• 대한전기학회:학술대회논문집
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• 대한전기학회 2001년도 하계학술대회 논문집 D
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• pp.2075-2077
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• 2001

For precise positioning, GPS carrier measurements are often used. In this case, accurate position having mm${\sim}$cm error can be obtained. For 3D positioning, in CDGPS, more than five carrier phase measurements are required. When GPS signals are blocked or carrier phase measurements are insufficient, it cannot provide positioning solution. By integrating CDGPS with INS, continuity of positioning solution can be guaranteed. However, when a vehicle moves in low speed or in stationary, the CDGPS/INS integrated system is difficult to compensate INS attitude errors because GPS velocity error become relatively lange. In this paper, we used the 3D attitude GPS receiver to compensate the INS attitude error. By field experiments, it is shown that the proposed integration system maintains the navigation performance even when a vehicle is in low speed or GPS signal is blocked for a period of time.

• 한국측량학회:학술대회논문집
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• 한국측량학회 2006년도 춘계학술발표회 논문집
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• pp.151-158
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• 2006

As GPS 'selective availability' was turned off in 2000, GPS related fields and markets are explosively extended. In mapping area, GPS/INS aided photogrammetry proved it is much cost and time effective method keeping enough accuracy as compared with traditional photogrammetry works. The advantage of GPS/INS integration is interdependence. Even if GPS signal was blocked in some time, the position accuracy is not affected. In this study, various GPS signal time gap was used in GPS/INS AT process. Field surveyed ground points were used in accuracy check with GPS/INS AT check points. And the result showed enough accuracy of photogrammetry work rule of NGII. y.

• 대한수학회보
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• 제53권4호
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• pp.985-1004
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• 2016

We consider the MAP/PH/c/K queue in which blocked customers retry to get service and servers may take vacations. The time interval between retrials and vacation times are of phase type (PH) distributions. Using the method of mean drift, a sufficient condition of ergodicity is provided. A condition for the system to be unstable is also given by the stochastic comparison method.

• 생명과학회지
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• 제25권2호
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• pp.231-236
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• 2015

Angiotensin II (AngII)는 혈관평활근세포의 수축을 통해 혈관을 수축시키는 강력한 작용을 나타낼 뿐만 아니라 혈관세포의 성장 등에 중요한 역할을 한다. 본 연구에서는 AngII에 의해 형성되는 활성산소가 phosphatidylinositol 3-kinase (PI3K)에 유리되는 칼슘에 의해 조절된다는 것을 검증하였다. 쥐의 대동맥으로부터 분리된 혈관평활근세포에서 AngII에 의해 활성산소가 농도 의존적, 그리고 시간 의존적으로 형성됨을 관찰하였다. AngII에 의해 형성되는 활성산소는 PI3K의 억제제에 의해 봉쇄되었으나 EKR의 억제제에 의해서는 봉쇄되지 않음을 알 수 있었다. AngII에 의해 유리되는 칼슘은 L-type 칼슘이온통로 봉쇄제인 Nifedipine 또는 배양액에 칼슘이 제거된 환경에서 억제됨을 확인할 수 있었다. 마지막으로 AngII에 의해 형성되는 활성산소는 배양액에 칼슘이 없는 조건이나 L-type 칼슘이온통로 억제제를 전처리 하였을 경우 억제되는 것을 확인하였다. 이러한 결과들을 바탕으로 쥐의 대동맥으로부터 분리된 혈관평활근세포에서 AngII에 의한 활성산소의 형성은 PI3K/L-type 칼슘이온통로를 통한 기전을 통해 조절됨을 제안한다.

• 한국태양에너지학회 논문집
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• 제32권2호
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• pp.74-86
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• 2012

For the improvement of environmental comfort in the buildings with the blind control, the objective of this study is to prevent the direct glare caused by the daylight inlet. During the process of solar profile prediction, time are significant factors that may cause error and glare during the blind control. This research proposes and evaluates the correction and control method to minimize prediction error. For the local areas with different longitude and local standard meridian, error occurred in the process of the time conversion from local standard time to apparent solar time. In order to correct error in time conversion, apparent solar time should be recalculated after adjusting the day of year and the equation of time. To solve the problems by the potential time errors, control method is suggested to divide the control sections using the calibrated fitting-curve and this method is verified through simulations. The proposed correction and control method, which considered potential time errors by loop lop leap years, could solve the problems about direct glare caused by daylight inlet on the work-plane according to the prediction errors of solar profile. And also these methods could maximize daylight inlet and solar heat gain, because the blocked area on windows could be minimized.

• 호남수학학술지
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• 제30권1호
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• pp.75-89
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• 2008

Interrupted blood flow diminishes the concentration of oxygen in tissues. Hypoxia first appears in the region distal to the capillaries and grows throughout the entire t issue. However, the time-wise evolution of hypoxic area is diverse when some of capillaries are blocked in a multi-capillary domain with different oxygen squirt. The process of the development of hypoxia through time course is analyzed mathematically in the domain. Each source in steady state is controlled by a time sensitive function to simulate the occlusion.

• Biomolecules & Therapeutics
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• 제12권4호
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• pp.242-249
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• 2004

The main aim of this study was to investigate stress related activities of Sun-ginseng extract as a candidate for anti-stress-related functional supplement by comparing its effect to those of red ginseng, which is also known to alleviate stress. Normal group was not exposed to stress while the control group was exposed to stress. Rats were orally administered once a day with 200 mg red ginseng (RG) extract, 100 or 200 mg Sun-ginseng (SG) extract/kg body weight. Mice were given water containing 400 mg red ginseng extract, 200 or 400 mg SG/100 mL potable water. Rats were given supplements for 5 days without stress, and 5 days with restraint and electroshock stress. After final stress, stress-related behavioral changes of experimental animals were recorded and levels of blood corticosterone were measured. Mice were given supplements for 5 days through drinking water, and then fatigue related motor activity were recorded. SG-supplementation partially blocked stress effect on locomotion and elevated plus maze test in rats, and also partially blocked stress-induced behavioral changes such as freezing, burrowing, smelling, facewashing, grooming and rearing behavior in rats. SG-supplementation decreased blood corticosterone level which is increased by stress in rats. Effects of SG may not be modulated by GABAnergic nervous system. SG-supplementation prolonged swimming time and staying time on the wire and rotarod wheel in mice. These results suggest that SG partially protects living organisms from stress attack in some cases and thus has the potential to be used as a functional food to alleviate stress response.

• The Korean Journal of Physiology and Pharmacology
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• 제9권6호
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• pp.353-361
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• 2005

The interaction of cyclosporine A (CsA), an immunosuppressant, with rat brain Kv1.5 (Kv1.5) channels, which were stably expressed in Chinese hamster ovary cells, was investigated using the whole-cell patch-clamp technique. CsA reversibly blocked Kv1.5 currents at +50 mV in a reversible concentrationdependent manner with an apparent $IC_{50}$ of 1.0μM. Other calcineurin inhibitors (cypermethrin, autoinhibitory peptide) had no effect on Kv1.5 and did not prevent the inhibitory effect of CsA. Fast application of CsA led to a rapid and reversible block of Kv1.5, and the onset time constants of the CsA-induced block were decreased in a concentration-dependent manner. The CsA-induced block of Kv1.5 channels was voltage-dependent, with a steep increase over the voltage range of channel opening. However, the block exhibited voltage independence over the voltage range in which channels were fully activated. The rate constants for association and dissociation of CsA were $7.0{\mu}M{-1}s^{-1}$ and $8.1s^{-1}$, respectively. CsA slowed the deactivation time course, resulting in a tail crossover phenomenon. Block of Kv1.5 by CsA was use-dependent. CsA also blocked Kv1.3 currents at +50 mV in a reversible concentration-dependent manner with an apparent $IC_{50}$ of $1.1{\mu}M$. The same effects of CsA on Kv1.3 were also observed in excised inside-out patches when applied to the internal surface of the membrane. The present results suggest that CsA acts directly on Kv1.5 currents as an open-channel blocker, independently of the effects of CsA on calcineurin activity.

• 인터넷정보학회논문지
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• 제15권6호
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• pp.55-64
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• 2014

웹 애플리케이션에서 클라이언트와 서버간의 정보전달의 핵심요소인 URL 파라미터는 F/W이나 IPS등의 네트워크 보안장비를 별다른 제약없이 통과하여 웹서버에 전달된다. 공격자는 이렇게 전달되는 파라미터를 변조하여 조작된 URL을 요청하는 것만으로도 인가받지 않은 기밀정보를 유출하거나 전자상거래를 통하여 금전적 이익을 취할 수 있다. 이러한 파라미터변조 취약점은 해당 애플리케이션의 논리적 판단에 의해서만 조작여부를 확인할 수 있어 웹 방화벽에서 차단할 수 없다. 이에 본 논문에서는 기존 방지기법의 취약점을 점검하고 이를 보완하는 OTACUS (One-Time Access Control URL System)기법을 제시한다. OTACUS는 파라미터가 포함된 복잡한 URL을 단순화 하는 간편URL기법을 이용하여 공격자에게 URL노출을 막음으로써 POST이나 GET방식으로 서버로 전달되는 파라미터의 변조를 효과적으로 차단할 수 있다. 실제 구현된 OTACUS의 성능 실험결과 3%이내의 부하가 증가함을 보여 안정적인 운영이 가능함을 증명한다.

• The Korean Journal of Physiology and Pharmacology
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• 제24권6호
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• pp.545-553
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• 2020

Aripiprazole is a quinolinone derivative approved as an atypical antipsychotic drug for the treatment of schizophrenia and bipolar disorder. It acts as with partial agonist activities at the dopamine D2 receptors. Although it is known to be relatively safe for patients with cardiac ailments, less is known about the effect of aripiprazole on voltage-gated ion channels such as transient A-type K⁺ channels, which are important for the repolarization of cardiac and neuronal action potentials. Here, we investigated the effects of aripiprazole on Kv1.4 currents expressed in HEK293 cells using a whole-cell patch-clamp technique. Aripiprazole blocked Kv1.4 channels in a concentration-dependent manner with an IC₅₀ value of 4.4 μM and a Hill coefficient of 2.5. Aripiprazole also accelerated the activation (time-to-peak) and inactivation kinetics. Aripiprazole induced a voltage-dependent (δ = 0.17) inhibition, which was use-dependent with successive pulses on Kv1.4 currents without altering the time course of recovery from inactivation. Dehydroaripiprazole, an active metabolite of aripiprazole, inhibited Kv1.4 with an IC₅₀ value of 6.3 μM (p < 0.05 compared with aripiprazole) with a Hill coefficient of 2.0. Furthermore, aripiprazole inhibited Kv4.3 currents to a similar extent in a concentration-dependent manner with an IC₅₀ value of 4.9 μM and a Hill coefficient of 2.3. Thus, our results indicate that aripiprazole blocked Kv1.4 by preferentially binding to the open state of the channels.