• The Journal of Korean Physical Therapy
• /
• v.28 no.3
• /
• pp.205-211
• /
• 2016

Purpose: This study investigated the influence of muscle activity of the trunk and lower limb during a bridge exercise using a unstable surface and during one-legged bridge hip abduction in healthy adults. Methods: Nineteen healthy participated in this study (12 males and 7 females, aged $29.0{\pm}5.0$). The participants were instructed to perform the bridge exercises under six different conditions. Trunk and lower limb muscle activation, such as the erector spinae (ES), gluteus maximus (GM), external oblique (EO), and internal oblique (IO), was measured using surface electromyography. The six different bridge exercise conditions were conducted randomly. Data analysis was performed by using the mean scores after three trials of each condition. Results: On the ipsilateral side, muscle activity of the IO, EO, and ES during the hip abduction condition (Single-legged hip abduction bridge, Bridge with use of a ball and single-leg hip abduction, Bridge with use of a sling and single-leg hip abduction) was significantly higher than those during Unstable surface (Bridge with use of a ball, Bridge with use of a sling) and General bridging exercise (p<0.05). In the contralateral side, activities of the GM and EO during Single-legged hip abduction bridge, Bridge with use of a ball and single-leg hip abduction and Bridge with use of a sling and single-leg hip abduction was significantly higher than that during Bridge with use of a ball, Bridge with use of a sling and General bridging exercise (p<0.05). Conclusion: This study demonstrated that performing a bridge exercise with use of a sling and single-leg hip abduction had an effect on trunk and gluteal muscle activation. The findings of this study suggest that this training method can be clinically effective for unilateral training and for patients with hemiplegia.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.20 no.3
• /
• pp.224-230
• /
• 2019

The purpose of this study is to investigate the effect of the hip positions in frontal plane on abdominal muscle activities during bridging exercise. Twenty six subjects who have healthy conditions were asked to perform bridging exercise in three starting positions which are hip abduction, neutral and hip adduction. We used surface electromyography to compare the activities of both external oblique, internal oblique and rectus abdominis muscle. We analyzed the data by using repeated one way ANOVA, The alpha level was set at 0.05. The results showed that the muscle activities of both sides of external oblique, and internal oblique were significantly different among three starting positions. The activity of both sides of rectus abdominis were insignificantly different among three positions. The muscle activities of both sides of external oblique muscle and left internal oblique in bridging exercise with hip adduction position were significantly greater than hip neutral positions. The muscle activity of right internal oblique in bridging exercise with hip abduction positions. Our results suggest that bridging exercise with hip adduction position is recommended to lumbar stabilization exercise and the factor of hip position is important for controlling exercise intensity when designing bridging exercise program.

• Journal of Pharmaceutical Investigation
• /
• v.36 no.5
• /
• pp.331-338
• /
• 2006

A rapid, selective and sensitive reverse-phase HPLC methods for the determination of atenolol and chlorthalidone in human serum and whole blood were validated, and applied to the pharmacokinetic study of atenolol and chlorthalidone combination therapy. Atenolol and an internal standard, pindolol, were extracted from human serum by liquid-liquid extraction, and analyzed on a $\mu$-Bondapak C18 $10-{\mu}$ column in a mobile phase of methanol-0.01 M potassium dihydrogenphosphate(30:70, v/v, adjusted to pH 3.5) and fluorescence detection(emission: 300 nm, excitation: 224 nm). Chlorthalidone and an internal standard, probenecid, were extracted form human whole blood by liquid-liquid extraction, and analyzed on a Luna C18 $5-{\mu}$ column in a mobile phase of acetonitrile containing 77% 0.01 M sodium acetate and UV detection at 214 nm. These analysis were performed at three different laboratories using the same quality control(QC) samples. The chromatograms showed good resolution, sensitivity, and no interference by human serum and whole blood, respectively. The methods showed linear responses over a concentration range of 10-1,000 ng/mL for atenolol and 0.05-20 ${\mu}g/mL$ for chlorthalidone, with correlation coefficients of greater than 0.999 at all the three laboratories. Intra- and inter-day assay precision and accuracy fulfilled international requirements. Stability studies(freeze-thaw, short-, long-term, extracted sample and stock solution) showed that atenolol and chlorthalidone were stable. The lower limit of quantitation of atenolol and chlorthalidone were 10 ng/mL and 0.05 ${\mu}g/mL$, respectively, which was sensitive enough for pharmacokinetic studies. These methods were applied to the pharmacokinetic study of atenolol and chlorthalidone in human volunteers following a single oral administration of Hyundai $Tenoretic^{\circledR}$ tablet(atenolol 50 mg and chlorthalidone 12.5 mg) at three different laboratories.

• Journal of muscle and joint health
• /
• v.20 no.3
• /
• pp.189-196
• /
• 2013

Purpose: The purpose of this study was to investigate electromyographic (EMG) activity of deep and superficial trunk muscles during trunk stabilization exercises with and without stabilization maneuvers. Methods: The relative muscle activity ratios and local muscle activities of 25 healthy males were measured using the 8 channel surface EMG system (Myosystem 1400A, Noraxon Inc., U.S.A). The surface EMG activities were tested during performing abdominal hollowing maneuver (AHM), abdominal bracing maneuver (ABM) and no stabilization maneuver (NSM) in random order. Data were analyzed using $1{\times}3$ repeated measures ANOVA. Results: During bridging exercises, the EMG activity ratio of transverse abdominis/internal oblique abdominis relative to rectus abdominis was significantly lower in NSM than in AHM and ABM. During bridging and kneeling exercises, the EMG activity ratio of multifidus relative to erector spinae was significantly higher in AHM than in NSM. Conclusion: The AHM can be clinically used by the physical therapist to activate selectively the trunk muscles when designing selective training programs for patients.

• The Journal of Korean Academy of Orthopedic Manual Physical Therapy
• /
• v.19 no.2
• /
• pp.61-66
• /
• 2013

Background: This study tried to identify the bridge exercise posture for efficient exercise application by comparing muscle activity of buttocks and thighs according to internal-external rotation and pronation & supination in bridge exercise. Method: Nine males in their 20s living in D city were randomly selected as subjects. Muscles such as vastus medialis oblique (VMO), vastus lateralis (VL), semitendinosus (ST), biceps femoris (BF), gluteus maximus (GMAX), gluteus medius (GMED), tensor fasciae latae(TFL), and adductor longus (ADL) were measured using eight channel surface electromyogram (MyoSystem 1400A, Noraxon, USA) to measure muscle activity. Statistics process was performed through paired t test. Results: In the changes in electromyogram signals according to internal-external rotations according to internal-external rotation of shinbones, in most cases muscle activity was higher in external rotation than in internal rotation, but there was no statistical significance (p>.05). In particular, it was lower in TFL and ADL. There was no statistical significance in the comparison between two groups (p>.05). In the changes in electromyogram signals according to internal-external rotations according to pronation & supination of thighs, GMED showed significantly higher value in supination than in pronation (p>.05), and in ADL pronation is significantly higher than supination (p<.05). Conclusion: In internal-external rotation of shinbone and pronation & supination of thighs in bridge exercise, changes in muscle length can make effects on muscle activity of buttocks and thighs. Therefore, muscle strength enforcement program on buttocks and thighs through bridge exercise can make effects on patients with lower limb functional damages in clinical situations.

• Journal of Korean Physical Therapy Science
• /
• v.24 no.2
• /
• pp.9-16
• /
• 2017

Purpose: This study was conducted in order to examine the changes of muscle activitis of erector spine muscles and Gluteus maximus during the bridge exercise with adductor muscles. Method: After attaching the EMG device to the Gluteus maximus and erector spine muscles of the 100 healthy adult males in their 20s, applying the stabilizer pressure biofeedback device between the knees, the bridge movement was carried out 10 seconds. Result: During the exercise of the bridge movement, the muscular activities in erector spine and gluteus maximus were significantly different in ralation to the simultaneous contractive adductor muscles of the bridge(p<.05). Conclusion: Thus, the bridge exercise is carried out in conjunction with the simultaneous contraction of adductor muscles that suggests that the training are more effective in erector spine and gluteus maximus activities.

• PNF and Movement
• /
• v.22 no.2
• /
• pp.201-211
• /
• 2024

Purpose: This study aimed to evaluate the effects of trunk stabilization exercises using a Reformer on trunk control, balance ability, and gait function in chronic stroke patients. Methods: The participants were 24 chronic stroke patients, randomly divided into two groups: trunk stabilization exercise using the Reformer group (TS-R, n = 12) and general trunk stabilization exercise group (GT-E, n = 12). Assessment methods included the Trunk Impairment Scale for trunk control, the AMTI force platform for static balance, the Timed Up and Go test for dynamic balance, and the Dynamic Gait Index for gait function. Assessments were conducted before and after the intervention. The intervention for the TS-R group consisted of bridging exercises using a Reformer, while the GT-E group performed bridging exercises on a mat. All interventions were performed for 17 minutes per session, five times a week, for a total of 20 sessions over four weeks. Statistical analysis was performed using repeated-measures ANOVA to analyze the interaction between groups and time. Results: The results of the repeated measures ANOVA indicated a significant interaction between the groups and time. The TS-R group showed statistically significant differences in all variables before and after the intervention. In contrast, the GT-E group did not show statistically significant differences in any variables before and after the intervention. Conclusion: The findings of this study suggest that trunk stabilization exercises using a reformer are effective in improving trunk control, balance ability, and gait function in chronic stroke patients.

• The Journal of Korean Physical Therapy
• /
• v.16 no.3
• /
• pp.205-216
• /
• 2004

The purpose of this study is to find application of combination of insotonic(CI) in clinical approach. This is a literature study with books and clinical experience. CI was developed after Margaret Knott that is very useful in clinically. CI has two lever system. It has class II lever system for eccentric contraction and class III lever system for concentric contraction. Therefore it make two different contraction that is not only magnitude of motion and speed increase of motion but also biomechanical advantage. Application of CI has much variety by patient position and treatment position. Especially, it is very effectable on mat activities and training for mid stance period. CI apply in supine position on treatment table, mat or high mat activities, bridging activities, all fourth activities and sit on chair activities. CI apply serially with different techniques. These are rhythmic initiation, dynamic reversal, approximation, rhythmic stabilization and replication.

• YAKHAK HOEJI
• /
• v.52 no.3
• /
• pp.195-200
• /
• 2008

Gabapentin, [1-(aminomethyl) cyclohexaneacetic acid], a structural analog of $\gamma$-aminobutyric acid (GABA), is being developed for the treatment of epilepsy. Unlike GABA, gabapentin crosses the blood-brain barrier after systemic administration. Gabapentin is an effective antiepileptic drug in patients with partial and secondarily generalized seizures who are uncontrolled with use of existing anticonvulsant drug therapy. The purpose of the present study was to evaluate the bioequivalence of two gabapentin 400 mg capsules, $Neurontin^{(R)}$ capsule 400 mg (Pfizer Inc.) and Gabatin capsule 400 mg (Korean Drug Co. Ltd), according to the guidelines of the Korea Food and Drug Administration (KFDA). The release of gabapentin from the two gabapentin formulations in vitro was tested using KP VIII Apparatus II method with various dissolution media (pH 1.2, 4.0, 6.8 buffer solution and water). Twenty six healthy male subjects, 23.58$\pm$1.50 years in age and 66.74$\pm$8.31 kg in body weight, were divided into two groups and a randomized 2$\times$2 cross-over study was employed. After one capsule containing 400 mg as gabapentin were orally administered, blood was taken at predetermined time intervals and the concentrations of gabapentin in serum were determined using HPLC with fluorescence detector. The dissolution profiles of two formulations were similar at all dissolution media. In addition, the pharmacokinetic parameters such as $AUC_t$, $C_{max}$ and $T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t$, $C_{max}$ and untransformed $T_{max}$. The results showed that the differences between two formulations based on the reference drug, $Neurontin^{(R)}$ capsule 400 mg, were 2.04, -3.68 and 16.79% for $AUC_t$, $C_{max}$ and $T_{max}$, respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log 0.8 to log 1.25 (e.g., log 0.91$\sim$log 1.16 and log 0.87$\sim$log 1.11 for $AUC_t$ and $C_{max}$, respectively). Thus, the criteria of the KFDA bioequivalence guideline were satisfied, indicating Gabatin capsule 400 mg was bioequivalent to $Neurontin^{(R)}$ capsule 400 mg.

• YAKHAK HOEJI
• /
• v.50 no.6
• /
• pp.386-392
• /
• 2006

Pramlintide, a synthetic analogue of human hormone amylin, is the first of a new class of amylinomimetic compounds. Present study was undertaken to compile and analyze the clinical trials of pramlintide, and thereby to facilitate the design of the bridging study for the earlier introduction of the drug, which might be needed by diabetes patients in Korea. Sixty-two articles from Pubmed and MEDLINE search were used to analyze the trials of pramlintide along with prescribing information and New Drug Application packet obtained form the manufacturer. The efficacy of the new drug was attributed to three mechanisms: delay of gastric emptying time, inhibition of post-prandial glucagon secretion, and reduction of food intake by enhanced satiety. Clinical trials consistently identified the effectiveness of the drug for the treatment of type 1and type 2 diabetes who have failed to achieve glycemic control despite optimal therapy with insulin. However, the six pivotal Phase III clinical trials were peformed with mostly caucasian and some black and hispanic people. None of the trials documented the proportion of either Asian or Korean participants. Since Korean diabetes patients show different epidemiology and characteristics in their disease state, it appears that the bridging study of pramlintide should be designed in the level of full scale Phase III clinical trial along with pharmacokinetic and pbarmacodynamic studies.