• The Journal of the Korean dental association
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• v.41 no.3 s.406
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• pp.190-196
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• 2003

Osteoblastoma is an uncommon lesion of bone that occurred in jaw bone. The etiology of the Osteoblastoma is still undiscovered. The most frequent symptom is consistent pain which is often severe, and localized swelling and bone expansion mat occur. We experienced a case of osteo-blastoma which occurred on the lingual surface of mandibular body. It resembled tours mandibularis clinically, alveolar abscess radiologically. Biopsy was done to evaluable the tours-like bony mass. The results of excisional biopsy demonstrated an osteoblastoma. The symptoms are subsided and no signs related with recurrence have been noted. Our experience and many literatures demonstrated that Osteoblastoma must be included in differential diagnosis of bone-producing lesion.

• Journal of Nutrition and Health
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• v.33 no.3
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• pp.241-249
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• 2000

The bone mineral density(vertebrae Ll-4, femoral neck, Ward's triangle and trochanter) of 160 healthy adult women aged 29-45 was measured and general characteristics, anthropomentric measurements, and dietary intake were also studied to determine the main factors affecting the bone mineral density(BMD) of adult women. The nutrient intake of the subjects was adequate to RDA level except energy, Ca, Fe, and vit A. The BMD of vertebrae L24 showed significant positive association with nutrient intake such as animal protein, P, Ca(animal) and Fe(animal). The BMD of the femoral neck correlated significantly with anthropometric measurements such as height, weight, waist circumference, hip circumference, body fat and body mass index. The BMD of both sites(vertebrae L24 and femoral neck) were significantly related to vertebrae L24 was daily Ca intake and that of femoral neck was daily energy expenditure. In conclusion, adequate nutrient intake, especially protein, P, Ca and Fe as well as increases in physical activity were suggested to prevent the loss of bone mineral density in adult women.

• Journal of Yeungnam Medical Science
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• v.16 no.2
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• pp.155-168
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• 1999

Osteoporosis is one of the most important public health problems facing the aging population. Drug therapy for osteoporosis can be divided operationally into two main categories: drugs that inhibit bone resorption, and thus reduce bone turnover, and those that stimulate bone formation, exerting an anabolic effect. Antiresorptive agents such as estrogens, calcitonin, and bisphosphonates are most effective in the prevention of osteoporosis. Formation-stimulating agents such as sodium fluoride or monofluorophosphate, parathyroid hormone fragments, and anabolic steroids are of potential value in the treatment of established osteoporosis, where bone mass is already low and benefit from antiresorptive drugs is likely to be small Recently, raloxifene, a selective estrogen receptor modulator, has become available in various countries for clinical use in the treatment of involutional osteoporsis. This paper will review the use of these drugs in postmenopausal woman.

• Journal of Veterinary Clinics
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• v.18 no.4
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• pp.465-468
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• 2001

Elbow hygroma and hypertrophic osteodystrophy were diagnosed in Doberman referred to Veterinary Teaching Hosptial of Chungbuk national University. Physical examination, plain radiography, and bone scan were performed in the patient. The radiography revealed soft tissue swelling on the caudal region of the elbow and irregular radiolucent zone involving the metaphysis subjacent and parallel to the distal radial and ulnar physes. The bone scan of the forelimbs revealed increased uptake in region where the soft, fluid-filled mass on the elbow was present. But the radiolucent areas (the distal radial and ulnar physes) were seen normal bone uptake. Therefore, hypertrophic osteodystrophy ruled out the diagnosis. $^{99m}Tc-MDP$ scan is suitable to routine clinical use for soft tissue inflammation and bone lesions detection.

• Journal of Veterinary Clinics
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• v.18 no.4
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• pp.469-473
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• 2001

A 12-year-old bitch, Yorkshire terrier, was admitted to the Chungbuk National University animal hospital with draining from mammary masses in the left and right mammary glands. She was involved in the mammary masses, suffering bilateral inguinal hernia. Physical examination during the hospitalization demonstrated the masses in right (3 cm) and left (1.5 cm) mammary glands. Blood pool images didn\`t show the subtle increase in blood flow to the inguinal hernia, and the increase of radionuclide distribution to the mammary gland on the soft tissue phase. However, delayed bone images showed a very focal lesion in the right mammary gland. These findings were confirmed on a subsequent biopsy, which also revealed adenocarcinoma with areas of malignant new bone formation. We present a case of primary mammary adenocarcinoma with $^{99m}Tc-MDP$ activity relative to normal bone. Tumor in the bitch demonstrates malignant new bone formation as the likely mechanism for the marked radiotracer avidity.

• Journal of Dairy Science and Biotechnology
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• v.34 no.3
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• pp.157-164
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• 2016

Osteoporosis is a systemic skeletal disease characterized by decreased bone mass, which results in a markedly increased risk of traumatic fractures. This disease is a worldwide health problem with a high prevalence. Recently, various dietary components have been found to minimize the risk of developing osteoporosis through their ability to stimulate bone formation and optimize bone health. Among them, probiotics and fermented milk can have beneficial effects to human health. Bioactive compounds derived from probiotics in fermented milk can especially modulate physiological functions related to bone health. Here, we review the evidence to support these insights into newly found functionality of dairy foods for osteoporosis prevention.

• Journal of the East Asian Society of Dietary Life
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• v.14 no.2
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• pp.113-122
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• 2004

This study was conducted to examine the correlation among growth development, bone mineral density, and nutrient intakes in preschool children. A total of 62 preschool children measured the anthropometric characteristics and the bone mineral density of carpus using DEXA. The questionnaires categorized to determine health status, life style, dietary behaviors, and dietary intakes were filled out by children's mothers. The average ages of the study subjects were 62.4 months in boys and 62.1 months in girls. The birth height and weight of the subjects were 50.9 cm and 3.4 kg in boys and 50.3 cm and 3.3 kg in girls, respectively. The average height, weight, % body fat, and obesity index were 111.7 cm, 19.6 kg, 15.0%, -2.1% in boys and 109.4 cm, 18.7 kg, 17.5%, 0.2% in girls, respectively. The bone mineral density in carpus was 0.25 g/cm$^2$ in boys and 0.24 g/cm$^2$. In girls. Proportions of children having regular meals were 69.0%, 94.7%, and 69.0% for breakfast, lunch, and dinner, respectively. The major reasons for irregular meal were poor appetite and lack of time for breakfast and snacks for dinner. Most of the children(52.6%) had breakfast with the whole family together, and all the children had lunch and dinner with a part of the family. Most of the children answered they had snack more than once a day, and 64.3% had an unbalanced diet. The intakes of energy, calcium, iron, zinc, vitamin A, vitamin B$_1$, niacin, and vitamin C did not meet the Korean RDAs. Average bone mineral density in carpus was positively correlated to the body weight, the total body water, the lean body mass, and the obesity index, respectively(p＜0.01, p＜0.01, p＜0.01 and p＜0.01). The body weight, the total body water, and the lean body mass showed the significant negative correlations with the animal iron intake(p＜0.05, p＜0.01 and p＜0.01). The bone mineral density in the distal carpus was negatively correlated to the animal protein intake and the animal iron intake(p＜0.05 and p＜0.05). And the bone mineral density in the ultradis carpus and the average bone mineral density in the carpus were positively correlated to the plant calcium intake(p＜0.05 and p＜0.05). Therefore, more systematic studies to investigate the roles of protein, iron, and calcium in growth development of preschool children were required.

• Journal of Veterinary Clinics
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• v.31 no.1
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• pp.46-50
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• 2014

A 7-year-old spayed female Welsh corgi presented with a mass of the skull. The mass was diagnosed as multilobular bone tumor and surgically removed. To treat a large bone defect after the tumor removal, custom-made artificial bone fabricated by a 3-dimensional ink-jet printer was implanted in the defect. Follow-up computed tomography evaluation was performed for 4.3 years. The implant was well integrated with the skull and had covered the large bone defect during the follow-up period. Gradual degradation of the implant began 6 weeks after surgery. It provides an additional option for the treatment of large bone defect.

• Journal of the East Asian Society of Dietary Life
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• v.6 no.3
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• pp.295-305
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• 1996

This study was done to evaluate the effectiveness of dietary calcium level(a diet which met 100% or twice the calcium level in AIN-76 diet) on preventing bone loss in ovariectomized rats. Forty female Sprauge-Dawley rats(body weight 200$\pm$5g) were divided into two groups. One group were ovariectomized(Ovx) while the others received sham operation(Sham). Thereafter, each rat group was further divided into normal calcium diet(NCD, 0.52%) and high calcium diet(HCD, 1.04%) sub-groups. All rats were fed on experimental diet and deionized water ad libitum for 8 weeks. Urinary pyridinoline & creatinine and serum estradiol, luteinizing hormone, calcium, phosphate, total protein, albumin, alkaline phosphatase and osteocalcin were determined. There were no significant differences in serum calcium. total protein and albumin in the two groups(Ovx vs Sham) of rats. Ovariectomized rats had significantly lower estradiol than sham operated rats. There was a highly significant correlation between total bone mineral density(TBMD) and overall level of esteradiol(r=0.59, p<0.05). Total bone mineral density did not correlate significantly with ALP or osteocalcin, although a negative trend was evident. However, the rats fed high calcium diet had a lower crosslinks value and osteocalcine than the rats fed normal calcium diet. An increased rate of bone turnover is usually associated with a decrease in bone mass bexause bone formation at each remodeling site is never as great as resorption. Ovariectomized rats fed high calcium diet had a lower crosslink value and osteocalcin; it means high cacium diet decreased bone turnover rate. The findings from the present study demonstrated that bone loss due to ovarian hormonal deficiency can be partially prevented by a high calcium diet. Futhermore, these findings support the strategy of the use of a high calcium diet in the prevention of estrogen depletion bone loss (postmenopausal osteoporosis).

• Journal of Nutrition and Health
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• v.25 no.7
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• pp.569-577
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• 1992

To study the effects of the age and the dietary protein content on Ca metabolism male rats of 1 month 6 month 12 month of age were fed experimental diets containing 5%, 15% or 50% casein for 4 weeks. Food and ca intake were higher in old rats and in high protein groups. The weight ash and Ca contents of femur and tibia were higher in old rats. The higher dietary protein level resulted in higher skeletal weigh ash and Ca contents. But high protein diet(50% casein) lead to reduced bone mineral density(ash/dry bone weight) and Ca density(Ca/dry bone weight) in 1 month old rats. Low protein diet(5% casein) on the other hand reduced the bone growth even though the bone density was higher in this group. The ill effect of low protein diet was not evident in 12 month old rats. Glomerular filteration rate(GFR) and urinary Ca excretionincreased with age and with dietary protein level especially in 12 month old rats. Serum immunoreactive parathyroid hormone(iPTH) level tended to be higher in aged rats but was not affected by dietary protein level except 1 month old rats where 50% protein group showed significantly higher value. This study showed that the dietary protein level seemed to have different effect on Ca metabo-lism in rats of different age., The low bone density in the high protein group of growing rats may be due to the higher iPTH level and increased urinary Ca. The dietary protein level however had no effects on the bone composition in aged rats even though the higher urinary Ca excretion. In conclusion this study suggests that high protein intake from young may lead to less peak bone mass and to increase the bone loss in later years, which would increase the risk for osteporosis.