• Journal of Biosystems Engineering
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• 제26권1호
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• pp.1-10
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• 2001

Interactions between cage wheel and soil under the wet paddy field condition were analyzed. The cage wheel as a traction aid to driving tires of tractor was attached to the outside of the tires. The driving torque transmitted only to the cage wheel was measured and its effect on the total driving torque by both the tires and cage wheel was analyzed. Mathematical models were developed to predict the soil thrusts y a single lug and by the cage wheel with many lugs, respectively. Experimental results showed that as the diameter of cage wheel increased, positive effects of the cage wheel on the traction also increased. About 33-40% of the total traction force was obtained by the cage wheel with a diameter 1,182mm and 49-55% with a diameter 1,222mm. The peak thrust of the single lug of cage wheel increased by 31% and 59%, respectively when the diameter of the cage wheel increased from 1,182mm to 1,222mm and 1,262mm. The thrust by the cage wheel was estimated by using the developed mathematical models and the results were proved that the models are reliable for the estimation of the traction by the cage wheels.

• Journal of Korean Neurosurgical Society
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• 제60권6호
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• pp.691-700
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• 2017

Objective : The authors prospectively analyzed the effect of one-level or two-level anterior cervical discectomy and fusion (ACDF), comparing stand-alone cages and cage-with-plate fixation constructs with respect to clinical outcomes and radiologic changes. Methods : A total of 84 patients who underwent one-level (n=52) or two-level ACDF (n=32) for cervical disc disease and who completed 2 years of follow-up were included in this study. The patients were divided by cervical level and grouped into ACDF-Cage-only and ACDF-Cage-with-plate groups. The following parameters were assessed using radiographs : subsidence, C2-C7 lordosis angle, fusion segment angle, adjacent disc space narrowing, and fusion status. Clinical outcomes were assessed using the neck disability index (NDI) and visual analog scale scores for arm pain. Results : In the comparison of one-level ACDF-cage-only and ACDF-cage-with-plate groups, the NDI score was better in the cage-only group at the 3-, 12-, and 24-month follow-ups : however, no significant difference in clinical outcomes was observed. In the comparison of two-level ACDF-cage-only and ACDF-cage-with-plate groups, no difference in any clinical outcome was observed between the two groups. At the 24-month follow-up, subsidence was observed in 45.8% of patients in the one-level cage-only group and 32.1% of patients in the one-level cage-with-plate fixation group. There was no statistically significant difference in the incidence rate between the two groups (p=0.312). Subsidence in the two-level cage-only group (66.6%) was significantly more frequent than in the two-level cage-with-plate fixation group (30%; p=0.049). The fusion rate for patients in the one-level cage-only group was not significantly different from that in the one-level cage-with-plate fixation group (cage-only, 87.5%; cage-with-plate fixation, 92.9%; p=0.425) ; fusion rate in the two-level patients were also similar between groups (cage-only, 83.3%; cage-with-plate fixation, 95%; p=0.31). Conclusion : Our clinical results showed that for single-level cases, plate fixation had no additional benefit versus cage-only; for two-level ACDF cases, the fusion rate and clinical outcomes were similar, although the cage-with-plate fixation group had a lower incidence of cage subsidence than did the cage-only group. We conclude that physicians should be aware of this possible disadvantage associated with using cervical plates in one-level ACDF. However, in two-level ACDF, subsidence is more likely to occur without plate fixation, and thus the addition of plate fixation should be considered.

• Molecules and Cells
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• 제39권3호
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• pp.229-241
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• 2016

We have previously reported the role of miR-326-HDAC3 loop in anti-cancer drug-resistance. CAGE, a cancer/testis antigen, regulates the response to anti-cancer drug-resistance by forming a negative feedback loop with miR-200b. Studies investigating the relationship between CAGE and HDAC3 revealed that HDAC3 negatively regulated the expression of CAGE. ChIP assays demonstrated the binding of HDAC3 to the promoter sequences of CAGE. However, CAGE did not affect the expression of HDAC3. We also found that EGFR signaling regulated the expressions of HDAC3 and CAGE. Anti-cancer drug-resistant cancer cell lines show an increased expression of $pEGFR^{Y845}$. HDAC3 was found to negatively regulate the expression of $pEGFR^{Y845}$. CAGE showed an interaction and co-localization with EGFR. It was seen that miR-326, a negative regulator of HDAC3, regulated the expression of CAGE, $pEGFR^{Y845}$, and the interaction between CAGE and EGFR. miR-326 inhibitor induced the binding of HDAC3 to the promoter sequences in anti-cancer drug-resistant $Malme3M^R$ cells, decreasing the tumorigenic potential of $Malme3M^R$ cells in a manner associated with its effect on the expression of HDAC3, CAGE and $pEGFR^{Y845}$. The down-regulation of HDAC3 enhanced the tumorigenic, angiogenic and invasion potential of the anti-cancer drug-sensitive Malme3M cells in CAGE-dependent manner. Studies revealed that $PKC{\delta}$ was responsible for the increased expression of $pEGFR^{Y845}$ and CAGE in $Malme3M^R$ cells. CAGE showed an interaction with $PKC{\delta}$ in $Malme3M^R$ cells. Our results show that HDAC3-CAGE axis can be employed as a target for overcoming resistance to EGFR inhibitors.

• Journal of Korean Neurosurgical Society
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• 제66권6호
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• pp.703-715
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• 2023

Objective : This retrospective study investigated the factors that affect cage obliquity angle despite orthogonal maneuvers performed during oblique lateral interbody fusion (OLIF) and assessed the relationship between cage obliquity angle and radiological outcomes post-surgery. Methods : Twenty-nine males who underwent L4-L5 OLIF for lumbar degenerative disease between 2019 and 2021 with a followup duration greater than 12 months were analyzed. Radiological parameters were measured including psoas muscle volume, total psoas area index (total psoas muscle area [cm²]/height squared [m²]), distance from the iliac artery to the origin of the psoas muscle (DIAPM), angle between the origin of the psoas muscle and the center of the vertebral disc (APCVD), iliac crest height, disc height, lumbar flexibility (lumbar flexion angle minus extension angle), cage location ratio, cage-induced segmental lumbar lordosis (LL) (postoperative index level segmental LL minus used cage angle), foraminal height changes, fusion grade. Results : DIAPM, APCVD, iliac crest height, postoperative index level segmental LL, and cage-induced segmental LL were significantly correlated with OLIF cage obliquity angle. However, other radiological parameters did not correlate with cage obliquity. Based on multiple regression analysis, the predictive equation for the OLIF cage obliquity angle was 13.062-0.318×DIAPM+0.325×1APCVD+0.174×iliac crest height. The greater the cage obliquity, the smaller the segmental LL compared to the cage angle used. Conclusion : At the L4-L5 level, OLIF cage obliquity was affected by DIAPM, APCVD, and iliac crest height, and as the cage obliquity angle increases, LL agnle achievable by the used cage could not be obtained.

• 한국신뢰성학회지:신뢰성응용연구
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• 제14권4호
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• pp.243-247
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• 2014

The Spinal cage is the cage-shaped implantable medical device used to treat structural abnormalities caused by degenerative intervertebral disks. In order to secure enough space to provide the mechanical stability and the intervertebral fusion, after removing the intervertebral disc, the Spinal cage is transplanted between the intervertebral space. A hammer is used to push the spinal cage into a narrow space during the spinal cage transplant surgery. Due to the impact and pressure, damage occurs frequently on the spinal cage. In this study, a test model is constructed to measure the value of impulse generally applied on the Spinal cage. The figures of internal impulse before and after the improvement of the Spinal cage are then compared to suggest direction to improve the reliability of the spinal cage.

• 수산해양기술연구
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• 제35권2호
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• pp.201-208
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• 1999

To develop a new fish cage which is required for offshore or moving cage culturing system has been gradually increased against being closely dense of fish cage in shallow water. Though submersible fish cage culturing system is essential technology for converting from shallow water into the offshore, it was pointed out the serious problem about stability of which are sinking and floating state. This study is presented conceptual design of submersible fish cage centered with a mooring steel pile to acquire stability and faculty. Design of mooring steel pile for submersible fish cage culturing system needs to carry out optimal design of mooring steel pile for which much efforts are required. Formulation and optimal design process of submersible fish cage are organized into using Sequential Quadratic Programming method of numerical optimization. For submersible fish cage system centered with a mooring steel pile, process of the optimal design is proposed and the optimal solutions are obtained.

• Wind and Structures
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• 제36권1호
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• pp.31-40
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• 2023

This paper investigates the mechanical behavior of full-scale offshore fish cages under hydrodynamic loads. To simulate different cases, different materials were used in the fish cage and analyzed under different flow velocities. The cage system is studied in two parts: net cage and floating collar. Analyses were performed with the ANSYS Workbench program, which allows the Finite Element Method (FEM) and Computational Fluid Dynamics (CFD) method to be used together. Firstly, the fish cage was designed, and adjusted for FSI: Fluid (Fluent) analysis. Secondly, mesh structures were created, and hydrodynamic loads acting on the cage elements were calculated. Finally, the hydrodynamic loads were transferred to the mechanical model and applied as a pressure on the geometry. In this study, the equivalent (von Mises) stress, equivalent strain, and total deformation values of cage elements under hydrodynamic loads were investigated. The data obtained from the analyses were presented as figures and tables. As a result, it has been shown that it is appropriate to use all the materials examined for the net cage and the floating collar.

• 수산해양기술연구
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• 제46권1호
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• pp.20-31
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• 2010

In this research, the submersible fish cage was designed to avoid structural and biological damage during harsh sea conditions. The submersible cage system consists of netting, mooring ropes, a floating collar, floats, sinkers and anchors. Whole elements of the cage were modeled on the mass-spring model. The computer simulations were carried out to investigate the dynamic behavior of the cage and to calculate mooring line tension subjected to tidal currents and waves. As expected, the tension values in the mooring line of the submerged position are 36% less compared to that of the surface cage under the same loading conditions. As the wave was used in combination with the current velocity of 1m/s, the average tensile load for the submerged cage showed 85% of the value for the floating cage. The simulation results provide an improved understanding of the behaviors of the structure and valuable information on the optimized design of the cage system exposed to open ocean environmental factors.

• 수산해양기술연구
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• 제50권2호
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• pp.176-184
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• 2014

Nowadays, consumption of fisheries products is increasing. There are several factors, one of which is a quantitative development through aquaculture. Another factor is an increase qualitative consumption of fish which require that fish be supplied alive. This requires a lot of technical effort to transport the live fish that have low survival rate (c.f. tuna and mackerel) in coastal waters and in the open sea. To develop a towing cage for transporting the live fish, model test in a circulate water channel and simulation by computer tool were carried out. In order to spread vertically, floats were attached at the upper part of the cage, and iron chains attached at the lower part of the cage. For horizontal spreading, kites were attached on the cage. The tension and spreading performance of the cage were measured. The result shows that the tension and reduction ratio of inside volume of the cage were tended to increase with increased towing speeds. The suitable operation condition in towing cage was 1.0 m/s towing speeds with vertical spreading force 8.7 kN, horizontal spreading force 5.6 kN; in this case the reduction ratio of inside volume of the cage was estimated as 25%.

• 수산경영론집
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• 제52권2호
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• pp.33-54
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• 2021

This study is aimed to analyze the economic feasibility of yellowtail culture using the copper alloy net cage in Gyeongsangbuk-do. First of all, in order to evaluate the copper alloy net cage on yellowtail culture, I review the trend on the yellowtail culture industry and research the concept of copper alloy net cage. The copper-alloy net cage is now recognized as an advantages of its system stability, recycling, antibiosis and food safety. The results were summarized as follows: first, there was significant meaning of the profit model of yellowtail culture by the price difference. Second, I analyzed in the economic feasibility of yellowtail culture using the copper alloy net cage, internal rate of return (IRR) was 51.58%, a benefit-cost ratio was shown to be 2.27 and net present value (NPV) was 1,087,337 thousand won, which indicates the economic feasibility of yellowtail culture using the copper alloy net cage is profitable. Finally, in order to improve the economic valuation, it is necessary to focus more on the developing of technology and cost reduction strategy on the copper alloy net cage.