• Genomics & Informatics
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• 제16권4호
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• pp.29.1-29.5
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• 2018

Hybrid capture-based targeted sequencing is being used increasingly for genomic variant profiling in tumor patients. Unique molecular index (UMI) technology has recently been developed and helps to increase the accuracy of variant calling by minimizing polymerase chain reaction biases and sequencing errors. However, UMI-adopted targeted sequencing data analysis is slightly different from the methods for other types of omics data, and its pipeline for variant calling is still being optimized in various study groups for their own purposes. Due to this provincial usage of tools, our group built an analysis pipeline for global application to many studies of targeted sequencing generated with different methods. First, we generated hybrid capture-based data using genomic DNA extracted from tumor tissues of colorectal cancer patients. Sequencing libraries were prepared and pooled together, and an 8-plexed capture library was processed to the enrichment step before 150-bp paired-end sequencing with Illumina HiSeq series. For the analysis, we evaluated several published tools. We focused mainly on the compatibility of the input and output of each tool. Finally, our laboratory built an analysis pipeline specialized for UMI-adopted data. Through this pipeline, we were able to estimate even on-target rates and filtered consensus reads for more accurate variant calling. These results suggest the potential of our analysis pipeline in the precise examination of the quality and efficiency of conducted experiments.

• 한국농촌건축학회논문집
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• 제17권1호
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• pp.113-120
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• 2015

In recent years, the population composition of rural area is changing due to the decreasing population growth of the aged with disability and people returning to farming. Since 1970's the rural community facilities have been spreaded out across most rural villages. Although the rural community facilities are the most widely used facilities, the existing facilities are need to be new built or remodeled according to demographic changes, usage of facilities, and environmental condition. Given this reality, the rural community facilities such as village assembly hall and nursing home for senior citizen are not only used for daily life place but also used like co-residence having meals and sleeping together. Therefore the rural community facilities have the potential to become welfare service space for rural elderly people. This research focuses on the current situation of universal design applied community facilities. According to the research, most of the village community facilities were built in the 1990s and 82% of the buildings were more than 15 years old. Furthermore, 45% of the village community facilities more than 15 years old most have a ground floor in masonry structure. The area of the building is 65% less than $100m^2$. The width of the access entrance, the height of the sink, gas safety valve and so forth were relatively well designed. However, the handrail of the entrance, space in front of the toilet bowl, the height difference between the entrance and floor, the installation of the width of the ramp and stair handrail was relatively incomplete. Village community facilities to be built in the future should be universal design fundamentally.

• Earthquakes and Structures
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• 제11권6호
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• pp.1101-1121
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• 2016

Base isolation, one of the popular seismic protection approaches proven to be effective in practical applications, has been widely applied worldwide during the past few decades. As the techniques mature, it has been recognised that, the biggest issue faced in base isolation technique is the challenge of great base displacement demand, which leads to the potential of overturning of the structure, instability and permanent damage of the isolators. Meanwhile, drain, ventilation and regular maintenance at the base isolation level are quite difficult and rather time- and fund- consuming, especially in the highly populated areas. To address these challenges, a number of efforts have been dedicated to propose new isolation systems, including segmental building, additional storey isolation (ASI) and mid-storey isolation system, etc. However, such techniques have their own flaws, among which whipping effect is the most obvious one. Moreover, due to their inherent passive nature, all these techniques, including traditional base isolation system, show incapability to cope with the unpredictable and diverse nature of earthquakes. The solution for the aforementioned challenge is to develop an innovative vibration isolation system to realise variable structural stiffness to maximise the adaptability and controllability of the system. Recently, advances on the development of an adaptive magneto-rheological elastomer (MRE) vibration isolator has enlightened the development of adaptive base isolation systems due to its ability to alter stiffness by changing applied electrical current. In this study, an innovative semi-active storey isolation system inserting such novel MRE isolators between each floor is proposed. The stiffness of each level in the proposed isolation system can thus be changed according to characteristics of the MRE isolators. Non-dominated sorting genetic algorithm type II (NSGA-II) with dynamic crowding distance (DCD) is utilised for the optimisation of the parameters at isolation level in the system. Extensive comparative simulation studies have been conducted using 5-storey benchmark model to evaluate the performance of the proposed isolation system under different earthquake excitations. Simulation results compare the seismic responses of bare building, building with passive controlled MRE base isolation system, building with passive-controlled MRE storey isolation system and building with optimised storey isolation system.

• 한국신재생에너지학회:학술대회논문집
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• 한국신재생에너지학회 2011년도 추계학술대회 초록집
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• pp.47.1-47.1
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• 2011

We report on a direct measurement of two-dimensional chemical and electrical distribution on the surface of photovoltaic Cu(In,Ga)$Se_2$ thin-films using a nano-scale spectroscopic and electrical characterization, respectively. The Raman measurement reveals non-uniformed surface phonon vibration which comes from different compositional distribution and defects in the nature of polycrystalline thin-films. On the other hand, potential analysis by scanning Kelvin probe force microscopy shows a higher surface potential or a small work function on grain boundaries of the thin-films than on the grain surfaces. This demonstrates the grain boundary is positively charged and local built-in potential exist on grain boundary, which improve electron-hole separation on grain boundary. Local electrical transport measurements with scanning probe microscopy on the thin-films indicates that as external bias is increases, local current is started to flow from grain boundary and saturated over 0.3 V external bias. This accounts for carrier behavior in the vicinity of grain boundary with regard to defect states. We suggest that electron-hole separation at the grain boundary as well as chemical and electrical distribution of polycrystalline Cu(In,Ga)$Se_2$ thin-films.

• 인터넷정보학회논문지
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• 제20권4호
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• pp.13-19
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• 2019

애플의 어플리케이션 마켓인 App Store에 어플리케이션을 등록하기 위해서는 애플 검증 센터를 통해 엄격한 검증 과정을 통과해야 한다. 그렇기 때문에 스파이웨어 어플리케이션의 유입이 까다롭다. 하지만 정상적인 어플리케이션의 취약점을 통해서도 악성코드가 실행될 수 있다. 이러한 공격을 방지하기 위해서는 어플리케이션에서 발생할 수 있는 잠재적 취약점을 패치하기 위해 조기에 발견하고 분석하는 연구가 필요하다. 잠재적 취약점을 증명하기 위해서는 취약점의 근본 원인을 파악하고 악용 가능성을 분석해야 한다. iOS 어플리케이션을 분석하는 도구로는 개발 도구인 Xcode에 내장되어 있는 LLDB라는 이름의 디버거를 활용할 수 있다. LLDB에는 다양한 기능이 존재하며 이 기능들은 API로도 제공되어 Python에서도 사용이 가능하다. 따라서 본 논문에서 LLDB API를 활용하여 iOS 어플리케이션의 잠재적 취약점을 효율적으로 분석하는 방법에 대해 제안한다.

• 한국방재학회 논문집
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• 제1권2호
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• pp.123-137
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• 2001

본 연구는 우리나라의 도시재해의 특성과 자료확보 가능성을 기반으로 청주를 사례로 화재, 시설, 피난위험도에 한정하여 재해위험도 평가모형을 제시하고 있다. 평가기준에 있어 동별 기준으로 화재위험도는 화재발생건수와 피해액을 기준으로 하고 있으며, 시설위험도의 경우 중점관리시설의 개소 수와 관리등급을 기준으로 하고 있고, 피난위험도는 지목별 면적과 지목별 가중치로 모형을 설정하였다. 청주시에 대한 모형 적용 결과 화재위험도는 불량주거지역과 생활편익시설이 집중되어 있는 중심 상업지역내의 시가화구역이 상대적으로 높게 나타났으며, 반대로 시설위험도와 피난위험도는 신흥 아파트 밀집지역과 구주거지역 모두가 높게 나타났다 종합위험도에 있어서는 중심상업지역과 그 주변밀집주거지역에서 높은 점수를 나타내는 것으로 판명되었다.

• 한국주거학회논문집
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• 제24권4호
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• pp.97-107
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• 2013

The purpose of this paper is to investigate the planning characteristics of certain cases of elderly welfare housing (hitherto EWH), and analyze any problems by comparing this against the actual needs of potential residents. To this end, 38 distinct housing plans from twelve EWH built after 2005 were examined, and a survey on housing needs was taken by 198 people between 48 and 62 years of age. The results are as follows: Firstly, the most common size found among the 10 cases was 42-66 $m^2$, however larger sizes are becoming more frequent. The most popular response on the survey was one favoring smaller housing options. Secondly, the most common floor plan examined consisted of 1 bedroom + LDK and 2 bedroom + LDK. Likewise, the survey reflected that 1 or 2 bedroom housing was preferred. Thirdly, a floor plan composed of a smaller bedroom and LDK is commonly found in smaller floor plans of EWH. The survey reflected potential residents preferred this same style of floor plan, with a smaller bedroom and LDK set up. However, lower-income participants preferred a single, larger bedroom which also can serve as a living space, to go along with a kitchen/dining room (DK). Fourthly, 2 bedroom housing typically included a single bathroom, however the survey indicated that participants preferred a second bathroom to go along with a second bedroom. Consequently, the planning of elderly welfare housing is to a large extent meeting the demands of its potential residents, however house size and the planning of bathrooms have yet to meet these demands, especially with potential lower-income residents when it comes to housing size and space composition.

• 대한토목학회논문집
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• 제31권4D호
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• pp.547-553
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• 2011

본 연구는 대중교통취약지역 평가척도인 이동성 지표와 잠재수요에 대한 개념을 새로 정립하고 이들 지표를 적용하여 대중교통이동성 취약지역 선정과 이들 지역 간을 연결하는 대중교통 직결노선 선정방법을 제시하였다. 이동성 지표와 잠재수요평가지표를 적용하여 4개 대도시권의 대중교통 취약지역을 선정하고 이들 지역 간을 운행하는 직결 버스 노선을 사례연구를 통해 분석하였다. 분석결과 대중교통 이동성 사각지대는 대중교통통행시간이 승용차에 비해 현저히 높게 소요되거나 대중교통노선의 서비스가 제공되지 않은 지역으로 분석되었다. 또한, 이러한 대중교통취약지역을 해소하기 위한 직결버스노선은 대중교통통행시간을 승용차 통행시간과 동등한 수준을 유지할 수 있도록 자동차 전용도로로 운행하고 승 하차로 인한 통행시간 손실을 최소화 시키고 연계를 극대화 할 수 있는 노선체계가 구축되어야 할 것으로 분석되었다.

• Environmental Engineering Research
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• 제19권2호
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• pp.175-184
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• 2014

Weirs are conventional structures that control water level and velocity in streams to facilitate water resource management. Despite many weirs built in streams, there is little information how weirs change hydrology regime and how that translates to sediment and phosphorus (P) responses. This study evaluated the influence of weirs on P retention and mobilization in an urban tributary of the Han River in Korea. Total P concentrations in sediments upstream of weirs were higher than the downstream site, mainly due to the increase of potentially available fractions (labile P and aluminum- and iron-bound P) (p < 0.05). Equilibrium phosphorus concentrations ($EPC_o$) were lower than soluble reactive phosphorus (SRP) concentrations of stream waters, but there was an increasing trend of sediment $EPC_o$ upstream of weirs compared to the downstream site (p < 0.001) indicating a greater potential for P release upstream of weirs. Sediment core incubation showed that SRP release rates upstream of weirs were higher than the downstream site under anoxic conditions of the water column (p < 0.01), but not under oxic conditions. SRP release rates under anoxic conditions were greater than that measured under oxic conditions. Un-neutral pH and increased temperature could also enhance SRP release rates upstream of weirs. We conclude that weirs can increase P retention within stream sediments and potentially promote significant P releases into waters, which in turn cause eutrophication.

• Experimental and Molecular Medicine
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• 제50권12호
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• pp.7.1-7.14
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• 2018

Dysregulation of long noncoding RNA (lncRNA) expression is linked to the development of various diseases. Recently, an emerging body of evidence has indicated that lncRNAs play important roles in the pathogenesis of inflammatory bowel diseases (IBDs), including Crohn's disease (CD) and ulcerative Colitis (UC). In IBD, lncRNAs have been shown to be involved in diverse processes, including the regulation of intestinal epithelial cell apoptosis, association with lipid metabolism, and cell-cell interactions, thereby enhancing inflammation and the functional regulation of regulatory T cells. In this review, we aim to summarize the current knowledge regarding the role of lncRNAs in IBD and highlight potential avenues for future investigation. We also collate potentially immune-relevant, IBD-associated lncRNAs identified through a built-by association analysis with respect to their neighboring protein-coding genes within IBD-susceptible loci. We further underscore their importance by highlighting their enrichment for various aspects of immune system regulation, including antigen processing/presentation, immune cell proliferation and differentiation, and chronic inflammatory responses. Finally, we summarize the potential of lncRNAs as diagnostic biomarkers in IBD.