• Journal of Physiology & Pathology in Korean Medicine
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• v.31 no.1
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• pp.75-81
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• 2017

Dangguisoo-san (DGSS), a traditional Korean herbal formula, has been prescribed to patients who suffer from various symptoms related with blood stagnation. Since inflammation can cause blood stagnation, we hypothesized that DGSS suppresses inflammation, relieving the symptoms associated with blood stagnation. In this study, given that DGSS is prepared in a mix of alcohol and water, we prepared the methanol (mDGSS) and water extract (wDGSS) of DGSS and compared their activities in suppressing inflammatory reaction. Western blot analyses show that mDGSS was more effective than wDGSS in activating Nrf2, a key factor that suppresses inflammation. Semi-quantitative RT-PCR shows that mDGSS activating Nrf2 resulted in the induction of Nrf2-dependent genes expression. However, mDGSS was not effective in suppressing the nuclear translocation of $NF-{\kappa}B$, a key factor that promotes inflammation, and the expression of $NF-{\kappa}B$-dependent genes such as TNF-a and IL-1b. When comparing with wDGSS, mDGSS was less effective in suppressing luciferase activity driven by $NF-{\kappa}B$. Therefore, our results show that mDGSS has the anti-inflammatory function by mainly activating Nrf2, while wDGSS does by both activating Nrf2 and suppressing $NF-{\kappa}B$. Our results suggest that preparing DGSS in a mix of water and methanol is a better way to achieve a strong anti-inflammatory efficacy of DGSS.

• Journal of Society of Preventive Korean Medicine
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• v.23 no.2
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• pp.101-115
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• 2019

Objective : This study is aimed to application possibility and status of pattern identification in middle and high school students. Method : This study was cross-sectional study. We recruited 277 students through school doctor program of Seongnam city in 2017. Male students are 66 in middle school, 32 in high school. Female students are 117 in middle school, 62 in high school. For pattern identification, we used the tool of Qui Xui Shui pattern identification in students. Students fill questionnaires in inquiry of pattern identification and Korean medicine doctor diagnosis inspection and palpation of students. Results : Among 277 students, no pattern identification were 114(41.2%). It appeared in the order of phlegm, blood deficinecy, qi deficiency, qi stagnation and qi reversal. Qi deficiency, qi stagnation, qi reversal, blood deficiency and phlegm pattern are statistically significant by gender except blood stagnation. of 277 students, 105 (37.9%) had one more pattern identification. Conclusions : This study showed possibility of Qui Xui Shui pattern for student health management. In the future, large scale follow up study will be needed to clarify the relationship of pattern identification and student's health.

• Journal of Acupuncture Research
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• v.23 no.5
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• pp.31-37
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• 2006

Objectives & Methods : We investigated the cases for which spleen tonifying Sa-Am acupuncture was applied in ${\ulcorner}$Sa-Am-chim-gu-jeong-jeon(舍巖鍼灸正傳)${\lrcorner}$ and classified them according to the concepts of cold-heat & deficiency-excess for a better understanding of the application of spleen tonifying Sa-Am acupuncture. Results : 1. Tonification of Spleen Sa-Am acupuncture can be used to treat heat syndromes such as deficient fire caused by collapse of the spleen qi, stagnation of evil qi or spleen yin deficiency, by way of tonifying spleen qi, activating the flow of qi and blood or harmonizing spleen yin and yang. 2. Tonification of Spleen Sa-Am acupuncture can be used to treat cold syndromes such as weakness of spleen yang by way of promoting fire to generate earth, strengthening spleen yang and raising the clear yang. 3. Tonification of Spleen Sa-Am acupuncture can be used to treat deficiency syndromes such as malnutrition or poor appetite caused by spleen deficiency by way of tonifying spleen qi. 4. Tonification of Spleen Sa-Am acupuncture can be used to treat excess syndromes such as stagnation of qi and blood, abdominal mass or toxication by way of tonifying spleen qi and promoting the flow of qi and blood.

• The Journal of Internal Korean Medicine
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• v.18 no.2
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• pp.53-64
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• 1997

Many types of cancer, current therapy other than surgery and/or radiotherapy was of only limited efficacy. At the basic chinese traditional medicine(TCM) there was increased understanding of the additional basic and clinical neoplasm treatment research. The metastasis and recurrence of neoplasm was the basis of yudu(餘毒) on remained neoplasm cell and stagnation of blood, thermotoxo, phlegm, asthenia of healthy enerngy, stagnation of vital energy. The principles therapy of neoplasm on metastasis and recurrence was based on knowledge of the method of support the healthy energy and strengthen the body resistance, promote blood circulation to remove blood stasis, clear away heat and toxic materials, dissipate phlegm and disperse the accumulation of evils, regulate vital energy and disperse the depressed vital energy. But the major clinical features of neoplasm was to be considered in developing a treatment plan include (1) distinguish between clinical and pathologic staging - acute and chronic, (2) classification of pathologic pattern, and (3) distinction of body situation : for examples asthenia - sthenia etc. It was most important to distinguish between supporting the healthy and eliminating the evil factors and to treat differently at the root and the branch cause of a neoplasm. This paper's results indicate that identification and effective use of TCM medicines inhibited netastasis and decreased recurrence and then we were able to expect increasing survival rate.

• Journal of Physiology & Pathology in Korean Medicine
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• v.28 no.3
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• pp.251-262
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• 2014

This article is for understanding dementia with the perspective of Korean Medicine through research on syndrome differentiations of dementia clinically applied and relations between modern diseases and Korean Medicine pattern types of dementia. clinical papers were searched in China Academic Journals(CAJ) of China National Knowledge Infrastructure(CNKI) from 2012 to 2013. Conclusions are as follows. First, dementia was expressed in many ways such as imbecility, stupidity, fatuity, idiocy, vacuity, etc and was related with amnesia, forgetfulness, speech not in the right order, depressive psychosis(quiet insanity), manic psychosis, depression syndrome. Second, prescriptions such as QiFuYin and ZuoGuiWan from JingYueQuanShu, XiXinTang and ZhiMiTang from BianZhengLu, TongQiaoHuoXueTang, XueFuZhuYuTang and BuYangHaiWuTang from YiLinGaiCuo, HaiShaoDan from YiFangJiJie, HuangLianJieDuTang from WaiTaiMiYao were suggested for dementia. Third, syndrome differentiation pattern types of dementia are kidney deficiency and marrow decrease, qi-blood depletion, liver-kidney depletion, spleen-kidney depletion, heart-spleen deficiency as deficiency patterns and effulgent heart-liver fire, ascendant hyperactivity of liver yang, qi stagnation and blood stasis, phlegm turbidity obstructing orifice, phlegm-blood stasis obstructing orifice, intense heat toxin as excess patterns and qi deficiency with blood stasis, yin deficiency with yang hyperactivity as deficiency-excess complex patterns. Major pattern types are kidney deficiency and marrow decrease, phlegm-blood stasis obstructing orifice, qi stagnation and blood stasis, liver-kidney depletion, phlegm turbidity obstructing orifice.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.7 no.1
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• pp.35-51
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• 1994

This is the study on causes and remedies of hearing disturbance in chinese medical journals(1991-1993). The results were as follows. 1. The causes of sudden deafness(突發性耳聾) were usually fire in the liver(肝火).phlegmatic fire(痰火), deficiency of the vital function and essence of the kidney(腎虛), blood stasis or sludge due to stagnation of vital energy stagnation(氣滯血瘀). Remove endogenous heat or fire method(淸瀉火熱法). circulation of phlegm and dampness(運化痰濕). using tonics to cure disease due to deficiency of vital essence of both the liver and the kidney(滋補肝腎) were used for each treatment. 2.The causes of menieres disease were usually mental disturbance due to phlegmatit fire(痰化上搖). dampness-phlegm long standing(痰濕內停), water-dampness retention(水濕停滯), Method of remove heat and circulation phlegm(淸熱化痰法), method of remove water and dampness(利水渗濕法), invigorate function of the spleen and circulation of dampness method(健脾化濕法) were used for each treatment. 3. The causes of toxico-deafness(中毒性 耳聾) were usually heart, liver and kidney functional weakness(心肝腎虛), vital essence and blood weakness(氣血虛弱). Remove obstruction in the flow and circulation phlegm(通窮化痰), reinforce vital energy and tonify blood (補氣活血), using tonics to cure disease due to deficiency of vital essence of both the liver and the kidney(滋補肝腎) were used for each treatment. 4. The causes of deafness (耳聾), tinitus(耳鳴) were usually mental disturbance due to wind and heat(風熱上搖). flaming up of excessive heat of the liver(肝火上亢). exhaustion seat of reproductive essence in kidney(腎精虧虛). Remove endogenous heat and disperse wind(淸熱疏風). remove the fire of liver(淸肝瀉火), through nourish kidney check exuberance of yang(滋腎潛陽), nourish kidney yang(補腎陽). replenish vital energy and improve essential substance(益精血), blood activate for treatment of blood stasis(活血化瘀) were used for each treatment. 5. The effects of mainly used drugs were classified into method of water and dampness remove medicine(利水渗濕藥), nourishing liver and kidney medicine(補肝腎藥), improve blood and vital energy activate medicine(活血行氣藥), through nourish yan medicine check exuberance of yang(滋陰潛陽藥).

• Journal of Oriental Neuropsychiatry
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• v.16 no.2
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• pp.53-64
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• 2005

Objects : This study was aimed to investigate the treatment on Mental disorder of Women. Methods : Research data is based on Buindaejoenyangbang and Dong-uibogam. And study the treatment in Mental disorder of Women. Results : 1. Owing to women's physiological extraordinary nature, Mental disorder of Women’s treatment does not match Dongyipogam’s about the same symptoms. 2. Most of happing the symptom is due to blood Wind(four flavors) and deficiency of the Heart, treatments are dispelling Wind, tonifying blood of the Heart and calming the spirit. 3. At postpartum, Mental disorder of Women’s causes are deteriorating blood vanquished blood and external affections with a blood deficiency from the loss of blood, treatments are tonifying the blood, expel Wind and clear Cold and remove blood stagnation to promote regeneration. Conclusion : The results suggest that the extraordinary nature of the circumstances due to women specific pathology must be considered.

• The Journal of Internal Korean Medicine
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• v.21 no.1
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• pp.169-180
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• 2000

Objectives : To satisfy the demand of good treatment of constipation Methods : we investigated the literatures of Oriental Medicine about Constipation. Results: 1. There are three categories of etimological factors of constipation, that is, endogenous, exogenous and non-exo-endogenous factor. The endogenous factor is caused by seven emotions, called depression of Ki and stagnation of Ki. The exogenous factor is six excessive atmospheric influences, for example, wind, cold, dampness, heat and dryness. And the non-exo-endogenous factors are overfatigue, improper diet, stagnated blood and deficiency of Ki and blood that comes from old age, long disease and after delivery. 2. Classification: According to cause of disease it is classified by constipation due to cold, heat, wind, dryness, retention of undigested and phlegm. According to Internal Organs there are constipation due to deficiency syndrome of the stomach, excess syndrome of the stomach, deficiency syndrome of kidney and splenic constipation. And Differentiation of syndromes according to Ki and blood, there are constipation of deficiency type and excess type. There are constipation due to stagnation and deficiency of Ki, deficiency of blood and stagnated blood. 3. Principles and Methods of treatment 1) Herbal Medicine (1) Excess type [1] Constipation due to heat : Seunggitang(承氣湯) and Majainwhan(麻子仁丸) [2] Constipation due to stagnation of Ki : Samatang(四磨湯) and Yukmatang(六磨湯) (2) Deficiency type [1] Constipation due to deficiency of Ki : Whanggitang(黃?湯) [2] Constipation due to deficiency of blood: Yunjangwhan(潤腸丸) [3] Constipation due to cold : Jechunjun(濟川煎) and Banyuwhan(半硫丸) 2) Enema therapy: It is a method to induce defecation by honey or pig's bile juice for weak people. 3) Acupuncture and Moxibustion: Acupoints used to treat constipation are BL25, ST25 and TE6. Moxibustion at CV8, CV6 is good for constipation due to cold. (4) Diet therapy: It is very important that we eat meals regularly and defecate on the same time even if you don't. And we have to eat food like fruits, vegetables and beans. (5) finger pressure: Finger pressing around these points like ST25, SP25, BL25, BL31, BL32, BL33 and BL34 is good for it. (6) Kigong therapy: Abdominal breathing (7) Old man' s constipation: Hip bath or diet therapy is commended. Laxation with lubricant like Supungyunjangwhan(搜風潤腸丸) is used. (8) Women' s constipation: After delivery, we have to administer tonifying prescription Sipjundaebotang(十全大補湯) and enema can be used. Conclusion : We have to examine the cause of disease and bowl movement carefully. After comprehensive analysis of the data gained by the four methods of diagnosis, we diagnose and treat patients on the base of overall of symptoms and signs.

• Journal of Physiology & Pathology in Korean Medicine
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• v.16 no.1
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• pp.181-185
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• 2002

The thrombosis is the category of blood stasis. Blood stasis is a pathologicial state resulting from the reverse or impeded flow of blood in the body or the stagnation of blood flow in local parts as well as abnormal blood outside of the vessles which remains in the body and fails to disperse. Hwao-tang has been reported to have a hypolipidemic effect in patients with hypercholesterolemia, and in highcholesterol-induced experimental models. The present paper reports the effects of HOT on atherosclerosis using a spontaneous experimental model, Kurosawa and Kusanagi-hypercholesterolemic (KHC) rabbits. We have also investigated the pharmacological effect of extracts obtained from HOT on collagen-and ADP-induced blood platelet aggregation, thrombin-induced conversion of fibrinogen and fibrinolysis in in vitro experiments. In conclusion, the protection of extracts of Korean herbs' HOT on the ischemic infarction induced artificially might be involved to their inhibition of thrombotic action.

• The Journal of Internal Korean Medicine
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• v.31 no.1
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• pp.40-53
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• 2010

Background : It was not enough to apply three kinds of syndrome differentiation in our oriental medical textbook to tremor's treatment according to reports of Korea and traditional medical textbook of China. Objective : To investigate syndrome differentiations by types of diseases related to tremor through Chinese journals review and to suggest adding possible syndrome differentiations. Methods : Literature search was performed using China Academic Journal (CAJ), the search engine of China National Knowledge Infrastructure (CNKI) from January 1994 to December 2009. Searching key words were Chinese characters in combination meaning tremor, paralysis agitans, and syndrome differentiation. We included all types of articles that explained or referred to definite syndrome differentiations. The symptoms and oriental medications by syndrome differentiation in selected articles were extracted and summarized. Results : 56 Chinese journals were ultimately selected. 37 kinds of syndrome differentiations about tremor were investigated, which included dual deficiency of qi and blood (氣血兩虛) quoted 31 times, liver-kidney yin deficiency (肝腎陰虧) 23 times, liver-kidney deficiency (肝腎不足) 21 times, and phlegm-heat stirring wind (痰熱動風) 20 times. 37 kinds of syndrome differentiation could by group into eight types, such as liver-kidney yin deficiency (肝腎陰虧), dual deficiency of qi and blood (氣血兩虛), phlegm-heat stirring wind (痰熱動風), heart deficiency and spirit weakness (心虛神弱), blood stasis due to qi stagnation (氣滯血瘀), sea of marrow deficiency (髓海不足), liver qi depression (肝氣鬱結), and liver yang transforming into wind (肝陽化風). Conclusion : We suggest that the syndrome differentiations of tremor, such as heart deficiency and spirit weakness (心虛神弱), blood stasis due to qi stagnation (氣滯血瘀), sea of marrow deficiency (髓海不足), liver qi depression (肝氣鬱結), and liver yang transforming into wind (肝陽化風), can be added to liver-kidney deficiency (肝腎不足), dual deficiency of qi and blood (氣血兩虛), and phlegm-heat stirring wind (痰熱動風) of the textbook. Further systematic research will be needed on them.