• 통합자연과학논문집
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• 제15권4호
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• pp.153-161
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• 2022

c-Jun N-terminal kinases (JNKs) are members of MAPK family. Many genes can relay signals that promote inflammation, cell proliferation, or cell death which causes several diseases have been associated to mutations in the JNK gene family. The JNK2 gene is significantly more important in cancer development than the JNK1 and JNK3 genes. There are several different ways in which JNK2 contributes to breast cancer, and one of these is through its role in cell migration. As a result, this study's primary objective was to employ computational strategies to identify promising leads that potentially target the JNK2 protein in a strategy to alleviate breast cancer. We have derived these anticancer compounds from marine brown seaweed called Turbinaria conoides. We have identified compounds Ethane, 1, 1-diethoxy- and Butane, 2-ethoxy as promising anti-cancer drugs by molecular docking, DFT, and ADME study.

• 한국안전학회지
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• 제22권3호
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• pp.98-104
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• 2007

산업사회의 발전과 더불어 인간의 삶에 대한 욕구도 날로 급변하고 있으며, 주 40시간제가 도입되면서 피크닉을 즐기는 세대가 늘어나고 있는 실정이다. 또한 가스에 의한 사고는 토요일과 일요일에 가장 많이 발생하고 있다. 따라서 가스안전교육원에서는 이러한 가스의 폭발사고에 대한 영향이 매우 위험하다는 것을 교육생에게 알려 현장에서 가스안전관리에 만전을 기하도록 하고자 폭발실험을 실시하고 있다. 본 논문에서는 이러한 폭발실험으로 교육에 참관하는 교육생에게 미치는 영향을 알아보고자 폭발로 인한 과압은 Hopkinson의 삼승근법을 이용하여 계산하고, 인간에게 미치는 영향은 Probit 모델에 적용하여 사고피해예측을 평가하였다. 폭발위치에서 50m 떨어진 곳에서의 피크과압은 1.35kPa이고, 25m 떨어진 곳에서는 3.2kPa이다. 이 값은 Probit 모델에 적용하면 손상가능성이 0%로 나타났다.

• 한국신재생에너지학회:학술대회논문집
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• 한국신재생에너지학회 2009년도 추계학술대회 논문집
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• pp.218-221
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• 2009

Solid oxide fuel cells (SOFCs), as high-temperature fuel cells, have various advantages. In some merits of SOFCs, high temperature operation can lead to the capability for internal reforming, providing fuel flexibility. SOFCs can directly use CH4 and CO as fuels with sufficient steam feeds. However, hydrocarbons heavier than CH4, such as ethylene, ethane, and propane, induce carbon deposition on the Ni-based anodes of SOFCs. In the case of the ethylene steam reforming reaction on a Ni-based catalyst, the rate of carbon deposition is faster than among other hydrocarbons, even aromatics. In the reformates of heavy hydrocarbons (diesel, gasoline, kerosene and JP-8), the concentration of ethylene is usually higher than other low hydrocarbons such as methane, propane and butane. It is importatnt that ethylene in the reformate is removed for stlable operation of SOFCs. A new methodology, termed post-reforming was introduced for removing low hydrocarbons from the reformate gas stream. In this work, activity tests of some post-reforming catalysts, such as CGO-Ru, CGO-Ni, and CGO-Pt, are investigated. CGO-Pt catalyst is not good for removing ethylene due to low conversion of ethylene and low selectivity of ethylene dehydrogenation. The other hand, CGO-Ru and CGO-Ni catalysts show good ethylene conversion, and CGO-Ni catalyst shows the best reaction selectivity of ethylene dehydrogenation.

• International Journal of Automotive Technology
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• 제7권4호
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• pp.407-413
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• 2006

The liquefied petroleum gas(LPG), mixture of propane and butane, has the potential to reduce toxic hydrocarbon emissions and inhibit ozone formation due to its chemical composition. Conventional mixer systems, however, have problems in meeting the future lower emission standards because of the difficulty in controlling air-fuel ratio precisely according to mileage tar accumulation. Liquid Phase LPG injection(LPLi) system has several advantages in more precise fuel metering and higher engine performance than those of the conventional mixer type. On the other hands, leakage problem of LPLi system at the injector tip is a main obstacle for meeting more stringent future emission regulations because these phenomena might cause excessive amount of THC emission during cold and hot restart phase. The main focus of this paper is the development of a leaked fuel recirculation system, which can eliminate the leaked fuel at the intake system with the activated carbon canister. Leaked fuel level was evaluated by using a fast response THC analyzer and gas chromatography. The result shows that THC concentration during cold and hot restart stage decreases by over 60%, and recirculation system is an effective method to meet the SULEV standard of the LPLi engine.

• 한국유체기계학회 논문집
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• 제12권1호
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• pp.16-21
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• 2009

In the last five years, 91 accidents from portable gas ranges and non-refillable metallic gas cartridges have occurred. The gas cylinder installed with a relief valve was developed to prevent an explosive accident from the gas cartridge. In this study it was carried out to evaluate the safety of a gas cylinder mounted with a relief valve which can prevent an explosion. Under the real using condition and the extreme condition the gas cylinder is heated with an electric heater. Simultaneously, the operating pressure is checked and the suitability of releasing flux is evaluated. And the possibility of fire or explosion was tested when the gas was released from the relief valve at the real using condition. Using a numerical simulation method, the diffusion of butane gas released from a relief valve was visualized.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.280.2-281
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• 2002

This presentation reports the trends of the drug abuses(DA) and the mortalities related to drug-toxicants(MDT) in the Central area of Korea in 2001. We surveyed the DA cases and MDT. which were requested to analyze the drug-toxicants in the Central district office of National Institute of Scientific Investigation. he detected drugs on DA cases were methamphetamine. marihuana. opiates. inhalants(toluene. butane. ropane). dextromethorphane. carisoprodol. benzodiazepines, nalbuphine. fenfluamine. and iscellaneous in order of cases. Men are more liable to drug abuses than women. and the most common age group was 30s. Surveys of MDT shows that the defected toxicants are paraquat(sedative). methomy(insecticide). dicholrvos (insecticide). benxodiaxeqines(anxiolytic), and miscellaneous in order do cases. Men's intoxications by the drug-toxicants are more occured than woman's And most common intoxicated age group was 40s. These trends of the DA cases and the MDT in Central Area fo Korea. can help the forensic toxicologists and government to plan the prevention policy of the DA cases and MDT as well as its future estimation.

• 한국분무공학회지
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• 제8권1호
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• pp.9-15
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• 2003

The liquid phase LPG injection (LPLI) system is considered as one of the next generation fuel supply systems for LPG, vehicles, since it can accomplish the higher power, higher efficiency, and lower emission characteristics than the existing mixer type fuel supply system. However, during the injection of liquid LPG fuel into the inlet duct of an engine, a large quantity of heat is extracted due to evaporation of fuel. A problem is that the moisture in the air freezes around the outlet of a nozzle, which is called icing Phenomenon. It may cause damage to the outlet nozzle of an injector. The frozen ice deposit detached from the nozzle also may cause a considerable damage to the inlet valve or valve seat. In this work, the experimental investigation of the icing phenomenon was carried out. The results showed that the icing phenomenon and process were mainly affected by humidity of inlet air instead of the air temperature in the inlet duct. Also, it was observed that the icing occurs first in the inlet of a nozzle, and grows considerably at the upper part of the nozzle inlet and the opposite side of the nozzle entrance. An LPG fuel, mainly consisting of butane, has lower latent heat of vaporization than that of propane, which is an advantage in controlling the icing phenomenon.

• Journal of Advanced Marine Engineering and Technology
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• 제28권5호
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• pp.754-761
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• 2004

In this paper, evaporating heat transfer characteristics in the refrigeration and air-conditioning facilities were studied using the environmentally friendly refrigerants R-1270 (Propylene). R-290 (Propane). R-600a (Iso-butane) and HCFC refrigerant R-22 The test tube was surrounded by an annulus with water flowing counter to the refrigerant. The tube is copper. with an outside diameter of 12.7mm and the wall thickness of 1.315mm. The test results showed that the local evaporating heat transfer coefficients of hydrocarbon refrigerants were superior to that of R-22 and the maximum increasing rate of heat transfer coefficient was found in R-1270. The average evaporating heat transfer coefficient increased with the increase of the mass velocity and it showed the higher values in hydrocarbon refrigerants than R-22 Comparing the heat transfer coefficient of experimental results with that of other correlations. the presented results had agood agreement with the Kandlikar's correlation. This results form the investigation can be used in the design of heat transfer exchangers using hydrocarbons as the refrigerant for the air-conditioning systems.

• Bulletin of the Korean Chemical Society
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• 제26권1호
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• pp.38-42
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• 2005

Bis(2-methylbenzaldehyde)butane-2,3-dihydrazone(TDSB) was used as new N-N Schiff's base which plays the role of an excellent ion carrier in the construction of a La(III) membrane sensor. The best performance was obtained with a membrane containing, 30% poly(vinyl chloride), 60% benzyl acetate, 6% TDSB and 4% sodium tetraphenyl borate. This sensor reveals a very good selectivity towards La(III) ions over a wide variety of cations, including alkali, alkaline earth, transition and heavy metal ions. The proposed electrode exhibits a Nernstian behavior (with slope of 19.8 mV per decade) over a wide concentration range (1.0 ${\times}$ 10$^{-5}$-1.0 ${\times}$ 10$^{-1}$ M). The detection limit of the sensor is 7.0 ${\times}$ 10$^{-6}$ M. It has a very short response time, in the whole concentration range ($\sim$5 s), and can be used for at least twelve weeks in the pH range of 3.0-9.4. The proposed sensor was successfully applied as an indicator electrode for the potentiometric titration of a La(III) solution, with EDTA. It was also successfully applied in the determination of fluoride ions in three mouth wash preparations.

• 한국수소및신에너지학회논문집
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• 제22권5호
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• pp.699-705
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• 2011

A combined heat and power cogeneration system driven by low-temperature sources is investigated by the first and second laws of thermodynamics. The system consists of Organic Rankine Cycle (ORC) and an additional process heater as a series circuit. Seven working fluids of R152a, propane, isobutane, butane, R11, R123, isopentane and n-pentane are considered in this work. Maximum mass flow rate of a working fluid relative to that of the source fluid is considered to extract maximum power from the source. Results indicate that the second-law efficiency can be significantly increased due to the combined heat and power generation. Furthermore, higher source temperature and lower turbine inlet pressure lead to lower second-law efficiency of ORC system but higher that of combined system. Results also show that the optimum working fluid varies with the source temperature.