• Journal of Nutrition and Health
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• 제14권2호
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• pp.105-116
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• 1981

분만전후 4주동안 Sqraque Dawley 암컷 쥐에게 양적으로 식이를 제한했다. 임의로 먹인 control group의 1일평균성취량의 1/2의 시중사로를 식이제한 group에게 주었다. Deficient I group에서는 분만후부터 이유시까지 식이제한을 했고, deficient II group에서는 임신 15일부터 이유시까지 계속 식이제한을 했다. 식이제한 group의 체중과 뇌무게는 control group의 새끼쥐보다 유의적으로 낮았지만, 체중에 대한 뇌무게의 비는 control group보다 높았다. 이유시에는 두 식이제한 group사이에서 체중과 뇌무게의 유의적인 차가 나타났다. 뇌의 DNA, RNA 및 단백질함량은 control group보다 식이제한 group에서 유의적으로 낮았지만 RNA/DNA, 뇌무게/DNA 및 단백질/DNA은 control group보다 식이제한 group에서 높았다. 이것은 새끼쥐뇌에서 세포분열이 세포의 크기성장보다 이 기간중의 어미쥐의 식이제한에 의해 더욱 심한 영향을 받았음을 시사해준다. 뇌의 DNA와 RNA는 두식이제한 group간에 유의적인 차를 나타내지만, 단백질의 경우는 유의적인 차를 나타내지 않았다.

• Asian-Australasian Journal of Animal Sciences
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• 제21권3호
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• pp.404-413
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• 2008

Major objectives were to evaluate effects of three schemes of bST-supplementation of Holstein cows (142.8 mg/14 d, POSILAC) during the prepartum and/or postpartum periods through 63 d (${\pm}3d$) of lactation. Measures evaluated the potential of treatments to improve body weight (BW) and body condition score (BCS), provoke changes in plasma concentrations of somatotropin (ST) and IGF-I, and improve milk yield, milk composition (percentages of protein and fat, and somatic cell counts), and several calving variables. Multiparous Holstein cows were randomly assigned to a $2{\times}2$ factorial arrangement of treatments (TRT) to give four groups (I = no bST, n = 26; II = bST postpartum, n = 25; III = bST prepartum, n = 27; IV = bST prepartum and postpartum, n = 25). During the prepartum period, cows in groups I and II were not supplemented but those in groups III and IV were supplemented every 2-wk beginning 21 d before expected calving date through calving. During the first 63 DIM only cows in groups II and IV were supplemented with bST. From 64 DIM through the end of lactation cows in all groups were supplemented with the full lactation dose of bST (500 mg/14 d). The BW and BCS were recorded weekly throughout the prepartum and postpartum periods and every 2-wk beyond 70 DIM. Blood samples were collected 3-times a week for analyses of ST and IGF-I. Milk yields were recorded daily though 150 DIM. Prepartum supplementation of bST did not affect BW or BCS, but mean concentrations of ST were increased 12.2% and were 15.5% greater at calving. Overall, mean concentration of IGF-I was not affected by treatment but concentrations were greater at 1 and 2 wk before calving in bST-supplemented cows. During the first 63 DIM the BW and BCS were not affected by treatment. Significant effects of bST-supplementation were detected on concentrations of ST, IGF-I and on milk yield compared to non-supplemented cows in group I. Postpartum concentrations of ST were greater in bST-supplemented cows (TRT II and IV; +41.9 and 54.6%). However, concentrations of IGF-I were greater only in cows in group IV (+25.9%) during the postpartum period. Overall, the three bST-supplemented groups had greater actual milk yield than the control group (I) during the first 63 and 150 DIM. The actual milk yields during 63 and 150 DIM were 6.5 and 4.6 kg/d greater for cows in group IV than cows in group I and the 305-d ME milk yield also was 15.6% greater. No adverse effects of TRT were observed on calf birth weight, colostrum immunoglobulins, ease of calving or other measures evaluated.

• 대한의생명과학회지
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• 제11권3호
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• pp.275-279
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• 2005

High-salted mineral water (Daehan Deep Water, Korea) that is pumped up from below the sedimentary rock layer of Dadaepo, Busan, Korea has a composition similar with that of deep sea water. Under the well-being boom, the mineral water is processed for various uses including washing or oral administration. However, high concentrations of various minerals in the mineral water are suspected to affect on the physiology of human body, especially on blood pressure (BP). Here, we examined the effect of Hot Mineral(R), dried powder of the mineral water, on the change of BP. Sprague­Dawley rats were grouped and orally administered $2.5\%$ Hot Mineral(R) (group M), $2.5\%$ NaCl (group S) or normal water (group C). Excreted urine was collected in metabolic cage for 24 hours. The systolic blood pressure (SBP) of the group S was remarkably increased (P<0.005) compared with that of the group M and the group C, which showed little changes of the SBP during 2 weeks. While average daily sodium intake were 0.32 mg in the group C, 6.64 mg in the group M and 4.07 mg in the group S, average daily sodium excretion were 11.37 mg, 53.70 mg and 7.75 mg, respectively. These results indicate that the sodium excretion in the group M was much higher than the other two groups. In this study, we suppose that the plenty amount of minerals such as calcium, potassium and magnesium in Hot Mineral? have an effect not to increase the SBP and to prompt sodium excretion out of the body. Therefore, these results suggest that oral administration of appropriate amount of Hot Mineral(R) for limited period does not induce increased SBP.

• 대한지역사회영양학회지
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• 제10권4호
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• pp.525-535
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• 2005

This study was conducted to investigate the effect of a 3 week low calorie diet (LCD) and a 9 week of behavior modification (BM) program on the weight loss, mineral and vitamin status in 22 obese women. The subject were healthy, obese (PIBW> $120\%$) women aged 20 - 50 Yr and not taking any medications known to influence body composition, mineral or vitamin metabolism During the LCD program, subjects were provided commercial liquid formulas with 125 kcal per pack and were instructed to have a formula for replacement of one meal and at least one regular meal per day within the range of daily 800 - 1200 kcal intake. During the BM program the subjects weekly attended the group nutrition counseling session to encourage themselves to modify their eating behavior and spontaneously restrict their energy intakes. The BM program focused on stimulus control, control of portion sizes and modification of binge eating and other adverse habits. The initial mean energy intake of subjects was 2016.9 $\pm$ 129.8 kcal ($100.8\%$ of RDA) and dropped to 1276.5 $\pm$ 435.7 kcal at the end of a 3 week of LCD program and elevated to 1762 $\pm$ 329.3 kcal at the end of a 9 week of BM program. Carbohydrate, protein and fat intakes were significantly decreased at the end of the LCD but carbohydrate was the only macro nutrient that showed significant decrease (p < 0.05) at the end of the BM program compared to baseline. Calcium and iron intakes decreased significantly (p < 0.01, respectively) with no significant changes in other micronutrients at the end of the LCD. The mean weight of the subjects decreased from 73.8 $\pm$ 8.0 kg to 69.2 $\pm$ 7.7 kg with LCD and ended up with 67.7 $\pm$ 7.1 kg after 9 weeks of BM. The 3 weeks of LCD reduced most of the anthropometric indices such as BMI, PIBW, fat weight, wast-to-hip ratio and subscapular and suprailiac skinfold thickness. The 9 weeks of behavior modification showed slight change or maintenance of each anthropometric measurements. Weight loss and decreased WHR with the diet program induced significantly decreased systolic blood pressure. SGOT, SGPT and serum insulin levels with improved serum lipid profiles. Biochemical parameters related to iron status such as hemoglobin, hematocrit were significantly decreased (p < 0.01) at the end of the LCD. But their mean values were within normal range. The mean serum 25 (OH) vitamin $D_3$ level significantly increased after whole diet program. Serum folate level significantly decreased after 12 weeks of diet program. In conclusion 3 weeks of LCD brought 4.6 kg reduction in body weight without risk of iron, zinc or vitamin D deficiency and 9 weeks of the BM was effective to maintain nutritional status with slightly more weight reduction (1.5 kg). However calcium intake and serum folate should be monitored during the LCD and BM because of increased risk of deficiencies.

• 한국버섯학회지
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• 제10권4호
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• pp.224-235
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• 2012

최근 식용버섯에 대한 자실체의 아미노산 성분함량은 자료별로 수집하면 종류 및 성분함량에 있어서 그 차이가 크며, 성분에 대한 일정한 어떤 경향치를 확인하기 곤란한 상황이다. 버섯품종 및 저장 온도에 따른 영양성분의 손실을 비교 조사하고 그 기준을 정립하기 위한 기초자료 수집을 목적으로 팽이버섯 자실체 내의 아미노산을 함량을 HPLC로 분석 정량하여 버섯 자실체의 영양성분의 변화를 검토하고자 하였다. 수확후 시료에서 가장 높은 함량을 보인 성분은 cystein, arginine, gultamic acid, proline 등이었으나 품종 및 저장기간에 따라 많은 차이를 보인다. 저장온도별 분석결과에서는 $-1^{\circ}C$ 보다 $4^{\circ}C$에서 저장하는 것이 저장기간에 따른 성분손실이 적은 것으로 나타났다. 계통간에 저장기간에 따른 아미노산 종류별 함량에서 백색계열은 그 변화가 심하지 않았으나 갈색계통은 그 변화가 심하여, 백색 및 갈색 계통간의 차이가 크고, 계통내의 품종간에서도 그 차이가 있었다. 아미노산 함량은 일부 Proline등과 같이 증가하는 경우를 보이는 경우를 제외하고, 일정하지는 않으나 저장기간에 따라 감소하는 경향을 보이고 있다. 종합해보면 팽이버섯 자실체의 아미노산 함량은 계통, 품종, 저장기간 등에 따라 차이를 있는 것을 확인할 수 있었다.

• 생명과학회지
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• 제21권11호
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• pp.1532-1540
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• 2011

본 연구는 7주령의 S D계 흰쥐를 이용하여 12주 동안의 사다리 오르기 저항성 운동 수행 후 가자미근과 비복근 내 GLUT-4 발현량 및 LDH 동위효소들의 변화를 측정하여 당 대사 및 젖산 기전에 대한 연구로 다음과 같은 결론을 얻었다. 12주간의 사다리 오르기 저항성 운동은 체중감소에 효과적인 것으로 나타났으며, 가자미근 및 비복근 조직 GLUT-4 단백질 발현을 유의하게 증가시키는 것으로 나타났다. 또한 가자미근 및 비복근 조직 LDHA B-type 동위효소의 발현을 유의하게 증가시키는 것으로 나타났다. 본 연구의 결과를 종합해 볼 때 12주간의 저항성훈련은 체중의 감소와 골격근 내 GLUT-4의 증가 그리고 LDH A4 동위효소를 제외한 LDH B-type 동위 효소의 증가와 같은 신체조성의 균형과 당대사능력 및 미토콘드리아의 기능 개선에 영향을 미치는 것으로 사료된다. 추후 연구에서는 휴식시간이나 운동 강도의 차이와 근형태별에 따른 유 무산소적 저항훈련 프로그램의 효과에 따른 다양한 연구가 실시되어야 할 것으로 생각된다.

• 생명과학회지
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• 제20권1호
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• pp.71-76
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• 2010

본 연구는 중년 남성들을 대상으로 3년간 1년에 1회씩 3차례에 걸쳐 운동부하 검사 시 심전도 반응을 측정하여 야외 및 트레드밀 걷기 운동 참여 여부에 따라 부하 심전도의 변화에 어떠한 양상이 나타나는지를 규명하고자, 안정 시 신체조성 분석, 운동부하 검사 시 심전도 반응을 측정하였다. 안정 시 신체조성 분석은 체지방율과 BMI를 측정하였고, 안정 시 및 운동부하 검사 시 심전도 반응은 ST/HR 경사 및 QRS 벡터를 측정하였는데, 그 결과는 다음과 같다. 1. ST/HR 경사의 변화에 있어서 운동 6분부터 통제 집단은 감소하기 시작하여 운동 9분과 peak시에 $2.4\;{\mu}V/bpm$ 이하로 감소하여 허혈 증상이 나타났다. 2. QRS 벡터의 축 각도에 있어서 안정 시 전면 축은 시간이 경과함에 따라 통제 집단이 우측으로 유의하게 편향되었고, 안정 시 수평면 축은 시간이 경과함에 따라 통제 집단이 등 쪽으로 유의하게 향하였다. 안정 시 수평면 파고의 길이에 있어서 통제 집단은 시간이 경과함에 따라 유의하게 감소하였고 걷기 운동 집단은 유의하게 증가하였다. 결론적으로 비 활동의 중년 남성들은 운동 중 심근 허혈 유발, QRS 벡터의 편향 등이 현저하게 나타난 반면, 규칙적인 야외 및 트레드밀 걷기 활동에 참여한 중년 남성들은 심혈관계 질환 위험 요소의 감소로 심장기능이 향상된 결과를 알 수 있었다.

• 한국수산과학회지
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• 제34권3호
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• pp.173-178
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• 2001

저분자 alginate인 HAG-10, HAG-50, HAG-100 및 alginate를 랫드에 35일간 섭취시켰을 때, 혈청중의 지질성분과 동맥경화지수의 측정으로 특성이 가장 좋은 저분자 alginate인 HAG-50의 안전성을 확보하기 위해 랫드에 경구급성독성실험을 실시하였다. 혈청중 total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides 및 phospholipid 함량과 동맥경화지수는$5\%$ 와 $10\%$HAG-50에서 모두 유의적으로 뚜렷히 감소하여 지질대사 개선효과를 나타내었다. HAG-50의 경구급성독성실험을 검토한 결과, 투여할 수 있는 최고 용량인 랫드 체중 kg당 5.0g의 용량에서도 암$\cdot$수 모두 일반상태의 이상 반응과 폐사 및 병리$\cdot$조직학적 이상을 나타내는 예는 전혀 관찰되지 않아서 $LD_{50}$치의 산출이 불가능하였으므로 HAG-50은 아주 안전한 제재임이 검증되었다. 이상의 결과를 종합해 볼 때, 평균분자량 50,000 정도의 저분자 alginate인 HAG-50이 가장 우수한 지질대사 개선효과의 기능적 특성을 발휘하였으며, 경구급성독성실험 에서도 독성이 전혀 없었고, alginate가 가지고 있는 고유의 생리적 기능을 유지 향상시키면서 이용에 제한이 되고 있는 점성을 줄이고 용해도를 높혀서 alginate의 이용성을 높일 수 있는 새로운 형태의 식품소재라고 사료된다.

• Nutrition Research and Practice
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• 제16권1호
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• pp.60-73
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• 2022

BACKGROUND/OBJECTIVES: The extract from Dendropanax morbifera exhibited diverse therapeutic potentials. We aimed to evaluate the efficacy and safety of D. morbifera leaf extract for improving metabolic parameters in human. SUBJECTS/METHODS: A 12-week, double blind, placebo-controlled and randomized trial included a total of 74 adults, and they were assigned to the placebo group (n = 38) or 700 mg/day of D. morbifera group (n = 36). The efficacy endpoints were changes in glycemic, lipid, obesity, and blood pressure (BP) parameters, in addition to the prevalence of metabolic syndrome (MetS) and the numbers of MetS components. Safety was assessed by monitoring adverse events (AEs). RESULTS: After 12 weeks of treatment, the hemoglobin A1c (HbA1c) level significantly decreased in the D. morbifera group compared to that of the placebo group (difference: -0.13 ± 0.20% vs. 0.00 ± 0.28%, P = 0.031; % of change: -2.27 ± 3.63% vs. 0.10 ± 5.10%, P = 0.025). The homeostatic model assessment for insulin resistance level also decreased significantly from its baseline in the D. morbifera group. The systolic BP of D. morbifera group decreased significantly than that of placebo group (difference: -3.9 ± 9.8 mmHg vs. 3.3 ± 11.7 mmHg, P = 0.005; % of change: -2.8 ± 7.7% vs. 3.3 ± 10.2%, P = 0.005). However, the lipid parameters and body composition including body weight did not differ between the groups. The prevalence of MetS (36.8% vs. 13.9%, P = 0.022) and the incidence of MetS (10.5% vs. 13.9%, P = 0.027) at 12 weeks was significantly lower in the D. morbifera group than it was in the placebo group. No serious AEs occurred in either group. CONCLUSIONS: Supplementation with D. morbifera extracts over a 12-week period improved metabolic parameters such as HbA1c and BP and reduced the prevalence of MetS.

• Journal of Nutrition and Health
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• 제8권1호
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• pp.15-37
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• 1975

I. Subject of the study A study on the nutritive value and utilization of powdered seaweeds. II. Purpose and Importance of the study A. In Korea the shortage of food will be inevitable by the rapidly growing population. It will be very important study to develop a new food from the seaweeds which were not used hitherto for human consumption. B. The several kinds of seaweeds have been used by man in Korea mainly as side-dishes. However, a properly powdered seaweed will enable itself to be a good supplement or mixture to certain cereal flours. C. By adding the powdered seaweed to any cereals which have long been staple foods in this country the two fold benefits; saving of cereals and change of dietary pattern, will be secured. III. Objects and scope of the study A. Objects of the study The objects will come under four items. 1. To develop a powdered seaweed as a new food from the seaweeds which have been not used for human consumption. 2. To evaluate the nutritional quality of the products the analysis for chemical composition and animal feeding experiment will be conducted. 3. Experimental cocking and accepability test will be conducted for the powdered products to evaluate the value as food stuff. 4. Sanitary test and also economical analysis will be conducted for the powdered products. B. Scope of the study 1. Production of seaweed powders Sargassum fulvellum growing in eastern coast and Sargassum patens C.A. in southern coast were used as the material for the powders. These algae, which have been not used for human consumption, were pulverized through the processes of washing, drying, pulverization, etc. 2. Nutritional experiments a. Chemical composition Proximate components (water, protein, fat, cellulose, sugar, ash, salt), minerals (calcium, phosphorus, iron, iodine), vitamins (A, $B_1,\;B_2$ niacin, C) and amino acids were analyzed for the seaweed powders. b. Animal feeding experiment Weaning 160 rats (80 male and 80 female rats) were used as experimental animals, dividing them into 16 groups, 10 rats each group. Each group was fed for 12 weeks on cereal diet (Wheat flour, rice powder, barley powder, potato powder, corn flour) with the supplementary levels of 5%, 10%, 15%, 20% and 30% of the seaweed powder. After the feeding the growth, feed efficiency ratio, protain efficiency ratio and ,organs weights were checked and urine analysis, feces analysis and serum analysis were also conducted. 3. Experimental cooking and acceptability test a. Several basic studies were conducted to find the characteristics of the seaweed powder. b. 17 kinds of Korean dishes and 9 kinds of foreign dishes were prepared with cereal flours (wheat, rice, barley, potato, corn) with the supplementary levels of 5%, 10%, 15%, 20% and 30% of the seaweed powder. c. Acceptability test for the dishes was conducted according to plank's Form. 4. Sanitary test The heavy metals (Cd, Pb, As, Hg) in the seaweed powders were determined. 5. Economical analysis The retail price of the seaweed powder was compared with those of other cereals in the market. And also economical analysis was made from the nutritional point of view, calculating the body weight gained in grams per unit price of each feeding diet. IV. Results of the study and the suggestion for application A. Chemical composition 1. There is no any big difference in proximate components between powders of Sargassum fulvellum in eastern coast and Sargassum patens C.A. in southern coast. Seasonal difference is also not significant. Higher levels of protein, cellulose, ash and salt were found in the powders compared with common cereal foods. 2. The levels of calcium (Ca) and iron (Fe) in the powders were significantly higher than common cereal foods and also rich in iodine (I). Existence of vitamin A and vitamin C in the Powders is different point from cereal foods. Vitamin $B_1\;and\;B_2$ are also relatively rich in the powders.'Vitamin A in ·Sargassum fulvellum is high and the levels of some minerals and vitamins are seemed4 to be some influenced by seasons. 3. In the amino acid composition methionine, isoleucine, Iysine and valine are limiting amino acids. The protein qualities of Sargassum fulvellum and Sargassum patens C.A. are seemed to be .almost same and generally ·good. Seasonal difference in amino acid composition was found. B. Animal feeding experiment 1. The best growth was found at.10% supplemental level of the seaweed Powder and lower growth rate was shown at 30% level. 2. It was shown that 15% supplemental level of the Seaweed powder seems to fulfil, to some extent the mineral requirement of the animals. 3. No any changes were found in organs development except that, in kidney, there found decreasing in weight by increasing the supplemental level of the seaweed powder. 4. There is no any significant changes in nitrogen retention, serum cholesterol, serum calcium and urinary calcium in each supplemental level of the seaweed powder. 5. In animal feeding experiment it was concluded that $5%{\sim}15%$ levels supplementation of the seaweed powder are possible. C. Experimental cooking and acceptability test 1. The seaweed powder showed to be utilized more excellently in foreign cookings than in Korean cookings. Higher supplemental level of seaweed was passible in foreign cookings. 2. Hae-Jo-Kang and Jeon-Byung were more excellent than Song-Pyun, wheat cake, Soo-Je-Bee and wheat noodle. Hae-Je-Kang was excellent in its quality even as high as 5% supplemental level. 3. The higher levels of supplementation were used the more sticky cooking products were obtained. Song-Pyun and wheat cake were palatable and lustrous in 2% supplementation level. 4. In drop cookie the higher levels of supplementation, the more crisp product was obtained, compared with other cookies. 5. Corn cake, thin rice gruel, rice gruel and potato Jeon-Byung were more excellent in their quality than potato Man-Doo and potato noodle. Corn cake, thin rice gruel and rice gruel were excellent even as high as 5% supplementation level. 6. In several cooking Porducts some seaweed-oder was perceived in case of 3% or more levels of supplementation. This may be much diminished by the use of proper condiments. D. Sanitary test It seems that there is no any heavy metals (Cd, Pb, As, Hg) problem in these seaweed Powders in case these Powders are used as supplements to any cereal flours E. Economical analysis The price of the seaweed powder is lower than those of other cereals and that may be more lowered when mass production of the seaweed powder is made in future. The supplement of the seaweed powder to any cereals is also economical with the criterion of animal growth rate. F. It is recommended that these seaweed powders should be developed and used as supplement to any cereal flours or used as other food material. By doing so, both saving of cereals and improvement of individual's nutrition will greatly be achieved. It is also recommended that the feeding experiment for men would be conducted in future.