• Journal of the Korean Society of Food Science and Nutrition
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• v.30 no.6
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• pp.1204-1209
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• 2001

As a basic study to find bioactive principles for the hypolipidemic effect from natural sources, various biological influences of MeOH extracts of Thuja accidentalis L. and Juniperus chinensis var. horizontalis Nakai on rats were examined. The concentrates obtained from the organic layer and aqueous layer fractions of each species were orally administered to rats and then their effect on the body weight, organ weight, serum lipids profile, and blood glucose concentration were examined. Among the samples tested, the organic layer of Juniperus chinensis var. horizontalis exhibited the possibility of the hypolipidemic effects. The corresponding layer was chromatographed to give three fractions and reexamined their effects on rats. The results demonstrated that the fraction corresponding for the R$_{f}$ 0.4~0.7 which was the mixture of many minor components showed the effect of lowering the blood-lipid bevel effectively without any side effects. Besides, communic acid, identified from and isolated as a major component of the species exhibited the possibe hypolipidemic effects.s.

• Journal of Sasang Constitutional Medicine
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• v.25 no.1
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• pp.1-13
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• 2013

Objectives This study is to investigate the related factors to contribute the metabolic syndrome according to Sasang Constitution. Methods Nine hundred twenty six persons out of 1774 persons, over 40 years old, participated in community-based cohort in Wonju City of South Korea from June 2006 to August 2009. The diagnosis of metabolic syndrome was carried out by NCEP-ATP III(National Cholesterol Education Program in Adult Treatment Panel III) and Asian Pacific Criteria for abdominal obesity. The related factors were checked using questionnaire and blood samples. Sasang Constitution was verified by a Sasang Constitution specialist using the results of PSSC(Phonetic System for Sasang Constitution), facial pictures and simplified Sasang Constitutional questionnaires. Metabolic syndrome incidence rate according to Sasang Constitution and binary logistic regression analysis were performed with SPSS 19.0. Results Metabolic syndrome incidence rate was 30.3% and the majority of newly categorized as metabolic syndrome was Taeeumin(40.7%). There were significant risk factors like systolic blood pressure, fasting blood sugar, triglyceride and female and a significant defense factor like HDL-cholesterol. In terms of constitutional view, there were significant risk factors like waist circumference, systolic blood pressure, triglyceride in Soyangin, female, waist circumference, systolic blood pressure, fasting blood sugar, triglyceride in Taeeumin, female, waist circumference, systolic blood pressure, triglyceride in Soeumin. And there was a significant defense factor like HDL-cholesterol in only Taeeumin. Conclusions Regimens on metabolic syndrome were considered to be changed according to Sasang Constitution. Taeeumin female and Soeumin female should be cautious of body weight and metabolic syndrome when elderly. There are more cautious risk factors in each constitution; systolic blood pressure and triglyceride in Soyangin and fasting blood sugar and serum lipids levels in Soeumin and Taeeumin.

• Journal of Community Nutrition
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• v.2 no.2
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• pp.110-118
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• 2000

One-hundred thirty-six Chinese men and women who are members of the Malaysian Confucian Association from Kuala Lumpur city and suburbs were included in the study. They have been vegetarians for a mean period of about 6 years with the majority of them(91.2%) at lacto/ovo vegetarians. The average age of the male and female subjects in 33 and 34 years respectively. The mean BMI for the men and women are 22.5$\pm$2.4kg/$m^2$ respectively. The mean levels of serum total cholesterol, HDL-chol and LDL-chol for men are 4.27$\pm$0.77, 1,11$\pm$0.26 and 2.60$\pm$0.54mmol/L, while the corresponding values for women are 4.24$\pm$081, 1.34$\pm$0.29 and 2.41$\pm$0.28 mmol/L, All the respondents showed TC/HDL-chol levels within the normal cut-off point of <5.8mmol/L. Majority of the subjects showed normal range levels for serum retinol, carotenoids and $\alpha$-tocopherol. The mean systolic blood pressure for men and women are 122$\pm$16mmHg and 115$\pm$13mmHg, while their diastolic blood pressure are 82$\pm$7mmHg and 79$\pm$7mmHg respectively. Hypertension was found at a higher prevalence in men(17.6%) than among the women(7.1%). None of the respondents smoke cigarettes while approximately two-thirds of them carry out physical exercise at least once a week. their usual dietary intake includes frequent consumption of a wide variety of vegetables, fruits, nuts and legumes. In summary, Malaysian vegetarians have a low cardiovascular risk based on their health-oriented lifestyle.

• Journal of Korean Biological Nursing Science
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• v.19 no.4
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• pp.241-251
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• 2017

Purpose: This study aimed to examine the factors related to the bone mineral density (BMD) in male and female adults aged 50 years or older. The factors included were socio-demographics, body mass index (BMI), blood pressure, blood lipids, and health habits. Methods: As a secondary data analysis, this study used raw data from the 5th Korean National Health and Nutrition Examination Survey, and selected 2,295 adults aged over 50 years who participated in the survey and had BMD values. The T-score of the femoral neck was evaluated for BMD. Data were analyzed using descriptive statistics, ANOVA and multiple regression. Results: The factors influencing the BMD in men were age (${\beta}=-.029$, p<.001), BMI (${\beta}=.100$, p<.001), triglyceride (${\beta}=-.001$, p=.001), and calcium (${\beta}=.001$, p=.003), and the suggested regression equation explained 25.6% of the variance in BMD (F=16.32, p<.001). The factors related to BMD in women were age (${\beta}=-.060$, p<.001), BMI (${\beta}=.091$, p<.001), total cholesterol (${\beta}=-.002$, p=.028), HDL cholesterol (${\beta}=.009$, p=.001), and calcium (${\beta}=.001$, p=.004), and the suggested regression equation explained 47.0% of the variance in BMD (F=61.72, p<.001). Conclusion: Based on the findings of this study, the modifiable factors, such as BMI, blood cholesterol, and calcium, should be targeted to improve the BMD in both men and women.

• Preventive Nutrition and Food Science
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• v.8 no.1
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• pp.40-45
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• 2003

Acanthopanax senticosus was grown by a novel, proprietary method, of culturing isolated cells in a bioreactor. An extract from the cells was evaluated for its effect on lipid metabolism in rats fed a high fat diet. Male Sprague-Dawley rats (n＝6) were fed either an AIN-76 diet (control, NDCon), control diet plus Acanthopanax senticosus extract (ND＋Ex), a modified AIN-76 diet supplemented with 20% beef tallow (high fat, HFCon), or a high fat diet plus Acanthopanax senticosus extract (HF＋Ex), for 5weeks. Body weight gain was significantly higher in the HFCon group than the NDCon group. Feed consumption was significantly lower, but energy intake higher, in the groups fed high fat diets compared with the groups fed control diets. Serum HDL-cholesterol concentrations were significantly increased but serum LDL-cholesterol concentrations were decreased in the groups fed the Acanthopanax senticosus extract. Abdominal fat accumulation and serum leptin levels were significantly higher in the HFCon group than the other groups. Carnitine palmitoyltransferase-I (CPT-I) mRNA levels were increased in the groups fed Acanthopanx senticosus extract. These results suggest that supplementation of cell cultured Acanthopanax senticosus extract regulates CPT-I mRNA levels in liver and has an effect on the normalization of lipids in rats fed a high fat diet.

• Journal of Environmental Health Sciences
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• v.26 no.2
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• pp.97-107
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• 2000

PCBs [Polychlorinated biphenyls] are halogenated aromatic compounds with the empirical formula C12H10-nCln(n=1~10), and are a mixture of possible 209 different chlorinated congeners. PCBs were widely used as dielectric fluids for capacitors, transformers, plasticizers, lubricant inks, and paint additives. once released into the environment, PCBs persist for years because they are so resistant to degradation. In addition to their high degree of lipophilicity. In 1970s, the worldwide production of PCBs seem to be still in use. The environmental load of PCBs was prohibited since 1983 in Korea. In spite of these actions, many PCBs seem to be still in use. The environmental load of PCBs will continue to be recycled through air, land, water, and the biosphere for decades to come. This study was conducted to measure the concentrations of PCBs I the serum samples of 112 women by GC/MSD(Hewlett Packard 5897 Gas Chromatography-Mass Chromatography Detector) and CG/ECD(Hewlett Packard 5890 series-II gas chromatography-Electron capture detector, U.S.A). The main results of this study were as follows; The mean and standard deviation of serum PCBs were 3.613, 0.759 ppb, respectively and median of it was 3.828 ppb. The correlation coefficients of the concentrations of 13 PCB congeners ranged from 0.7913 to 0..9985 and were significantly correlated between each items(p=0.0001). The PCB concentrations were positively associated with age(simple linear regression; R2=0.86, =0.08023, p<0.001) and with total lipids in serums(simple linear regression; R=0.7058, =0.00486, p<0.001). The age adjusted model (Y=$\beta$0+$\beta$1age+$\beta$2X) was applied for possible predictors of PCBs levels in serum. For BMI(Body Mass Index), major residential area, and fish, meat, and dairy consumption, there was no association with PCBs levels, Also there was negative association for the number of pregnancy and lactation period with PCBs levels.

• Nutrition Research and Practice
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• v.12 no.3
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• pp.222-232
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• 2018

BACKGROUND/OBJECTIVES: Since gain or loss of skeletal muscle mass is a gradual event and occurs due to a combination of lifestyle factors, assessment of dietary factors related to skeletal muscle is complicated. The aim of this study was to investigate the changes in total energy intake according to the level of skeletal muscle mass. SUBJECTS/METHODS: A total of 8,165 subjects ${\geq}30years$ of age from the Korean National Health and Nutrition Examination Surveys (KNHANES) 2008-2011 were included in the analysis, and multivariate-adjusted regression analyses were performed to analyze the association of the quartiles of sarcopenia index (SI) with energy intake of the study population after adjusting for age and metabolic parameters. RESULTS: The increase in SI quartile was in proportion to the gradual decrease in systemic lipids and the anthropometric measurement of fat accumulation (P < 0.001). Subjects in higher SI quartiles tended to consume more total energy and energy-producing nutrients than those in lower quartiles (P < 0.001). After age, body weight, alcohol consumption, and metabolic parameters were adjusted in the analysis, total energy intake gradually increased according to the increase in SI quartile, and the association between total energy intake and SI was more pronounced in men. However, the risk (odd ratio) of having a low SI was not affected by any single macronutrient intake. CONCLUSION: In this study, total energy intake was positively associated with SI and relative skeletal mass in both men and women. However, no significant association or a weak association was observed between any single macronutrient intake and skeletal muscle mass. The data indicated that acquiring more energy intake within the normal range of energy consumption may help to maintain skeletal muscle mass.

• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.4
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• pp.1092-1096
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• 2003

This study was carried out to investigate the clinical effects of Tongbiyeum(TBY) ₂on hyperlipidemia. The hyperlipidemia of rats was induced by feeding high cholesterol diet for 4 weeks. We checked serum lipids and body weight weekly for 4 weeks. After the termination of treatment, we measured liver weight and observed histopathological change. We compared result of TBY group with control group. Thereafter, we made a study of 37 hyperlipidemic patients who visited us, the oriental medical center Daejeon and cheongju of Daejeon University, from November, 2001 to April, 2002. After administering TBY for 1 month, we followed up their total cholesterol, triglyceride and HDL-Cholesterol levels. The results were as follows; TBY treatment inhibited the liver weight gain induced by high cholesterol diet as compared with control group. TBY treatment inhibited lipid droplet accumulation and apoptotic change in liver as compared with control group. TBY treatment significantly inhibited the increasing of serum triglyceride and total cholesterol levels induced by high cholesterol diet as compared with control group but not affect HDL-cholesterol level. After administering TBY, the serum total cholesterol, triglyceride and LDL-cholesterol levels of hyperlipidemic patients were decreased significantly. After administering TBY, the serum HDL-Cholesterol level of hyperlipidemic patients had no significant changes. According to above mentioned results, we can infer that TBY has hypolipidemic effect to be applicable to artheriosclerosis.

• Biomolecules & Therapeutics
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• v.23 no.4
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• pp.357-366
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• 2015

Isorhamnetin (3-methylquercetin) is a flavonoid derived from the fruits of certain medicinal plants. This study investigated the photoprotective properties of isorhamnetin against cell damage and apoptosis resulting from excessive ultraviolet (UV) B exposure in human HaCaT keratinocytes. Isorhamnetin eliminated UVB-induced intracellular reactive oxygen species (ROS) and attenuated the oxidative modification of DNA, lipids, and proteins in response to UVB radiation. Moreover, isorhamnetin repressed UVB-facilitated programmed cell death in the keratinocytes, as evidenced by a reduction in apoptotic body formation, and nuclear fragmentation. Additionally, isorhamnetin suppressed the ability of UVB light to trigger mitochondrial dysfunction. Taken together, these results indicate that isorhamnetin has the potential to protect human keratinocytes against UVB-induced cell damage and death.

• Korean Journal of Community Nutrition
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• v.4 no.1
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• pp.103-110
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• 1999

The purpose of this study was to determine the effects of taurine supplementation and taurine depletion on blood glucose and blood lipid concentrations in insulin-treated diabetic rats. Four groups of Sprague-Dawley male rats were fed the purified diet for 3 weeks ; nontaurine-supplemented diabetic rats(E0), nontaurine-supplemented diabetic rats with insulin treatment(E0＋I), 1% taurine-supplemented diabetic rats with insulin treatment(E1＋I) and taurine-depleted diabetic rats with insulin treatment(EA＋I). Diabetes was induced by streptozotocin injection(50mg/kg B.W.). Isophane insulin was given subcutaneously into the abdominal wall of the diabetic rats(4 unit/rat/day). E1＋I were supplemented with 1% taurine in drinking water. To induce taurine depletion, EA＋I were treated with 5% $\beta$-alanine in drinking water. E1＋I had significantly higher body weight compared to that of E0. The food intakes of E1＋I and E0＋I were significantly decreased compared to that of E0. There was no sigfniciant difference in food intake between E1＋I and E0＋I. The water intake of rats was significantly different among the groups ; E0>E0＋I>E1＋I>EA＋I. The urine volume of E0 was significantly increased compared to those of insulin-treated goups. The blood glucose concentration of E0 was significantly increased compared to those of insulin-treated groups. In the oral glucose tolerance test(OGTT), E0＋I and E1＋I had significantly lower blood blucose concentrations compared to E0 after 30 min. Also EA＋I had significantly lower bloodglucose concentrtion compared to E0 and E0＋I. The plasma total cholesterol and LDL-cholesterol concentratons of EA＋I were significantly incrased compared to those of other groups. Therefore, it may be suggested that tuarine supplementation is useful for insulin-dependent diabetes in order to prevent diabetic complications suchas cardiac vascular diseases.