• Elastomers and Composites
• /
• v.16 no.3
• /
• pp.178-192
• /
• 1981

• Journal of Digital Convergence
• /
• v.13 no.8
• /
• pp.503-514
• /
• 2015

The effects of Flavonol contents from Ginkgo biloba leaf on anti-atopy activity have not rarely been verified. This study is to investigate the effects of flavonol on Th2 cytokine production in MC/9 mast cells. For this, flavonol was analyzed by ELISA and Real-time PCR. Analysis results showed that flavonol significantly suppressed production of Th2 cytokines(IL-13, MIP-1a) in a dose dependent manner. The mRNA expression of IL-4, IL-5, IL-13, TNF-a were effectively restrained by Flavonol at the concentration 25,50,$100{\mu}g/m{\ell}$. And decrease of expression of NFAT-1, c-jun protein was confirmed by western blot analysis. These results indicate that flavonol has effects of decreasing the Th2 cytokine production in the MC/9 mast cell causing inhibition of transcription factors such as NFAT-1, c-jun. Thus, we would like to brief that flavonol may have the applicability as therapeutic agent for atopic dermatitis.

• Molecules and Cells
• /
• v.40 no.11
• /
• pp.837-846
• /
• 2017

As a component of the neurovascular unit, cerebral smooth muscle cells (CSMCs) are an important mediator in the development of cerebral vascular diseases such as stroke. Epoxyeicosatrienoic acids (EETs) are the products of arachidonic acid catalyzed by cytochrome P450 epoxygenase. EETs are shown to exert neuroprotective effects. In this article, the role of EET in the growth and apoptosis of CSMCs and the underlying mechanisms under oxygen glucose deprivation (OGD) conditions were addressed. The viability of CMSCs was decreased significantly in the OGD group, while different subtypes of EETs, especially 14,15-EET, could increase the viability of CSMCs under OGD conditions. RAPA (serine/threonine kinase Mammalian Target of Rapamycin), a specific mTOR inhibitor, could elevate the level of oxygen free radicals in CSMCs as well as the anti-apoptotic effects of 14,15-EET under OGD conditions. However, SP600125, a specific JNK (c-Jun N-terminal protein kinase) pathway inhibitor, could attenuate oxygen free radicals levels in CSMCs as well as the anti-apoptotic effects of 14,15-EET under OGD conditions. These results strongly suggest that EETs exert protective functions during the growth and apoptosis of CSMCs, via the JNK/c-Jun and mTOR signaling pathways in vitro. We are the first to disclose the beneficial roles and underlying mechanism of 14,15-EET in CSMC under OGD conditions.

• Proceedings of the Korean Society of Applied Entomolohy Conference
• /
• 2004.05a
• /
• pp.66-66
• /
• 2004

• Proceedings of the Korean Nuclear Society Conference
• /
• 2004.10a
• /
• pp.225-226
• /
• 2004

• 프린팅코리아
• /
• s.5
• /
• pp.54-57
• /
• 2002

1971년 충무로에서 조그마한 인쇄사로 출발하여 30여년 만에 코스닥 상장회사로 정장한 한진 P&C. 한진 P&C가 생산하는 통기성 필름은 국내외에서 최고의 기술력을 자랑한다. 이 회사가 생산하는 각종 상업 인쇄물도 최고의 품질로 인정받아 수출물량이 매년 증가하고 있다. 이에 창업주 이종상 회장을 만나 30여년 만에 코스닥 상장기업으로 성장할 수 있었던 배경과 앞으로의 계획 등을 들어봤다.

• Proceedings of the Materials Research Society of Korea Conference
• /
• 2007.11a
• /
• pp.108.1-108.1
• /
• 2007

• 프린팅코리아
• /
• v.12 no.8
• /
• pp.92-93
• /
• 2013

(주)리코코리아(대표 사카이 하루히사)가 지난 6월25일 서울시 서초구 서초대로에 위치한 본사에서 RICOH Pro C751EX Taurus 전시회를 개최했다. 지난 4월 1일 한국에 공식 출범한 리코코리아는 이날 행사를 통해 RICOH Pro C751EX Taurus 제품을 공개하고, 국내 디지털 인쇄 시장 진출을 공식화했다.

• Bulletin of the Korean Chemical Society
• /
• v.10 no.1
• /
• pp.114-116
• /
• 1989

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.14
• /
• pp.5667-5672
• /
• 2014

Folate receptor alpha ($FR{\alpha}$) mediates folate uptake by endocytosis, and while folate is essential to DNA methylation and synthesis and may have an important role in proliferating cells. $FR{\alpha}$ is known to be expressed in rapidly proliferating cells, including many cancer cell lines, but there has been no systematic assessment of expression in cervical cancer cell lines. The aim of the present study was to evaluate the effects of $FR{\alpha}$ on proliferation and apoptosis of cervical cells and correlation mechanism. In this study, we investigated the biological function of $FR{\alpha}$ in Hela cells using RNA interference. Cell proliferation was evaluated by Cell Counting Kit-8 (CCK8) assay, while cell cycling and apoptosis were assessed by flow cytometry, mRNA levels by real time-PCR and protein levels of $FR{\alpha}$, c-Fos and c-Jun by Western blotting. The results revealed that $FR{\alpha}$ was highly expressed in Hela cells and its silencing with a small interfering RNA (siRNA) inhibited cell proliferation and induced cell apoptosis, arresting the cell cycle in G0/G1 stages while decreasing the proportion in S and G2/M stages, and suppressed the expression levels of c-Fos and c-Jun. In conclusion, the results of this study indicated that $FR{\alpha}$ down-regulation might be capable of suppressing cervical cancer cell proliferation and promoting apoptosis. It suggested that $FR{\alpha}$ might be a novel therapeutic target for cervical cancer.