. 4일간 nystatin 400,000 단위씩을 자궁내 주입하였더니 성공적으로 치유되었으며, 마지막 주입 후7일에 직접도말 검사와 배양에서 병원체가 다시 발견되지 않았다.

• 펄프종이기술
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• 제33권3호
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• pp.69-74
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• 2001

Diaper rash is found on the skin inside of babys diaper area. Most diaper rashes are caused by prolonged contact with the moisture, germs, and ammonia of the stool and urine. Some diaper rashes are caused by fungi infection such as candida albicans and Preteus vulgaris. In this study, Candida albicans was used as a test microorganism and experiment was carried out to inhibit diaper rash. Handsheets were treated with chitosan oligosaccharide, bamboo extractives, as well as mixture of monolaurin as an emulsifier and bamboo extractives. Both shake flask method and halo test were applied in order to examine the antimicrobial activity of each sample. It was found from both results of the halo test and shake flask method that handsheets treated with chitisan oligosaccharide or bamboo extractives showed antimicrobial property. In the treatment of bamboo extractives without emulsifier, no distinct difference in antimicrobial effect was found between bamboo branch and bamboo leaves extractives. In case of mixture of bamboo extractives and emulsifier, the result also suggested that bamboo branch showed better syngergistic effect than bamboo leaves. Both chitosan oligosaccharide and bamboo extractive can be used as antifungal agents against Candida albicans for making diaper.

• KSBB Journal
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• 제31권4호
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• pp.312-314
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• 2016

This study was carried out to determine the antifungal activity of $SeO_2$ against pathogenic fungus, Candida albicans. Concentration-dependent Inhibitory activity of $SeO_2$ against C. albicans was shown. When $400{\mu}g/disc$ of $SeO_2$ was tested, the inhibition size ranged from 20.7 to 26.8 mm (avg. 23.4 mm). MIC values of $SeO_2$ against cell growth of C. albicans ranged from 50 to $100{\mu}g/mL$ (avg. $70{\mu}g/mL$). These results could be applied to antibiotics-resistant C. albicans and other pathogenic fungi.