• Journal of Breast Disease
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• 제6권2호
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• pp.52-59
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• 2018

Purpose: This study aimed to determine whether clinicopathological factors are potentially associated with successful breast-conserving surgery (BCS) after neoadjuvant chemotherapy (NAC) and develop a nomogram for predicting successful BCS candidates, focusing on those who are diagnosed with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative tumors during the pre-NAC period. Methods: The training cohort included 239 patients with an HR-positive, HER2-negative tumor (${\geq}3cm$), and all of these patients had received NAC. Patients were excluded if they met any of the following criteria: diffuse, suspicious, malignant microcalcification (extent >4 cm); multicentric or multifocal breast cancer; inflammatory breast cancer; distant metastases at the time of diagnosis; excisional biopsy prior to NAC; and bilateral breast cancer. Multivariate logistic regression analysis was conducted to evaluate the possible predictors of BCS eligibility after NAC, and the regression model was used to develop the predicting nomogram. This nomogram was built using the training cohort (n=239) and was later validated with an independent validation cohort (n=123). Results: Small tumor size (p<0.001) at initial diagnosis, long distance from the nipple (p=0.002), high body mass index (p=0.001), and weak positivity for progesterone receptor (p=0.037) were found to be four independent predictors of an increased probability of BCS after NAC; further, these variables were used as covariates in developing the nomogram. For the training and validation cohorts, the areas under the receiver operating characteristic curve were 0.833 and 0.786, respectively; these values demonstrate the potential predictive power of this nomogram. Conclusion: This study established a new nomogram to predict successful BCS in patients with HR-positive, HER2-negative breast cancer. Given that chemotherapy is an option with unreliable outcomes for this subtype, this nomogram may be used to select patients for NAC followed by successful BCS.

• 대한한의학회지
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• 제40권2호
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• pp.17-34
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• 2019

Objectives: This study was carried out to observe and compare the effects of Pinellia ternata, Zingiber officinale and Sobanhatang on the reflux esophagitis induced by gastric fundus and pylorus ligation in mice with esomeprazole. Methods: Antioxidant effects were measured by DPPH radical scavenging activity at four different concentration of 0.125, 0.25, 0.5 and $1.0mg/102{\mu}{\ell}$. Zingiber officinale water extract(ZE), Pinellia ternata water extract(PE) and Sobanhatang water extract(SBE) and esomeprazole were treated orally for 14 days before gatric fundus and pylorus ligation. In the histochemistry, changes in suface mucous cells, muscle tissue and connective tissue in gastro esophageal junction(GEJ) and mast cell on the esophageal mucosa were observed. The change of Hemo oxygenase(HO)-1, ghrelin, gastrin and substance P in gastric body tissue were measured by immunohistochemistry. Results: DPPH radical scavenging activity exhibited concentration dependently increases in ZE, PE, SBE. ZE was significantly higher at all concentrations than PE. The gastric surface mucous cells were more in the treated group than in the reflux esophagitis elicited group(GE) in the order of PE, SBE, ZE and esomeprazole treateded group(PT, SBT, ZT, ET). Lower esophageal sphincter muscle damage and intercellular space in the GEJ were less in the treated group than GE. In the esophageal mucosa, the mast cell distribution and the migration of inflammatory cells were lower in the treateded troup than GE in order to ZT, SBT, PT and ET. The antioxidative enzyme, HO-1 was more in the order of ZT, SBT, control group, PT, ET than in GE. ZT was significantly higher than the other groups and SBT was significantly higher than ET. Ghrelin was found to be higher in ZT, ET, SBT and PT than in GE, and ZT was significantly higher than all other groups except ET. Gastrin showed the highest positivity in GE, and was lower in the order of ET, ZT, SBT, PT, and control group. Substance P was the highest in GE, and was lower in the order of ET, ZT, SBT, PT and control group, and PT were significantly lower than ET. Conclusion: ZT, PT and SBT showed superior antioxidative, anti-inflammatory and mucosal protective effects on mouse reflux esophagitis as compared with ET. In particular, ZE was more effective in antioxidant and gastric motility enhancement, while PE was more effective in mucosal protection and anti-inflammatory effects. Sobanhatang is expected to be effective treatment because it has advantages of both drugs and reduces toxicity.

• 한국식품영양학회지
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• 제14권6호
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• pp.548-561
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• 2001

본 연구에서는 이 지역에서 유통되고 있는 해수 및 어패류를 직접 채취하여 Listeria spp.를 분리 하였으며, 각각의 검체에 대한 균종별 분리율, 생화학적시험과 표준균주를 사용한 pH에 대한 시간별 균의 생육관계를 조사하였으며, L. monocytogenes에 대한 마늘, 향신료, 녹차 등의 농도에 따른 시판용 TSB(0.6%ye, pH 7.3)에서의 시간별 균의 생육관계를 조사하였고, 또한 항균제 10종에 대하여 감수성 시험을 하여 다음과 같은 결과를 얻었다. 1. 총 검 체 200건에서 Listeria spp.가 검출된 것은 32건으로 분리율 16%이었고, 검체별로는 전어(japanese gizzard shad)에서 37.5%(6/16)로 가장 높았으며, 병어(pomfret)와 새우(metapenaeus shell) 에서 각각 31.3%(5/16). 맛(sinonoracula constricta)과 조기 (yellow tailrunner)에서 각각 18.8% (3/16), 해수(sea water)에서 14.3%(8/56), 바지락(little neck clams)에서 12.5%(2/16)이었으며, 홍합(hard- shelled mussels) 소라(top shell), 꼬막(cockle clam)에서는 검출되지 않았고, 균종별로는 L. innocua가 14.0%(28/200), L. monocytogenes와 L. seeligeri는 각 각 1.0%(2/200)가 분리 되었다. 2. L. monocytogenes를 비롯한 4종의 표준균주 모두는 pH 3.0에서 균의 생육이 정지되었고, pH 10.0에서는 미약하지만 균의 생육이 진행되었으며, 산성보다는 알칼리성에서 균의 생육이 활발함을 알 수 있었으며, pH 7.0∼8.0에서는 균의 생육이 가장 왕성하였고,4종의 표준균주 중 L. seeligeri가 최대의 0.D값인 0.627로 가장 높았다. 3. 마늘, 겨자, 와사비, 녹차 등의 농도에 따른 시판용 TSB(0.6%ye 포함, pH 7.3)에서 1. monocytogenes의 생육은 마늘추출물에서 0.D값이 0.078에서 0.210으로 가장 저해를 받았으며, 겨자와 와사비는 균의 생육에 큰 저해를 주지 못하였으나, 녹차 추출물은 미약하지만 18시간 이후에 균의 생육저해에 관여하고 있음을 알 수 있었다 4. 10종의 항균제 감수성시험에서 L . innocua 16주는 ampicillin, kanamycin, penicillin, trimethopriml/sulfamethoxale, vancomycin에 대하여 모두 100%의 감수성을 보였고, ciprofloxacin과 gentamicin은 각각 43.7%, 97.7%로 감수성 이 나타난 반면, tetracycline (5주, 31.3%), cefotaxime(12주, 75%)은 내성을 나타내었고, 특히 nalidixic acid는 100%모두 내성을 나타내었다.