• 대한한방내과학회지
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• 제29권1호
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• pp.189-199
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• 2008

Background & Objective : Jichul-hwan(JCH) has been used for the treatment of functional dyspepsia, regarded as a gastric dysmotility disease. We investigated the effects of JCH on gastric motility and its mechanisms of action in rats. Methods : The gastric wall was injured by tracting a part of stomach body in rats. Gastric emptying was measured after administration of normal saline(NS) or JCH in normal rats and gastric wall injured rats. To evaluate the mechanism of JCH under delayed gastric emptying conditions, normal rats were treated with atropine sulfate(1mg/kg, s.c.), quinpirole HCl(0.3mg/kgg, i.p.), $NAME(N^{G}-nitro-L-arginine$ methyl ester, 75mg/kg s.c.) and cisplatin(10mg/kg, i.p.). The gastric slow waves were measured for 30 minutes before and after administration of each solution(NS, JCH). Results : JCH 110.1mg/kg improved gastric emptying for 2 hrs(p=0.014). JCH 110.1mg/kg improved gastric emptying in the gastric wall injured rats(p=0.001). Under the delayed gastric emptying, JCH 110.1mg/kg improved gastric emptying in the group treated with atropine $sulfate(1.83{\pm}0.96$ vs $8.43{\pm}8.46$, p=0.003), but aggravated it with quinpirole $HCl(4.7{\pm}2.9$ vs $1.61{\pm}2.09$, p=0.021). Administration JCH 110.1mg/kg increased EGG power in rats. Conclusions : JCH stimulates gastric motility through the cholinergic pathway, so we expect that it would be effective in the treatment of dysmotility-like functional dyspepsia with low activity of vagus nerve.

• Biomolecules & Therapeutics
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• 제10권1호
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• pp.19-24
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• 2002

The effects of a newly synthesized $H^+/K^+$ ATPase inhibitor,1-(2-methyl-4-methoxypheny)-4-[(3-hy-droxypropyl)amino] -6-methyl-2,3-dihydropyrrolo (3,2-c) quinoline (DBM-819) , on the central nervous system, isolated smooth muscle, cardiovascular and digestive systems and renal function were investigated in various experimental animals. Oral administration of DBM-819 had no effect on the central nervous system except body temperature of mice slightly decreased at doses of 15 and 50 mg／kg. DBM-819 produced a moderate analgesic effect in acetic acid-induced writhing test in mice at 50 mg／kg (p.o.). In conscious rats, DBM-819 (15 and 50 mg／kg, p.o.) showed a slight increase in blood pressure and a small decrease in heart rate. DBM-819 had an significant effect on agonist-induced contraction of guinea pig ileum at $1.5{\times}10^{-5}g/ml.$ No significant effect of DBM-819 (5 and 15 mg／kg, i.p) on urinary volume or urinary excretion of $Na^+,\;K^+$ and Cl- was observed in rats. DBM-819 had no significant effect on intestinal transport of a semisolid meal in mice at 15 and 50 mg／kg (p.o.). These findings suggest that DBM-819 exerts no significant pharmacological effects on the central nervous system and renal function at 15 mg／kg (p.o.), but produces some effects on the smooth muscle and circulatory system.

• 패션비즈니스
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• 제22권1호
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• pp.1-19
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• 2018

The purpose of this study is to analyze the fashion style of Kate Middleton, the Royal Family, and to examine the social and cultural influence of Middleton fashion. We selected 314 photographs collected from a Google site and Gettyimages.com April 2011-December 2016 as the final research subjects. We categorized the situation by domestic events, royal events, diplomatic activities, and social contribution activities, and analyzed fashion styles focusing on item composition, color, material, silhouette, detail, trimming, and length. As a result of the study, the one piece was the highest in the combination of items, and the color was the most in white. The color tones were mostly vivid, and the material texture was silky. The image was classic, and the dress code was high in semi-formal. In a situational style, the coat was the most common at the Royal Family events and blue or white of the light tones appeared in the formal style of the classic image. In domestic events, there were many silky textures of modern image, and vivid, strong tonal knee length H line dress was the most prevalent. During diplomatic activities, various colors such as red, green, gray appeared in addition to blue or white and in social contribution activities, many dresses of vivid and dark tones of red appeared in the dress code as semi-formal. In conclusion, the stylistic features of Kate Middleton and the Royal Family are largely in the form of royal and noble, low cost and chic, and body-conscious styling.

• 패션비즈니스
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• 제23권1호
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• pp.14-24
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• 2019

Various types of functional bedding for inducing and maintaining sleep, are developed and launched with the importance of improving health through sleep emphasized currently. The purpose of this study is to examine development status and direction of functional bedding in the $4^{th}$ Industrial Revolution era, through systematic classification of elements of IoT-based smart bedding cases actively developed as functional bedding at home and abroad. Through previous research, literature and Internet data, characteristics and functional extension of smart bedding and the background of smart bed development was analyzed. And it was analyzed that smart bedding pursues recent functionalism and convergence of physical and digital concept such as IoT or AI, and also mental value to improve sleep quality. As bedroom where smart bedding place in has the private and limited characteristics and users are in sleep-conscious, that hard to ensure power and discomfort in carrying are moderated and the aesthetic elements are not very important, and that the smart bedding performance while sleeping were affected on developmental background. Based on CES case study and analysis on how smart beds are functionally expanded from conventional bedding, smart beds have gained information through digital sensing, and common properties that can be controlled anytime, anywhere, using a smart phone. Some set up the right environment and pose, while others stimulate nerves directly as active intervention. It is expected that smart bedding will be developed to cure user's body and mind, through active intervention when sleeping.

• Tuberculosis and Respiratory Diseases
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• 제82권4호
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• pp.335-340
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• 2019

Background: Snoring is the cardinal symptom of obstructive sleep apnea (OSA). Snoring and upper airway obstruction associated with major oxygen desaturation may occur in populations undergoing flexible bronchoscopy. Methods: To evaluate the prevalence of patients at a high risk of having OSA among patients undergoing bronchoscopy with sedation and to investigate whether snoring during the procedure predicts patients who are at risk of OSA, we prospectively enrolled 517 consecutive patients who underwent the procedure with moderate sedation. Patients exhibiting audible snoring for any duration during the procedure were considered snorers. The STOP-Bang (Snoring, Tiredness, Observed apnea, high blood Pressure-Body mass index, Age, Neck circumference and Gender) questionnaire was used to identify patients at high (score ${\geq}3$ out of 8) or low risk (score <3) of OSA. Results: Of the 517 patients, 165 (31.9%) snored during bronchoscopy under sedation. The prevalence of a STOP-Bang score ${\geq}3$ was 61.9% (320/517), whereas 200 of the 352 nonsnorers (56.8%) and 120 of the 165 snorers (72.7%) had a STOP-Bang score ${\geq}3$ (p=0.001). In multivariable analysis, snoring during bronchoscopy was significantly associated with a STOP-Bang score ${\geq}3$ after adjustment for the presence of diabetes mellitus, chronic obstructive pulmonary disease, chronic kidney disease, and stroke (adjusted odds ratio, 1.91; 95% confidence interval, 1.26-2.89; p=0.002). Conclusion: Two-thirds of patients undergoing bronchoscopy with moderate sedation were at risk of OSA based on the screening questionnaire. Snoring during bronchoscopy was highly predictive of patients at high risk of OSA.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제48권6호
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• pp.348-355
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• 2022

Objectives: To compare the vital sign stability and cost of two commonly used sedatives, midazolam (MDZ) and dexmedetomidine (DEX). Patients and Methods: This retrospective study targeted patients who underwent mandibular third molar extractions under intravenous sedation using MDZ or DEX. The predictor variable was the type of sedative used. The primary outcome variables were vital signs (heart rate and blood pressure), vital sign outliers, and cost of the sedatives. A vital sign outlier was defined as a 30% or more change in vital signs during sedation; the fewer changes, the higher the vital sign stability. The secondary outcome variables included the observer's assessment of alertness/sedation scale, level of amnesia, patient satisfaction, and bispectral index score. Covariates were sex, age, body mass index, sleeping time, dental anxiety score, and Pederson scale. Descriptive statistics were computed including propensity score matching (PSM). The P-value was set at 0.05. Results: The study enrolled 185 patients, 103 in the MDZ group and 82 in the DEX group. Based on the data after PSM, the two samples had similar baseline covariates. The sedative effect of both agents was satisfactory. Heart rate outliers were more common with MDZ than with DEX (49.3% vs 22.7%, P=0.001). Heart rate was higher with MDZ (P=0.000). The cost was higher for DEX than for MDZ (29.27±0.00 USD vs 0.37±0.04 USD, P=0.000). Conclusion: DEX showed more vital sign stability, while MDZ was more economical. These results could be used as a reference to guide clinicians during sedative selection.

• Clinical Endoscopy
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• 제57권2호
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• pp.196-202
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• 2024

Background/Aims: Hypoxemia is a common side effect of propofol sedation during endoscopy. Applying mild positive airway pressure (PAP) using a nasal mask may offer a simple way to reduce such events and optimize the conditions for diagnostic and therapeutic upper gastrointestinal endoscopies. Methods: We compared overweight patients (body mass index >25 kg/m²) with a nasal PAP mask or standard nasal cannula undergoing upper gastrointestinal endoscopies by non-anesthesiologists who provided propofol sedation. Outcome parameters included the frequency and severity of hypoxemic episodes. Results: We analyzed 102 procedures in 51 patients with nasal PAP masks and 51 controls. Episodes of hypoxemia (oxygen saturation [SpO₂] <90% at any time during sedation) occurred in 25 (49.0%) controls compared to 8 (15.7%) patients with nasal PAP masks (p<0.001). Severe hypoxemia (SpO₂ <80%) occurred in three individuals (5.9%) in both groups. The mean delta between baseline SpO₂ and the lowest SpO₂ recorded was significantly decreased among patients with nasal PAP mask compared to controls (3.7 and 8.2 percentage points difference, respectively). There were significantly fewer airway interventions performed in the nasal PAP mask group (15.7% vs. 41.2%, p=0.008). Conclusions: Using a nasal PAP mask may be a simple means of increasing patient safety and ease of examination.

• 대한방사선기술학회지:방사선기술과학
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• 제34권4호
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• pp.297-303
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• 2011

병원 근로자의 VDT 자각 증상에 대한 선행연구를 보면 대부분이 간호사 관련 직종으로 한정되어 있고, 방사선사에 대한 연구는 수행되지 않았다. 본 연구는 2009년 10월 15일부터 11월 2일까지 대전광역시에 소재하고 있는 종합병원에 VDT 작업을 시행하는 보험심사, 원무, 의무기록, 전산, 행정부서 근무자와 방사선사를 대상으로 구조화된 설문지를 활용하여 분석하였다. 연령이 20~29세, 임상경력이 5년 이하, 일반직원이며, 미혼인 대상자가 VDT 증후군 자각증상 중 피부, 심리 증상에서 유의한 차이를 보였으며, 연령이 30~39세, 임상경력이 6~10년, 관리자, 기혼인 대상자가 VDT 증후군 자각증상 중 안관련 증상, 전신 증상, 근골격 증상에서 유의한 차이를 보였다. VDT 증후군 자각 증상 점수를 종속변수로 한 다중선형회귀 분석 결과 관련 요인으로 안관련 증상에 영향을 미치는 요인을 보면 성별, 건강염려, 일상생활 방해이며, 전신증상은 운동, 스트레스, 건강상태 인지 관련, 근골격 증상에서는 임상경력 6~10년, 대인관계, 건강상태 인지 관련 건강염려와 일상생활 방해로 나타났으며, 통계적으로 유의한 차이를 보였다. 타부서 근로자와 방사선사의 VDT 증후군 자각 점수 차이가 크게 나타나지 않았다는 것은 방사선사의 업무가 VDT 작업환경으로 변함으로써 VDT 증후군 자각 증상이 일어날 수 있다고 말할 수 있다. 이는 정기적인 순환근무를 시행함으로써 VDT 작업환경에 지속적인 노출을 피하는 것이 예방 대책이라 할 수 있다.

• Tuberculosis and Respiratory Diseases
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• 제64권6호
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• pp.456-459
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• 2008

기관지 이물 흡인은 생명을 위협할 수 있는 응급 질환으로 자세한 병력 청취, 증상, 이학적 검사, 방사선학적 검사를 통해 진단할 수 있다. 하지만 흡인 물질이 방사선 투과성이거나 환자가 흡인 사실을 기억하지 못한다면 진단에 어려움이 따른다. 본 증례는 환자가 방사선 투과성 물질인 임시 수지 가공의치(temporary resin bridge)를 흡인하였으나, 환자가 이를 인지하지 못하였고 흉부 X선에서도 특이소견이 발견되지 않아 기관지 이물 흡인의 가능성을 예측하지 못하였던 경우였다. 또한 이와 관련되어 드물게 발생하는 염증성 용종을 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• 마케팅과학연구
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• 제20권3호
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• pp.249-261
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• 2010

随着消费者对环境的关注不断增加, 许多公司都积极从事环境营销来实现其目标. 不过, 有关环境的消费者的高度关注并不总是反映在他们的购买行为. 这表明需要有一个绿色消费的范围内个人的信仰体系的发展有深入的了解. 考虑到心理学的方法, 大量的研究机构已测试的基本因素和生态意识的消费者行为, 这些因素的相互关系. 然而, 以往的研究大多数集中于西方国家. 本研究使用韩国消费者为研究样本, 试图了解韩国绿色消费的基础, 发现跨文化在指导消费者的环保态度和行为的重要的普遍价值. 为此, 我们联系了Schwartz在1992年提出的10个普遍价值和价值-态度-行为层次模式的环境行为. 参照价值-态度-行为的框架, 我们提出的概念模型可以解释韩国消费者的环保态度中表现出了什么动机, 以及后来此态度如何影响他们的绿色选择. 其中, 可利用相关的环保价值的关系模式, 我们首先假设激励价值类型和环境态度之间存在特定的关系. 在假设2中, 环境态度被假定用来预测环境行为. 这个假设的基础是对环境有利的态度可能会产生许多不同的行为, 我们认为消费者对环境的有利的态度和各种环保行为是相关的. 因为有环保态度的人们会对环保行动方面的知识更感兴趣. 与假设2一致, 我们推测在不同的环保行为之间存在正相关关系. 564名大学生参加了这项研究. 样本包括308名男性, 254名女性, 2名参与者没有注明性别. 参加者的平均年龄为22.5(标准差=2.11)岁, 年龄范围从19岁到39岁. 至于专业, 我们作出了特别努力使得参与者来自于大学的不同学科. 所收集的数据是通过自我完成问卷调查. 问卷评估参与者的价值优先, 环境态度和行为. 我们进行了路径分来测试所提出的模型. 观测的模型的整体适配度为x2=72.01(p=0.00), GFI的=0.983, CFI=0.982, NFI=0.970, RMR=0.070, 和REMSEA=0.050. 大部分适配值表明了数据与模型拟合良好. 因此, 环境态度价值, 环境的非购买行为和环境的购买行为的层级关系得到了确认. 所有的预测路径被路径系数评估, 几个主要影响假设被确认. 在10个价值类型之外, 普遍性和力量是显著的但是与环境态度的关系是相反的. 与其他研究一致, 我们的结果证实了环境态度是引导各种关注环境的行为的一个重要因素. 最后我们发现环境非采购和购买行为之间有显著关系. 路径分析支持普遍性价值为韩国消费者的绿色意识提供了动机而且他们通过对环境的有利态度间接的支持了环保行为. 我们发现拥有高环境态度的参与者积极的投入到各种关注环境的消费者行为中. 在本研究中, 考虑到价值导致环保主义和进一步证实先前的结果我们提供了测试跨文化差异的机会. 此外, 我们已测试了关于三个不同类型的环境行为的态度与行为的关系. 环境的态度和行为之间的路径的不同优势, 研究人员建议, 应考虑行为的特异性, 努力改善低的态度-行为的相关性. 最后, 本文阐明了随着对环境不断增长的关注, 人们生活中的绿色行为也不断的增加.