• Tuberculosis and Respiratory Diseases
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• v.45 no.5
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• pp.984-991
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• 1998

Background: The 3p deletions has been shown to be the most frequent alteration in lung cancers, strongly suggesting the presence of at least one tumor suppressor gene in this chromosomal region. However, no solid candidate for the tumor suppressor gene(s) on 3p has as yet been identified. Recent attention has focused on a candidate 3p14.2 tumor suppressor gene, FHIT, which is located in a region that is homozygously deleted in multiple tumor cell lines and disrupted by the hereditary renal cell carcinoma t(3;8) chromosomal translocation breakpoint FHIT also spans FRA3B, the most common fragile sites in the human genome. In the present study, we have analyzed expression of the FHIT gene in lung cancer cell lines. Methods: RNA from 21 lung cancer cell lines (16 NSCLC, 5 SCLC) were extracted using standard procedures. Random-primed. first strand cDNAs were synthesized from total RNA and PCR amplication of coding exons 5 to 9 was performed. The RT-PCR products were electrophoresed in 1.5% ethidium bromide-stained agarose gels. Results: 12 of 21(57%) lung cancer cell lines exhibited absent or aberrant FHIT expression [7 of 16(44%) of non-small cell lung cancer and 5 of 5(100%) of small cell lung cancer cell lines]. Conclusion: The result shows that abnormal transcription of the FHIT gene is common in human lung cancer cell lines, especially in small cell lung cancer.

• Journal of Animal Science and Technology
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• v.48 no.1
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• pp.1-8
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• 2006

KIT encodes a mast/stem cell growth factor receptor and is known as a possible candidate gene responsible for dominant white coat color in mammals. To investigate the genetic variation of KIT gene in Korean wild boars(Sus scrofa coreanus), we carried out PCR-RFLP and DNA sequencing for three exons(exons 17, 19, and 20) and intron 19 of the KIT gene in Korean wild boars. PCR-RFLP results using NlaⅢ restriction enzyme in the breakpoint region between exon 17 and intron 17 and AciⅠ restriction enzyme in exon 19 indicate that Korean wild boars did not have previously identified white coat color related splicing mutation and missense mutation, respectively. These results also indicate matings between Korean wild boars could not give white coat color offsprings. We also found new SNPs in exons 19(C2661T) and 20(A2760G). Of these, the SNP in exon 20 is a missense mutation which might induce the change of amino acid iso-leucine to valine. However, no relationship was identified with this missense mutation and coat color. In this study, breed specific new SNPs were identified in exons 19, 20 and intron 19 and these results will give important information for genetic variation of porcine KIT gene.

• Journal of KIISE:Computing Practices and Letters
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• v.9 no.2
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• pp.166-181
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• 2003

With the rapid growth of Internet, many devices such as Web TVs, PDAs and Web phones, begin to be directly connected to the Internet. These devices need real-time operating systems (RTOS) to support complex real-time applications running on them. Development of such real-time applications called embedded internet applications, is difficult due to the lack of adequate tools, especially debuggers. In this paper we present a new tracepoint debugging tool for the Qplus-T RTOS embedded system, which facilitates the instrumentations of the real-time software applications with timing trace-points. Compared with traditional breakpoint debugger, this trace-point debugger provides the ability to dynamically collect and record application data for on-line examination and for further off-line analysis. And, the trace-points can also provide the means for assigning new values to the running application's variables, without neither halting its execution nor interfering with its natural execution flow. Our trace-point debugger provides a highly efficient method for adding numerous monitoring trace-points within a real time target application such as Qplus-T internet applications, utilizing these trace-points to monitor and to analyze the application's behavior while it is running. And also, our trace debugger is different from previous one in that we can specify and detect the timing violations using its RTL (Real-Time Logic) trace experiments.

• Journal of Korean Tunnelling and Underground Space Association
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• v.9 no.2
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• pp.121-131
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• 2007

Recently, the probability of rock joints being exposed to free faces is getting higher for the scale of rock mass structures gets larger. Also, the frequency of occurring dynamic events such as earthquakes and blasting has been increasing. Thus, the shear behavior of rock joints under different conditions needs to be investigated. In this study, a series of direct shear tests were carried out under various conditions to examine the velocity-dependent shear behavior of saw-cut rock joints. Two types of direct shear test were carried out. The first was to examine the velocity-dependent shear behavior of saw-cut rock joints at seven different shear velocities, each with three different normal stresses. The second was to examine the shear behavior of saw-cut rock joints when three different instantaneous shear velocities changed. As a result, the coefficient of friction was affected by normal stress. The breakpoint velocity, the point when the change of shear velocity starts to affect the frictional behavior, became lower as normal stress increased. Also, as the shear velocity became lower, the degree of stress-drop on stick-slip behavior became larger. As a result of examining the changes of friction coefficient, velocity weakening (decrease of friction coefficient) was observed. The decrement of friction coefficient due to the changes of shear velocity under slow shear velocity was larger than that under fast shear velocity.

• Journal of KIISE:Computing Practices and Letters
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• v.9 no.1
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• pp.95-99
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• 2003

In addition to wired communication technology, wireless communication technology has had communication revolution nowadays. Bluethooth technology carries out data/voice communication within pico-net. Nowadays the various services are supported by access network connected to public network. This paper presents implementation of bluetooth protocol analyser which simulates bluetooth protocol. MS window98 and visual C are used for development environment and application program is operated over the firmware loaded on the bluetooth device connected to the PC through UART which of the maximum transmission rate is 115kbps because transmission rate less than 20kbps affects rarely the performance. The performance analysis on the propose system is carried out as simulating the signalling information for the voice test and the traffics between two bluetooth systems for file transfer. The throughput analysis for file transfer service and call processing capacity for voice service are considered as performance analysis parameters. File access time is very important parameter and throughput is 13 kbps in case breakpoint time to file access is 0.04sec. Also call processing time is about 16.6ms in case of communication with the headset. The performance analysis of simulation results satisfies with bluetooth device development.

• Parasites, Hosts and Diseases
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• v.23 no.2
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• pp.241-246
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• 1985

The epidemiological status of ascariasis was analyzed in 8 rural villages in Korea, through observation of its epidemiological parameters such as prevalence, worm burden and basic reproductive rate. Total 978 inhabitants were subjected to stool examination and recovery of worms after chemotherapy with pyrantel pamoate. The results were as follows: 1. The worm positive rate in each village was 16.5~79.5%, while the egg positive rate was 9~18% lower, 3.3~66.7%. The average worm burden (among all inhabitants) ranged from O. 21 to 8. 44 by villages and the frequency of cases with each worm burden showed negative binomial distributions with 'k' values of O. 38-0. 54. 2. The prevalence rates (worm) in each village was almost identical with the theoretical ones from Anderson and May's equation; $p=1-(1+M^*/k)^{-k}$, where 'p' is worm prevalence and '$M^*$' equilibrium average worm burden. The basic reproductive rate 'R' was calculated from 1.03 to 2.11. lt is suggested that, although 'R' in lower endemic areas is approaching to the breakpoint of reinfection (R=1), control programs of ascariasis in Korea should be continued until it becomes below the level nationwidely.

• Journal of Life Science
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• v.20 no.5
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• pp.703-709
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• 2010

Glucuronidation is a major pathway for NNAL [4-(methylnitrosamno)-1-(3-pyridyl)-1-butanol] and UGT2B17 (UGT, uridine diphospho-glucuronosyltransferase) is from the UGT2B family that glucuronidates carcinogens. UGT2B17 deletion was associated with decreased levels of NNAL and with increased risk of some cancers. The UGT2B17 gene varies in copy number from zero to two per individual in humans. To examine whether UGT2B17 gene deletion is associated with the risk of lung cancer, we investigated copy number variants (CNV) in 271 cancer-free controls and 176 cases of lung cancer in Koreans by a PCR-based method. The frequency of the UGT2B17 deleted alleles was much higher than in other Caucasian and African-American groups which have already been reported. While only up to 10% of Caucasians have zero copies of the gene, up to 74% of Koreans in this study showed that both copies of the gene were deleted. Furthermore, the overall frequency of this dual deletion in female groups was higher than in male groups. However, there was no association between CNV in UGT2B17 and lung cancer. This result suggested that the UGT2B17 deletion allele was not associated with the susceptibility of lung cancers in the Korean group. However, this UGT2B17 CNV polymorphism may be a useful marker for evolutionary analysis among races.

• Journal of Korean Society of Environmental Engineers
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• v.34 no.1
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• pp.1-6
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• 2012

Down Stream K River has high COD (4-10 mg/L) and high $NH_3$-N concentration (3.5 mg/L during winter period). Although $NH_3$-N itself is not reported harmful at this level, it must be removed to meet drinking water standard (0.5 mg/L). We constructed a pilot plant modifying the processes of conventional drinking water facilities. Prechlorination and powdered activated carbon (PAC) dechlorination was adopted prior to a flocculation tank to remove ammonia and prevent disinfection byproducts (DBPs) formation. Also, GAC processes was included after sand filter to remove residual DOC. This pilot having a capacity of 36 ton/day was operated for one year. The GAC processes were successful to remove ammonia and many organic pollutants (DOC, MBAS, UV-254 nm absorbance, etc). Influent DOC concentrations were very high as 3~6 mg/L throughout the plant operation. It was impossible to achieve 1.0 mg/L effluent DOC, indicating that bed depth (2 m) should be increased to achieve more strict DOC quality standards. When $Cl_2$ dose was well controlled ($Cl_2/NH_3$-N ratio 10~11 on a weight basis), $NH_3$-N removal was 98% and THMs was very low possibly due to low free residual chlorine and PAC dechlorination.

• Journal of the Korean Wood Science and Technology
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• v.37 no.6
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• pp.566-577
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• 2009

The modification of wood color occurs rapidly during the service period at indoor. It is crucial to investigate the characteristics of color change, chemical and microscopical modification of wood at indoor. Wood products made of Japanese cedar at different years were used for this work. The tests were performed in order to evaluate the degree of color change of wood surface, breakpoint of brightness from surface to inside of wood, chemical analysis with FT-IR, and microscopical characteristics using the LM and TEM. Surface color of cedar wood stored indoor were rapidly changed at early stage, particularly ${\Delta}a$ (yellow), and ${\Delta}b$ (red) values were steeply decreased for one year old indoor wood, ${\Delta}L$ (white) value was dropped until 5 years old indoor wood compared with control sample. Decrease of peaks related to polysaccharide and lignin was noticed, especially, lignin was severely degraded. Although degradation of cell wall limited only to surface layers of indoor wood, degradation pattern of indoor wood showed similar degradation pattern to natural weathering of wood during outdoor weathering or wood behavior under artificial UV irradiation.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.42 no.4
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• pp.481-491
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• 2022

This study investigates the characteristics of the GAC adsorption behavior during the operation of a multi-stage cross-flow filtration and GAC adsorption process for the purpose of devising an advanced treatment of combined sewer overflows (CSOs) and evaluates the regeneration efficiency of spent GAC that has reached the design breakpoint. During the filtration process, suspended substances are easily removed, but dissolved organic substances are not removed, necessitating a process capable of removing dissolved organic substances for the advanced treatment of CSOs. In general, GAC adsorption has been applied under low-concentration organic conditions, such as for water purification and tertiary treatments of sewage, and has rarely been applied under conditions with high organic concentrations, such as with sewage or CSOs. Accordingly, this study will provide a new and interesting experience. Also in this study, the continuous operation and breakthrough characteristics of GAC according to the strength of the inflow organic matter were investigated, electrochemical regeneration was applied to the used GAC, and the regeneration efficiency was evaluated through desorption and re-adsorption tests. The results showed that the breakthrough period was 21 days under high concentration conditions, 28 days at medium concentrations, and 32 days under low concentration conditions. The desorption of adsorbed organic matter through electrolysis occurred in the range of 188 to 609 mgCOD/L depending on the electrolysis conditions, and the effect of the electrolyte type led to the finding that NaOH was slightly higher than H₂O₂.