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Nie, Zhenzhao;Yoon, Seokmin
- Journal of Popular Narrative
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- v.25 no.1
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- pp.193-215
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- 2019
According to ethical literary criticism, every type of literature has its text. The original definition of oral literature refers to the literature disseminated orally. Before the dissemination, the text of oral literature is stored in the human brain, which is termed as "brain text". Brain text is the textual form used before the formation of writing symbols and its application to a recording of information, and it still exists after the creation of writing symbols. Other types of texts are written text and electronic text. Brain text consists of brain concepts, which, according to different sources, can be divided into objective concepts and abstractive concepts. Brain concepts are tools for thinking while thought comes from thinking with understanding and an application of brain concepts. Brain text is the carrier of thought. The termination of the synthesis of brain concepts signifies the completion of thinking, which produces thoughts to form brain text. Brain text determines thinking and behavioral patterns that not only communicate and spread information, but also decide our ideas, thoughts, judgments, choices, actions and emotions. Brain text is also a deciding factor for our lifestyle and moral behaviors. The nature of a person's brain text determines his thoughts and actions, and most importantly determines who he is.
https://doi.org/10.18856/jpn.2019.25.1.006 인용

Jungwhoi Lee;Jungsul Lee;WooGwang Sim;Jae-Hoon Kim;Chulhee Choi;Jongwook Jeon
- BMB Reports
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- v.56 no.11
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- pp.594-599
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- 2023
A number of therapeutic drugs have been developed from functional chemicals found in plants. Knowledge of plants used for medicinal purposes has historically been transmitted by word of mouth or through literature. The aim of the present study is to provide a systemic platform for the development of lead compounds against breast cancer based on a traditional medical text. To verify our systematic approach, integrating processes consisted of text mining of traditional medical texts, 3-D virtual docking screening, and in vitro and in vivo experimental validations were demonstrated. Our text analysis system identified rutin as a specific phytochemical traditionally used for cancer treatment. 3-D virtual screening predicted that rutin could block EGFR signaling. Thus, we validated significant anti-cancer effects of rutin against breast cancer cells through blockade of EGFR signaling pathway in vitro. We also demonstrated in vivo anti-cancer effects of rutin using the breast cancer recurrence in vivo models. In summary, our innovative approach might be proper for discovering new phytochemical lead compounds designing for blockade of malignant neoplasm including breast cancer.
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