• International Journal of Oral Biology
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• 제36권4호
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• pp.187-194
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• 2011

Periodontitis is an inflammatory disorder of the periodontium, characterized by destruction of the tooth supporting tissues including alveolar bone and mediated by various pro-inflammatory mediators. Here, we demonstrated that HP08-0106, composed of four crude drugs-Gardenia jasminoides Grandiflora, Angelica gigas Nakai, Rehmannia glutinosa, and Schizonepeta tenuifolia in a weight ratio of 2:2:1:2, perturbs inflammatory responses, osteoclast formation in LPS-induced RAW 264.7 cells and alveolar bone resorption in ligature-induced periodontitis. HP08-0106 decreased the protein level of iNOS and COX2 as well as the secreted level of IL-$1{\beta}$, indicating that HP08-0106 has antiinflammatory effects. HP08-0106 also inhibited the expression of genes associated with osteoclastogenesis including c-Fos, MMP-9 and TRAP. Moreover, HP08-0106 exhibited a protective effect from alveolar bone loss in ligature-induced periodontitis animal models. Our results strongly suggest that HP08-0106 represent an important therapeutic tool to treat inflammatory disorders associated with bone loss such as periodontitis.

• Journal of Oral Medicine and Pain
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• 제46권3호
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• pp.69-74
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• 2021

As for temporomandibular joint arthritis (TMJ OA), managing the contributing factors at an early stage through accurate diagnosis is necessary to prevent irreversible bone changes. TMJ OA, which is a multi-organ disease caused by various pathophysiological mechanisms, is developed mainly due to mechanical overload. It is a disease characterized by degeneration of articular cartilage and subchondral bone as a low-level inflammatory arthritis condition developed by dysregulation of catabolic and anabolic activity of chondrocytes. Age, mechanical overload sensing of cartilage, chondrocyte apoptosis, catabolic enzymes, inflammatory factors, abnormal remodeling of subchondral bone, and estrogens may be involved in the pathogenesis of arthritis. Therefore, a comprehensive evaluation is needed to diagnose and manage progressive cartilage degeneration, subchondral bone remodeling, and associated symptoms of TMJ OA.

• 대한근관절건강학회:학술대회논문집
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• 대한근관절건강학회 1996년도 제4회 춘계학술대회
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• pp.110-121
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• 1996

It is well defined that osteoporosis is an age related disorder and associated with decreased bone mass. It is one of the most important disease lacing the aging population because of its association with fracture of the hip, vertebrae and distal radius. The disease provoke a significant economic burden and major public health problem of an elderly. The life-time risk of hip fracture in white women is approximately 15% which is equal to the combined risk of breast, uterine, and ovarian cancer. Despite its deleterious effect on women's health, knowledge of the epidemiology of osteoporosis in Korea is only beginning. 1970 in Korea has non as the crossover period between the chronic and an Infectious diseases. As the result, the infant mortality declined and an elderly population in Korea increased significantly in the past decade, The average life expectancy of women in Korea is now about 75 years. Thus, the majority of Korean women will spend approximately one-third of their life in the postmenopause state. Therefore, better understanding of bone metabolism and fracture incidence in Korean population is a great interest for the medical community as well as for public health. Currently, no population based epidemiologic data are available to support the incidence of osteoporotic fractures in Korea. However, available data suggest that significant declining of bone mineral density (BMD [g/$cm^2$]) has been occurring in Korean women after menopause. In same population, peak BMD was observed around 33-39 years of age and continue to decline thereafter. An accelerated bone losses occur after the menopause and the average loss is approximately 13% within 15 years from the menopause. The incidence of fracture was highly correlated with an age and bone mineral density. The mean age of menopause in Korean women was 47 years and this age appears to getting younger when analyzed by the birth cohort. An earlier menopausal age and increase life expectancy place Korean women at increase risk for osteoporosis and bone fracture. Korean or Asian women are no longer protected from the risk of bone fracture. Therefore, an early prevention or intervention schemes are essential before the outbreak of osteoporosis and/or fracture occurs in Korean or Asian women.

• Asian Pacific Journal of Cancer Prevention
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• 제16권15호
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• pp.6261-6265
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• 2015

Background: Even though rarely found in Indonesia, the incidence of multiple myeloma (MM) is increasing every year. Bone involvement of MM is the most often a clinical disorder which leads to worsening clinical conditions and low quality of life of patients. Purpose: To determine the clinicopathology profile of bone involvement of MM patients in Indonesia. Materials and Methods: The cross-sectional study of MM conducted at Dharmais National Cancer Hospital (DNCH) by collecting data from medical records of MM patients who came to DNCH in period 2008-2012. Results: There were 39 MM patients all with age above 60 years. There were 56.4% male and 43.6% female patients. Most were diagnosed at stage III (32.4%), and 41% had obesity. The comorbid conditions were anemia (82.9%), hypoalbuminemia (60%), increased creatinine level (38.5%), increased ${\beta}2$ microglobulin level (94.1%), increased LDH level (23.1%) and plasmocytes above 30% (65%), but only 4.2% patients presented with hypercalcemia. Meanwhile, bone involvement occurred in 76.9% of MM patients with 4 lesions on average and a maximum of 16 lesions. The locations of bone lesions were spine (70%), skull (70%), pelvis (33.3%), humerus (30%), and femur (30%). Conclusions: The incidence of MM in Indonesia is increasing annually with bone involvement in more than three-fourths, but interestingly without hypercalcemia.

• Journal of Oral Medicine and Pain
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• 제37권1호
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• pp.33-45
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• 2012

2007년부터 2011년까지 부산대학교 병원 구강내과를 내원한 측두하악장애 환자 중 임상 검사 및 방사선 검사, cone beam computed tomography(CBCT) 영상 촬영 결과 측두하악장애 골관절염으로 진단된 환자 114명 228개의 관절을 대상으로, 치료 후 6~35.5개월(평균 10개월)후 CBCT를 재촬영하고, 임상 검사를 실시하였다. 구강내과 전문의와 구강악안면방사선과 전문의가 영상 진단을 하였고, 임상 검사 결과와 CBCT의 영상 결과를 추적 연구 비교하여 다음과 같은 결과를 얻었다. 1. 측두하악관절 관절염의 골변화 양상은 다음과 같다. 1) 관절염의 골변화 진행 양상은 대부분 초기 상태를 유지하였다. 2) 침식은 침식, 편평화, 정상 관절, 골경화, 골증식체 순으로 골변화 진행 양상이 나타났다. 3) 편평화는 편평화, 골증식체, 정상 관절 및 골경화 순으로 진행 양상이 나타났다. 4) 골증식체는 골증식체, 침식, 골경화, 편평화 순으로 진행 양상이 나타났다. 5) 골경화는 골경화, 골증식체, 침식, 정상 관절 순으로 진행 양상이 나타났다. 2. 골변화에 따른 임상 증상의 변화는 다음과 같다. 1) 침식은 침식으로 유지된 경우 통증, 관절음, 개구제한, 최대 편이 개구량 모두 증상 개선이 있었고, 편평화로 이행된 경우 통증, 개구제한, 최대 편이 개구량에서, 정상 관절면으로 이행된 경우 통증, 관절음, 개구제한에서 증상 개선이 있었다. 침식에서 침식으로 유지된 경우 보다 침식에서 편평화로 이행된 경우 최대 편이 개구량에 있어 개선 효과가 높았다. 2) 편평화는 편평화로 유지된 경우 통증, 관절음, 개구제한에서 증상 개선을 보여 주었고, 편평화가 골경화로 이행된 경우, 개구제한에 있어 유의성있는 증상 개선을 보여주었다. 3) 골증식체가 골증식체로 유지된 경우 통증, 개구제한, 최대 편이 개구량에서 증상 개선 효과가 있었다.

• 치과방사선
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• 제19권1호
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• pp.151-159
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• 1989

The author has studied radiographic bony cnages of mandibular condyle head in temporomandibular disorder patients using Oblique lateral transcranial projection, Orthopantomography, and Tomography. The bony change types and the frequencies of occurrence and the incidences of bony changes in three different radiographic techniques were examined. The coincidences of bony change types between the Oblique lateral transcranial projection and the lateral part of Tomogram, the Orthopantomogram and the medial part of Tomogram were also examined. The results were as follows: 1. The mean age of patients was 31.7 years and under 40 years were 24 patients, women werw 27 patients, men were 4patients. 2. The observable case of bony changes in all three radiographic techniques were 19 cases (50%) of 38 cases and the observable cases of bony changes in only Tomography were 5 cases(13.2%) 3. The most frequent radiographic bony change type was osteophyte and next orders were flattening, erosion, concavity. 4. The positional incidences of bony change in Tomogram were 31 cases in lateral part and 27 cases in central part. 5. The coincidence of bony change types between the Oblique lateral transcranial projection and the lateral part of Tomogram was 80%, and the coincidence between the Orthopantomogram and the medial part or Tomogram was 76.0%.

• 대한치과의사협회지
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• 제57권4호
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• pp.204-212
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• 2019

Introduction : Patients with temporomandibular disorder may have various ear-related symptoms. If an excessive load is applied to the ear area due to the skeletal shape of the mandibular condyle or malposition of the disc, an auditory problems may occur. Case report : The patient was referred to our clinic due to the suspicion of temporomandibular disorder from the local otorhinolaryngology clinic. A few days ago, his right ear could not be heard. MRI showed that the left TMJ disc was anterior displacement with reduction, the right TMJ disc was anteromedial displacement without reduction. Also Right mandibular condyle showed sclerotic bone change, subchondral cyst and was compressing the frontal wall of the ear on MRI view. Right TMJ arthroplasty was done under the diagnosis of right TMJ osteoarthritis and osteochondroma. Postoperative intermaxillary fixation was done with SAS screw and elastics for 2 weeks. One month after the operation, hearing and TMJ discomfort were recovered without any complications. Conclusions As seen in this case, hearing loss due to benign tumor-like lesions of the temporomandibular joint should be treated surgically to restore the TMJ function and hearing.

• 대한골관절종양학회지
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• 제10권1호
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• pp.50-55
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• 2004

진행성 골화성 섬유이형성증은 매우 드문 유전적 질환이기는 하나 영유아 초기에 경부나 두부의 종괴에 동반하여 나타나는 특징적인 양측성의 족부 모지의 선천성 기형으로 진단이 가능하다. 그러나 오진으로 인한 잘못된 치료와 그로 인한 합병증이 병의 진행을 더 악화시킬 수 있으며 불필요한 처치를 행할 수 있어 처음 진단에 주의를 요하는 질환이다. 이에 저자는 이질환의 자연적 경과와 더불어 잘못된 치료로 인해 발생한 성인에서의 양상을 보고하는 바이다.

• The Korean Journal of Pain
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• 제26권2호
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• pp.173-176
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• 2013

The hallucal interphalangeal sesamoid bone is usually asymptomatic, but it is not uncommon for it to be symptomatic in cases of undue pressure, overuse, or trauma. Even in symptomatic cases, however, patients often suffer for extended periods due to misdiagnosis, resulting in depression and anxiety that can steadily worsen to the extent that symptoms are sometimes mistaken for a somatoform disorder. Dynamic ultrasound-guided evaluations can be an effective means of detecting symptomatic sesamoid bones, and a simple injection of a small dose of local anesthetics mixed with steroids is an easily performed and effective treatment option in cases, for example, of tenosynovitis.

• Research in Vestibular Science
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• 제17권4호
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• pp.125-129
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• 2018

Posttraumatic vertigo can be defined as the vertiginous disorder occurred after head and neck trauma without other pre-existing vestibular disorder. Central, peripheral, and combined deficits might cause this condition. Especially, various peripheral vestibulopathies are possible causes of posttraumatic vertigo; benign paroxysmal positional vertigo, temporal bone fracture, perilymphatic fistula, labyrinthine concussion, posttraumatic hydrops, and cervical vertigo. Since the differential diagnosis of the posttraumatic vertigo is often difficult, it is essential to acquire knowledge of their pathophysiology and clinical features. In this review, peripheral vestibulopathy as the possible causes of posttraumatic vertigo were described according to the current literature.